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This fully updated and expanded second edition of a highly popular text book focuses on the structure and mechanism in carbohydrate chemistry and biochemistry. Carbohydrates play important roles in biological systems as energy sources, as structural materials, and as informational structures (when they are often attached to proteins or lipids). Their chemical reactivity and conformational behaviour is governed by mechanistic and stereochemical rules, which apply as much to enzymic as to non-enzymic reactivity. The same principles of reactivity and conformation govern changes brought about in the process industries, such as pulp, paper and food. Extensively referenced with citations and a detailed index, the book contains everything the reader needs to know to start a carbohydrate research project with one of the real strengths being the treatment and integration of the important physical-chemical principles and methods (though lead references only are given to the finer points of carbohydrate synthesis). The book is suitable for both researchers who are new to the subject and those more established as well as a readership from diverse backgrounds and interests, including chemists, biochemists, food scientists and technologists involved with the processing of polysaccharides in the paper, textile, cosmetics, biofuels and other industries.

The International Conference on Phytochemistry, Textile, & Renewable Energy Technologies for Sustainable Development (ICPTRE 2020) was hosted by the World bank funded Africa Centre of Excellence in Phytochemicals, Textile and Renewable Energy (ACEII-PTRE) based at Moi University in conjunction with Donghua University, China and the Sino–Africa International Symposium on Textiles and Apparel (SAISTA). The theme of the conference was Advancing Science, Technology and Innovation for Industrial Growth. The research relationships between universities and industry have enabled the two entities to flourish and, in the past, have been credited for accelerated sustainable development and uplifting of millions out poverty. ICPTRE 2020 therefore provided a platform for academic researchers drawn from across the world to meet key industry professionals and actively share knowledge while advancing the role of research in industrial development, particularly, in the developing nations. The conference also provided exhibitors with an opportunity to interact with professionals and showcase their business, products, technologies and equipment. During the course of the conference, industrial exhibitions, research papers and presentations in the fields of phytochemistry, textiles, renewable energy, industry, science, technology, innovations and much more were presented.

This book brings together the molecular aspects of the pathogenesis of entomopathogenic fungi, various aspects of mycoinsecticide development, and regulatory aspects to highlight the immense contribution of the agricultural sector. The chapters address aspects of entomopathogenic fungi, including host-pathogen interactions (susceptibility and resistance), fungus-insect and fungus-fungus dual interactions, phylogeny and taxonomy, biochemistry, and molecular basis of enteropathogenesis, market potential of entomopathogens, regulatory aspects, bioprospecting of fungi, fungi as crop bodyguards and in disease suppression, and consortia for the control of insect pests and pathogens in single crop systems. Written by experts in academia and industry from Algeria, Brazil, Hungary, India, Italy, Malaysia, Oman, Pakistan, and the United States, the book overviews entomopathogenic fungi used as biological control agents against insect pests and other arthropods, their mode of action, pathogenesis, bioactive metabolites, mycotoxins involved, their mass production, limitations, and agricultural- and environment-related issues. It also includes developing various biopesticide products, with special references to formulations and prospects. In agriculture, crop protection and production depend on insect pests controlled by entomopathogenic fungi. Understanding the pathogenicity, mechanism of action, formulations, and applications of a wide array of entomopathogenic fungi as biopesticides is a valid eco-friendly approach. The book provides advances in pathogenicity, biochemistry, virulence, and interaction that facilitate the application of Beauveria, Metarhizium, and other entomopathogens as potential biopesticides against major insect pests. Developments in bioactive compounds, secondary metabolites, enzymes, and toxins of entomopathogenic fungi have facilitated precise applications and management to target insect pests. Further advances in molecular aspects, the formulation of nanobiopesticides, and biofabricated technology paved the way for insect pest control. This book will be a helpful resource for students, teachers, researchers, scientists, and professionals in the industry working on biological sciences, applied entomology, mycology, zoology, forestry, biochemistry, molecular biology, and nanotechnology.

This book focuses on the fundamental processes involved in calcium signaling through fractional mathematical modeling. The intended reader of the book is mathematically proficient students of cell biology, applied mathematics and mathematical biology who are interested in learning about modeling in cell biology. The book will inspire the graduate students and researchers to collaborate with experimentalists while studying the direction needed to explore the modeling literature. Organized into four chapters, the book introduces to fractional calculus and devoted to understanding the receptor activation by the ligand, that is Thrombin via fractional model incorporating the Caputo-Fabrizio fractional operator. It studies the calcium profile in red blood cells with the help of the advection-diffusion equation. The book further studies the process of buffering, aiding to the lowering of the calcium concentration in the cytosol, which rises due to calcium influx from extracellular space and intracellular storage. A mathematical model is studied to characterize the anomalous subdiffusion of cytosolic calcium.

Biochemistry is concerned with the chemical processes that occur within living organisms and microorganisms. There have been a number of publications focusing on biochemistry and its use for understanding biochemical and molecular mechanisms, with the majority of the literature focusing on bench scale items. To date there has not been a comprehensive work focusing on the techno-economic and industrial aspects of biochemistry from the microeconomic and pilot scales. This text covers current innovations and advances in plant biochemistry, animal biochemistry, microbial biochemistry and medicinal biochemistry plus potential uses of proteomics, genomics, recombinant DNA technology and protein application. Recent Advances in Industrial Biochemistry focuses on methods for recombinant proteins production and purification plus metabolic engineering and other source technologies from the industrial viewpoint, providing comprehensive, up-to-date information and evidence on contemporary development in the field of industrial biochemistry. The major focus of this book is the key issues, opportunities, approaches, advancements, products, innovations and technologies in current biochemistry from micro scale to production at pilot scale. Chapters highlight the many potential commercial prospects in various industries from food to to pharmaceuticals to bioenergy, providing a valuable and unique single resource for researchers.

This book overviews ongoing and upcoming clinical applications of basic immunology. Recent advances in our knowledge of immunology coupled with new technologies have aided in the development of efficient cancer immunotherapy, as well as the control of emerging microorganisms such as SARS-CoV-2. However, knowledge of basic immunology has not been fully utilized even after the discoveries of immune checkpoint inhibition for cancer immunotherapy and the development of mRNA vaccination against SARS-CoV-2. There is still room for improving the clinical application of basic immunology. The book summarizes the achievements in clinical applications of basic immunology and highlights what can be further extended to make immunology a more practical human science. Basic immunology and its clinical applications are two wheels of the same cart in the immunology field, which aids in the development of more efficient cancer immunotherapy and rapid control of infectious diseases against microorganisms, including new viruses and classical toxoplasmosis. The exploration of ongoing and upcoming applications of basic immunology in this book makes it a useful resource for immunologists, physicians, molecular and genome biologists, bioinformaticians, and students in these fields.

Molecular hydrogen (H2) has emerged as a promising therapeutic and preventive medical gas. Hydrogen gas has garnered significant attention in recent years due to its remarkable antioxidant and anti-inflammatory properties. H2 exhibits exceptional pharmacokinetics, swiftly traversing cellular biomembranes to access subcellular organelles indirectly regulating hormones and cytokines through various signal transduction pathways. H2 has the potential to address a wide range of issues, including clinical medical treatment in the areas of healthcare: myocardial ischemia, heart failure, cardiac arrest, metabolic syndrome, advanced-stage cancer, inflammatory diseases, Alzheimer's dementia, aging-related disorders, sports activities, and even beauty, agriculture, etc.Selected world-known authors in the field provide readers with a comprehensive overview of molecular hydrogen's remarkable effects and its physical, chemical, and therapeutic properties and potential in biomedical applications. This contributed volume fills the current gap in information and is intended for everyone who wants to be better informed about the wide possibilities of using molecular hydrogen. However, it is mainly intended for use by medical students, physiologists, pharmacologists, physicians, and other healthcare personnel who can use molecular hydrogen to improve the health of everyone who needs it.

This textbook introduces the clinical applications of biomolecules in disease diagnosis, covering a range of topics in biochemistry. The book discusses carbohydrate and protein metabolism abnormalities, lipid digestion and absorption defects, disorders of purine and pyrimidine metabolism, and the chemistry and biological roles of water- and fat-soluble vitamins. It also covers the roles of different macroelements and essential trace elements in physiological processes and the prevention of chronic diseases. The final chapter focuses on recent developments in our understanding of the role of enzymes in disease development and diagnosis. The book chapter also explores the causes and effects of free radicals in the body, including oxidative stress and diseases such as cardiovascular and neurodegenerative diseases. Finally, the chapter discusses cancer development, causes, diagnosis methods, biomarkers, and current treatments such as targeted drug therapy, chemotherapy, and radiation therapy. This book is a useful resource for undergraduate and postgraduate students, researchers and practitioners in biochemistry, medicine, and health sciences.

The second edition of this book presents the role of osmolytes in human health and diseases. Some of the chapters deal about the possibility of the use of osmolytes as diagnostic biomarkers and potential drug design for neurodegenerative and other human diseases. Other chapters also include reviews on the role of osmolytes in cancer, metastasis, infectious diseases, metabolic disorders, immunological disorders, and tissue regeneration. Importantly, the book also contain recent updates on the role of naturally occurring osmolytes in protein folding pathway, protein stability, and their underlying mechanisms. The book also covers the aspects that osmolytes could promote conformational alterations of transcription factors that favor metastatic behavior. Potential of the osmolytes in the various process of vaccine development, including enhancing the efficacy, production, and purification steps are also succintly described. Towards the end, the book also elucidates the use of specific molecules for the prevention of toxic gain of functions and restoration of function to disease-causing mutant protein. This book is an invaluable asset for the researchers especially working in osmolyte biology and scientists involved in basic and clinical research particularly neurodegeneration, diabetes, cancer, and metabolic disorders.

This book covers polyextremophiles, the latest biotechnological advances, and developments in the study of extremophilic diversity with a focus on genetics, proteomics and the impact of climate change. It sets out new perspectives on the polyextremophiles'mechanism of tolerance to extreme conditions, and it also outlines their applications in bioremediation, therapeutics, and astrobiology research. Expert contributors discuss topics such as genes associated with polyextremophiles, the applications of genome editing in extremophiles, secondary metabolites from extremophiles, and the biocatalytic potential of extemozymes isolated from extremophiles. Readers will find in this book several case studies that collate the diverse applications of polyextremophiles for bioremediation, including the use of extremophilic algae in wastewater treatment, nutrient recovery and animal feed production, the treatment of industrial waste, pharmaceuticals and personal care products, and the removal of microplastics, heavy metals and E-waste. Particular attention is given to the use of polyextremophiles for bioremediation of abandoned mining sites. The book also presents bioactive compounds from halophiles and their biomedical applications and discusses the implications of polyextremophiles in astrobiology research. Given its breadth, this book is a valuable contribution to the biotechnology of polyextremophiles by overviewing research to date and exploring challenges and opportunities for future research. It also benefits a broad readership, from scholars, researchers and students to industry professionals interested in the study and development of biotechnological applications of polyextremophiles.

This book focuses on the various invasive and non-invasive techniques which can be used for the characterization of starch macromolecules along with, the various types of physical, chemical, and enzymatic modifications of starch to enhance its usage in the food industry. It discusses various biophysical techniques, including scanning electron microscopy, Fourier transforms infrared spectroscopy, X-ray diffraction, Raman scattering, and second harmonic generation microscopy for the understanding of the Physico-chemical properties of starch. The book also sheds light on the visual, rheological characterization of different types of starches that are responsible for altered digestibility. The chapters also cover the applications of starch in food industries, non-food industries, pharmaceuticals, drug delivery systems, and green flexible electronics. Towards the end, the book reviews the chemical, physical, and enzymatic modifications of the starch for improving its properties and applications. This book provides a valuable reference for students and researchers in the field of food science and technology, food science, and nutrition.

The goal of the American Chemical Society's Chemistry in Context is to establish chemical principles on a need-to-know basis for non-science majors, enabling them to learn chemistry in the context of their own lives and significant issues facing science and the world. The non-traditional approach of Chemistry in Context reflects today's technological issues and the chemistry principles within them. Climate change, renewable energy, alternate fuels, nutrition, and genetic engineering are examples of issues that are covered in Chemistry in Context.

This book offers a comprehensive perspective of herbal medicine phytochemistry and explores the application of plant extracts as bioactive compounds in disease prevention and treatment in modern or traditional medicine. The book starts with an introduction to the history and value of herbal medicine, followed by 3 parts covering the main phytochemical components and metabolites in herbal medicine, different uses and practices in herbal medicine, including a region-wise analysis of methods and practices and an overview of regulations and policies for herbal medicinal practitioners, and the advances and challenges in quality assessment of herbal medicine. Plants generally have the tendency to bioaccumulate trace metals from the environment and they are easily contaminated by microorganisms from water sources and poor hygiene practices of the herbalist. Quality assessment and assurance is, thus, a pertinent challenge in herbal medicine practice (i.e., in remedy formulation and application), and this book offers an authoritative perspective on this topic, covering aspects such as quality control strategies, preparation techniques, chemical quantification in phytomedicine, and the efficacy and safety of herbal remedies. Moreover, in this book, readers will find valuable insights into the latest trends and developments in the field, and a critical review of the application of medicinal plants to treat cardiovascular, digestive, respiratory neurological and reproductive diseases. Particular attention is given to the advances and trends in the field, and readers will learn about the latest biotechnological approaches, the use of nanotechnology in herbal medicine, metabolomic analysis of medicinal plants, big data application in herbal medicine, and the value of herbal medicine towards sustainability. Given its breadth, this book is aimed at researchers, academics, practitioners and professionals working in the fields of natural, life, health, clinical, and biomedical sciences, and interested in herbal remedies, pharmacology, pharmacognosy, human nutrition and dietetics, plant biology, and biotechnology/microbiology.

This book reviews the potential of metallodrugs against different cancer. It summarizes the classification of metal-based anti-cancer drugs, their plausible biochemical and mechanistic pathways, combining drug strategies for hitting multiple therapeutic targets at the intracellular level, and advanced drug delivery strategies. The book covers the metallodrugs for the efficacious treatment of diverse cancerous strains and recent advances in drug delivery strategies that are used for developing these metal-based therapeutics as potent anticancer agents in vitro and in vivo. The book also covers different biophysical and analytical techniques for studying metal-ligand and metal-macromolecular interactions. The book further presents the recent examples of metallomics studies on the different types of cell death induced by metal-based anticancer drugs, especially on the three major forms of programmed cell death (PCD) in mammalian cells: apoptosis, autophagy, and regulated necrosis, alsocalled necroptosis. Lastly, the book explores the modulation of reactive oxygen species (ROS) by metallodrugs.

This book reviews the latest developments and applications in the field of biosensing, providing readers with an update of the earlier, successful edition, Biosensing for the 21st Century. In this book, readers will find comprehensive key information on the advances and challenges in biorecognition elements and transduction principles, including examples of new materials and new methods. Ranging from engineering chimeric enzymes to the progress in electrochemical sensing of drugs, the book discusses the latest innovations in the field and thus, provides the reader with a profound overview. In the field of biological recognition the focus will be on switchable sensors by engineering new proteins, the development of Molecular Imprinted Polymers (MIPs) for proteins or even larger biological entities, the construction of complex nucleic acid – protein structures for affinity sensing and the application of whole microbes. The book covers new trends in signal transduction which includes graphene-based field effect transistors, nanopores designed for high selectivity and sensitivity in analysis, plasmonic and nanophotonic sensing applying metal nanostructures up to new developments in microarray construction. An introduction in to the challenges in skin-interfaced systems for continuous biochemical sensing, offers a glimpse into the future of wearable technologies. Furthermore, actual areas of application of new sensing strategies such as the detection of various types of viruses and bacteria or the analysis of drugs will be highlighted. Each chapter provides a scholarly yet accessible perspective on the latest trends in biosensor technology. Given its breadth, the book has an interdisciplinary appeal and engages a wide readership, from students and researchers to practitioners in academia and industry, interested in the fields of biochemical/biomedical engineering and in biosensing methodologies and applications.

This book provides a comprehensive overview of piezoelectric sensor devices and instrumentation and their use for chemical and biochemical analysis. Sensors relying on established transducers, such as the quartz crystal microbalance (QCM) and the surface acoustic wave resonator (SAW) are covered, and novel devices like surface transverse wave (STW) resonators, film bulk acoustic resonators (FBAR) as well as non-piezoelectric devices with mass-sensitive properties are presented. As their name implies, such devices respond directly to mass changes on their surfaces and thus address the most fundamental quality of any analytes. First, the book presents the fundamentals of new measuring strategies with these devices. Then, it introduces a variety of chemo- and biosensing application scenarios of these devices. In addition, the book covers both the state-of-the-art of academic research and prospects concerning the commercialization of these sensors. Given its scope, the book is of interest to academics, specialists in industry, and advanced students in the areas of analytical chemistry, rapid analysis, and sensor technology, giving them the unique possibility to familiarize themselves with this chemical sensing strategy. Readers will benefit from the coverage of both cutting-edge research results and applications that help bridge the gap between academia and industry.

Modern research in biology increasingly relies on multiple techniques for describing structures and mechanisms. This book provides an overview of the contemporary integrated biology approaches for solving structures and understanding mechanisms of complex biological systems. It includes several methodology chapters discussing the current developments in the areas of cryo-electron microscopy (EM) and cryo-electron tomography (ET), computational biophysics, solution NMR spectroscopy, solid-state NMR spectroscopy and dynamic nuclear polarization (DNP), electron paramagnetic resonance (EPR), (photo-)chemically induced dynamic nuclear polarization (CIDNP), X-ray crystallography and small-angle X-ray and neutron scattering (SAXS/SANS). Several subsequent chapters demonstrate how these methods are used in synergy to address problems at the forefront of structural biology, with particular emphasis on examples where individual techniques are insufficient. Examples of biological systems include membrane proteins, viral protein assemblies, cytoskeleton protein assemblies, photosynthetic reaction centers, large enzyme complexes and whole cells. The book is targeted to both the current practitioners of structural biology and scientists who are interested in entering the fields of structural biology or biophysical chemistry.

This book provides new knowledge about the nutrition and metabolism, as well as the roles of nutrients in the immunity, health, and management of companion animals (dogs and cats). The domestic dog (facultative carnivore) and the domestic cat (obligate carnivore) have evolved differentially in their digestive tract, nutrition, metabolism, chemical sensing, and feeding behavior. These animals have been human companions for at least 12,000 and 9,000 years, respectively, and continue to contribute to the mental health and well-being of children, adolescents, and adults. Both dogs and cats have become increasingly popular in many countries and worldwide over the past decades. Comprehensive update about how the animals utilize dietary nutrients for optimum growth, development, and health is beneficial for their owners, as well as students and researchers. Chapter 4: Characteristics of Nutrition and Metabolism in Dogs and Cats is available open access under a Creative Commons Attribution 4.0 International License

This textbook is for students studying medicine and other biosciences. Understanding biochemistry requires basic understanding of organic chemistry. The main purpose of this book is, therefore, to help students to understand biomolecule-related organic chemistry. Fundamental theories such as the molecular orbital method, thermodynamic law, frontier orbital theory, and molecular interactions, which have not been covered in basic organic chemistry textbooks, are.

This book helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. The book covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms. This model has been successfully applied in various conditions, including inborn errors of metabolism, primary immunodeficiency, and endocrine disorders. However, integrating metabolomics with other omics datasets and clinical phenotypes requires careful study design, analytical tools, and data analysis and interpretation. This groundbreaking new book provides essential guidance for researchers, students, and professionals looking to leverage metabolomics in their own work, including biochemical and clinical geneticists, pharmacogenomics and pharmacometabolomics experts, pharmaceutics and diagnostic researchers, medical scientists, clinical dietitians, metabolic engineers, clinical chemists, and personalized medicine specialists.

This book presents the latest cutting-edge research on phase separation. It discusses the benefits and risks of phase separation for living cells from the perspectives of physics, chemistry, biology, and medicine.Phase separation is a physico-chemical process that induces a single solution of solvent and intrinsically disordered proteins (IDPs) to separate into two phases, one phase containing only solvent and the other containing IDPs in the solvent. A key molecule in phase separation is the intrinsically disordered region (IDR) proteins (IDPs), mostly comprised of RNA-binding proteins (RBPs). One of the major roles of phase separation is to generate condensates, membrane-less organelles including stress granule, Cajal body, and nucleolus.Biological actions of phase separation in various aspects of science have received increasing attention in recent years. The book consists of four parts; Part I on physics and chemistry includes topics on structural biology of RBP FUS/TLS and chaperone for phase separation, computational approach of phase separation, and chemistry of G-quadruplex of DNA and RNA. Part II on molecular biology presents molecular mechanism of IDR sequence phase separation and potential cellular function of these labile fibers, formation of membrane-less organelles, and roles of noncoding RNAs in phase separation. Part III on biology covers topics from nuclear pore complex, developmental biology regarding force-dependent remodeling, and neurobiology and higher order brain functions. Finally, Part IV on medicine presents condensates and cancer therapy, pathogenesis of neurodegenerative diseases based on IDPs, and responses of microglia to amyloid. The last chapter highlights the latest topic on how the SARS-Cov-2 virus takes advantage of phase separation for its infections.This book brings together the studies of phase separation in each area in a single volume. The comprehensive approach provides new insights to the research andwill benefit the readers by responding to the emerging needs for understanding phase separation.

This book presents a major research program on epigenetic mechanisms of cell programming and reprogramming. The program was launched by the National Natural Science Foundation of China during the 11th Five-Year Plan period, which was started in October 2008 and concluded at the end of 2016. It first summarizes the epigenetic research plans and the current situation of epigenetic research in China and the international frontier. With the application of interdisciplinary research methods, the book discusses the development trends of epigenetic research, such as mechanisms of establishment and maintenance of epigenetic information and epigenetic regulation on reproduction and development. It also presents a variety of research achievements. For example, the discovery of new epigenetic regulators and chromatin remodulaters and their biological functions and mechanisms are highlighted. Several regulation mechanisms of cell differentiation and trans-differentiation are discussed, especially the discovery of the key factors to promote the trans-differentiation of somatic cells to hepatocytes. In addition, this book puts forward some key academic fields with increasing importance, such as biochemistry, cell biology, and clinical medicine. Given its scope, the book is of interest to researchers who work in cell biology, biochemistry, structural biology, bioinformatics, clinical medicine, and other related fields.

This book provides a comprehensive and authoritative review of cyanobacteria and their applications as solar cell factories. Cyanobacteria are able to perform oxygenic photosynthesis and they are utilized in many different bioprocesses. The book covers two major aspects of a cyano-based bioprocess: the biological whole-cell catalyst and the technical environment in which the catalyst is applied. In the biocatalyst itself electron and carbon flow play an essential role for the performance of the cell and need to be tackled likewise for successful biocatalyst development. In the first chapters of this volume, cyanobacterial biotechnology and the fundamentals of cyanobacterial bioenergetics are introduced followed by an overview on tools and strategies for cyanobacteria engineering. Further on, examples of applications, engineering and production of different industrially relevant compounds in these organisms are provided, and finally process technology specific for cyanobacteria is covered. In this book, particular attention is given to topics such as cyanobacterial bioenergetics, metabolic engineering design strategies, utilizing cyanobacteria in biophotovoltaics, and production of pigments as well as photobiohydrogen in cyanobacteria, among others. This book will provide interested students and researchers in the area of photo-biotechnology with a deeper understanding of the cyanobacterial cell-factory, including the latest innovations and persistent challenges in the field.

The book is aimed at providing an exposure to some important topics which are generally not covered adequately in formal courses in biotechnology. It informs the readers about: How micro-fluidics are proving useful in enzyme kinetics. Chemi-proteomics; combinatorial chemistry and high-throughput screening in the context of drug discovery. How enzymes can be used with gaseous substrates? How to source more robust enzymes from marine resources for diverse applications? Why some nano-materials can be chiral? Synthesis of diverse quantum dots as powerful fluorescent probes in biology. How basics of surface chemistry and immunology are vital in dealing with endemics/pandemics like Covid-19.

Biochemistry is the study of the structure and functions of biological macromolecules such as nucleic acids, proteins, carbohydrates and lipids. The book is organized in five chapters which covers the basic concepts and fascinating chemistry of biomolecules. It also exposes students to different metabolic pathways and concept of energy in biological system, and provides valuable material for the students of Chemistry, Biochemistry, Biotechnology and Bioscience.

This book provides the latest comprehensive methods for isolation and other novel techniques for marine product development. Furthermore, this book offers knowledge on the biological, medical, and industrial applications of marine-derived medicinal food substances.There has been a tremendous increase in the products derived from marine organisms for commercial application in industries every year. Functional foods of medicinal value are particularly in demand as new technology allows the stabilization of natural ingredients and their availability in pure forms to solve various human diseases. Marine flora and fauna have essential elements and trace minerals that nurture various hormones produced in the endocrine system to regulate the respective metabolisms, thereby providing a safe and healthy life to humans.The overall presentation and clear demarcation of the contents by worldwide contributions is a novel entry point into the market of medicinal foods from the sea. The exploration of marine habitats for novel materials are discussed throughout the book.The exploration and exploitation of the biochemistry of sea flora and fauna are limited, and this book extends the research possibilities into numerous marine habitats.Various approaches for extracting and applying the flora and fauna are discussed. This book will be of value to researchers, marine biotechnologists, and medical practitioners, due to the vast information, as well as industrial and medical applications of marine substances all in one place.

This book provides the latest comprehensive methods for isolation and other novel techniques for marine product development. Furthermore, this book offers knowledge on the biological, medical, and industrial applications of marine-derived medicinal food substances.There has been a tremendous increase in the products derived from marine organisms for commercial application in industries every year. Functional foods of medicinal value are particularly in demand as new technology allows the stabilization of natural ingredients and their availability in pure forms to solve various human diseases. Marine flora and fauna have essential elements and trace minerals that nurture various hormones produced in the endocrine system to regulate the respective metabolisms, thereby providing a safe and healthy life to humans.The overall presentation and clear demarcation of the contents by worldwide contributions is a novel entry point into the market of medicinal foods from the sea. The exploration of marine habitats for novel materials are discussed throughout the book.The exploration and exploitation of the biochemistry of sea flora and fauna are limited, and this book extends the research possibilities into numerous marine habitats.Various approaches for extracting and applying the flora and fauna are discussed. This book will be of value to researchers, marine biotechnologists, and medical practitioners, due to the vast information, as well as industrial and medical applications of marine substances all in one place.

This thesis addresses deep questions that cut to the physical and informational essence of central chemical quantities such as transition paths and reaction mechanisms and proposes fundamental new connections between transition-path theory, linear-response theory, nonequilibrium thermodynamics, and information theory. The author investigates slow, energetically efficient driving protocols that drive a system between conformations corresponding to endpoints of a reaction, aiming to find connections between principles of efficient driving and the spontaneous transition mechanism in the absence of driving. First, an alternative perspective of transition-path theory is developed that unifies it with stochastic thermodynamics to describe flows of entropy, energy, and information during the reaction. This also provides an optimization criterion for selecting collective variables. Next, protocols are designed which invert the magnetization of a 3×3 Ising model with minimal energetic cost,and it is determined that using multiple control parameters allows the system to be driven along a fast-relaxing pathway between reaction endpoints. Finally, the author compares these protocols with the spontaneous transition mechanism for magnetization inversion in the same Ising model, finding that designed protocols capture general features of the spontaneous mechanism and energetics given the constraints on the control parameters. This work represents a major step forward in our understanding of rare events and provides a basis for investigating the connection between efficient protocols and spontaneous transition mechanisms which can be further probed in a wider variety of systems.

Cholesterol is an essential component of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), although a minor phospholipid, is the most abundant membrane phosphoinositide. Both lipids play key roles in a variety of cellular functions including as signalling molecules and major regulators of protein function. Studies on these important lipids have traditionally focused on the effect of each lipid individually. Accumulating evidence indicates, however, that these lipids may cross-regulate each other's levels. Furthermore, it is becoming evident that cholesterol and PI(4,5)P2 can act together to modulate protein function and biological processes. This book provides an overview of cellular functions and molecular mechanisms in which cholesterol and PI(4,5)P2 functions extend from parallel existence to crosstalk. It includes four sections. The first section introduces the reader to cholesterol and PI(4,5)P2. The second section demonstrates the mutual influence of these two critical lipids on their levels. The third section, divided into two parts, describes the co-modulation of protein function by cholesterol and PI(4,5)P2. The first part focuses on ion channels and the second - on lipid transfer proteins. The fourth section highlights other cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement. Collectively, the book portrays the emerging relationship between cholesterol and PI(4,5)P2 in a broad array of biological systems and processes. The book will be of interest to a wide audience of research scientists with an interest in the biophysical properties of lipids and the physiological consequences of their presence in biological systems, as well as graduate students, postdoctoral trainees, basic and clinical researchers, and pharmaceutical scientists. Specifically, the content will be relevant to researchers in the fields of biochemistry, molecular biophysics, pharmacology, neurobiology, cardiovascular biology, among others.Provides a comprehensive overview of the current knowledge of the interplay between cholesterol and PI(4,5) P2Provides an overview of the emerging relationship between cholesterol and PI(4,5)P2 in biological systems and processesDiscusses cellular processes and molecular mechanisms where lipid functions extend from parallel existence to crosstalk

This book contains five selected chapters on the chemistry, properties, and uses of pyrene. Chapter One reviews the analytical applications of pyrene in forensic science. Chapter Two examines pyrene as a chromophore in various organic materials applications. Chapter Three reviews how the presence of micro and nanoplastics can influence pyrene toxicity. Chapter Four looks at the self-assembling supramolecular structure of pyrene.

Biochemistry is the foundation for solving the complexity of life on earth. All living organisms on earth contains nucleic acids, lipids, carbohydrates, proteins, enzymes and hormones that are crucial for survival. Biochemistry plays essential role in understanding the mechanism, action and regulation of biomolecules in different metabolic pathways. Several analytical techniques are reported to characterize, analyse and quantify the biomolecules present in living organism. This book covers the diversity of biomolecules present in living organisms, their characterization techniques, clinical biochemistry and genetic information transfer process. This book has been designed to suit the knowledge and pursuit of the researcher and scholars and to empower them with various aspects of biochemistry so that they are updated with the information.

This book offers a comprehensive review of the latest developments in medicinal mushroom biochemical engineering and biotechnology, and it also analyses the circular economy of mushroom bioproduction. Divided into 13 chapters, the book begins with a historical perspective of medicinal mushrooms, followed by authoritative chapters that explore the farming of medicinal mushrooms and bioeconomy, as well as the limitations of using medicinal mushrooms to produce metabolites. Subsequent chapters cover topics such as solid-state and submerged cultivation of medicinal mushroom mycelia in bioreactors, pilot and industrial bioreactor cultivation experiences, downstream processing of medicinal mushroom products, and biochemistry of medicinal mushroom bioactive compounds. Particular attention is given to the recent genetic engineering techniques applied in mushroom cultivation. The book closes with a chapter devoted to the health and clinical benefits of medicinal fungi, where readerswill find expert insights into the therapeutic implications of medicinal fungi. In this book, readers will find an authoritative perspective on the past, present and future of medicinal mushrooms, and will also learn about some recent clinical studies with isolates from these natural products. Given its breadth, this book will appeal to biotechnologists working in mushroom cultivation, as well as to professionals interested in traditional pharmacy and medicine.

This book deals with analytical techniques and methods applied in several sectors of technology and industry and serves as a concise and up-to-date reference for the practical application of analytical chemistry. Divided into 10 chapters, the book starts with an introduction to the fundamentals of analytical chemistry, followed by a review of modern analytical technologies and their application in different industrial sectors and activities such as agrochemicals and pharmaceuticals, ores and mining, polymers, biotechnology, and oil & gas. Particular attention is given to industrial environmental issues, where the author discusses the advanced analytical techniques used to provide quantitative information about pollutants in aqueous and gaseous effluents and their carbon footprint. The book finishes with a chapter summarizing the main remarks and conclusions on advanced analytical techniques used in different industrial sectors, as well as on topics of sustainability, and instrumental analysis. In this book, readers will find valuable insights, including real-life examples, of how classical and instrumental techniques can be used by industry, to help professionals in the quality control of raw materials, products and processes, in the assessment of the formulation contamination, environmental pollution and in the evaluation of sustainability, among others. Given its breadth, the book appeals to professionals (mainly chemists, biochemists, and engineers), researchers, professors, and graduate students.

This book outlines the use of supramolecules as different pharmaceutical drugs. Supramolecular chemistry in pharmaceutical sciences is quite a young and rapidly developing field. Supramolecular assemblies might offer an alternative for existing pharmaceutical formulations, as they facilitate the improvement of physicochemical and pharmacological properties i.e., higher bioavailability, better biocompatibility and drug-targeting, fewer multidrug-resistances. This book offers an overview of the recent advances in supramolecular structures and discusses the future aspects and challenges related to the development of these molecules, providing also a perspective on how to overcome these issues. Divided into 13 chapters contributed by experts in their field, the book provides a deeper understanding of intermolecular forces playing pivotal roles in mediating the interactions between chemical molecules and biological systems by focusing on different applications of supramolecularcompounds. In this book, readers will find valuable insights into the preparation of supramolecules and the latest research and development trends of supramolecules as anticancer drugs, including liquid-crystalline supramolecular assemblies, and as antimicrobial, antiviral, anti-inflammatory and cardiovascular drugs. Particular attention is given to the application of supramolecules in the fields of biomedicine, bioimaging, and vaccine development. Given its breadth, this book will appeal to a wide readership from researchers and students interested in these fields to professionals in the pharma industry.

New Horizons in Natural Compound Research provides the latest updates in natural compound research (plant, microbes, algae, fungi) and their novel applications in health, agriculture and environment. The book gives recent advances in the extraction of natural compounds, cutting-edge approaches for natural compound purifications, and emerging trends in natural compound screening and identification. In addition, it provides a detailed explanation of the databases and libraries of natural compounds, as well as their significance. Sections focus on research and multidisciplinary practical techniques of natural product research, encouraging young scientists to pursue unique research while also generating strong research ideas. From a future perspective, this book acts as a guide to identify potential areas and new research opportunities in the field of natural products and their service towards human beings, animals and the environment. - Provides a one–stop solution for concepts, cutting-edge techniques, methods, and novel applications of natural products in health and the environment - Focuses on current gaps in natural product research, as well as methodologies and techniques to assist researchers in resolving existing challenges and speeding up the pace of drug discovery from natural sources - Highlights new avenues of natural product research - Contains contributions from well-experienced researchers from academia, research institutes and top-notch young scientists from industry

This book aims to summarize the latest research progress of biomedical nanozymes in diagnostic and therapeutic related fields. In terms of diagnostics, it will cover in vitro diagnostics, live analysis, and some emerging bioanalysis. In terms of therapeutics, it will introduce antioxidant therapy, peroxidation therapy and emerging therapy respectively. Furthermore, the research results previously scattered in many journals and conferences worldwide are methodically edited and presented in a unified form. Based on the new ideas and developments presented in this book, it will be of interest to readers from different areas, such as chemistry, materials, nanoscience and nanotechnology, biomedical and clinical studies, etc.

This book presents a collection of chapters on Covid-19 topics, with focus on the metabolomics and diagnosis. The chapters report on diagnostic tests for detection of SARC-CoV-2 virus and related proteins as well as post-Covid omics. This book covers Fourier-Transform Infrared spectroscopy and spectromicroscopy applied to Covid-19 studies and Carbon Nanomaterials as Covid-19 Electrochemical sensors. Moreover, the reader will find content on 3D printing for virus diagnosis, as well as organ-on-a-chip models for viral infection proteomics interaction.

This book covers foundational topics in the emerging field of radiopharmaceutical therapy. It is divided into three sections: fundamentals, deeper dives, and special topics. In the first section, the authors examine the field from a bird's-eye view, covering topics including the history of radiopharmaceutical therapy, the radiobiology of radiopharmaceutical therapy, and the radiopharmaceutical chemistry of both metallic and non-metallic radionuclides. The second section provides a more in-depth look at specific radiotherapeutics. Chapters include broader discussions of the different platforms for radiopharmaceutical therapy as well as more focused case studies covering individual radiotherapeutics. The third and final section explores a number of areas for further study, including medical physics, artificial intelligence, in vivo pretargeting, theranostic imaging, and the regulatory review process for radiotherapeutics.This book is the first of its kind andis useful for a broad audience of scientists, researchers, physicians, and students across a range of fields, including biochemistry, cancer biology, nuclear medicine, radiology, and radiation oncology.

This contributed volume provides an overview of the recent advances in solid-state nanopore technology, featuring contributions by leading experts in the field. It discusses several aspects of solid-state nanopores, covering their fabrication as well as multiple biosensing applications. It successfully bridges the gap between various scientific and engineering disciplines and highlights the progress made in this area. This title is a useful tool for acquiring basic knowledge of this field and following recent progress. It is a valuable contribution to the area of nanopore biosensing and is of interest to graduate students, postdocs, or senior researchers working in the fields of physical chemistry, biochemistry, bio- and electrical engineering, and biophysics.

This book provides an up-to-date overview of the biological functions of melanins, their biotechnological production, and their industrial applications. The melanins form a group of polymeric pigments found in most organisms. These natural products are generated by the oxidation of phenolic and indolic molecules yielding melanins, which include eumelanin, pheomelanin, pyomelanin, and the allomelanins. These pigments have diverse biological functions, including photoprotection, thermoregulation, antioxidation, virulence, and metal ion sequestration. Melanins have physicochemical properties that have proven useful in the optical, electronic, material, agriculture, cosmetic, pharmaceutical, and medical industries. The chapters in this book provide an in-depth analysis of the current issues and challenges in this field. Topics covered include the properties, biogenesis, and evolution of melanosomes. The book also addresses the synthesis and industrial production of melanins by microorganisms. The metabolic pathways for the synthesis of several types of polymeric pigments in microorganisms and their role in pathogenesis are reviewed. The large-scale production and purification of melanins to provide this product for industrial applications is a formidable challenge. Two chapters present and discuss the state-of-the-art used for the generation of microbial melanin-production strains and the processes for the biotechnological synthesis and purification of these pigments. Melanins are polymers that can interact with metals, a chapter reviews this capacity in the context of technological applications, including electrochemical energy storage and metal recovery. These polymers are materials having favorable characteristics for photonic applications, including UV blocking and broadband absorption. The current advances in the application of these pigments in optically active materials are presented and discussed.

This book focuses on the different compounds (polyphenols, sterols, alkaloids terpenes) that arise from the secondary metabolism of plants and fungi and their importance for research and industry. These compounds have been the backbone and inspiration of various industries like the food, pharmaceutical and others to produce synthetic counterparts. Furthermore, many of these compounds are still widely used to carry out specific functions in all these industries. This book offers a compilation of different texts from world leading scientists in the areas of chemistry, biochemistry, plant science, biotechnology which compile information on each group of secondary metabolism compounds, and their most important applications in the food, pharmaceutical, cosmetic and textile industry. By showcasing the best uses of these compounds, the chemistry behind their production in plants and fungi, this book is a valuable resource and a'go to'artifact for various audiences. The new approach this book offers, by linking research and the application of these compounds, makes it interesting as an inspiration for new research or as a hallmark of what has been done in the secondary metabolism of plants and fungi in recent years. Although this book may be technical, it is also enjoyable as an integral reading experience due to a structured and integrated flow, from the origins of secondary metabolism in organisms, to the discovery of their effects, their high intensity research in recent years and translation into various industries. Beyond learning more on their chemistry, synthesis, metabolic pathway, readers will understand their importance to different research and industry.

Living organisms are distinguished by their chemical basis. Thus, knowledge of the properties of the elements and the interactions of the resulting compounds is a prerequisite for understanding biology.Chemistry answers the questions of why, among the more than 100 elements of the periodic table (PSE), carbon and not silicon is the dominant element in biology and why precious metals, such as gold and silver, do not play a role. The PSE provides information about why phosphoric acid and not sulfuric acid acts as a bridge in polynucleic acids and why DNA had to evolve from RNA. At the same time, only chemistry makes clear why D-glucose is so central in building biopolymers such as cellulose and glycogen, and why the citrate cycle is logically self-contained and without alternative. Biochemistry is also a synthesis chemistry that differs from'man-made'synthesis chemistry'only'in terms of the framework conditions. Individuals are selected from the multitude of elements of the PSE and the almost infinite number of chemical compounds. The selection is based on the environmental conditions on Earth, such as moderate temperatures, preferably atmospheric pressure, solvent water and as primary reaction partner oxygen.The hypothesis is developed that the guiding principle of modern biology, the theory of evolution, has its roots in the underlying chemistry. This turns Darwinism from its biological head to its chemical feet. For example, the effect of phenols as radical scavengers is a priori chemical, before biological phenomena could evolve from it as differences in distinction in colored flowering plants. The book develops a completely new, chemistry-centered view of'animate nature'and challenges a changed, biologically oriented didactics of chemistry in schools and universities.

This book offers to provide a brief explanation of the key terms and concepts of Biochemistry. Biochemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and metabolism.

This book provides a comprehensive reference for various plant bioactive compounds for research and pharmacological significance across the entire spectrum of phytochemical genomics. The book opens with general information on diversity, analysis and genomic basis of phytochemicals, computational approaches, databases for responsible genes, and biosynthetic pathways, and it delves very much into the details behind phytochemical diversity and diverse roles of plant metabolites. The later parts of the book also explore the direct drug discovery and omics approaches including metabolomics, transcriptomics, as well as gene editing technology experiments to further inspire readers into its unlimited potentials. Each chapter includes detailed analysis and relevant experiments for better and deeper understanding of the concepts. The book will be an invaluable aid for medicinal plant researchers and a rich source of information and advice for advanced undergraduates and graduates in the fields of medicine, nutraceuticals, cosmetics, flavor, and fragrance studies.

Advances in Nano and Biochemistry: Environmental and Biomedical Applications gives insights into this advanced interdisciplinary science that encompasses the principles of physics and physical chemistry for the investigation of various processes and problems in biological systems. The book is a concise culmination of biophysical chemistry knowledge acquired through core concepts and advanced technologies for addressing emerging challenges in environmental and biomedical applications. Sections cover early diagnostic techniques and accurate treatment strategies using bioinspired, sustainable technologies, including nanomaterials, nanoenzymes, biopolymers, electrochemical biomolecule sensors, biocompatible magnetic nanomaterials, quantum dots and hybrid structures, and DNA nanotechnology. Other sections discuss advanced technologies for sensing and remedying environmental pollutants, including but not limited to, photocatalytic oxidations, gum polysaccharides based nanostructured materials, bio-inspired and biocompatible nanomaterials, hydrogel nanocomposites, and contemporary enzymes and nanozymes based?technologies. Ultimately, the state-of-the-art chapters in this book will empower researchers to combine two complementary elements - chemical analysis use and biomedical applications. - Provides the fundamental concepts of biophysical chemistry and emerging technologies to solve environmental and biomedical problems - Describes the latest breakthrough research in biophysical chemistry and its applications to better understand biological systems - Supports development of the latest disease diagnostic and treatment technologies - Includes advances in physical chemistry and biology for the monitoring and remediation of environmental pollutants

This book follows up the debate on the future of science and technology at the Curious2022 – Future Insight Conference, the second event in this conference series initiated on the occasion of Merck's 350th anniversary. In the chapters, some of the world's top scientists, managers and entrepreneurs explore breakthrough technologies and how they can be applied to make a better world for humanity. The book begins with an introduction to the vision of the conference “United by science for a better tomorrow” and the impacts caused by the pandemic, highlighting the importance of gathering like-minded people to discuss and support the advancement of science and technology for the benefit of humanity. In the first part of the book, readers will also find a chapter written by the Executive Board of Merck KGaA discussing the importance of curiosity for innovation and an overview of the company's contribution in the areas of life sciences, healthcare andelectronics forward-moving the scientific discovery. The second part of the book offers insights of some of the scientific topics discussed at the conference, and particular attention is given to new therapies and sustainability. In the final part of the book, readers will find some thoughts on ethical principles guiding our application of science and technology to create a bright future for humanity, and diverse perspectives on topics such as health, life sciences, nutrition, material sciences, digitalization, AI, energy, mobility, space flight, robotics, the secrets of the human mind and new ways of working together. Given its interdisciplinary appeal, the book will inspire curiosity in a wide readership, from scholars and researchers to professionals with an interest in exploring the future of science and technology, solving the problems of today, and paving the way for a better tomorrow. Chapters “From a 350th Anniversary to a Global Movement: United by Science for a Better Tomorrow” and “ Advancing Human Progress as a Twenty-First-Century Science and Technology Pioneer” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book provides comprehensive information on starch modification using physical approaches – a field that has attracted increasing interest in recent years due to the fact that it is no longer desirable to label starch a modified. The required functionalities can be conveniently achieved by physical methods that are less expensive and more environmentally friendly. In the second edition, chapters are updated according to the recent research progress. Three new chapters are added including pulsed electric fields, dry heating and physical treatments that produce chemical changes. Chapter one is rewrote into three individual chapters including Molecular Structure of Starch, Granular Structure of Starch and Physicochemical Properties of Starch, aiming to help the readers better understand the structure of starch. This book summarizes recent developments in the areas of starch physical modifications and reviews the structure, function and potential industrial applications of modified starch. It provides valuable information for researchers and product developers to work on starch.