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Discover a comprehensive and up-to-date reference resource for bone marrow pathology, complete with an extensive list of references The diagnosis and treatment of bone marrow pathologies is one of the most critical areas of medical research and care. For years, Bone Marrow Pathology has served as the essential reference and teaching tool in the field of haematology, with an authoritative treatment of the subject written by acknowledged leaders in the field. Now fully updated to reflect urgent new changes to the theory and practice of haematology, it promises to serve a new generation of practitioners. In the book, the characteristics and function of normal bone marrow are extensively discussed. Bone marrow pathology, including both aspirate films and trephine biopsy sections, is examined in a clinical context. The content is augmented by discussion of the peripheral blood findings and supplementary bone marrow tests. Readers of the sixth edition of Bone Marrow Pathology will also find: Lavish illustrations with high-quality images of bone marrow and other associated imagesIncorporation of new classifications including the WHO and International Consensus classifications, as well as new and expanded research areasEmphasis on practical tools including differential diagnosis and common problems and pitfallsA practical, integrated approach to diagnosis Perfect for trainee and consultant haematologists and haematopathologists, Bone Marrow Pathology will also prove itself invaluable for cytogeneticists, molecular geneticists and anyone working in immunophenotyping.

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This second edition addresses all aspects of the disorder, from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, novel topics including CSS associated with Castleman disease, pregnancy, therapeutics, transplantation, and cardiac bypass, as well as treatment with JAK inhibitors are addressed.

This important collection provides an epidemiological perspective on the continuing scope of sickle cell disease (SCD) in sub-Saharan Africa, alongside the clinical attempts to provide comprehensive care in a resource-limited setting.The book moves from a clinical profile of SCD to screening for the disease and ongoing patient care. There are chapters on pain management, organ failure, infections and transfusions, as well as nutrition and neurocognitive complications. The book concludes with chapters on anti-sickness medication, cell transplantation and nursing care.The first in a two-volume set offering a multi-disciplinary perspective on SCD, this is a comprehensive resource that applies clinical knowledge to the practical challenges faced in sub-Saharan Africa. It will be important reading for medical students taking courses in haematology as well as those studying Public Health in sub-Saharan Africa. Practitioners in the region will also find it invaluable in developing their understanding of this pervasive disease.

Comprehensive Hematology and Stem Cell Research is the first major reference to cover both stem cell research and therapy as well as the range of hematological disorders they are currently used to treat and may potentially be able to treat in the future. This five volume set includes fundamentals, such as the underlying mechanisms of the blood and immune system, highlighting blood disorders and cancers of the blood, including lymphoma, leukemia, and myeloma. Other sections cover stem cell research and therapy, from harvesting stem cells to their utilization in cancer treatments. Finally, the work looks to the future and explores newer stem cell research that may lead to future treatments. This book is an excellent resource for students at the graduate and post-graduate levels, academics, and researchers in the fields hematology, immunology and oncology. - Compiles foundational knowledge and breakthrough research into one concise, comprehensive reference - Takes a translational, bench-to-bedside approach to hematological disorders and stem cell therapies - Covers clinical applications of stem cells, advances in the field, and promising new research

Hematology Timely morphology resource based on ongoing series of morphology updates published in the American Journal of Hematology since 2008 This is the first book of its kind, written by renowned author Professor Barbara J. Bain, featuring a collection of instructive cases with interesting morphological features initially published in the American Journal of Hematology. This new book aims to bring these interesting and instructive cases to a wider readership. This book features updated cases and a “Test Yourself” section to aid in reader comprehension and information retention. Cases covered in Hematology: 101 Morphology Updates include: The significance of irregularly contracted cells and hemighosts in sickle cell disease, and striking dyserythropoiesis in sickle cell anemia following an aplastic crisis Prominent Howell-Jolly bodies when megaloblastic anemia develops in a hyposplenic patient, and unusual aspects of G6PD deficiency The cause of sudden anemia revealed by the blood film, chorea-acanthocytosis and dysplastic neutrophils in an HIV-positive woman Neutrophil dysplasia induced by granulocyte colony-stimulating factor, and diagnosis of pyrimidine 5'-nucleotidase deficiency suspected from a blood film Hematology: 101 Morphology Updates is a key resource for consultant hematologists and clinical scientists, trainee hematologists and biomedical scientists. The audience may use this book to solve difficult diagnostic problems or as a source of teaching cases: for both personal learning, including exam revision or solving difficult cases, and as a teaching resource.

Selected peer-reviewed full text papers from the 3rd International Conference on Materials Science and Manufacturing Technology (ICMSMT 2021)Selected peer-reviewed full text papers from the 3rd International Conference on Materials Science and Manufacturing Technology (ICMSMT 2021), April 08-09, 2021, Tamil Nadu, India

This book is quick guide on the hematopoietic stem cell transplant (SCT), also called bone marrow transplant (BMT) - an evolving field of hematology and hemato-oncology. This book covers the various types of stem cell transplants like autologous and allogeneic stem cell transplants, indications, ways of doing a transplant, and stem cell transplants basic principles. Written in a question-answer format, readers will find it more interesting as one question sequentially leads to another. This book explains the complications of SCT in individual chapters along with the biology of T cells which are the most important cells involved in the success of SCT This book is beneficial to the budding hematologists, oncologists, and postgraduates interested in SCT and helps students in their exams. The book would be helpful for readers globally as SCT is a procedure done worldwide and is an ever-increasing field for treating various benign and malignant hematological diseases.

Nanocomposites (both heterogeneous and anisotropic) are hard to machine due to their enhanced properties and there is a need to know about the problems associated with the machining of nanocomposites by various conventional as well as non-conventional machining operations. Machining of nanocomposites emphasizes on different fabrication methods to develop nanocomposites (polymers, metals, and ceramics) and different machining processes used in industries. Further, it describes issues and challenges including research trends associated with the same. It also evaluates mechanical and wear properties of the composites as well.Features: Covers manufacturing process of nanocomposites. Includes conventional and non-conventional machining process and relevant applications. Addresses effect of different nano-reinforcements on machinability. Discusses usage of design of experiments and optimization technique to improve the machinability of nanocomposites. Reviews challenges on machining of nanocomposites and its remedies. This book aims at Researchers, Graduate students in Mechanical Engineering, and Materials Sciences including Composites, Nanotechnology, and Machining.