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With the exponential growth of science and technology, the delivery of dental care has shifted from conventional methods to intelligent techniques. In addition to adapting intelligent techniques, sustainable dental practice is of the utmost importance. Eco-friendly dentistry, sustainable dentistry, or green dentistry are approaches that reduce the environmental impact of dental practice and help safeguard planetary and community well-being. This handbook provides the latest and most comprehensive evidence-based guidance on intelligent and sustainable approaches in dentistry.Handbook of Intelligent and Sustainable Smart Dentistry: Nature and Bio-Inspired Approaches, Processes, Materials, and Manufacturing highlights how Dentistry 4.0 has come to the rescue after COVID-19 and how it has helped in providing needed e-healthcare. This handbook bridges the gap between research and development in the field of smart dentistry for professionals and clinicians. Intelligent materials, equipment, instrumentation, and the latest behavior management techniques and how these techniques provide superior care and treatment to society are explored in detail. The scope of nature-inspired techniques and procession, along with green solutions, are also discussed in this one-of-a-kind handbook.This valuable handbook is a single-stop solution for practitioners, researchers, scholars, students, academicians, and clinicians interested in updating their knowledge on intelligent and sustainable dentistry. The handbook will bestow the readers with not only theoretical knowledge but will equip them with clinical skills as well.