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Distinguished scientists provide an overview of the molecular pathology of human disease. Each chapter provides an analysis of the molecular biological approaches to individual diseases, such as leukaemia, cardiovascular disease and cancer. To celebrate the formation of the new Department a I-day meeting entitled'From Genetics to Gene Therapy'was held on 14 December 1992, at which a large audience was inspired by talks from a variety of distinguished speakers. This volume is based on the meeting and contains contributions provided by the invited speakers.

Cell-based Cancer Immunotherapy, Volume 183 provides the latest progress concerning research on anticancer cellular immunotherapies and their immunological, translation, or clinical aspects. Topics covered in this volume include Methods behind clinical DC vaccine products against glioblastoma, Fully closed and automated isolation of natural blood dendritic cells for cancer immunotherapy, Methods behind Oncolytic virus-based DC vaccines in cancer: towards a multiphase combined treatment strategy for Glioblastoma (GBM) patients, Identification of TCR repertoire patterns linked with anti-cancer immunotherapy, Training of epitope-TCR prediction models with healthy donor-derived cancer-specific T cells, Methods behind neoantigen predictions for anticancer vaccines, Methods behind CD137L-DC-EBV-VAX anticancer vaccine, and much more. Additional sections cover Gold Standard Assessment of Immunogenic Cell Death Induced by Photodynamic Therapy: From In Vitro to Tumor Mouse Models and Anti-Cancer Vaccination Strategies, Methods behind TCR analyses for colorectal cancer-associated TILs, The use of xCELLigence, Incucyte, and/or Cr/LDH/maker-release assays, Humanized mouse models for anti-cancer therapy, In vitro re-challenge of CAR T cells, Methods behind adoptively transferred tumor draining lymphocytes? for anticancer immunotherapy, and A murine glioblastoma platform to test cellular therapies with the standard of care. - Provides comprehensive method articles from front-line experts on the topic of anticancer cellular immunotherapies - Provides useful schematic material and cutting-edge discussions - Presents the latest insights and future perspectives on the covered topics, along with their implications for immuno-oncology, as well as clinical perspectives

This book offers unprecedented knowledge about how social work practice education has been restructured under the challenges of the COVID-19 pandemic and how the adaptations and innovations generated during this time have become a supplementary tool of current social work education worldwide. Based on the European research project'SWooPEd – Social Work Practice Education in Times of Pandemics, and Beyond. Continuities, Changes and Innovations in Europe', this contributed volume provides a unique international perspective from different European countries that are accomplished through insights from authors in other continents. The book addresses topics through a'glocal'approach, using a comparative perspective and a multi-method design. It adopts the IASSW-IFSW'Global Standards for Social Work Education and Training', as well as considers the heterogeneity of national social work education systems in Europe, North America, Africa, and the Asia and Pacific region. The volume's contents are organized in three sections: In Part I, the authors compare the structures and designs of social work practice education programs and the reactions of the schools of social work to the COVID-19-related restrictive measures on a European level. In Part II, the authors provide in-depth analyses on how the pandemic experimentations have been re-adapted and used in some European countries and which innovations and findings were identified that could be integrated now and in the context of other crises. In Part III, the authors contextualize these experiences and display the paths and analyses from schools in non-European countries, as well as finally identify the crucial current challenges and opportunities for social work practice education at a global level. Social Work Practice Education Beyond the Pandemic is a key reference for the global community of social work education including academics, educators, field instructors, practitioners, and students. It provides an inspiring source for all the innovators in the field of higher education in social work and highlights how social work practice education can be designed in a more resilient and sustainable way that directs social work practice education into the future.

Exemplos de séries temporais podem ser encontrados em diversas áreas do conhecimento, como registros de temperatura diária, de precipitação mensal, preços de produtos, valores de ações, dados de eletromiografia e eletrocardiograma, entre outros muitos campos. Os modelos estatísticos para séries temporais utilizam o passado histórico da variável em análise para caracterizar o seu comportamento. Em relação a redes de comunicação, modelos estatísticos podem capturar importantes características do tráfego de redes, melhorando sua compreensão e permitindo o estudo dos efeitos dessas características no desempenho das redes. Modelos Markovianos são utilizados para descrever séries temporais que apresentam curta-dependência entre suas amostras no tempo. Entretanto, os fluxos de tráfego nas redes atuais podem exibir outras características como invariância em escala associada a modelos autossimilares. Modelos multifractais possuem, além de dependência de longa duração como os modelos monofractais, diferentes leis de escala, podendo descrever melhor algumas séries temporais. Neste livro, são apresentados diferentes modelos estatísticos (Markovianos, Autorregressivos, de Cauda Pesada, Autossimilares, Monofractais e Multifractais) cada um com suas peculiaridades. Apesar das análises deste livro estarem voltadas às séries de tráfego de redes encontradas em redes de comunicações atuais, os modelos considerados nesta obra podem ser aplicados a outras séries temporais.

The first full treatment of truth as a core philosophical concept in the late Foucault, this volume examines his work on the ancient world and the early church. Each essay features a deep examination as to how the topics of truth and sexuality intersect with and focus on Foucault's engagement with ancient philosophy and thought. Truth in the Late Foucault offers readings on Plato, Artemidorus, Cicero, Sophocles and the Stoics, and pays close attention to Cassian, Paulinus of Nola, and early Christian practices of confession. With the publication of the long-awaited volume 4 of the History of Sexuality: Confessions of the Flesh, the shape of the final Foucault is now brought into stark relief. As well as looking at ancient thought, the contributors explore Foucault's work in relation to philosophers such as Gadamer, Heidegger, Derrida and Descartes. Foucault's long-running and often contentious dialogue with psychoanalysis, on the relation between truth and the subject, is also examined. Each essay not only makes an important statement, but also is part of an interconnected arc of topics and understanding, covering both the ancient and modern periods. This book reveals that Foucault's concern with antiquity raises questions deeply pertinent to the present moment.

This concise volume examines the characteristic electronic parameters of semiconductor interfaces, namely the barrier heights of metal–semiconductor or Schottky contacts and the valence-band discontinuities of semiconductor–semiconductor interfaces or heterostructures. Both are determined by the same concept, namely the wave-function tails of electron states overlapping a semiconductor band gap directly at the interface. These interface-induced gap states (IFIGS) result from the complex band structure of the corresponding semiconductor. The IFIGS are characterized by two parameters, namely by their branch point, at which their charge character changes from predominantly valence-band- to conduction-band-like, and secondly by the proportionality factor or slope parameter of the corresponding electric-dipole term, which varies in proportion to the difference in the electronegativities of the two solids forming the interface. This IFIGS-and-electronegativity concept consistently and quantitatively explains the experimentally observed barrier heights of Schottky contacts as well as the valence-band offsets of heterostructures. Insulators are treated as wide band-gap semiconductors.

Was ist eine gute Weltanschauung? Die Aufsätze behandeln einige der großen Themen der westlichen Philosophie unter neuen Gesichtspunkten, wie z. B. das Apeiron des Anaximander, das Leib-Seele-Problem bei Descartes und Wittgensteins Begriff der Sprache und Lebensform. Sie beleuchten aber auch Seitenwege wie z. B. einen Ausflug Schopenhauers, ein „Plagiat'Nietzsches und einige der Aphorismen Ludwig Hohls.

This book examines how the shift to remote teaching in March 2020 due to the global pandemic created new opportunities for innovation and creativity and shaped how social work classes were taught, with many temporary changes now part of permanent, standard practice. Drawing on narratives from 20 social work leaders across 17 different countries, the chapters explore particular themes and viewpoints on lessons learned during the pandemic, including case studies to examine copying mechanisms, insights into the transition to remote teaching, and the creative lessons that were learned. By taking an international perspective, it represents a key contribution to the scholarship of social work leaders from around the world concerning how institutions transitioned to remote learning and teaching and how these lived experiences and new discoveries are contributing to and influencing current practice. As such, it will appeal to social work educators, researchers, and field educators around the world with interests in experimental curriculum and field practice.

Pili in Mycobacterium Tuberculosis: Structure, Function, and Therapeutic Advances discusses the types of pili produced by the tuberculosis-causing bacterium, Mycobacterium tuberculosis (MTBC. The book examines the structure of pili shown under electron and atomic force microscopy and by using whole genome sequencing, outlines the importance of pili in mycobacterium tuberculosis. It also explores the role of pili in bacteria-host interactions and in drug development and delivery. Pili in Mycobacterium Tuberculosis opens with an overview of the structure, synthesis, and function of pili in bacteria. This includes taxonomy and the role of pili in diseases. The book also examines the preparation of Mycobacterium tuberculosis for electronic and atomic microscopy and looks at the different life cycles and susceptibility patterns of MTBC. It does on to discuss the expression and function of pili using whole genome sequencing and PCR-based methods and delves into bacteria host interactions. Lastly, it explores the development of new drugs and its delivery by pili. - Covers the structure, synthesis, and function of pili produced by the tuberculosis-causing bacterium, MTB - Introduces seven types of pili in MTB - Explains the mechanism of bacteria–host attachment and importance of this phenomena in MTB pili and other bacteria - Emphasizes the use of advances techniques to study and investigate the TB-bacilli and its interaction with host cells

Recent years have seen rapid advances in our understanding of genetic diseases in terms of their molecular origins. The book focuses on DNA mutations which give rise to abnormalities of protein structure and function in genetic disease.

Technology innovations have changed how social work educators teach and students learn. This book is designed to assist social work academics and educators in enhancing their students'critical thinking, reflective capacity and skills in clinical and research settings through the integration of social work content podcasting.It delves into the philosophical and theoretical underpinnings of podcasting within social work education and offers a framework for those looking to integrate podcasts into their pedagogical strategies. The book positions the co-creation of podcasts as a way forward in storytelling lived experience, enriching the lifelong educational journey for educators and students.Written by Mim Fox and Jonathan B. Singer—social work educators, practitioners, and hosts of the award-winning Social Work Stories Podcast and The Social Work Podcast, respectively—this book is an indispensable resource. It is packed with practical tips, insightful advice, compelling case studies, and helpful media links. Essential for all social work educators and practitioners, this book is essential reading for any social worker who is interested in podcasting in social work.

Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic'step by step'manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. - Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships - Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to'translational research', i.e., drug discovery, drug target prediction, and precision medicine - Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways