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Drug Discovery Stories: From Bench to Bedside presents a collection of cases on the development of highly successful pharmaceuticals. It delves into the realm of drug discovery, exploring the structural biology and biological functions of the sought-after targets. The book covers the identification of promising compounds, their transformation from hits to leads through meticulous optimization, and the elucidation of how key compounds interact with the target (in essence, providing invaluable insights for drug design). Additionally, it covers essential information such as the pivotal biological and PK data of lead compounds, any noteworthy clinical results, and a comprehensive overview of other candidate compounds. The field of drug discovery and development has experienced rapid evolution, with numerous new drugs receiving approval each year. While several books have been published on this subject, there is a pressing need for a new book series that accurately reflects the current advancements in drug discovery. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology. - Analyzes the drug discovery stories of different blockbuster drugs - Includes the newly approved drugs - Covers key aspects related to the drug development of the drugs

Encyclopedia of Food Allergy, organized in 10 sections, with ~200 chapters, and written by world-renowned clinician-scientist authors, is the most comprehensive resource for food allergy ever compiled. With online and physical presence, intuitive and easily accessible organization of information, the reader can quickly access overview and general topics as well as detailed information to inform solutions to clinical or research questions. Research topics provide the necessary background for the novice as well as the details required for those in the field. Clinical topics provide comprehensive and practical information, with generous use of tables, figures, and key points/clinical pearls, to inform clinical decision-making, and promote evidence-based management decisions. Food allergy may affect up to 10% of the population in developed countries and appears to be increasing in prevalence worldwide, with many food allergies proving life-long, severe and potentially fatal. The last decade has witnessed a sea change response to the impact of food allergy through basic science research on the immunology, food science research on the triggers, clinical approaches to daily management, treatment and prevention, and an increasing understanding of the psychosocial and societal implications and how to address them. With the expanding breadth and depth of the field, there is no existing comprehensive resource available for those professionals interested in learning about or contributing to food allergy research and clinical care. This is a complete resource covering broad and detailed aspects of food allergy and adverse food reactions for clinicians, researchers, regulators, food industry, students and other stakeholders who need and will benefit from a rich resource with in-depth and practical information. - Presents in-depth, comprehensive coverage from an outstanding international author base of domain experts - Ideal for new researchers and clinicians who will have a single resource that includes general topics to get them started - Includes access to detailed information in their areas of work AND for many related topics that will help improve their research or clinical care

With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley's Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment?including key data on outcomes to better inform clinical decision making. - Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.

Atopic dermatitis (eczema) is one of the most common and most challenging skin conditions, for patients and practitioners alike. Uniquely organized by intrinsic and extrinsic etiologies, Atopic Dermatitis: Inside Out or Outside In? examines a myriad of causes that start from both the inside of the body and from the external environment, offering physicians practical ways to design treatments that specifically address these causes. Drs. Lawrence S. Chan and Vivian Y. Shi, along with a team of expert contributing authors, examine the etiology of this complex disorder and provide targeted, comprehensive solutions and the most useful therapeutic plans based on pathophysiology, including evidence-based integrative management. - Analyzes the pathophysiology of atopic dermatitis from two distinct fronts: inside out and outside in—an approach that is unique in the field. - Begins with an overview of the disease, then delves into both internal and external pathogenic factors, followed by the Clinician's Corner, which offers practical recommendations for treatment. - Organizes therapeutic discussions by corresponding pathophysiology rather than a one-size-fits-all approach. - Covers recently FDA-approved and emerging medications, as well as atopic comorbidities.

Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields. - Contains chapters that follow a consistent and templated approach, resulting in well-structured content that enhances user experience and appeal - Offers a comprehensive review on a wealth of information on pharmacology and how it utilizes concepts and techniques from a broad array of sciences, ranging from chemistry to physiology to medicine - Includes a wider use of color and multimedia content, with interactive features, links, computational modeling and animations to illustrate the effects of toxic substances in various contexts

Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential. - 2023 PROSE Awards - Winner: Finalist: Reference Works – Biological and Life Sciences: Association of American Publishers - Offers a contemporary review of current infection and immunity research, and insights into the future direction of the field - Meticulously researched and cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily - Includes chapters written by academics and practitioners from various fields and regions, ensuring that the knowledge within is easily understood by, and applicable to, a large audience

Written by global experts in the field of chemical- and drug-related ocular problems, Drug-Induced Ocular Side Effects, 8th Edition, provides need-to-know information on all aspects of ocular toxicology in one concise reference. This best-selling, user-friendly resource features a templated format, numerous full-color illustrations, and sweeping content updates throughout – all designed to eliminate uncertainty and ensure accurate diagnosis and treatment guidance. - Provides comprehensive coverage of drugs'generic and trade names, primary uses, ocular and systemic side effects, and clinical significance. - Features a unique side effect index, a new concise paperback format for portability, and clinical photos of ocular symptoms of adverse drug reactions. - Covers dozens of new drugs used in the U.S. and internationally, as well as extensive updates to drug registry information to ensure access to the latest data. - Includes expanded sections on how to follow patients with visual adverse drug reactions to chloroquine, hydroxychloroquine, isotretinoin, ethambutol, and more. Guidelines can be copied to use as patient handouts. - Offers extensive discussions of principles of therapy, ocular drug delivery, methods to evaluate drug-induced visual side effects, and the role of electrophysiology and psychophysics. - Provides the WHO classification system to help you determine whether a particular side effect is certain, probable, or likely to occur. - Ideal for ophthalmologists, optometrists, and busy clinicians in primary care, emergency medicine, and more – anyone who needs quick, on-the-spot consultation on ocular toxicology. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Get a quick, expert overview of the use of current and novel immunotherapies for use in the management and treatment of allergic reactions and diseases. This concise resource by Dr. Linda Cox covers the full range of allergic disease, including aeroallergens, asthma, food allergies, atopic dermatitis, and stinging insects. With essential coverage of allergen immunotherapies in addition to key topics on emerging allergen-associated immunomodulators, this succinct, comprehensive reference consolidates today's available information on this timely topic into a single convenient resource. - Discusses timely topics such as food tolerance, allergy, and allergen unresponsiveness; biologics for COPD and pediatric asthma; and adherence and pharmacoeconomics. - Summarizes practical guidelines and recommendations for use of immunotherapies in clinical practice. - Provides insight into the background and history of immunotherapies as a treatment for allergic disease. - Includes developments on the horizon, including alternative immunotherapy routes and modified allergens.

'The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold's Pilgrimage,'I awoke one morning and found myself famous.'The twelfth edition of this long-established textbook of clinical pharmacology (first published in 1960) continues its fine tradition of balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy. - Coverage of all major therapeutic topics by body system. - Introductory sections give brief chapter synopses. - Case studies where relevant. - Covers the needs of the developing world with a focus on practical prescribing and health technology assessment. - Definition, tips, brief explanation boxes throughout. - Interesting histories, etymologies and provenances of terms throughout. - Entertaining footnotes throughout. - Fully updated throughout. - New co-editor: Fraz Mir, Addenbrooke's Hospital and Department of Medicine, University of Cambridge. - Now with free e-book on StudentConsult.

Get a quick, expert overview of nail diseases and procedures with this concise, practical resource. Dr. Antonella Tosti covers high-interest clinical topics including anatomy and physiology of the nail, benefits and side effects of nail cosmetics, nail diseases in children and the elderly, and much more. - Covers key topics such as nail psoriasis, nail lichen planus, onychomycosis, traumatic toenail disorders, self-induced nail disorders, the nail in systemic disorders, nail disorders in patients of color, and more. - Includes basic nail procedures useful to students, residents, fellows, and practitioners. - Consolidates today's available information and experience in this important area into one convenient resource.

Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. - Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry - Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets - Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

A brand-new title in the field of dermatology, Therapy for Severe Psoriasis provides the ultimate coverage of the treatment options available for today's most serious cases, including biologics and oral therapies. It features discussions of the newest drug therapies, recent FDA-approved biosimilars, and combination approaches to care, while an overview chapter was designed to aid those new to the field in understanding the nuances of difficult-to-treat subtypes of psoriasis. Comprehensive and focused, Therapy for Severe Psoriasis will be a welcome addition to the library of any dermatologist seeking in-depth information on the challenges of this condition. - Each of the 16 chapters includes either an in-depth focus on a single therapy or an overview of a unique aspect of psoriasis, including: UVB therapy, methotrexate, acitretin, cyclosporine, apremilast, etanercept, infliximab, adalimumab, ustekinumab, secukinumab, and ixekizumab. - Takes an evidence-based approach to hard-to-treat severe psoriasis. - Discusses the newest drug therapies (such as ixekizumab), plus recent FDA-approved biosimilars, a topic unique to this particular psoriasis text. - Presents combination approaches for instances when standard treatments are not successful. - Includes an overview chapter to help beginners understand the nuances of the disorder.

Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions was first published in 1977, and has been continually published as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each annual provides clinicians and medical investigators with a reliable and critical survey of new data and trends in the area of adverse drug reactions and interactions, with an international team of specialists contributing their expertise each year. - Provides a critical yearly survey of the new data and trends regarding the side effects of drugs - Authored and reviewed by worldwide pioneers in the clinical and practice sciences - Presents an essential clinical on the side effects of drugs for practitioners and healthcare professionals alike

Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 40, first published in 1977, and continually published as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs, presents clinicians and medical investigators with a reliable and critical survey of new data and trends in the area of adverse drug reactions and interactions, with an international team of specialists contributing each year. Topics covered in this release include Central Nervous System Stimulants and Drugs that Suppress Appetite, Antidepressant drugs, Lithium, Drugs of abuse, Hypnotics and sedatives, Antipsychotic Drugs, and much more. Provides a critical yearly survey of the new data and trends regarding the side effects of drugs Authored and reviewed by worldwide pioneers in the clinical and practice sciences Presents an essential clinical on the side effects of drugs for practitioners and healthcare professionals alike

Psoriasis is the most prevalent autoimmune disease in the U.S. • ~125 million people worldwide have psoriasis. Commonly misunderstood and interpreted as a “cosmetic” problem, psoriasis is a complex and potentially debilitating disease; nearly 60% of people with psoriasis reported their disease to be a large problem in their everyday life. This issue of Dermatologic Clinics devoted exclusively to psoriasis is edited by two leaders of the International Psoriasis Council, Dr Alan Menter and Dr Chris Griffiths. Topics include: Genetics of psoriasis; Immunopathogenesis of psoriasis; Phenotypical expressions of psoriasis; Psoriasis as a systemic disease with multiple comorbidities; Outcomes measures in the assessment of psoriasis in clinical practice and trials; Update on topical therapies for mild to moderate psoriasis; Phototherapy and photochemotherapy (PUVA) for psoriasis; Current and future oral systemic therapies for psoriasis; Current biological therapies for psoriasis; Future biological therapies for psoriasis; Psoriatic arthritis for the dermatologist; Pharmacogenomics and the future of psoriasis therapies. This information that goes to the heart of clinical practice is equally appropriate, beyond dermatologists, for internal medicine clinicians, primary care physicians, bone & joint specialists; hematologists/oncologists, and researchers in genetic targeted therapy development.

Beyond the skin as protective barrier, surgeons and dermatologists explore the science of skin as they work with it every day on patients and clients with aging skin, facial scars, deformities, skin cancer, sun damage, vascular lesions, and traumatic injuries. This compilation of topics in Facial Plastic Surgery Clinics provides a primer on the basic science of skin, wound healing, exploration of genes, stem cells, and molecular science, along with direct clinical information related to surgery and medicine applicable in skin disorders, cosmetic procedures, and reconstructive procedures. Guest Editors David Hom and Adam Ingraffea lead a group of facial plastic surgeons and dermatologists who present an Overview of a specific skin problem, Therapeutic options, Clinical outcomes, Complications and sequela, along with a review of the most current literature to date on the subject of skin as is clinically and surgically relevant for dermatologists, facial plastic surgeons, plastic surgeons, and general practitioners.