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Comprehensive Hematology and Stem Cell Research is the first major reference to cover both stem cell research and therapy as well as the range of hematological disorders they are currently used to treat and may potentially be able to treat in the future. This five volume set includes fundamentals, such as the underlying mechanisms of the blood and immune system, highlighting blood disorders and cancers of the blood, including lymphoma, leukemia, and myeloma. Other sections cover stem cell research and therapy, from harvesting stem cells to their utilization in cancer treatments. Finally, the work looks to the future and explores newer stem cell research that may lead to future treatments. This book is an excellent resource for students at the graduate and post-graduate levels, academics, and researchers in the fields hematology, immunology and oncology. - Compiles foundational knowledge and breakthrough research into one concise, comprehensive reference - Takes a translational, bench-to-bedside approach to hematological disorders and stem cell therapies - Covers clinical applications of stem cells, advances in the field, and promising new research

This manual covers all possible aspects of managing a child with differences in sex development, an entity easily missed by the unsuspecting clinician. Managing such children is challenging due to various processes (genetic, hormonal, environmental, chromosomal, and environmental) involved in developing gonads and brain imprinting. The entity of Gender dysphoria adds further to this complexity. With a global uproar caused by the cropping up of medicolegal issues concerning sex allotment and sex of rearing, a need is felt to know about the line of approach to address the problems of management of these children, which does not stop at medical and surgical treatment. Whereas many social and legal organizations are relentlessly working for the cause of such children, there is a lack of comprehensive literature on the round management of such children, which makes the book more of an essential addition to the existing reading material. Esteemed writers give all these aspects and explain lucidly with the help of tables, figures, and diagrams.

This edited book contains chapters that describe bespoke three-dimensional (3D) printing aimed at democratizing anatomy education by providing open-source scans for download and printing as 3D models. The long history of anatomical models as educational resources is explored in fascinating detail, from wax models through to a range of cutting-edge 3D printers. In a related chapter, a veterinary anatomy educator describes a transformation in teaching and learning methods in veterinary education using Augmented Reality (AR), Virtual Reality (VR) and 3D visualization methods like CT or MRI images which can be used to reconstruct complete 3D virtual models, as well as 3D prints from these reconstructed scans. The first digital, cloud-based human skeletal repository in southern Africa is an extensive and categorized ‘bone library'globally accessible for use in education and research. A chapter details a digital protocol for the bioprinting of a 3D acellular dermal scaffold (ADS) for use in wound healing, as an alternative to skin grafting for secondary intention wound healing. A chapter offers an extensive guide to applied anatomy for acupuncture and is provided in 4 parts viz, upper limb, lower limb, trunk, head and neck. Each part of the chapter is replete with beautiful cadaveric images including annotations that relate specifically to information in the text. We look at vertebral artery variations and its role in clinical conditions, current insights into polycystic ovarian syndrome, and visual interpretation using multiplex immunoassay of serum samples. This book will appeal to educators of both human and animal anatomy who have a keen interest and focus on the use of bespoke 3D printing, augmented and virtual reality, as well as acupuncture practitioners, clinicians, regenerative medicine specialists, surgeons, tissue engineers and artists.

This text focuses on the anatomical, physiological, pathological, and technical aspects of post robotic prostatectomy and post radiation urinary continence and erectile function. This edition has a wider focus than the previous, incorporating radiation, focal therapy, personalized medicine, and medical oncology. It serves as a one-stop shop of pearls on how to maximize functional outcomes in patients undergoing treatment for prostate cancer. This volume provides a comprehensive insight into the mechanisms responsible for maintaining urinary continence and erectile function and elucidates the key concepts and techniques utilized to achieve early return of urinary continence and erectile function after robotic radical prostatectomy and radiation. It includes a state-of-the art exhaustive review of tips and tricks utilized to achieve the trifecta of cancer control, urinary continence, and erectile function in different clinical scenarios like large prostates, post TURP, and in salvage settings. Authors discuss step-by-step surgical techniques with pre- and post-operative interventions that are known to improve urinary and sexual function. All chapters are written by world-renowned experts in their fields and include extensive illustrations and videos to make this the most interactive and visually appealing text available. Urinary Continence and Sexual Function After Robotic Prostatectomy, Radiation, and Novel Therapies will be an invaluable addition to every urologist's library.

Regenerative Medicine in the Genitourinary System gives the reader a comprehensive overview of tissue engineering used to treat genitourinary disorders and infertility, also providing a great learning platform for researchers in different fields such as cell biology, pharmaceutics, clinicians, chemists, material scientists, and more. The book covers the latest innovations on the subject, but also acts as a resource for tissue engineering applications and regenerative medicine. Over the last several decades, tissue engineering has continued to make considerable advancements in therapeutic and clinical strategies that address male/female urological or genitourinary diseases. Although several articles have been published on this topic, there are very few book chapters and no single book currently available dedicated to this topic. - Provides extensive principles of tissue engineering in urinary and reproductive systems - Presents excellent examples of tissue engineering and regenerative medicine (translational medicine) to tackle diseases and disorders related to the urinogenital system - Includes chapters covering erectile disfunction, as well as tissue engineering strategies to treat male and female infertility

Genetics and Epigenetics of Genitourinary Diseases aims to provide a comprehensive collection of data on genetics and epigenetics in almost all genitourinary diseases for researchers, clinicians, and graduate students. This book discusses several genetic and epigenetic changes like DNA methylation, mutations, single nucleotide polymorphisms, DNA rearrangements, chromosomal remodeling, microsatellite instability, and chromosomal instability (CIN) in genitourinary cancers. This book is split into 18 chapters, beginning with the importance of genetics and epigenetics in genitourinary diseases. It then goes on to cover the genetics and epigenetics of various diseases and tumors. Certain chapters present novel techniques of next-generation sequencing (NGS). Furthermore, RNA-Seq is discussed as a sequencing technique that uses NGS to reveal the presence and quantity of RNA in a biological sample. This book is a valuable resource for researchers, practitioners, and students in genetics and epigenetics who want to broaden their understanding of the field. - Provides a unique collection of genetics and epigenetics in genitourinary - Covers the subject of genetic and epigenetics in urological malignancies, infertility, and urolithiasis - Gives novel insights into genitourinary diseases even the rare ones and sheds light on genitourinary diseases from DNA methylation to CIN

The first 3 editions of'Robotic Urology'have already become a gold-standard in the robotic community worldwide.This book provides a systematic and well-structured content which includes all fields of urology – general aspects on robot-assisted urologic surgery, kidney and adrenal, pelvis, bladder, prostate, reconstructive urology, and the male genital tract. The book brings together leading robotic surgeons from around the world to provide an updated text that covers all oncologic and reconstructive procedures in urologic surgery that are performed with robotic assistance.Additional questions via app: Download the Springer Nature Flashcards app for free and use exclusive additional material to test your knowledge.

In the ever-evolving field of urology, percutaneous renal surgery (PCNL) for kidney stones stands at the forefront of innovation and excellence and offers an alternative to traditional open surgery. This book, Percutaneous Renal Surgery, delves into the intricacies of percutaneous renal surgery, providing a thorough exploration of the latest techniques, advancements, and best practices. Featuring contributions from international experts in the field, each chapter covers the key aspects of percutaneous renal surgery, including patient selection, preoperative evaluation, procedural nuances, postoperative care, and potential complications. From navigating renal anatomy to mastering the latest instruments and technologies, you'll gain the knowledge and confidence needed to excel in this specialized discipline. Discover the benefits of percutaneous renal surgery, such as reduced invasiveness, shorter hospital stays, enhanced patient outcomes, and improved quality of life. Explore its applications in treating kidney stones, urothelial cancer, and other urological conditions. Delve into the art of accessing the kidney through percutaneous techniques, utilizing fluoroscopy, ultrasound, and other imaging modalities.With its comprehensive coverage and insightful guidance, Percutaneous Renal Surgery empowers urologists to push the boundaries of patient care and redefine what is possible in the field of urology.

Pediatric Surgery provides an authoritative, up-to-date and comprehensive analysis of current practice in the field. It is divided into three topical volumes, with a total of seven sections focusing on general principles, newborn surgery, general pediatric surgery, tumor surgery, trauma, transplantation, and pediatric urology surgery. Detailed descriptions of surgical techniques and pre- and postoperative management are provided by experts from various parts of the world.The result is an international reference on the surgical management of both common and rare diseases of infants and children that will be an ideal source of information and guidance for pediatric surgeons, pediatric urologists, neonatologists, pediatricians, and all those seeking more detailed information on surgical conditions in children. The three topical volumes are as follows:General Principles and Newborn SurgeryGeneral Pediatric Surgery, Tumors, Trauma andTransplantationPediatric Urology

This book provides a practically applicable guide to the latest techniques in kidney transplantation in an easy-to-digest format. Background is provided on relevant aspects of anatomy and physiology. Detailed step-by-step procedural guidance describes how to successfully perform benching surgery, kidney transplantation and graftectomy techniques. Surgical methods of non-laparoscopic kidney procurement from deceased and living donors are also covered. Potential complications with relevant prevention and resolution strategies are discussed to assist the reader in developing a deep understanding of the methodologies presented. In this book, the author shares his knowledge and experience gained over 35 years in the field of kidney procurement, preparation and transplantation. The book is a monograph and contains many of the author's individual views on certain kidney procurement and transplantation techniques.Kidney Transplantation: Step-by-Step Surgical Techniques is a concise overview of techniques for kidney procurement, benching and transplantation. Therefore, it is a valuable resource for all practicing and trainee practitioners who encounter these patients in their day-to-day practice.

Dit boek is een praktische handleiding bij het diagnosticeren en behandelen van seksuele problemen. De probleemgerichte en uniforme hoofdstukopbouw geeft houvast aan allen die in de klinische praktijk werken met mensen met seksuele problematiek. Stapsgewijs wordt onderscheiden welke interventies bij welke klacht passend zijn. Het boek biedt de seksuologische hulpverlener een praktisch naslagwerk in aanvulling op bekend veronderstelde kennis die zoveel mogelijk is geactualiseerd. Voor de niet-seksuologische professional biedt het boek een compact overzicht van noodzakelijke kennis om te kunnen diagnosticeren en vormt het een basis voor eenvoudige interventies en voor het adequaat verwijzen naar de seksuologische hulpverlening. Het boek is een herziening van het in 2010 gepubliceerde boek Seksuele disfuncties. Diagnostiek en behandeling. De hoofdstukken over seksuele disfuncties zijn geactualiseerd en drie hoofdstukken zijn toegevoegd: Hyperseksualiteit, Parafilie en Genderdysforie. De toegenomen inzichten in definitie, concept, diagnostiek en behandeling van deze problematiek, en de behoefte vanuit de klinische praktijk om meer houvast en eenduidigheid, zette ons tot deze uitbreiding aan. Tevens zijn vignetten aan elk hoofdstuk toegevoegd om de klinische toepassing te illustreren. Naast de tekst bevat elk hoofdstuk een beslismatrix waarin de te volgen strategieën in diagnostiek en behandeling beknopt worden weergegeven. De matrix duidt aan welke interventies bruikbaar zijn, mede afhankelijk van de complexiteit van het probleem en van de competenties waarover de clinicus beschikt. Diverse interventies zijn online beschikbaar. Redactie Dr. P. (Peter) Leusink, huisarts, seksuoloog NVVS, supervisor NVVS, docent, werkzaam bij de Seksuele Zaak, Utrecht Drs. G. (Gertruud) Borst, GZ-psycholoog/psychotherapeut, seksuoloog NVVS, systeemtherapeut NVRG, supervisor NVVS en NVRG, docent, werkzaam bij GGZ PsyQBeverwijk Drs. Y. (Yvonne) Merkies, klinisch psycholoog/psychotherapeut, supervisor EMDR en VGCt, docent, manager behandelzaken bij Sinai Centrum

This book provides comprehensive information to all medical doctors regarding novel angiogenic and bioengineering medical treatments. Tissue healing is significantly hampered by ineffective neovascularization at the site of the defect, resulting in poor clinical outcomes. The fabrication of biomaterial-based scaffolds with adequate vascularizing abilities is the prevailing challenge that has drawn considerable attention from the scientific community. The decisive roles of vascularized biomaterials as bone and skin substitutes, and in various soft and hard tissue engineering, have been investigated widely. Cell-based and scaffold encapsulating bioactive molecules-based approaches are essential means of developing efficient angiogenesis in tissue defects. To fulfill the necessity of an optimum long-term vascularizing scaffold, it should essentially be economic, controlled, and reproducible. While a lot has been achieved towards acknowledging newer molecules with vascularizing abilities; there is a broad gap wherein we need to develop in vitro vascularized implants as well as tissues and organs with the advanced technologies and knowledge at our disposal.

Understanding Comics-Based Research focuses on the contribution that comics can make to social research as part of a'Graphic social science'construct. Comics and graphic novels offer a juxtaposition of text and images bringing community-based participatory research multiple opportunities for communication. In this exploratory volume, Veronica Moretti illustrates how the graphic medium can help elicit participant's narratives and how it supports new guiding principles in research, along with what barriers researchers may encounter using comics, and to what extent comics can be incorporated within traditional social research techniques.

This book comprehensively covers the techniques available for robot- assisted prostatectomy. Chapters feature detailed descriptions of how to successfully perform a variety of relevant techniques including the reconstruction of continence mechanisms and the use of the transperitoneal RALP anterior approach. Potential complications, preoperative and postoperative management strategies are also discussed, enabling the reader to develop a thorough understanding of how to apply a range of relevant methodologies into their day-to-day clinical practice and avoid commonly encountered pitfalls.Robot-Assisted Radical Prostatectomy: Advanced Surgical Techniques provides a practically applicable resource for all practicing and trainee urologists seeking a detailed overview of the latest advances in robot-assisted surgical procedures and current management strategies applicable to prostatectomy.

This book provides a concise, yet comprehensive overview of pediatric nephrolithiasis. The text covers the epidemiology and pathophysiology of pediatric stone disease, describes the appropriate workup for children with nephrolothiasis, and reviews strategies for managing the disease and preventing stone recurrence. Examples of complex cases of pediatric stone disease are also presented in the book.Written by experts in the field, Diagnosis and Management of Pediatric Nephrolithiasis is an essential guide for medical providers who care for pediatric patients with nephrolithiasis.

This contributed volume gathers the latest knowledge in the field of stem cells in human reproductive organs, as well as animal models, and to consider the possibility of using this knowledge for clinical purposes. The scope of the book covers both clinical and basic knowledge of stem cells in both reproductive medicine (gynecology and obstetrics) and regenerative medicine as well as cellular and molecular medicine and reproductive biology. Chapters on basic stem cell knowledge in human reproductive tissues and organs or animal models are included, as well as clinical knowledge on their role in the manifestation of infertility and cancer and their clinical use.

Andrology & Sexual Medicine is a comprehensive source for urologists, andrologists, sexologists and general practitioners. It contains general and up-to-date information about almost all topics within andrology and sexual medicine, and is a unique source that can be used for both exams and general daily practice. Easily accessible to clinicians and researchers and specialists, it tackles the controversial and complex topics of andrology and sexual medicine for urologists.