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Chronic kidney disease is a non-communicable disease that has experienced a global surge in incidence and prevalence over the past few decades, and it has been increasingly considered a major contributor to the global disease burden and mortality. In prior years, most of the awareness and treatment of patients with chronic kidney disease, particularly in the developed world, had focused on patients with end stage renal disease, one of the potential outcomes of chronic kidney disease. More recent epidemiological data has shown that the majority of the burden of chronic kidney disease occurs in patients who are in the earlier stages of this condition, prior to end stage renal disease. The opportunities to recognize the signs, symptoms, and complications, and to consider extant treatment paradigms are useful in the global environment (both in developed and developing nations). We are very happy to present this work, authored by an international panel of experts, as a useful addition and tool for the global efforts to address the burden of chronic kidney disease.

Nanotechnology is the study of the controlling of matter on an atomic and molecular scale and is also very diverse, ranging from extensions of conventional device physics to completely new approaches based upon molecular self-assembly, from developing new materials with dimensions on the nanoscale to investigating whether we can directly control matter on the atomic scale. This book discusses nanostructures and their properties which are critical to understanding and developing innovations in biological systems, therapeutic agents, and medicine and health

Changes in temperature, either hot or cold, is sensed through direct activation of members of the temperature-sensitive transient release potential (TRP) ion channel superfamily, the so-called “thermoTRPs”. Of the 28 TRP channels discovered today, seven sense hot or warm temperatures whereas two are activated by cold. Together, these channels cover a wide temperature range with extremes that fall between 10 C and 53 C. This new and unique book reviews research on TRP channels and their relation to health and disease.