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This volume is an accessible introduction to RNA viruses and the infectious outcomes that they cause in the central nervous system (CNS). Chapters cover the major RNA viruses, their impact on the CNS, and the similarities and differences in pathological outcomes that can be observed. Neuroscientists, be they students, researchers, or clinicians, will benefit from the timely coverage provided.Our understanding of viruses, and specifically RNA viruses and their pathological impact, is rapidly evolving. For example, the close molecular interaction of viruses with the CNS cell types in the human host is poorly understood. Readers can use the book to understand clearly the cellular and molecular mechanisms governing pathological outcomes of RNA virus infection in the cell types of the human brain (e.g., neurons, endothelial cells, astrocytes, resident immune cells) based on summarized case studies, and gain insight into how cell type-specific defects affect brain function and cause poor clinical outcomes.The book is aimed primarily at neuroscience students and postgraduates wishing to learn about virology and professionals who are interested to learn more about virus-associated neuropathology. A basic knowledge of cell and molecular biology is assumed; however, readers across the disciplines of science, technology, engineering, and mathematics will find this topical and timely publication of value.

Neuro-ophthalmology is a merged subspecialty of neurology and ophthalmology dealing with complex multisystem diseases presenting with visual manifestations. This book helps the reader in recognizing, approaching, and managing such a patient. It covers the afferent and efferent systems, pupillary disorders, and Radiology of neuro-ophthalmic conditions. It features individual symptomatology with salient points, their management and differential diagnosis. It has case scenarios, key points, and algorithms along with self-assessment MCQ questions. Its simplified, step wise approach will be a useful resource for neurologists, ophthalmologists, physicians, pediatricians, and optometrists.Key Features• Features a simplified and stepwise clinical approach to neuro-ophthalmic disorders.• Includes case studies and clinical pearls along with self-assessment sections.• Covers to the point and crisp analysis of common complaints faced in neuro-ophthalmology.All the royalties of this book are donated to the Poor Patients Cell of PGIMER, Chandigarh.

This book focusses on the clinical aspects and management of pediatric skin disorders, especially seen in darker skin types. It includes unique conditions that the authors have encountered in their lifetime with their independent observations and approach to management. Original high-quality images are used to illustrate most dermatoses described in the book enabling a strong visual impression of the discussed diseases. It hopes to provide readers with a blend of evidence and experience based pediatric dermatology. This book aims to be a hands-on manual that can be referred to during a busy practice as it discusses the practical approach to dermatoses. Key Features Focusses on darker skin types. Examines unusual presentations with detailed clinical features. Discusses the ways to differentiate between similar-appearing diseases. Explores approaches to therapy, especially in resource-poor settings. Covers topics with high quality illustrations.

Written in a unique and innovative style, this book presents pediatric surgery in an interactive clinical context. Each chapter is built upon a specific disease or group of diseases, beginning with a typical case, presented interactively, just as it would be in encountered in clinical practice. These are actual cases that have been encountered by the author and are likely to be managed on any pediatric surgical service. The discussion that follows presents the most relevant issues pertaining to the topic, drawing on the index case, as well as multiple other cases that depict the entire spectrum of the disease or anomaly. The carefully selected suggested readings emphasize sentinel papers, high-quality reviews, and the best and most recent evidence published on the subject. A large number of illustrations help bring the clinical concepts to light. A number of high-quality videos provide a dynamic atlas of common procedures. The book is useful to the entire range of pediatric surgical trainees and practitioners, from the medical student or resident rotating on pediatric surgery, to the fellow preparing for certification, to the seasoned surgeon looking for an update on a particular subject or preparing for recertification. A large number of other physicians will find this book very useful, including general surgeons who evaluate and treat childhood surgical diseases, paediatricians and pediatric hospitalists who co-manage patients with surgeons, and obstetricians, pathologists, and radiologists who work closely with pediatric surgeons. Key FeaturesProvides a hands-on guide to the management of typical clinical scenarios for all pediatric surgery trainees and other professionals involved in the care of childhood surgical diseasePresents more than 300 cases, covering the whole spectrum of pediatric surgery, illustrated in full-color and with an accompanying e-bookAllows the reader to apply their knowledge to real-life situations and assess their level of expertise by the use of a case-based Q&A format

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

This new edition of a groundbreaking book, now in two volumes, enables the reader more readily to understand pathogenesis, appropriate investigation, and application of both surgical and nonsurgical strategies and techniques.

This new edition of a groundbreaking book is now in two volumes, on'Fundamentals, Symptoms, and Conditions‘ on'Reconstructive and Fertility Preserving Surgery and Procedures. From a distinguished editorial team and internationally recognized contributors the text educates surgeons on the techniques and procedures now needed in gynecology, with a special focus on reconstructive vaginal, hysteroscopic, laparoscopic, and laparotomic surgery, including that designed to preserve or enhance fertility. The reader can now more readily understand pathogenesis, appropriate investigation, and application of both surgical and nonsurgical strategies and techniques. The two volumes contain over 20 new chapters and in the integral ebook, over 140 instructional videos; each chapter has Key Points summarized.

The fundamental goal of the revised edition of this acclaimed text is to provide comprehensive, practical, and straightforward information about the developing nervous system that is as relevant to those embarking on careers in pediatric neurology as it will be to the experienced practitioner who cares for infants, children, and adolescents. New to this edition are chapters on tumors of the nervous system, autism and related conditions, and practice parameters in child neurology.

Since the publication of the highly successful first edition, there has been an explosion of rigorous scientific evidence for interventions in clinical neurology. Hankey's Clinical Neurology, Second Edition is fully updated to accommodate the latest advancements in clinical neuroscience. Designed for students of clinical neurology, neurologists-in-

This two volume set covers the engineering and clinical benefits in diagnosis of human pathologies, including the protocols and potential of advanced tomography scanning with very high quality CT images. With contributions from world-class experts, the book examines all aspects of CT technologies related to neck-brain, cardiovascular systems, thorax, abdomen and GI system, pelvis and urinary system, and musculoskeletal system. It also provides coverage of CAD applications to CT along with a discussion of the potential dangers of CT in terms of over-radiation, particularly related to children.

Despite recent advances in healthcare, hypertension is a leading cause of death and remains a disease burden worldwide. Now in its second edition, the Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to this condition. Updating all mater

Developments in CT technology during the last 20 years have impressively improved its diagnostic potentialities. Part of a two-volume set that covers all aspects of CT imaging, Multi-Detector CT Imaging: Principles, Head, Neck, and Vascular Systems contains easily searchable clinical specialty chapters that provide specific information without need

Developments in CT technology during the last 20 years have impressively improved its diagnostic potentialities. Part of a two-volume set that covers all aspects of CT imaging, Multi-Detector CT Imaging: Abdomen, Pelvis, and CAD Applications contains easily searchable clinical specialty chapters that provide specific information without need of an

Crossing the boundaries of classically delineated medical and surgical specialties including neurosurgery, neuroradiology, and neurology, Interventional Neuroradiology uses advanced neuroimaging combined with endovascular techniques to guide catheters and devices through blood vessels to treat disease involving structures of the head, neck, and cen

This book provides a comprehensive and contemporary discussion about the three key areas of acute care surgery; trauma, surgical critical care, and surgical emergencies. The 65 chapters are arranged by organ, anatomical site and injury type, and each includes a case study with evidence-based analysis of diagnosis, management, and outcomes. Unless s

Now with over 3000 color coded illustrations, Melloni's Illustrated Medical Dictionary, Fourth Edition remains the reference against which all others are measured. It clearly and authoritatively defines nearly 30,000 medical terms in understandable everyday language. Long recognized for its excellence and expertise, its unique integration of illust

As a leading cause of death in developed countries, ST-segment elevation myocardial infarction and its various treatment options are of great concern to those in the cardiology field. This text presents evidence-based chapters that supply clinicians with real-life situations and strategies to treat STEMI patients more effectively and at a quicker p

As the number of patients with thrombosis and thrombolysis increases, there is a critical need for clinicians to learn the latest scientific discoveries and treatment options. This timely Third Edition is a comprehensive text for cardiologists, hematologists, and pharmacologists in need of a resource on current agent development technology for trea

Diagnostic Ultrasound, Second Edition explores the utilization of diagnostic ultrasound in all regions of the body. Offering numerous tables and charts containing practical tips and useful recommendations, this source lists specific pitfalls that may be encountered in each anatomical area within the body and offers methods to distinguish among diff

Neurology is an exciting and evolving clinical science. The fact that many previously untreatable diseases are now known to be not only treatable, but preventable, has raised new optimism for the probability that treatments will emerge for other currently incurable neurologic disorders. This book is written and illustrated for students of clinical

The first text designed specifically with clinical practitioners in mind, Functional Neuroimaging demonstrates the clinical application and utilization of functional neuroradiology for early diagnosis, neurological decision-making, and assessing response to cancer therapy. Edited by the Founding President of American Society of Functional Neuroradi

The European Society of Hypertension Guidelines are imparted throughout the text in order for the reader to achieve'better practice.'The data provided is all evidence-based and clearly referenced.Professor Guiseppe Mancia is a leading light on the management and treatment of hypertension and is particularly expert on the angiotensin II recept

The first up-to-date source on the subject in more than a decade, this authoritative and all-encompassing guide summarizes the latest findings on the epidemiology, pathogenesis, pathophysiology, clinical manifestations, diagnosis, and treatment of infective endocarditis. Written by a world recognized expert with more than 35 years of experience in

As the third leading cause of death in the United States, stroke accounts for one in every fifteen deaths and is the major cause of disability in the country. Compiled by a renowned editorial team, this reference bridges the gap between basic science and patient care protocols, and collects 43 expertly written chapters that range from laboratory-ba

The only in-depth source to focus specifically on surgical complications, this reference provides practical information on the incidence, management, and avoidance of complications encountered during and after surgical procedures. Spanning the vast array of complications related to a wide variety of preoperative, intraoperative, and postoperative e

Oppenheimers Diagnostic Neuropathology, A Practical Manual has become a modern classic in its field, covering the practical aspects of the work of the neuropathologist. Full of sensible advice and observations often omitted from neuropathology texts, it guides the neuropathologist through the methods available to them when facing diagnostic questio

Introduction to Neuropathology 3Ed remains an introductory text, but more clinical material has been introduced to make it relevant to neurologists and some psychiatrists, as well as pathologists. This involves the addition of small amounts of text throughout, plus neuroimages, including functional MRI, which is in colour. In addition, the text has

If you're a physician on call, you need a diagnosis and treatment guide to help you make quick and accurate decisions-one that's comprehensive concise. Now, for the first time, the new Mayo Clinic Medical Manual provides just the right information to complete almost any differential diagnosis you encounter. Conceived at Mayo Clinic, this ne

The only source to fully cover every aspect of brain embolism, this guide analyzes the causes, symptoms, diagnosis, and management of this disorder-providing a detailed overview of major topics pertinent to embolism including donor sources, recipient sites, embolic material, recipient brain supply arteries, vascular and brain pathology, and the tre

Supported by an extensive review of migraine pathogenesis and more than 200 case histories gleaned from the authors'personal experiences, this guide proposes two radical new concepts: all primary headaches are fundamentally a form of migraine and everyone may experience some manifestation of the migraine process in their life. Offering an in-depth

Addressing the pathology of the heart and cardiovascular system from a forensic perspective, Pathology of the Heart and Sudden Death in Forensic Investigations guides the pathologist toward the effective resolution of cases. It critically reviews pertinent facts by revisiting pathologic findings and comparing them to etiopathogenic hypotheses, prop

Emergency vascular and endovascular practice comprises almost half the workload undertaken by the majority of vascular surgeons. Most vascular emergencies are characterised by the sudden occlusion, rupture or injury of a blood vessel placing organ, limb and life at risk. An attitude of urgency and of good judgement, both in diagnostic assessment an

This is the third edition of a text which analyzes non-invasive cerebrovascular diagnostic techniques and the design of clinical trials for the evaluation of new treatments and methodologies. It considers the regression and stabilization of atherosclerosis through therapy.

The Melloni series of medical dictionaries are famous for their concise definitions and detailed illustrations. And Melloni's Pocket Medical Dictionary: Illustrated is no exception. A condensed and portable version of the award-winning and highly acclaimed Mellonis's Illustrated Medical Dictionary, the book features a wide range of beautifully drawn and carefully labeled illustrations to accompany the large number of expert and concise medical definitions. The pocketbook takes the most important qualities of the 4th Edition, reduces its size without sacrificing accuracy and clarity, and adds the most current information. When you can't take the big book with you, this book provides the information you need where you need it.

Focusing on one of the most exciting imaging modalities available in modern clinical cardiology, Atlas of Multiplane Transesophageal Echocardiography provides a comprehensive analysis of this modality drawn from the authors'experience. Designed to cover the breadth and depth of the topic, the book covers the evaluation of prosthesis, interventiona

With nearly 600 autopsy photographs, this atlas shows various trauma and diseases of the brain and spinal cord in the forensic context of sudden death investigation. It also provides a simple, straight forward, concise text organized in a primarily case-oriented format. Unlike most other neuropathology texts, attention is given to skull fractures and scalp injuries. Where necessary, radiologic and microscopic images have also been included to facilitate learning along with a brief general anatomy of the brain and spinal cord. Thus pathologists who are not specialized in neuropathology can compare a variety of autopsy findings with cases illustrated in the text.

Evaluating the major strategies used to prevent stroke recurrence, such as antiplatelet and anticoagulant therapies, this reference assesses the efficacy of pharmacological interventions, therapeutic regimens, and quality of care for stroke patients-detecting risk factors and potential mechanisms of stroke to prevent functional disability and incre

This valuable reference provides a wide range of practical, clinical information for physicians who care for patients with neurological and cardiac problems. Clinical Neurocardiologyconsiders neurological complications arising from cardiac surgery and other cardiac interventions describes neurological findings in heart dise

Demonstrates how MRS offers a useful tool for the noninvasive biochemical analysis of the brain. The book covers over 70 clinical cases and more than 100 spectra that enhance skills at interpreting MRS, including minimizing errors, highlighting artifacts, and expanding the clinical usefulness of this diagnostic modality.

These volumes provide information which will be helpful to comparative pathologists, veterinarians, and all marine scientists and other individuals who are interested in the study of marine mammals, and the diseases they develop in both their feral and captive environment.This publication is a reflection of the observations of the various authors, some of whom have pioneered in this field, and is an attempt to update the available information concerning the natural diseases, and the corresponding pathologic changes in marine mammals.