Search

The research and development process in modern drug discovery and development is a complex and challenging task. Using traditional biological test methods such as PCR to measure the expression levels or function of these genes is costly and time-consuming. RNA-seq can measure the expression patterns of thousands of genes simultaneously and provide insights into functional pathways or regulations in biological processes, which has revolutionized the way biological scientists examine gene functions. This book addresses the various aspects of the RNA-seq technique, especially its application in drug discovery and development.Features• One of the few books that focuses on the applications of the RNA-seq technique in drug discovery and development.• Comprehensive and timely publication which relates RNA sequencing to drug targets, mechanisms of action, and resistance.• The editor has extensive experience in the field of computational medicinal chemistry, computational biophysics, and bioinformatics.• Chapter authors are at the frontline of the academic and industrial science in this particular area of RNA sequencing.

Bone Histology: A Biological Anthropological Perspective, Second Edition builds on the success of the first edition, recognizing the significant advances that have occurred in bone biology, histology, and histological techniques and methods in subsequent years. Bones and teeth are of considerable importance for anthropological and related research, due to their nature as hard tissues. The physical remains of humans available to biological anthropologists, bioarchaeologists, paleopathologists, and paleontologists are, with exception to forensic anthropology, limited to skeletal material; fortunately, the same characteristics of hard tissues that lead to their persistence after death make them a storehouse of information about biological processes experienced during the life of the individual. This book covers important aspects of bone biology which underlie the microstructure of hard tissues that are crucial for histological analysis. This includes an overview of two major metabolic processes, bone remodelling and modelling, and their importance for understanding and interpreting bone histomorphology. Subsequent chapters apply histological methods to the biological profile, such as estimation of age and evaluation of pathological conditions that affect the skeleton, or to determine whether remains are human or nonhuman. Finally, there is a discussion of current research trends in bone histology, with a focus on technological advances in imaging and methods. Reviews of four well-documented skeletal collections—developed specifically for bone histological and imaging research—are discussed, as well as, the importance of such collections for future research. Bone Histology, Second Edition has assembled a collection of contributing authors, with extensive experience and expertise in various aspects of hard tissue biology, to provide readers with an overview of the current state of research and potential applications of histological analysis in biological anthropology, forensic anthropology, and skeletal biology. It serves as a valuable resource for students, researchers, and practitioners in these and related disciplines.

River Flow 2022 includes the keynote lecture and contributed papers presented at River Flow 2022, the 11th International Conference on Fluvial Hydraulics (8-10 November 2022, Kingston and Ottawa, Canada; held virtually).River Flow 2022 provides an overview of the latest experimental, theoretical and computational findings on fundamental river flow and transport processes, river morphology and morphodynamics, while covering also issues related to the effects of hydraulic structures on flow regime, river morphology and ecology; sustainable river engineering practices (including stream restoration and re-naturalization); and effects of climate change including extreme flood events. The book presents the state-of-the-art in river research and engineering, and is aimed at academics and practitioners in hydraulics, hydrology and environmental engineering.

This book covers various aspects of cancer chemoprevention, including an overview of chemoprevention in the process of tumorigenesis; the roles of various phytochemicals, functional foods, and dietary interventions in disease prevention; and techniques such as cancer stem cell targeting, nano-formulations, and so forth. The nutrigenomic and epigenetic effects of natural products at the molecular and genetic levels are also covered alongside their potential for additive and synergistic effect, as well as overcoming drug resistance. The key selling features of the book are as follows: Discusses holistic and comprehensive areas of chemoprevention Includes diverse techniques, such as cancer stem cell targeting, nano-formulations, and nanotechnology-based drug delivery systems Introduces various mechanisms involved in prevention of the diseases, including targeting cancer stem cells Reviews various aspects which can reduce the toxicity and cost of treatment of diseases by alternative medicine Explores various sources, mechanisms, and ways to develop cancer chemopreventive agents with minimal toxicity compared to traditional cancer therapy drugs This book is focused on researchers and graduate students in drug delivery and formulation, nanobiotechnology, cancer chemoprevention, prevention, and therapeutics.

The book delves into post-genomics advances in potato improvement since the potato genome sequencing in 2011. It includes recent developments in the field of potato genetic resources, genes and SNP markers discovery, and the progress in next-generation breeding applying various omics technologies and modern sequencing tools. It covers cutting-edge technologies in potato - a global perspective, genome sequencing and resequencing of various cultivated and wild species, potato germplasm management and characterization, prebreeding genomics, genome mapping and gene cloning, markers discovery, marker-assisted selection, transgenics, microRNAs, transcriptomics, proteomics, metabolomics, phenomics, next-generation potato breeding technologies including genome editing and genomic selection and bioinformatics applications in the post-genomics era in potato. As genome editing and genomic selection have become emerging tools in crop improvement including potato, several research works have been demonstrated and applied world over. This book concentrates on genomics-aided characterization of germplasm and markers discovery to accelerate potato breeding. Further, various omics technologies strengthen our understanding ondiscovery of new genes/proteins/metabolites and key traits based on high-throughput phenotyping involved in various biotic and abiotic stresses in potato crop. The book is a useful source of information related to genomics-led research and development of this crop. It will serve as a valuable resource for potato researchers working in the area of molecular biology and would be beneficial for college students, PhD scholars, scientists, academicians, farmers and policy makers.

A constant research effort to understand plant-microbe interactions makes it indispensable to keep abreast of the latest research developments. Researchers from a range of disciplines have used multiple approaches to infer this field. With the advent of next-generation techniques, both molecular and computational, the field has entered a new phase. These approaches often result in massive information, which is sometimes tangled and in need of further analysis. These types of analyses also require cutting-edge data analytics as well as efficient statistical models.Plant-Microbe Interactions: Harnessing Next-Generation Molecular Technologies for Sustainable Agriculture provides a comprehensive picture of the modern-day analytics and approaches being used to provide insights into the interactions between plant and microbe. A wide range of technologies are explored along with practical guides toward these techniques. A detailed understanding of omics data in various areas could be obtained from this compilation.Key Features:• Crosstalk between plant and microbe• Overview of advanced molecular techniques used to study plant-microbe interaction• Practical guide to technologies such as NGS• Omics data analysis used to study plant-microbe interaction• Role of soil metagenomics• Advanced technologies such as nanotechnology and CRISPR serving to study plant-microbe interactionThis book will serve as a great reference to various next-generation techniques in the field of plant-microbe interaction, thereby helping to better understand the mechanism. This will also help budding researchers to shape their research in similar areas.

The transport sector continues to shift towards alternative powertrains, particularly with the UK Government's announcement to end the sale of petrol and diesel passenger cars by 2030 and increasing support for alternatives. Despite this announcement, the internal combustion continues to play a significant role both in the passenger car market through the use of hybrids and sustainable low carbon fuels, as well as a key role in other sectors such as heavy-duty vehicles and off-highway applications across the globe.Building on the industry-leading IC Engines conference, the 2021 Powertrain Systems for Net-Zero Transport conference (7-8 December 2021, London, UK) focussed on the internal combustion engine's role in Net-Zero transport as well as covered developments in the wide range of propulsion systems available (electric, fuel cell, sustainable fuels etc) and their associated powertrains. To achieve the net-zero transport across the globe, the life-cycle analysis of future powertrain and energy was also discussed.Powertrain Systems for Net-Zero Transport provided a forum for engine, fuels, e-machine, fuel cell and powertrain experts to look closely at developments in powertrain technology required, to meet the demands of the net-zero future and global competition in all sectors of the road transportation, off-highway and stationary power industries.

The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.

Chromatin immunoprecipitation sequencing (ChIP-seq), which maps the genome-wide localization patterns of transcription factors and epigenetic marks, is among the most widely used methods in molecular biology. Practical Guide to ChIP-seq Data Analysis will guide readers through the steps of ChIP-seq analysis: from quality control, through peak calling, to downstream analyses. It will help experimental biologists to design their ChIP-seq experiments with the analysis in mind, and to perform the basic analysis steps themselves. It also aims to support bioinformaticians to understand how the data is generated, what the sources of biases are, and which methods are appropriate for different analyses.

Reservoir Sedimentation: Assessment and Environmental Controls appraises the issues of sedimentation in reservoirs and discusses measures that can be employed for the effective management of sediment to prolong the operational life of reservoirs. It provides information for professional consultants and policymakers to enable them to manage dams in the best possible way, in order to ensure their sustainability as well as the sustainability of water resources in general. It examines the effects of anthropogenic intervention and management of sediment in dams and reservoirs, as water resources become more sensitive and the demand for clean water continues to increase.Features: Examines the issue of sedimentation in dams and reservoirs and presents water management strategies to alleviate environmental issues Presents methods to help ensure the environmental sustainability of dams and reservoirs, as well as the sustainability of water resources- with consideration of climate change and increased demand Illustrates the spatial distribution of sedimentation characteristics for several dams using geographic information systems (GIS) Explains the relationships between loss in capacity and catchment characteristics Examines regional variation in sediment yield, defines geomorphic regions on the basis of similar hydrometeorology, physiography, geology, and vegetation affecting reservoirs

This volume combines incisive state-of-the-art research regarding nausea and vomiting with articles summarizing current medical knowledge of clinical problems associated with these symptoms. Topics include the historical perspective on research on nausea and emesis, clinical assessments of current and proposed anti-emetic drug therapy, and motion sickness and space sickness. The book features over 30 tables and 6 figures to help simplify the information presented. Nausea and Vomiting: Recent Research and Clinical Advances will interest all scientists who conduct research on how the brain and gastrointestinal system interact in the control of emesis. It will also contain valuable information for clinicians, researchers involved in anti-emetic drug development, and pharmaceutical companies.

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design.

Top Investigators Explore the Complexities of Angiogenesis Cancer ResearchThe targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bev