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This book constitutes the proceedings of the 27th International Symposium on VLSI Design and Test, VDAT 2023. The 32 regular papers and 16 short papers presented in this book are carefully reviewed and selected from 220 submissions. They are organized in topical sections as follows: Low-Power Integrated Circuits and Devices; FPGA-Based Design and Embedded Systems; Memory, Computing, and Processor Design; CAD for VLSI; Emerging Integrated Circuits and Systems; VLSI Testing and Security; and System-Level Design.

This book is a collection of peer-reviewed best selected research papers presented at the Fifth International Conference on Advances in Distributed Computing and Machine Learning (ICADCML 2024), organized by the School of Electronics and Engineering, VIT - AP University, Amaravati, Andhra Pradesh, India, during January 5–6, 2024. This book presents recent innovations in the field of scalable distributed systems in addition to cutting-edge research in the field of Internet of Things (IoT) and blockchain in distributed environments.

This textbook deals comprehensively with livestock production diseases and their prevention in the major species: ruminants, swine, and poultry. It gives an interdisciplinary view on pathophysiology, prophylaxis, and health management.Livestock breeding and husbandry is often accompanied by a conflict of interest between the animal´s biological requirements and economic producer needs. This conflict is increasingly gaining attention not only by producers, animal scientists, and veterinarians, but also by the public. It creates significant future challenges, which are described and addressed in this book. The main topics covered are: •the use of antimicrobials with emphasis on security and safety for producers/consumers•the impact of locomotion disorders on performance and welfare of farm animals •the interactions of gut microbiome, genetics, climate change, metabolic status and mineral homeostasis with reproduction, performance, animal health and welfare•infectious and respiratory diseases•the raising of neonatesA special section is devoted to behavioural signs indicating an impaired animal welfare. These are the basis for precision livestock farming (PLF) technology and the development of new management concepts. The present work is a valuable resource for veterinarians, students, as well as expert readers from animal and agricultural sciences, food safety and technology. Supplementary videos can be accessed online as well as directly from the print book; simply download the Springer Nature More Media App for free and scan the links with the play button.

Eine solide Gutachtentätigkeit basiert auf profunder medizinischer Sachkenntnis und neutraler, ausgewogener, wissenschaftlich begründeter Argumentation. Diese umfassende Nachschlagewerk beinhaltet alle Aspekte für die Gutachtenerstellung im HNO-Fachgebiet. Es wendet sich an alle Ärztinnen und Ärzte, die mit der Gutachtertätigkeit beginnen wollen, aber auch an bereits erfahrene Gutachter, die einen Überblick über Literatur, rechtliche Zusammenhänge u.a. suchen. Aus der Praxis: Zahlreiche Beispiele aus der langjährigen Gutachtenpraxis des Autors, Gerichtsurteile, aktuelle Rechtsprechung zum Zitieren, Berücksichtigung der neuesten Leitlinien, Empfehlungen, Verordnungen und Gesetze. Zum Nachschlagen: Formulierungsvorschläge, Querverweise auf Literaturdatenbanken und Originalquellen, Literaturverzeichnis mit DOI und Links zur Einsicht der OriginaltexteFür Zustands- und Zusammenhangsgutachten bis zum umfangreichen freien Gerichtsgutachten mit Sachverständigenanhörung in allen Rechtsgebieten geeignet.

In the last decades it has become more and more imperative for our societies, and for decision makers in all areas of society, to understand the dynamics through which innovation systems develop and through which socio-technical systems transform themselves. As both innovation and transformation are strongly intertwined, it has equally become imperative to analyse their dynamics as well as their interplay. This open access volume reflects on the research fields that have developed in the last five decades to do exactly that. It defines and delineates research on systems and innovation as encompassing the scientific study of, first, the conditions, dynamics and impacts associated with the generation and uptake of innovations and, second, the development and transformation of functional systems satisfying essential needs such as the provision of energy or water. Further, the area of Systems and Innovation Research (SIR) is characterised by problem and stakeholder oriented research. We chose five decades as time frame because we noted that roughly 50 years ago a number of research institutes dedicated to SIR were founded and the SIR area started to grow significantly. We present a systematic history of nine selected fields within the area of SIR (Innovation policy, Innovation indicators, Foresight, Policy Evaluation, Technology Assessment, Production Paradigms, Renewable Energies, Energy Efficiency, Water Use). We also present a conceptual framework to understand the processes by which the research fields have developed. This allows to draw general lessons as to what drives fields throughout their development and how their role vis-à-vis policy, businesses and societies changes over time. It also allows to speculate about future challenges and trends in the SIR area. This is important because, if anything, the need to govern transformation through innovation will further grow in the future, and with it the need to understand the underlying dynamics.

This volume highlights current research on how the neuroendocrine system helps to influence emotional states and ultimately behavioral output. Social relationships and context-appropriate behavioral responses are important for the survival of most vertebrate species. These relationships can range from transient social interactions to strong social bonding between sexual partners and social behaviors can be observed and evaluated from the individual- to the group-level. Further, behavioral output is shaped by complex interactions between the physical environment, genetics, experience, and context, and are often modulated by the neuroendocrine system. In this book, experts in the field will provide a sweeping look at novel research in the neuroendocrine regulation of important behaviors ranging from parental care to social homeostasis, with a focus on comparative studies across vertebrate species. The first part of the book is dedicated to theneuroendocrinology of relationships, including the coordination of acoustic signals in songbirds, the complexity of social relationships in primates, and cooperation and parenting in humans. The second part of the book focuses on social behaviors and provides some insights into their regulation, including the neuroendocrine regulation of maternal behavior in rodents, the roles of oxytocin and vasopressin in the modulation of sex-specific social behavior, the interactions between adult neurogenesis, the neuroendocrine system and social behavior, and a consideration of neuroendocrine influences on reproductive decision making across species. The book concludes with a section on environmental influences on neuroendocrine systems underlying behavior, including how social isolation and endocrine disrupting chemicals affect the neuroendocrinology of behavior and emotions. Given its breadth, this volume is appropriate for undergraduate students, graduate students, postdoctoral researchers, and established researchers who are interested in neuroendocrinology and behavior. This is the sixteenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

The successful book of andrology now in a new edition! This book gives a complete, interdisciplinary overview of the central topics of andrology, infertility, hypogonadism, contraception and erectile dysfunction. It contains detailed information on the clinical practice of couple treatment, andrology-relevant gynecology and modern methods of assisted fertilization, psychological factors of infertility, endocrinology and reproductive functions of the aging man as well as on an important sub-area of ​​andrology, the male contribution to contraception. In addition, the relevant scientific foundations (including molecular biology and genetics) are also covered. Completely revised and updated according to the latest scientific research, the new edition represents a reference for andrology, which no doctor who deals with the topic can miss. For andrologists, practitioners and residents, urologists, dermatologists and internists who deal with the area of​​andrology and male reproductive medicine.

This completely updated 4th edition now includes two volumes: it retains the easy-to-use handbook format of the previous successful book, while fulfilling the need for a review of the content. Taking into consideration recent advances in systemic and topical treatments, state-of-the-art lasers, and the latest evidence-based recommendations, it now includes biologic agents for psoriasis and their use as off-label treatments in other skin disorders, targeted agents for malignant melanoma and basal cell carcinoma, and new treatment modalities for rosacea, acne, atopic dermatitis, and urticaria, to name but a few. The European Handbook of Dermatological Treatments provides concise, up-to-date overviews of treatment guidelines and clinical pearls for a large number of skin diseases. It is divided into three main sections addressing the many different skin diseases, the drugs available for dermatological treatments, and the various methods applied in dermatology, including fillers, botulinum toxin, lasers, dermoscopy, cryosurgery, and electrosurgery. Written by a recognized expert in the field, each chapter focuses on a particular skin disease, illustrating current treatments while providing a brief synopsis of the etiology and clinical presentation of the disease. Treatment indications and contraindications, modes of action, and dosages are clearly identified and the content is enhanced by a wealth of clinical pictures and tables, making it an engaging tool for professionals, and a valuable learning resource for young practitioners, as well as postgraduate students and residents.

Das Standardwerk der Andrologie - jetzt komplett aktualisiert! Das Buch gibt einen vollständigen, interdisziplinären Überblick aller Themen der Andrologie, u.a. · der Infertilität, · des Hypogonadismus, · der männlichen Kontrazeption, · der erektilen Dysfunktion und · der Varianten der sexuellen Differenzierung. Der Leser erhält detaillierte Informationen über · die Physiologie der Hoden- und Spermienfunktion · die Diagnostik und Therapie einschl. operativer Verfahren in der Andrologie · die klinische Praxis der Paarbehandlung, · relevante Fakten aus der Gynäkologie, · moderne Verfahren der assistierten Fertilisation · psychologische Faktoren der Sexualität und Infertilität · Umwelteinflüsse auf die Fertilität · Therapie mit Testosteron und Missbrauch · endokrinologische und reproduktive Funktionen des alternden Mannes. · Fertilitätsprotektion · rechtliche und ethische Grundlagen der Andrologie Zusätzlich werden die relevanten naturwissenschaftlichen Grundlagen – einschließlich Molekularbiologie und -genetik – abgedeckt. Komplett nach dem neuesten Stand der wissenschaftlichen Erkenntnis überarbeitet, aktualisiert und praxisorientiert ist der Nieschlag das Standardwerk der Andrologie, an dem keine Ärztin und kein Arzt, der sich mit dem Thema befasst, vorbeikommt. Für Andrologen und Teilnehmer der Zusatzbezeichnung'Andrologie', Urologen, Dermatologen und Internisten, die sich mit dem Gebiet Andrologie beschäftigen. Für Reproduktionsbiologen und Reproduktionsmediziner mit Interesse an der Paarbehandlung.

This book delves into the anthropogenic activities responsible for environmental hazards, their compensation, and potential mitigation strategies. It sheds light on the major contributors to the climate change issues aggravated by non-sustainable practices for the overexploitation of natural resources. Critical topics such as high emissions in primary mining, the recovery of energy-critical metals by urban mining, solid waste management, and forest conservation are explored, offering insights into the urgent challenges we face.Amidst the rapid demand for resources and the expansion of human habitats, the book emphasizes the need for new approaches to natural resource management and introspection of our actions. Experts in the field discuss existing anthropogenic environmental hazards in detail, alongside environmental compensation, and effective mitigation approaches.The book begins with a chapter dedicated to risk assessment in primary mining activities for precious metals, proposing potential routes for mitigation. Chapter 2 focuses on assessing and mitigating the environmental footprints of energy-critical metals used in permanent magnets. In Chapter 3, a case study examines sustainable resource utilization through end-of-life room air conditioner recycling. Additional chapters provide critical insights into:The environmental impacts of e-waste and government policies for responsible managementHazards associated with industrial effluents and corresponding mitigation strategiesThe role of roadside plants in phytoremediation of heavy metal pollutionSustainable utilization of anthropogenic coal fly ash through mechanical and chemical activationEnvironmental damages resulting from the mismanagement of municipal solid wasteEnvironmental problems and remediation strategies for anthropogenic biomass wasteChallenges in sustainable municipal solid waste management and suggestionsfor environmental risk mitigation The book concludes with a chapter discussing collaborative governance and non-monetary compensation mechanisms for sustainable forest management. Given its breadth, this book serves as an indispensable resource for researchers, policymakers, and environmental professionals seeking sustainable approaches to tackle pressing environmental challenges.

Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.

This contributed volume discusses the current status of the occurrences, fate and transport of persistent pollutants in water and wastewater. This contents compile the state-of-the-art of emerging technologies such as nanotechnology, advanced oxidation process, membrane processes, sorption, etc. for the clean-up of persistent pollutants in water including heavy metals, pharmaceuticals, phenolic compounds as well as microplastics and their by-products. This volume will be useful as a guide for the researchers to build strategies to deal with persistent pollutant. It also discusses the principal aspects of degradation mechanism of the pollutants, toxic by-products and effectiveness of the emerging technologies. This volume will be a useful guide for those working in soil and water protection, and environmental civil engineering.

This open access book focuses on of the impact of endocrine disrupting chemicals (EDCs) on human reproduction. It comprehensively discusses the three most important topics in the field: the basic biology of EDCs; the effects of EDCs on human reproduction and human reproductive systems; and potential interventions and practical advice for dealing with the problems caused by EDCs.Presenting a translational approach to endocrine disrupting chemicals research, spanning both basic biology and clinical applications, the book provides a critical link between laboratory investigations and clinical practice. Written by international experts in the field, it is a valuable reference resource for gynaecologists, obstetricians, endocrinologists and experts in reproductive medicine, and a useful tool for anyone interested in the impact of the environment on human reproduction.

This book presents a comprehensive and detailed overview of indoor pollution, covering the main contaminants in the indoor environment – air and dust, the health aspects of exposure, and different possibilities for a risk assessment. The book outlines the chemical substances and physical and biological factors that occur more frequently indoors, which are of health significance, or for which only limited information on their occurrence indoors is available to date. It also provides guidance to identify where problems may arise in the future and where data is missing for a valid exposure and risk assessment as well as for consequent risk management. Written by a highly recognized and experienced medical expert in the field, the book starts with an introduction to the indoor environment, including topics such as indoor environmental quality and health, indoor climate, sampling of indoor pollutants, and measures to improve indoor air quality. The author then delves into the fundamentals of exposure assessment and special exposure indoor situations, followed by in-depth coverage of the health aspects, and indoor air occurrence of several substances such as volatile organic compounds, very volatile organic compounds, semi-volatile organic compounds, and particulate matters and fibers. Particular attention is given to bioaerosols like mold, microbial volatile organic compounds, mycotoxins, and viruses. Readers will also find chapters devoted to the main health aspects and indoor occurrence of inorganic gases, radon and metals, and smoking. The book closes with a chapter on risk assessment, in which readers will learn more about the basics of risk assessment, key points and processes of a health evaluation, and guidance for assessing indoor air contamination. This book is a unique compilation of the current worldwide exposure situation in private and public indoor spaces, and an important reference for researchers that are willing to assess the rising burdenof disease and potential causes behind degraded indoor air quality. Scientists, students, and policymakers interested in the fields of medicine and environmental sciences will understand the appeal of this book.

This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to ‘living editions'that are constantly updated using a dynamic peer-review publishing process.

The Handbook of Green and Sustainable Nanotechnology presents sustainable and green technologies for the development of products and processes which are environmental friendly, economically sustainable, safe, energy-efficient, decrease waste and diminish greenhouse gas emissions. It provides the overall spectrum of fundamentals, development and applications of sustainable and green technologies. Topics such as legal, health and safety issues are discussed as well. The book elucidates paths to real time utilization of green and sustainable nanotechnology at commercial scale.

This encyclopedia is the most comprehensive and up-to-date source of reference for sustainability in business and management. It covers both traditional and emerging concepts and terms and is fully international in its scope. More than 700 contributions of internationally renowned experts provide a definitive access to the knowledge in the area of sustainable and responsible management. All actors in the field will find reliable and up to date definitions and explanations of the key terms and concepts of management in this reference work. The Encyclopedia of Sustainable Management represents all aspects of management and business conduct. It takes sustainability as a management concept that gives due credit to the complexity and diverging constraints in which businesses and corporations act today, and it emphasizes and focuses approaches that help ensure that today's management decisions and actions will be the basis for tomorrow's prosperity.

Climate change is one of the most severe dangers for mankind worldwide. Beside the temperature increase, the sea level will rise and flood wide coastal areas, which is already remarkable today. The effects will be dramatic, in particular, at coasts with low elevation gradients such as at the German coasts of the North and Baltic Sea. The impact will be not only severe for coastal people, but still more for the unique coastal ecosystems, which harbors many plant and animal species that are already endangered today.This book focuses on the coastal terrestrial ecosystems of the German North and Baltic Sea. It describes the reactions of plants and animals (i.e. spiders, carabid beetles, bees and nematodes) on the future temperature and sea level increase. The combination of field and experimental studies is unique for Europe and for many parts of the world. It not only studies the actual elevation gradients and the climatic and saline gradients fromWest to East, but also the historical changes to document processes at coastal ecosystems that were already passed. In contrast to many books that studied the marine processes with similar backgrounds, this book concerns the terrestrial coastal ecosystems that were overall rarely studied and, in particular, never studied under this specific viewpoint.

Zu betrieblicher Gesundheitsförderung und zu Gesundheitsmanagement liegen zahlreiche Veröffentlichungen vor. Es fehlen jedoch Publikationen, in denen aktuelle Entwicklungen des Arbeitslebens, besonders Digitalisierung, hinreichend berücksichtigt werden. Digitalisierung hat für Gesundheit und für Gesundheitsförderung eine doppelte Relevanz: Sie verändert das Arbeitsleben und dabei Arbeitsverhältnisse, Arbeitsorganisation und Arbeitsbedingungen, und sie beeinflusst Methoden und Instrumente der Gesundheitsförderung. Dieser Band gibt praktisch nützliche und wissenschaftlich fundierte Handlungshilfen für gesundheitsbezogene Maßnahmen in der digitalisierten Arbeitswelt. Zentrale Entwicklungen der Arbeitswelt sowie digital gestützte Methoden der Gesundheitsförderung werden dargestellt und diskutiert.

This book constitutes the proceedings of the 20th International Symposium on Intelligent Data Analysis, IDA 2022, which was held in Rennes, France, during April 20-22, 2022. The 31 papers included in this book were carefully reviewed and selected from 73 submissions. They deal with high quality, novel research in intelligent data analysis.

This edited open access volume explores the role of forest bioeconomy in addressing climate change. The authors put a particular focus on planetary boundaries and how the linear, growth-oriented economy, is coupled with climate change and environmental degradation. Biobased products and sustainable production paths have been developed, but how can they be scaled in order to lead to an economic paradigm shift? This and other questions are discussed throughout the volume.Since science indicates that climate change will continue this century, the authors also analyse how forests can be adapted to increasing forest disturbances that changing climate are expected to cause. The authors propose climate-smart forestry as useful approach for climate mitigation and adaptation of forests to climate change, as wells as sustainable increase of economic well-being based on forestry. The book illustrates the application of climate-smart forestry in the Czech Republic, Finland, Germany and Spain, i.e., in EU countries with quite different forests and forest sectors. This proactive and inspiring volume is an essential resource for Forest Management professionals, decision makers, scientists, and forestry students.

This book aims to give a contribution to a more comprehensive and interdisciplinary understanding of the cross-cutting issues on energy, environment and health research topics in the current world scenario, where nations all over the world are struggling to accomplish the United Nations Sustainable Development Goals and to ensure sustainable patterns for all. This interdisciplinary implies a commitment between all fields of science, working together to provide knowledge that could result in the promotion of quality of life. At the present, it is evident that not all people benefit from sustainable policies and practices and the communication between health, energy, environmental and social problems is undeniable. A call for different views could be a pathway attracting universities, stakeholders, organizations and civil society to deeply discuss how one solution does not fit all societies. Few publications are coherently handling this matter. This book is expected to fill this gap and to develop an interest in a larger audience working in general sustainable development and cross-cutting issues. This book is produced by the European School of Sustainability Science and Research (ESSSR). It gives special emphasis to state-of-the-art descriptions of approaches, methods, initiatives and projects from universities, stakeholders, organizations and civil society across the world, regarding cross-cutting issues in energy, environment and health research.

This volume provides a collection of research findings on the distribution and risk associated with emerging contaminants (ECs) in water and wastewater across the globe, and effective remediation techniques and technologies. The book covers various monitoring techniques for ECs in water and wastewater and its related impacts on the ambient environment, and offers valuable information on cost-effective monitoring techniques and sustainable treatment technologies for ECs. The authors detail the risks and biological effects of ECs and legacy persistent organic pollutants (POPs) in freshwater and marine systems, including their adverse interactions with aquatic organisms, while also discussing the associated impacts on human health. The book comprehensively covers current research outcomes on treatment methods, cost-effectiveness, and infrastructure needs for effective removal of ECs. It will be of interest to students, researchers, and scholars in environmental science and engineering, water and wastewater, toxicology, environmental biotechnology, soil sciences, and microbial ecology.

This edited book first gives an overview of issues in the studies of atmospheric sciences and then elaborates on extreme events in air pollution, their assessment, impacts, and mitigation strategies. It covers general overview of factors governing in atmosphere that lead to air pollution, description about recent and hazardous air pollution episodes, emergencies and extremes in atmospheric sciences, impact studies on living organisms and atmosphere related to emergencies and possible remedies/mitigation strategies which may also include green growth strategies for management. Increase in anthropogenic activities from different sources results in very high concentrations of air pollutants in the atmospheres and they lead to cause disturbance in seasonal cycles and atmospheric phenomena, ecological imbalance and change in the quality of air. These impacts are the major cause of short-term or long-term effects on living and non-living systems. In the recent years, several instances of extremes atmosphere and air pollution related emergencies causing accidental episodes, fog, smog, health related, heat and cold wave etc. are experienced. This book brings the attention on such issues in atmospheric sciences and discuss the disaster preparedness and management plus emergencies. This book is valuable reading material for students in Environmental Science, Biological Science, Medical Science, Policy Planning, Disaster Management and Agriculture. It's useful for environmental consultants, researchers and other professionals involved in air quality, plant, humans and disasters related research.

This book highlights the vital necessity for combining sustainable development processes from different areas, with applications in areas such as science, education and production sectors. These sectors have previously been separated by linguistic and technological barriers. Breaking down these barriers will allow an interdisciplinary and transdisciplinary flow of information, leading to greater efficiency, and towards a more real resilient and sustainable economy development. This book fills in the gap in respect of publications addressing aspects of innovation and sustainable development and focuses on a range of areas, such as I. Gradual transition to innovative development; II. Continuity of technology in education, science and industry; III. Convergency directions, interdisciplinary relations in scientific research; IV. Digital technologies for sustainable development; V. Global trends and regional aspects of innovation and traditions in environmental management; VI.International legal regulations and environmental and economic relations among business communities. The publication fosters the global efforts towards taking better advantage of the many opportunities which innovation in specific areas may offer.

This volume discusses how environmental pollutants are involved in the pathogenesis of neurological disorders, and covers specific mechanisms and risk factors, as well as the necessary strategies to reduce the adverse impacts of environmental pollutants on the human nervous system. With a collection of contributions from experts in environmental pollution, neurology and pharmaceutical chemistry, the book provides both an introduction to the pathogenesis of neurodegeneration, including the types and different classes of neurological disorders, and studies demonstrating the clear link between environmental contaminants (e.g. pesticides, smoking, mycotoxins, persistent organic pollutants (POP's), polychlorinated biphenyls, phthalates, nanomaterials) and the development of neurological disorders in vulnerable populations. The book fills in a gap in research on the topic by also covering state-of-the-art treatment strategies and mitigation measures for each type of pollutant. The book will be of interest to environmental scientists, pharmacologists, toxicologists, biochemists, biotechnologists, and food and drug regulatory organizations.

This volume takes a multidisciplinary approach to study and evaluate the global human vulnerability to the exposure of contaminants of emerging concern (CECs) in the natural environment. It provides a comprehensive resource on structurally diverse groups of chemical compounds that have adverse effects on the aquatic environment. It explores the global strength, environmental status, chemical risk assessment and management strategies of CECs with relevant modern techniques. The principle focus is on concurrent emerging water quality issues. It defines the impacts of the environmental exposure of trace concentrations of CECs and/or their metabolites and discusses possible technological advances to combat the emerging pollutants. It will be useful to researchers, multi-stakeholder expert groups, policymakers, and graduate students.

The sixth edition of Contact Dermatitis covers in detail every conceivable aspect of irritant and allergic contact dermatitis and its modern-day management. The 1st edition of this book was published in 1992 and has served as the main reference book of contact dermatitis. In this new edition special emphasis is given to immunological mechanisms, molecular aspects of sensitizers, atypical clinical forms, patch test methodology, reactions to medicaments, and occupational and environmental factors. In order to optimize the diagnostic approach, a wide range of information is provided, including a dictionary of contact allergens and detailed information on exposure assessment. Retained chapters from the previous edition have been thoroughly revised to reflect the latest knowledge. Furthermore, completely new chapters have been added on a variety of topics, including contact allergy to medical implants, relevant allergens in gloves and immediate reactions to occupational materials. The editors and authors are all leading practitioners in the field. The comprehensive but approachable text is supplemented by a large number of full colour illustrations and tables. Core messages highlight the most important information and will help the reader to gain a better understanding of the subject and greater competence in everyday practice.

This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.

This volume describes the identification of emerging organic pollutants, mainly from industrial sources, their associated toxicological threats, and the latest green methods and biotechnological solutions to abate harmful impacts on people and the environment. The chapters present reviews on current applied toxicology research, occupational health hazards and green remedial solutions for pollution control in terrestrial and aquatic environments, with the aim of raising public awareness of these issues and providing chemists, toxicologists and environmental scientists with the knowledge to combat organic pollutants through sustainable means. Readers will learn about the multi-dimensional applications of materials and processes which harvest energy out of environmental remediation technologies, as well as the roles of biotechnology and nanotechnology in addressing high pollutant load. Specific attention is paid to technologies that draw energy through wastewater remediation, as this covers the primary means by which organic pollutants are introduced into the environment from industry and other sources. The book will be of use to pollution control boards, industry regulators, and students and researchers in the fields of biotechnology, biomedical science, hydrology and water chemistry.

This book is the third volume of a three-part textbook suitable for graduate coursework, professional engineering and academic research. It is also appropriate for graduate flipped classes. Each volume is divided into short chapters. Each chapter can be covered in one teaching unit and includes exercises as well as solutions available from a dedicated website. The salient ideas can be addressed during lecture, with the rest of the content assigned as reading material. To engage the reader, the text combines examples, basic ideas, rigorous proofs, and pointers to the literature to enhance scientific literacy. Volume III is divided into 28 chapters. The first eight chapters focus on the symmetric positive systems of first-order PDEs called Friedrichs'systems. This part of the book presents a comprehensive and unified treatment of various stabilization techniques from the existing literature. It discusses applications to advection and advection-diffusion equations and various PDEs written in mixed form such as Darcy and Stokes flows and Maxwell's equations. The remainder of Volume III addresses time-dependent problems: parabolic equations (such as the heat equation), evolution equations without coercivity (Stokes flows, Friedrichs'systems), and nonlinear hyperbolic equations (scalar conservation equations, hyperbolic systems). It offers a fresh perspective on the analysis of well-known time-stepping methods. The last five chapters discuss the approximation of hyperbolic equations with finite elements. Here again a new perspective is proposed. These chapters should convince the reader that finite elements offer a good alternative to finite volumes to solve nonlinear conservation equations.

Now in its updated second edition, this book describes emerging chiral environmental pollutants and their importance in environmental and human toxicology, as well as enantiomer selective separation and analytical methods. Compared to the first edition from 2001, the book has been completely restructured and a wealth of new material has been added to account for new developments. The book reports on the modern enantiomer selective separation methods, including enantio-selective chromatography techniques, which have even been successfully tested in space during the ESA Rossetta mission. The authors clearly outline why the topic of chiral environmental pollutants has become even more important: many new chiral compounds have been released in recent years (e.g. as new pharmaceuticals or agrochemicals), and traces of these compounds can now be found in the environment. The authors explain that (and how) chirality can be a very important feature for the bioactivityof anthropogenic pollutants. In this book, readers find an introduction to the topic, including all important aspects, from the introduction of new enantiomer selective analytical methods, and of emerging chiral environmental pollutants, to aspects on environmental and human toxicology and exposure, risk assessment, and aspects on climate change as well as other new aspects on chirality in the environment. The book is thus a must-read for everybody working in the field of chiral environmental pollutants, but it is also beneficial for teaching purposes in specialized post-graduate courses in advanced analytical chemistry, pharmaceutical analytics, or environmental chemistry.

Mobile Edge Computing (MEC) provides cloud-like subscription-oriented services at the edge of mobile network. For low latency and high bandwidth services, edge computing assisted IoT (Internet of Things) has become the pillar for the development of smart environments and their applications such as smart home, smart health, smart traffic management, smart agriculture, and smart city. This book covers the fundamental concept of the MEC and its real-time applications. The book content is organized into three parts: Part A covers the architecture and working model of MEC, Part B focuses on the systems, platforms, services and issues of MEC, and Part C emphases on various applications of MEC.This book is targeted for graduate students, researchers, developers, and service providers interested in learning about the state-of-the-art in MEC technologies, innovative applications, and future research directions.

This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to the impacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children's environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines furtherresearch directions and related policymaking aspects. Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children's health can be affected by harmful chemicals and other environmental toxicants.

This book discusses a major issue in the food contact materials industry: non-intentionally added substances (NIAS), and their impact on PET-bottled water. NIAS are chemical compounds that are present in food contact materials but have not been added for technical reasons during the production process, and consumers are usually unaware of their presence. NIAS can include decomposition or degradation products, impurities in the raw materials, unwanted by-products or contaminants from recycling processes, and they pose a challenge for packaging manufacturers.In Europe, the EU Regulations No. 1935/2004 and 10/2011 set out, respectively, the general principles of safety and inertness for all packaging materials, and rules on the composition of plastic food-contact materials. Among the plastics commonly used for bottled water and other non-alcoholic refreshment beverages, polyethylene terephthalate (PET) is the most favoured thanks to its chemical and physicalstability, its transparency, low weight and good recyclability. Further, very few additives are used for its manufacture. Nonetheless, due to the complex formulations of polymers, processes and storage, NIAS can also be found in PET-bottled water, with potential cancerogenic or toxic effects.This book provides an overview of the European regulation of NIAS in plastic packaging materials, offering insights into their chemical composition in PET-bottled water. Lastly, it provides a useful discussion on NIAS and their toxicity.

This book offers valuable insights into the latest concepts and findings from epidemiologic, clinical and basic studies in the burgeoning area of early-life environmental exposure and diseases. The book is divided into five parts, starting with an overview of environmental exposure measurement and evaluation, followed by a review of the effects of exposure to various substances like tobacco smoke, pesticides and metals as well as stress on offspring's health. It then discusses the developmental origins of a range of childhood diseases that affect growth, neural development and the immune system, and highlights the importance of longitudinal studies that measure exposure at potentially sensitive time points during childhood. It also provides up-to-date evidence of the intergenerational/transgenerational effects of early-life environmental exposure, especially via genetic and epigenetic pathways. Allowing readers to gain a thorough understanding of the predominating aspects of early-life environmental exposure and diseases, the book also provides a basis for developing environmental and health policies that could have wide and long-term impacts on human health.

Comprising 12 chapters, this book focuses on volatile methylsiloxanes (VMSs), the shorter-chained organosiloxanes, and reviews the main areas and environmental compartments where they have been found and studied. It opens with a detailed description of the structural and functional properties, toxic risks and possible transformations of VMSs in the environment and their main uses in various activities and products, as well as the identification of the main sources of emission. Further chapters examine the analytical strategies and protocols that have been used to address the quantification of VMSs, including the issue of possible cross-contaminations. The book also discusses the presence of VMSs in wastewater treatment plants (WWTPs) and in water bodies, their atmospheric fate and levels in biota, as well as occurrences of VMSs in remote areas of the world. It closes with a comprehensive conclusion and discussion on future directions for upcoming studies. This book is not intended as a finishing line, but rather as an important step towards improving our understanding of VMSs, to fuel new collaborations between research groups and/or with industry and lastly to convince more researchers to explore the mysteries of these ubiquitous, yet understudied, chemicals.

This book paints a fresco of the field of extrapolation and rational approximation over the last several centuries to the present through the works of their primary contributors. It can serve as an introduction to the topics covered, including extrapolation methods, Padé approximation, orthogonal polynomials, continued fractions, Lanczos-type methods etc.; it also provides in depth discussion of the many links between these subjects.A highlight of this book is the presentation of the human side of the fields discussed via personal testimonies from contemporary researchers, their anecdotes, and their exclusive remembrances of some of the “actors.” This book shows how research in this domain started and evolved. Biographies of other scholars encountered have also been included. An important branch of mathematics is described in its historical context, opening the way to new developments. After a mathematical introduction, the book contains a precise description of the mathematical landscape of these fields spanning from the 19th century to the first part of the 20th. After an analysis of the works produced after that period (in particular those of Richardson, Aitken, Shanks, Wynn, and others), the most recent developments and applications are reviewed.

This volume discusses the effects of indoor air environment and pollution in modern buildings on human health. Highlighting epidemiological studies and the determining factors, it offers proposals for improving indoor air quality (IAQ) in different environments. Focusing not only on homes and offices, but also vehicles and aircrafts, it details practical methods of measuring and assessing indoor air quality. Written by pioneering researchers, Indoor Environmental Quality and Health Risk toward Healthier Environment for All is a valuable resource for both new and established researchers as well as students seeking a comprehensive overview of the facts on indoor air quality and health. Also is also of interest to hygiene experts in industry, occupational health and safety professionals, governmental public health sectors and school physicians.

3624 Einträge und über 8800 Suchbegriffe zu allen Haupt- und Nebengebieten der Laboratoriumsmedizin:· Kenngrößen mit Präanalytik, Analytik und Interpretation· Analysemethoden gut verständlich beschrieben· Statistik und Qualitätsmanagement, Labororganisation und EDVDer schnelle Zugang zur gesuchten Information wird erleichtert durch den lexikalischen Aufbau von A bis Z und einheitlich strukturierte Beiträge mit Literaturverweisen; über 730 Abbildungen (davon über 400 in Farbe) und über 380 Tabellen tragen zur Anschaulichkeit bei.Neu in der 3. Auflage· Ein Großteil der Beiträge wurde aktualisiert und zahlreiche neue Einträge und Suchbegriffe aufgenommen· Parallel zur gedruckten und eBook-Ausgabe erscheint eine online-Version, die als Live Reference-Ausgabe kontinuierlich aktualisiert wirdFür Ärzte aller Fachgebiete, Biochemiker, Chemiker, Fachberufe im Gesundheitswesen, Pharmazeuten, Toxikologen und Verwaltungsmitarbeiter im Gesundheitswesen sowie Lernende in den entsprechenden Studien- und Ausbildungswegen.dsf

Rapid industrialization is a serious concern in the context of a healthy environment. With the growth in the number of industries, the waste generated is also growing exponentially. The various chemical processes operating in the manufacturing industry generate a large number of by-products, which are largely harmful and toxic pollutants and are generally discharged into the natural water bodies. Once the pollutants enter the environment, they are taken up by different life forms, and because of bio-magnification, they affect the entire food chain and have severe adverse effects on all life forms, including on human health. Although, various physico-chemical and biological approaches are available for the removal of toxic pollutants, unfortunately these are often ineffective and traditional clean up practices are inefficient. Biological approaches utilizing microorganisms (bacterial/fungi/algae), green plants or their enzymes to degrade or detoxify environmental pollutants such as endocrine disruptors, toxic metals, pesticides, dyes, petroleum hydrocarbons and phenolic compounds, offer eco- friendly approaches. Such eco-friendly approaches are often more effective than traditional practices, and are safe for both industry workers as well as environment. This book provides a comprehensive overview of various toxic environmental pollutants from avariety natural and anthropogenic sources, their toxicological effects on the environment, humans, animals and plants as well as their biodegradation and bioremediation using emerging and eco-friendly approaches (e.g. Anammox technology, advanced oxidation processes, membrane bioreactors, membrane processes, GMOs), microbial degradation (e.g. bacteria, fungi, algae), phytoremediation, biotechnology and nanobiotechnology. Offering fundamental and advanced information on environmental problems, challenges and bioremediation approaches used for the remediation of contaminated sites, it is a valuable resource for students, scientists and researchers engaged in microbiology, biotechnology and environmental sciences.

Electronic and electric waste (e-waste), defined as end-of-life electronic products, including computers, television sets, mobile phones, transformers, capacitors, wires and cables, are a major global environmental concern. The crude recycling of e-waste releases persistent toxic substances, such as heavy metals, polybrominated diphenyl ethers (PBDEs), polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs), and the environmental pollution and health risks caused by the improper disposal of e-waste has become an urgent issue. This book offers an overview of e-waste history, sources, and entry routes in soil, air, water and sediment. It also addresses e-waste transport and fate, bioavailability and biomonitoring, e-waste risk assessment, impacts on the environment and public health. In addition, it discusses the impact of e-waste on soil microbial community diversity, structure and function and reviews the treatment and management strategies, such as bioremediation and phytoremediation, as well as policies and future challenges. Given its scope, it is a valuable resource for students, researchers and scholars in the field of electronics manufacturing, environmental science and engineering, toxicology, environmental biotechnology, soil sciences and microbial ecology, as well as and plant biotechnology.

This volume presents a selection of research papers on various topics at the interface of statistics and computer science. Emphasis is put on the practical applications of statistical methods in various disciplines, using machine learning and other computational methods. The book covers fields of research including the design of experiments, computational statistics, music data analysis, statistical process control, biometrics, industrial engineering, and econometrics. Gathering innovative, high-quality and scientifically relevant contributions, the volume was published in honor of Claus Weihs, Professor of Computational Statistics at TU Dortmund University, on the occasion of his 66th birthday.

This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. At just over ten years since the term was coined by Christopher Wild in 2005, this is the first, field-defining volume to offer a holistic picture of the important and growing field of Exposomics. The term “Exposome” describes the sum of all exposures (not only chemical) that an individual can receive over a lifetime from both exogenous sources (environmental contaminants, food, lifestyle, drugs, air, etc.) and endogenous sources (metabolism, oxidative stress, lipid peroxidation, chemicals synthesized by the microbiome, etc.). The first section of this book contains chapters that discuss how the Exposome is defined and how the concept fits into the fields of public health and epidemiology. The second section provides an overview of techniques and methods to measure the human Exposome. The third section contains methods and applications for measuring the Exposome through external exposures. Section four provides an overview on statistical and computational techniques- including big data analysis - for characterizing the Exposome. Section five presents a global collection of case studies

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

This book mainly focuses on advances made over the past 10 years regarding the exposure, metabolism, transformation, toxicity, molecular mechanism and biomarkers for emerging chemicals in humans. A hot topic in the field of environmental health, the term “emerging chemicals” refers to a class of compounds that are frequently encountered and potentially harmful to the natural environment and human health. They are also the preferred target substances for future environmental control measures. The list of emerging chemicals includes pharmaceutical and personal care products (PPCPs), endocrine disruptor chemicals (EDC), persistent organic pollutants (POPs), and nanomaterials. However, the environmental and health hazard characteristics of many emerging chemicals remain unclear. The aim of this book is to stimulate further research in new directions by providing novel and provocative insights into the exposure assessment of and potential mechanisms regarding emerging chemicals in humans. It also offers a state-of-the-art report on recent discoveries concerning emerging chemicals and where the field is headed.

This two-volume work presents comprehensive, accurate information on the present status and contemporary development in phycoremediation of various types of domestic and industrial wastewaters. The volume covers a mechanistic understanding of microalgae based treatment of wastewaters, including current challenges in the treatment of various organic and inorganic pollutants, and future opportunities of bioremediation of wastewater and industrial effluents on an algal platform. The editors compile the work of authors from around the globe, providing insight on key issues and state-of-the-art developments in algal bioremediation that is missing from the currently available body of literature. The volume hopes to serve as a much needed resource for professors, researchers and scientists interested in microalgae applications for wastewater treatment. Volume 1 focuses on the different aspects of domestic and industrial wastewater treatment by microalgae. The case studies include examples such as genetic technologies as well as the development and efficient use of designer consortia for enhanced utilization of microalgae. This volume provides thorough and comprehensive information on removal of persistent and highly toxic contaminants such as heavy metals, organic pesticides, polyaromatic hydrocarbons, endocrine disruptors, pharmaceutical compounds, and dyes from wastewater by microalgae, diatoms, and blue-green algae. Design considerations for algal ponds and efficient use of photobioreactors and HRAPs for wastewater treatment are some other highlights. This volume addresses the applications, potentials, and future opportunities for these various considerations in water pollution mitigation using algal technologies.

This expanded, revised, and updated second edition of Innovations in Green Chemistry and Green Engineering provides a comprehensive introduction to the state-of-the-art in this key area of sustainability research. Processes that meet the objectives of green chemistry and chemical engineering minimize waste and energy use, and eliminate toxic by-products. Given the ubiquitous nature of products from chemical processes in our lives, green chemistry and chemical engineering are vital components of any sustainable future. Peer-reviewed articles from worldwide experts present the latest developments on topics ranging from organic batteries and green catalytic transformations to green nanoscience and nanotoxicology. Now under the leadership of distinguished Editors from the Chinese Academy of Sciences, this volume in the Encyclopedia of Sustainability Science and Technology, Second Edition, is an essential, one-stop reference for professionals in researchand industry. The book also fills the need for an authoritative course text in environmental and green chemistry and chemical engineering at the upper-division undergraduate and graduate levels.

This book gathers the peer-reviewed proceedings of the 12th Annual Meeting of the Bulgarian Section of the Society for Industrial and Applied Mathematics, BGSIAM'17, held in Sofia, Bulgaria, in December 2017. The general theme of BGSIAM'17 was industrial and applied mathematics, with a particular focus on: high-performance computing, numerical methods and algorithms, analysis of partial differential equations and their applications, mathematical biology, control and uncertain systems, stochastic models, molecular dynamics, neural networks, genetic algorithms, metaheuristics for optimization problems, generalized nets, and Big Data.