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Dieses Buch bietet eine umfassende Darstellung der Statik und Dynamik geschichteter Strukturen und ist in fünf Abschnitte unterteilt. Nachdem im ersten Abschnitt die Grundlagen der Elastizitätstheorie und der Energiemethoden der Elastostatik sowie der Festigkeitsanalyse kurz eingeführt wurden, widmet sich der zweite Abschnitt den Grundlagen der Berechnung von geschichteten ebenen Strukturen, den sog. Laminaten. Der nachfolgende dritte Abschnitt behandelt das Stabilitätsverhalten solcher Laminate, wobei neben analytischen Lösungen auch Näherungsverfahren besprochen werden. Der vierte Abschnitt dieses Buchs geht auf spezielle Themen bei der Behandlung geschichteter Strukturen ein, bevor der fünfte und letzte Abschnitt geschichteten Stäben und Balken gewidmet ist. Dieses Buch richtet sich an Studierende an Fachhochschulen und Universitäten, aber auch an Ingenieurinnen und Ingenieure in der Praxis sowie an Forscherinnen und Forscher der Ingenieurwissenschaften.

Including new drugs for weight loss, heart failure, anxiety, and postpartum depression. OZEMPIC | WEGOVY | ENTRESTRO | AND MORE! Hale's Medications & Mothers'Milk is the ultimate resource for safe medication practices during breastfeeding. This meticulously updated edition offers the most current, evidence-based information available, maintaining its reputation as the definitive standard for medication safety in lactation. Written by world-renowned clinical pharmacologists, the detailed manual helps lactation consultants, pharmacists, and healthcare providers who work with women and children weigh the relative risks associated with commonly used medications, drawing from the latest evidence-based studies. Structured for quick and efficient use, this guide features Dr. Thomas W. Hale's renowned Lactation Risk Categories (LRC), which provide essential insight, listing safe medication alternatives that can be used now or in the future. The manual is intuitively organized to highlight key points, offer practical tips, and present easy-to-understand diagrams, common abbreviations, and concise information for evaluating infant health. This indispensable resource helps healthcare professionals to ensure the safety and well-being of both mother and infant. Embrace the peace of mind that comes with having reliable, expert-vetted knowledge at your fingertips. To ensure you always have the most current information, consider our online or mobile app subscription! Visit halesmeds.com to get started today. New to the 2025-2026 Edition: 66 new drugs 10 drugs with FDA updates 575 updated medications (formerly medications updated with new information) 84 existing drugs with updated LRCs Key Features: Delivers current, evidence-based information on 1,300 drugs, diseases, vaccines, and syndromes in alphabetical order Provides critical updates on weight loss drugs such as Wegovy and Ozempic, heart failure drugs such as Entresto, medications for anxiety, postpartum depression, and much more Incorporates updates to Dr. Hale's world-renowned Lactation Risk Categories (LRC) Discusses adult concerns, adult dose, pediatric concerns, infant monitoring, and drug alternatives

This book gives a unified presentation of the field of stability. Buckling and post-buckling states are studied on the basis of total potential energy of structural systems. Emphasis is placed throughout the text on post-buckling analysis and behaviour. The sensitivity of buckling and post-buckling states to changes in design parameters is also discussed as well as changes due to imperfections and damage.

Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.Comprehensive coverage of the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decadeIntroduces the most recent imaging technologies to characterize factors, including aortic geometry, mechanical properties of aortic tissues, and cellular activity in the vessel wallSynthesizes advances in vascular biomechanics, medical imaging, and computational modeling of finite element fluid and solid models

This extensively revised edition examines renal pathophysiology and the rationale for renal denervation for the management of hypertension, as well as possible long-term benefits and risks of this therapy. Renal denervation is a minimally invasive, endovascular catheter-based procedure that makes use of radiofrequency ablation to treat resistant hypertension, with studies showing a high degree of effectiveness. The devices involved in the continued evolution of this therapy are discussed and the book incorporates analyses of the development of the technique while evaluating its cost effectiveness and future applications. Renal Denervation: Treatment and Device-Based Neuromodulation describes the technique in detail, its advances and its pitfalls. While it has been estimated that 50% of Western civilization has hypertension and approximately 20% of patients have resistant hypertension, hypertension remains the leading cause of cardiovascular morbidity and mortality thus strengthening arguments to consider a wider range of potential solutions to manage these patients.

Written by pioneers in the field of interventional cardiology, this new edition provides readers with the information and expert guidance needed to perform safe and effective transcatheter aortic valve implantation/replacement (TAVI/TAVR). The book is supplemented by visual aids, including more than 300 illustrations and videos.

This book builds upon the first edition with new and improved chapters. The book explores the rich assemblage of clinical wisdom from expert rheumatologists from a wide range of specialties including Vasculitis and Sjogren's syndrome. It examines the nuggets or ‘pearls'of wisdom gained from collective clinical experience about the diagnosis or treatment of various diseases whilst also aiming to debunk myths that have influenced the practice of rheumatology by many clinicians. The second edition of A Clinician's Pearls and Myths in Rheumatology is a critical resource for both practitioners and students of rheumatology. This book provides a clear guide for those wishing to take a “deep dive” into the diagnostic and therapeutic elements of rheumatology.

This book deals with the analysis of plates and shells and is divided into four sections. After briefly introducing the basics of elasticity theory and the energy methods of elastostatics in the first section, the second section is devoted to the statics of disk structures. In addition to isotropic disks in Cartesian and polar coordinates, approximation methods and anisotropic disks are also discussed. The following third section deals with plate structures, covering plates in Cartesian and polar coordinates, and also discussing approximation methods and higher-order plate theories. Other chapters in this section discuss plate buckling as well as geometric nonlinear analysis and laminated plates. The fourth and final section of this book is devoted to shells, i.e., curved thin structures, following the common division into membrane theory on the one hand and bending theory on the other hand. This book is intended for students at universities, but also for engineers in practice andresearchers in engineering science.

The worldwide gold standard for lactation support professionals Developed by world leaders in lactational pharmacology, this essential reference contains the most current, complete, and evidence-based information available on the transmission of maternal drugs into human milk. It thoroughly addresses one of the most commonly asked questions by breastfeeding mothers—which drugs are safe, and which are hazardous for the infant? The new twentieth edition adds 72 new drugs, updates 356 medications with new data, and adds new information to 927 drugs. The resource relies upon the most current evidence-based studies to evaluate the relative risk of commonly used drugs including Dr. Hale's highly renowned Lactation Risk Categories (LRC). Considered indispensable by hundreds of clinicians worldwide, the book lists safe alternatives for drugs one is currently taking or might need to take in the future. For ease of access to information, it includes key points and savvy tips in information boxes, common abbreviations, illustrative diagrams, concise information on evaluating the infant, and more. New to the 2023 Edition: 72 new drugs 356 medications updated with new data 3 drugs with FDA updates 927 medications updated with new information 74 existing drugs with updated LRC NEW TABLES on monoclonal antibodies and migraines New information on Cannabis. Key Features: Delivers current, evidence-based information on over 1300 drugs, diseases, vaccines, syndromes Incorporates recent updates to Dr. Hale's world-renowned LRC Includes key points and savvy tips about breastfeeding and medications for quick reference Lists common abbreviations and drugs in easily-accessible alphabetical order Discusses adult concerns, adult dose, pediatric concerns, infant monitoring, and alternatives Includes succinct information on evaluation of the infant

Covering both the theoretical and practical aspects of critical care,Irwin & Rippe's Intensive Care Medicine, Ninth Edition, provides state-of-the-art, evidence-based knowledge for specialty physicians and non-physicians practicing in the adult intensive care environment. Drs. Craig M. Lilly, Walter A. Boyle, and Richard S. Irwin, along with a team of expert contributing authors and education expert, William F. Kelly, offer authoritative, comprehensive guidance from an interprofessional, collaborative, educational, and scholarly perspective, encompassing all adult critical care specialties.

This book presents the latest findings in the field of cardiac mechanobiology in health and disease.Cardiac mechanobiology provides knowledge of all aspects of mechanobiology of the heart. Cardiomyogenesis is discussed as well as the mechanobiology of cardiac remodeling and regeneration. The molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes are explained, as well as stretch induced differentiation of cardiomyocytes derived from induced pluripotent stem cells. This volume of the series Cardiac and Vascular Biology complements the volume Vascular Mechanobiology in Physiology and Disease (volume 8) published in this series. The book is aimed at clinicians as well as researchers in cardiovascular biology, bioengineering and biophysics, and also represents an educational resource for young researchers and students in these fields.

Stress: Immunology and Inflammation, Volume Five in the Handbook of Stress series, covers the influence physiologic stress has on immunity, immunology and inflammation. It provides a quick orientation to the subject for research, in clinic use, and in everyday life. Integrated closely with new behavioral findings and with relevance to human conditions, the concepts and data in this volume offer readers cutting-edge information. It will be of prime interest to neuroscientists, clinicians, researchers, academics, and students in Neuroendocrinology, Neuroscience, Biomedicine, Immunology, Endocrinology, Psychology, Psychiatry and some aspects of the Social Sciences. The effect of stress on our emotional and physical health can be devastating. There have been significant advances in our understanding of the influence stress has on inflammation in the human body and also our immunity to various afflictions. - Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge - Richly illustrated with explanatory figures and tables - Each chapter includes a boxed'Key points'call out section - The volume is fully indexed - All chapters are electronically available via ScienceDirect - Affordably priced, self-contained volume for readers specifically interested in the interaction between stress inflammation and the immune response, obviating the need to purchase the whole Handbook series

Principles of Forensic Pathology: From Investigation to Certification offers a conceptual framework and foundational approach to a forensic practice grounded by evidence-based and mechanistic thinking. This book uses a systematic approach to address, explain, and guide the reader through diverse topics relevant to forensic pathologists and medicolegal death investigators. Nineteen chapters provide a comprehensive overview of the field of forensic pathology and discusses central topics such as scene investigation, the pathophysiology of death, death certification, the forensic autopsy, forensic imaging, pediatric forensic pathology, the importance of context, and approaches to frequently encountered medicolegal death circumstances, with mental checklists and suggestions for a consistent and considered approach. Written by forensic professionals, this book is a practical, yet comprehensive compendium for practicing forensic pathologists, coroners, medicolegal death investigators, forensic pathology fellows, pathology residents, medical students interested in forensic pathology, lawyers, and law enforcement professionals. - Presents a primary text that is ideal for daily forensic practice - Discusses how to properly investigate and certify death in a consistent and defensible way - Emphasizes best practices in the field, providing an approach that is in line with today's forensic pathologist

The field of interventional orthopedics is changing the landscape of orthopedic care as patients seek less invasive options for the treatment of common conditions like arthritis, rotator cuff tears, and degenerative disc disease. Offering easy-to-follow, step-by-step guidance on both peripheral joint and spinal procedures, Atlas of Interventional Orthopedics Procedures is the first reference to provide this practical content in one authoritative, user-friendly text. Abundantly illustrated and easy to read, it presents simple to advanced injection skills covering all orthopedic and physical medicine procedures using up-to-date imaging techniques. - Presents foundational knowledge for interventional orthopedics as well as ultrasound and x-ray guided techniques for both peripheral joint and spinal procedures. - Features nearly 1,000 high-quality images including fluoroscopy, MRIs, procedural images, and unique anatomical illustrations drawn by a physical medicine and rehabilitation physician. - Covers need-to-know topics such as autologous orthobiologics, allogenic tissue grafts, prolotherapy, and principles of fluoroscopy and ultrasound injection techniques. - Offers several ultrasound and fluoroscopy images for each procedure, as well as step-by-step descriptions and the authors'preferred technique. - Walks you through general injection techniques such as interventional spine procedures, peripheral joint injections, and spinal and peripheral ligament, tendon, and nerve techniques; advanced techniques include intraosseous injections, needle arthroscopy, perineural hydrodissection, and emerging interventional techniques. - Provides an up-to-date review on regenerative medicine for musculoskeletal pathology from editors and authors who are leading physicians in the field. - Follows the core tenets of interventional orthopedics, including injectates that can facilitate healing of musculoskeletal tissues, precise placement of those injectates into damaged structures using imaging guidance, and the eventual development of new tools to facilitate percutaneous tissue manipulation.

Contains patterns of allergic reactivity for disorders such as asthma, atopic dermatitis, urticaria, and anaphylaxis. Written by leading experts in the field, Inflammatory Mechanisms in Allergic Diseases covers non-anaphylactic drug disorders; synthesis and formation of IgE antibodies; new treatments using allergenic peptides, immunostimulatory oligonucleotides, and pharmacogenomics;recent advances targeting effector mechanisms; hypersensitivity reactions to drugs and more! With over 3100 references, tables, drawings, and micrographs, Inflammatory Mechanisms in Allergic Diseases is an essential reference for allergists, pulmonologists, immunologists, dermatologists, ophthalmologists, otolaryngologists, internists, pediatricians, family practitioners, and medical students in these disciplines.

Keeping up to date with advances in comprehensive ophthalmology and in the ophthalmic sub-specialties is extremely difficult because of the accelerating rapidity with which new information and technology become available and the diminishing time and opportunity for practitioners and trainees to read and learn. The first edition of Albert and Jakobiec's Principles and Practice (1994) was conceived with the idea of utilizing an electronic, updated version in which the chapters were revised by the chapter authors on an annual or semi-annual basis, but the technology was not sufficiently advanced to achieve this goal. Subsequent editions (2000 and 2008) were organized by Saunders and the last published by Elsevier (of which Springer has obtained the complete rights to move forward with the 4th edition). For nearly three decades, this text has provided its readers with authoritative and comprehensive coverage of clinical ophthalmology, written and edited by a group of authors who represented a “Who's Who” in ophthalmology. By using Springer's Meteor platform, with its ability to allow authors and editors access to updating their chapters online annually/semi-annually, and with the recruitment of select chapter authors, this work's usefulness as the standard text in ophthalmology will be maintained and expanded upon by Springer. The 4th edition of this comprehensive and authoritative text is written by hundreds of the most distinguished authorities from around the world and edited by four leaders in the field, providing today's best answers to every question that arises in ophthalmology practice. Richly illustrated with thousands of high quality, full color, clinically-relevant images, Albert and Jakobiec's Principles and Practice of Ophthalmology, 4th Edition covers every scientific and clinical principle in ophthalmology, ensuring that the reader will always be able to find the guidance needed to diagnose and manage patients'ocular problems and meet today's standards of care. Written for practicing ophthalmologists and trainees, this book delivers in-depth guidance on new diagnostic approaches, operative techniques, and treatment options, as well as coherent explanations of new scientific concept and its clinical importance. The 4th edition will prove to be the source every practicing clinician needs to efficiently and confidently overcome any clinical challenge they may face. Updates include new chapters on anterior and posterior segment diseases, as well as chapters more focused on treatment, plus thousands of new, high-quality, color images and illustrations, updated references, and information on the most cutting-edge technology used by clinicians in their practices today. Additionally, readers will enjoy the same, user-friendly, full-color design they remember from the previous edition, complete with many at-a-glance summary tables, algorithms, boxes, and diagrams that allow the reader to locate the assistance needed more rapidly than ever.

INTERVENTIONAL CARDIOLOGY The updated guide to understanding and implementing today's interventional cardiology procedures Minimally invasive methods of cardiovascular intervention are developing apace, propelled by unprecedented advancements in technology and procedural expertise. Bearing exciting implications for a broad range of adjacent fields of surgery and patient care, these innovative techniques are of ever-increasing importance, not only within cardiology, but across medicine as a whole. This third edition of Interventional Cardiology is designed to equip practitioners of all levels with a working knowledge of today's best and most up-to-date practices, as well as the fundamental principles that underlie their use. Expertly revised to span coronary interventions, interventional pharmacology, structural heart interventions, endovascular therapy, and more, its modular sections are accompanied by multiple-choice questions to help aid learning and self-assessment. The new edition of Interventional Cardiology features: A thorough survey of the field, including atherogenesis and inflammation, vascular access controversies, radiation protection concepts, acute and chronic interventional pharmacology recommendations for high risk subjects/procedures Evaluations with imaging and physiology, including physiologic assessment in the cardiac catheterization lab, intravascular ultrasound, and optical coherence tomography Discussions of revascularization in various clinical settings, including stable coronary heart disease, acute myocardial infarction, he management of cardiogenic shock, and hemodynamic support devices and techniques Examinations of coronary interventions in various lesion types, including complex lesions, left main, bifurcations, CTO Heart valve disease and relevant percutaneous interventions, including preop imaging and clinical evaluations and outcomes assessment in great depth and with technical details; left atrial interventions are an expanding frontier Peripheral vascular, carotid and aorta/branch diseases are covered in greater detail than previous editions; venous disease treatments have become well established Accompanied by a companion website featuring videos illustrating key procedures and interactive multiple choice questions Whether studying for certification or already working in advanced practice, medical professionals of all kinds will benefit greatly from the practical instruction and cutting-edge knowledge found within this vital third edition.

This heavily revised book features a variety of cases detailing potential complications in cardiac surgery. Clinical scenarios associated with conundrums and unforeseen circumstances are presented, including minimally invasive and hybrid procedures as well as temporary mechanical circulatory support. Discussions emphasize critical details in preoperative assessment and intraoperative sensemaking, decision making and error recovery. Chapters are structured as unknowns, presenting findings as one would experience the events clinically and challenging the reader to develop their own rescue strategies. Relevant references for further reading are included, enabling the reader to further develop their knowledge base.Near Misses in Cardiac Surgery is a concise case-based resource featuring instructions on how to deal with potential complications associated with cardiac surgery. The work's multi-disciplinary authorship ensures it is a valuable resource for all medical professionals involved in the care of cardiac surgical patients.

Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Eric J. Strauss, MD, FAAOS (editor) and Brian J. Galinat, MD, MBA, FAAOS (assistant editor), Instructional Course Lectures, Volume 71 offers solutions for the most current issues and challenges faced at all stages of your career. Filled with current, clinically relevant presentations and approaches, the book broadens your treatment options with experience-based solutions from today's most respected surgeons and specialty experts. Based on selected Instructional Course Lectures presented at the AAOS Annual Meeting 2021 in San Diego Lead innovation and raise the standard of care in your operating room with new techniques and proven practical approaches. Expand and refresh your general orthopaedic, specialty, and practice knowledge Learn new approaches and surgical techniques from thought leaders Update your action plans for rehabilitative care with expert insights Review new techniques for solving the tough challenges you encounter in your practice every day Chapters are abundantly illustrated with radiographs, drawings, and intraoperative photographs. Some chapters are enhanced with video that bring the techniques to life

Written and edited by an outstanding team of experts in the field, Transcatheter Aortic Valve Implantation offers a multidisciplinary approach to this rapidly expanding procedure. Recent studies have shown transcatheter aortic valve implantation (TAVI) to be as effective as surgical aortic valve repair (SAVR), with demonstrably better outcomes for low, intermediate, and high-risk patients. Under the editorial leadership of Drs. Catherine M. Otto, Bernard D. Prendergast, and Simon Redwood, this practical reference incorporates recent research on patient selection, discusses current guidelines, and covers the new devices developed to address this fast-growing area. - Follows the patient journey from indications, patient selection for TAVI, choice of valve, and pre-TAVI evaluation through the procedure itself, complications, and long-term outcomes—all with a multidisciplinary team approach. - Features consistent headings and user-friendly content in every chapter: Checklists, Decision Pathways, Data/Evidence Summaries, and Essential Readings. - Contains multidisciplinary TAVI Decision Pathways that provide a uniquely visual yet comprehensive approach for quick retrieval and application of all the latest clinical implications for TAVI. - Includes the latest evidence-based data on TAVI vs. SAVR from the new AHA/ACC guidelines and implications for practice. - Provides clear visual guidance with 150 pre-, intra-, and post-imaging illustrations, plus 50 TAVI procedural video clips.

Cardiac tissue engineering aims at repairing damaged heart muscle and producing human cardiac tissues for application in drug toxicity studies. This book offers a comprehensive overview of the cardiac tissue engineering strategies, including presenting and discussing the various concepts in use, research directions and applications. Essential basic information on the major components in cardiac tissue engineering, namely cell sources and biomaterials, is firstly presented to the readers, followed by a detailed description of their implementation in different strategies, broadly divided to cellular and acellular ones. In cellular approaches, the biomaterials are used to increase cell retention after implantation or as scaffolds when bioengineering the cardiac patch, in vitro. In acellular approaches, the biomaterials are used as ECM replacement for damaged cardiac ECM after MI, or, in combination with growth factors, the biomaterials assume an additional function as a depot for prolonged factor activity for the effective recruitment of repairing cells. The book also presents technological innovations aimed to improve the quality of the cardiac patches, such as bioreactor applications, stimulation patterns and prevascularization. This book could be of interest not only from an educational perspective (i.e. for graduate students), but also for researchers and medical professionals, to offer them fresh views on novel and powerful treatment strategies. We hope that the reader will find a broad spectrum of ideas and possibilities described in this book both interesting and convincing. Table of Contents: Introduction / The Heart: Structure, Cardiovascular Diseases, and Regeneration / Cell Sources for Cardiac Tissue Engineering / Biomaterials: Polymers, Scaffolds, and Basic Design Criteria / Biomaterials as Vehicles for Stem Cell Delivery and Retention in the Infarct / Bioengineering of Cardiac Patches, In Vitro / Perfusion Bioreactors and Stimulation Patterns in Cardiac Tissue Engineering / Vascularization of Cardiac Patches / Acellular Biomaterials for Cardiac Repair / Biomaterial-based Controlled Delivery of Bioactive Molecules for Myocardial Regeneration

Plant Regeneration from Seeds: A Global Warming Perspective comprehensively reviews the effects caused by climate change on global plant regeneration, growth and seed germination. Initial chapters discuss specific geographical regions such as steppes, the artic, boreal and alpine zones, dry and tropical forests and deserts. Subsequent chapters explore special seed-related topics like fire, soil seed banks, crops, weed emergence, and invasive species Written by leaders in the field of seed germination and plant growth, this is an essential read for researchers and academics interested in plant growth, plant regeneration, seed germination and the effects of these in relation to climate change. - Guides readers through the global effects of climate change on plant growth and seed germination, including chapters on special seed-related topics - Provides fundamental research on plant regeneration - Includes detailed coverage on specific geographic regions

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety.Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses'What-Why-When-How'highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the EditorsJoy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies.Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Bachelorarbeit aus dem Jahr 2019 im Fachbereich Gesundheitswissenschaften - Gesundheitspsychologie, Note: 1,1, Duale Hochschule Baden-Württemberg, Stuttgart, früher: Berufsakademie Stuttgart, Sprache: Deutsch, Abstract: Das Ziel dieser Arbeit ist die literaturgestützte Erarbeitung von Folgen und Ursachen von non-adhärentem Verhalten und von Interventionen bezüglich der Förderung der Adhärenz bei der oralen Medikamenteneinnahme. Ein weiteres Ziel ist die theoretische und praktische Erstellung eines schriftlichen Informationsangebotes für Menschen mit chronischer Herzinsuffizienz in Bezug auf die orale Medikamenteneinnahme. Immer mehr Menschen erkranken an einer chronischen Herzinsuffizienz, welche sich durch hohe Mortalitäts- und Hospitalitätsraten auszeichnet. Ein non-adhärentes Verhalten bezüglich der Medikation wird mit schlechten klinischen Ergebnissen verbunden. Denn viele kennen ihre Medikamente, unerwünschte Wirkungen und Wechselwirkungen nicht, wodurch die Non-Adhärenz und die schlechten klinischen Ergebnisse verstärkt werden. Bei einer chronischen Krankheit ist es jedoch wichtig das Kohärenzgefühl zu steigern und die Erkrankung und die Therapie zu akzeptieren. Hierfür sind das Kennen, Mitwirken und Einhalten der Therapie notwendig. Es wurde eine umfassende Literaturrecherche in den Datenbanken PubMed und CINAHL mit den Suchbegriffen heart failure, medication adherence und medication compliance durchgeführt. Ergebnisse in englischer und deutscher Sprache der letzten zehn Jahre wurden eingeschlossen. Weiter wurde ein schriftliches Informationsangebot für Menschen mit chronischer Herzinsuffizienz auf der Grundlage des Krankheitsbildes, der medikamentösen Therapie, der Literaturrecherche zu Adhärenz, dem Konzept der kooperativen Pflegeberatung, dem Hamburger Verständlichkeitskonzept, dem Konzept der leichten Sprache und der Wittener Liste erstellt.

Debulking in Cardiovascular Interventions and Revascularization Strategies: Between a Rock and the Heart aims to provide a comprehensive overview on the diagnostic and therapeutic aspects of resistant lesions as well as tailored debulking processes in revascularization strategies. Cardiovascular interventionalists and surgeons alike frequently encounter technical challenges and increased risk when attempting to diagnose and treat resistant cardiovascular lesions, bio-tissues and vessels. Calcified plaques, fibrotic or thrombotic lesions, total occlusions, degenerative plaques, complex lesions and vessels impose morphologic obstacles to the safe and effective delivery and deployment of balloons and stents. In such instances, a debulking strategy involving the actual drilling and extraction of the targeted plaque/bio-tissue constitutes a unique option that ensures safe and efficacious subsequent balloon dilatations and stenting. A range of topics is included in the book, from the characteristics and constituents of various resistant targets and bio-tissues, to the corresponding options of debulking methods, and finally the technologic and pharmacologic means available for application. The book also provides an up-to-date description of related management solutions and tools, exploring the medical issues pertaining to the patients with these targets; procedural results and clinical outcomes as related to debulking strategies and associated diagnostic and therapeutic technology and revascularization options. Review and discussion of the pathophysiology of cardiovascular resistant lesions Analysis of the impact on revascularization outcome of cardiovascular lesions/bio-tissues which exhibit resistance to standard revascularization Introduction of the concept of debulking for revascularization of cardiovascular diseases: comprehensive description Presentation of the clinical scenarios associated with resistant cardiovascular lesions and bio-tissue that require debulking Delineation of various state-of-the -art diagnostic imaging modalities for detection and demonstration of the lesions and tissues that require debulking Presentation of the expansive array of mechanical revascularization tools available for debulking Description of surgical debulking approaches to resistant cardiovascular lesions Summary of debulking outcomes

An ideal resource for both pediatricians and endocrinologists, Sperling's Pediatric Endocrinology, 5th Edition, brings you fully up to date with accelerating research; new discoveries in metabolic, biochemical and molecular mechanisms; and the resulting advances in today's clinical care. The editorial team of world-renowned pediatric endocrinologists led by Dr. Mark Sperling, as well as expert contributing authors, cover comprehensive and current aspects of both basic science and clinical practice. Whether you're preparing for certification or have extensive clinical experience, this detailed, authoritative reference helps you increase your knowledge and determine the best possible course for every patient. - Delivers trusted guidance in every area of the field: including Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests. - Features new topics such as transgender issues in children and adolescents and endocrinology of pregnancy, the fetus and the placenta. - Offers expert coverage of hot topics such as disorders of sexual development, molecular basis of endocrine disorders, hypoglycemia in newborns and infants; neonatal and other monogenic forms of diabetes; Type I and Type II diabetes and their treatment with new insulins together with the progress in an artificial pancreas and new medications for T2DM in adolescents; the obesity epidemic and role of bariatric surgery; and advances toward personalized medicine. - Includes easy-to-follow algorithms and numerous quick-reference tables and boxes in every clinical chapter, plus interactive questions online for self-assessment. - Offers state-of-the-art information and fresh perspectives from new and award-winning authors in such areas as disorders of growth, multiple endocrine tumors, and puberty and its disorders in girls and boys.

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. - Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact - Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation - Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field - Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

This book provides a comprehensive yet concise presentation of the analysis methods of lightweight engineering in the context of the statics of beam structures and is divided into four sections. Starting from very general remarks on the fundamentals of elasticity theory, the first section also addresses plane problems as well as strength criteria of isotropic materials. The second section is devoted to the analytical treatment of the statics of beam structures, addressing beams under bending, shear and torsion. The third section deals with the work and energy methods in lightweight construction, spanning classical methods and modern computational methods such as the finite element method. Finally, the fourth section addresses more advanced beam models, discussing hybrid structures as well as laminated and sandwich beams, in addition to shear field beams and shear deformable beams. This book is intended for students at technical colleges and universities, as well as for engineers in practice and researchers in engineering.

Taking the reader from an understanding of the basic mechanisms of heart failure through to an appreciation of the complexities of heart failure management and the remarkable improvements possible with good treatment, the Oxford Textbook of Heart Failure 2e covers all aspects necessary to manage a patient with heart failure. In full colour throughout, containing over 300 illustrations, and supported by detailed referencing from the huge evidence base that has developed over the last two decades, the textbook also includes extensive chapters on common co-morbidities. The new edition has been completely updated in line with new British and European Guidelines and contains new chapters on; Natriuretic Peptides and Novel Biomarkers in Heart Failure, The Future of Heart Failure, and Regenerative Therapies. Essential reading for consultant cardiologists and those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses.

This heavily revised second edition of this critical book details the structure, function and imaging of the normal right heart both at rest and under the stresses of high altitude and exercise. Extensively revised chapters cover the pathophysiology and pathobiology of right heart dysfunction, both in experimental models and human disease, including congenital heart disease and pulmonary hypertension.The Right Heart provides a concise up-to-date guide on the latest advances in our understanding of role of the right heart in the cardiopulmonary circuit and is an indispensable up-to-date resource for clinicians interested in this topic.

The ESC Textbook of Intensive and Acute Cardiovascular Care is the official textbook of the Acute Cardiovascular Care Association (ACVC) of the ESC. Cardiovascular diseases (CVDs) are a major cause of premature death worldwide and a cause of loss of disability-adjusted life years. For most types of CVD early diagnosis and intervention are independent drivers of patient outcome. Clinicians must be properly trained and centres appropriately equipped in order to deal with these critically ill cardiac patients. This new updated edition of the textbook continues to comprehensively approach all the different issues relating to intensive and acute cardiovascular care and addresses all those involved in intensive and acute cardiac care, not only cardiologists but also critical care specialists, emergency physicians and healthcare professionals. The chapters cover the various acute cardiovascular diseases that need high quality intensive treatment as well as organisational issues, cooperation among professionals, and interaction with other specialities in medicine. SECTION 1 focusses on the definition, structure, organisation and function of ICCU's, ethical issues and quality of care. SECTION 2 addresses the pre-hospital and immediate in-hospital (ED) emergency cardiac care. SECTIONS 3-5 discuss patient monitoring, diagnosis and specific procedures. Acute coronary syndromes (ACS), acute decompensated heart failure (ADHF), and serious arrhythmias form SECTIONS 6-8. The main other cardiovascular acute conditions are grouped in SECTION 9. Finally SECTION 10 is dedicated to the many concomitant acute non-cardiovascular conditions that contribute to the patients'case mix in ICCU. This edition includes new chapters such as low cardiac output states and cardiogenic shock, and pacemaker and ICDs: troubleshooting and chapters have been extensively revised. Purchasers of the print edition will also receive an access code to access the online version of the textbook which includes additional figures, tables, and videos to better to better illustrate diagnostic and therapeutic techniques and procedures in IACC. The third edition of the ESC Textbook of Intensive and Acute Cardiovascular Care will establish a common basis of knowledge and a uniform and improved quality of care across the field.

Note to Readers: Publisher does not guarantee quality or access to any included digital components if book is purchased through a third-party seller. Written by a world-renowned expert in perinatal pharmacology, this essential reference contains current, complete, and evidence-based information on the transmission of maternal drugs into human milk. Because so many women ingest medications while breastfeeding, one of the most common questions encountered in pediatrics is: Which drugs are safe and which are hazardous for the infant? This 2021 edition has been extensively revised, and now includes 50 completely new and 356 updated medications, and state-of-the-art coverage of multiple diseases, vaccines, and syndromes. It addresses the use of radiopharmaceuticals, chemotherapeutic agents, and vaccines in breastfeeding mothers, and covers adult concerns, methods of reducing risk to infants, and infant monitoring. New to the 2021 Edition: 50 New Drugs Added 356 Drugs Updated with new data 817 Drug References Updated An updated 7x10 trim size and streamlined design for ease of use in patient education The latest information on the impact of prescription medications, over-the-counter drugs, herbs, and street drugs Key Features: Evidence-based, current information on over 1300 drugs, diseases, vaccines, and syndromes Dr. Hale's renowned'Lactation Risk Categories'incorporate recent updates Key points and savvy tips about breastfeeding and medications for quick reference Common abbreviations and drugs listed in alphabetical order Adult concerns, adult dose, pediatric concerns, infant monitoring, and alternatives Succinct information on evaluation of the infant Subscribe to www.springerpub.com/haleand experience all the benefits of using Hale's Medications and Mothers Milk online and on mobile devices! Go to www.springerpub.com/haleto learn more and subscribe today!

Significant biological differences exist between men and women that contribute to sex-specific differences in cardiovascular disease (CVD) risk factors, pathophysiology, presentation, response to therapy, and prognosis. It is essential for clinicians to be cognizant of these sex-specific differences in order to reduce the disparity in diagnosis and management of cardiovascular diseases in both genders.Sex Differences in Cardiac Disease provides a timely review of the contemporary data on these sex-specific differences in pathophysiology, clinical presentation, diagnostic evaluation, and management of cardiovascular diseases that fills a void for clinicians in practice and training. With contributions from renowned experts in the field and guideline writers, the text provides a state-of-the-art review of each topic encompassing the full spectrum of CVD in men and women. Sex-specific guideline-based recommendations are highlighted when available. Tailored to meet the needs of the busy clinicians and researchers, this text provides concise practical data to care for men and women at risk for or with CVD. The book serves as an essential resource for researchers, cardiologists, obstetricians, gynecologists, internists, family practitioners, nurse practitioners and physician assistants, and respective trainees who treat men and women with CVD. - Provides a comprehensive state-of-the-art text written by internationally renowned experts in the field of CVD disease, serving as an indispensable resource for clinicians and researchers - Enables the reader to understand the sexual dimorphism in the pathophysiology, diagnosis, management, and outcomes of the full spectrum of cardiovascular issues including ischemic heart disease, valvular disorders, arrhythmias, and heart failure - Provides a concise evidence-based practical review of medical topics, with key points and eye-catching visual infographics to meet the needs of the busy clinicians, policy makers and researchers

This volume of the series Cardiac and Vascular Biology presents the most relevant aspects of vascular mechanobiology along with many more facets of this fascinating, timely and clinically highly relevant field. Mechanotransduction, mechanosensing, fluid shear stress, hameodynamics and cell fate, are just a few topics to name. All important aspects of vascular mechanobiology in health and disease are reviewed by some of the top experts in the field. This volume, together with a second title on cardiac mechanobiology featured in this series, will be of high relevance to scientists and clinical researchers in the area of vascular biology, cardiology and biomedical engineering.

Cardiology: An Illustrated Textbook is the latest edition of this comprehensive two volume textbook, including revised chapters with the latest advances in the field of cardiology. This edition is edited by professors from the Carver College of Medicine, Iowa, and the University of California, San Francisco. This book is comprised of 120 chapters across fifteen sections. The first four sections cover basic cardiology, cardiovascular pharmacology, diagnosis, and electrophysiology. Subsequent sections cover groups of diseases and conditions, including vascular diseases, heart failure, myocardial and pericardial diseases, coronary heart diseases, valvular heart diseases, congenital heart disease, and secondary disorders of the heart. Each section incorporates new advances and step-by-step diagnosis and treatment. The closing sections of the book cover current issues in cardiology, preventive strategies for various cardiac diseases, and a final section on ‘evolving concepts', bringing this edition firmly up to date. Cardiology: An Illustrated Textbook is enhanced by 1600 full colour images and illustrations

Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. - Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease - Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research - Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare - Features chapter contributions from a wide range of international researchers in the field

This book gathers the peer-reviewed papers presented at the XXIV Conference of the Italian Association of Theoretical and Applied Mechanics, held in Rome, Italy, on September 15-19, 2019 (AIMETA 2019). The conference topics encompass all aspects of general, fluid, solid and structural mechanics, as well as mechanics for machines and mechanical systems, including theoretical, computational and experimental techniques and technological applications. As such the book represents an invaluable, up-to-the-minute tool, providing an essential overview of the most recent advances in the field.

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more. - Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology - Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research - Authored by expert editors and contributors who are among the best PBPK modelers in the world

Cardiothoracic surgery is constantly evolving in many aspects and there are many text books exist to fulfil the gap of new evidences. Most of these books are written for surgeons, anaesthetist and there is a significant deficit in many important areas which are explored in this book. It is aimed for all perioperative practitioners such as surgical care practitioners, surgical cardiothoracic trainees, anaesthetic trainees, anaesthetic practitioners, recovery practitioners, ward advanced nurse practitioners and perfusionists. It is very important for the perioperative practitioner who wants to start their career in cardiothoracic surgery to understand the step by step surgical procedure is vital. Cardiothoracic Manual for Perioperative Practitioners is devoted to delivering comprehensive coverage of all aspects of cardiothoracic surgery with emphasis on the roles and importance of the full theatre team. Details are provided throughout initial theatre set up and surgical instrumentation selection. A step by step walk through of routine surgical procedures, cardiopulmonary bypass guidance, investigations undertaken during the intraoperative period and a detailed background of surgical anatomy is provided. The book also covers essential aspects associated with recovery of the patient and the common pit falls in surgery and recovery and how these can be avoided. The structure and organisation of the theatre environment, ethical and legal issues, preventive and protective measures and the importance of swab counts are explained succinctly and systematically by experts in this field. The reader will have reliable and complete guidance to provide all the knowledge required to be ready to work in the theatre environment. Each chapter contains important references for further reading and greater in-depth study. All chapters are written by an experienced practising surgeons, anaesthetists, and practitioners.

This book is an evidence-based guide to the prevention and current management of acute and late toxicities of radiation therapy for a wide range of malignancies. Each chapter focuses on a particular anatomic site and provides information on normal sectional anatomy, contouring of target volumes and organs at risk, dose constraints, the pathophysiology of radiation toxicity, and treatment approaches for each potential toxicity. The information provided will assist in the planning and delivery of intensity-modulated radiation therapy, including volumetric modulated arc therapy, stereotactic radiosurgery, and stereotactic body radiotherapy. It will also enable the selection of appropriate, evidence-based management options in individual patients who experience radiation toxicities, taking into account the organ-specific pathophysiology of radiation injury. Written by acknowledged experts and featuring numerous high-quality illustrations, the book will be an ideal reference aid for practicing clinical and radiation oncologists, radiotherapists, fellows, residents, and nurses.

This book provides up-to-date and user-friendly guidance on the evaluation, diagnosis, and treatment of heart and vascular disease. Chapters cover a broad range of issues related to valve disease, including rheumatic fever, aortic root dilatation, infective endocarditis, and heart disease in pregnancy. The physical examination of major valve lesions, imaging techniques, and choosing a balance therapy are also discussed. Valvular Heart Disease aims to give readers exposure to guideline-directed therapy and therapeutic decisions and is relevant to trainee and practising cardiologists, cardiac surgeons, vascular surgeons, and cardiac radiologists.

This book provides a practically applicable guide to the use of multimodality imaging for managing aortic valve disorders. Details of how to successfully diagnose a range of aortic valve diseases is presented, with detailed information covered on the techniques and relevant criteria for pre-operative screening, surgical and transcatheter planning, intraprocedural imaging and related postoperative follow-up. Multimodality Imaging for Cardiac Valvular Interventions, Volume 1 Aortic Valve: From Diagnosis to Decision-Making enables the reader to develop a thorough understanding and confidence of how to make appropriate clinical decisions when confronted by a range of aortic valve diseases. It is therefore a key resource for practicing cardiac imagers, cardiologists and interventional cardiologists who encounter these patients in their day-to-day clinical practice and trainees in cardiology seeking insight on the appropriate management of these patients.

Ecocardiografia e Imagem Cardiovascular, publicação oficial do Departamento de Imagem Cardiovascular (DIC) da Sociedade Brasileira de Cardiologia (SBC), traz, em seus 70 capítulos divididos em nove partes, as mais recentes técnicas das diversas modalidades de investigação diagnóstica por imagem destinadas às cardiopatias em suas mais variadas apresentações clínicas. • Tem como objeto o estudo, a investigação do entendimento da fisiologia e da fisiopatologia das cardiopatias e patologias vasculares associadas ao coração, assim como aponta a escolha e acompanhamento da abordagem terapêutica adequada. • Apresenta atualização em Ecocardiografia, Ultrassonografia Vascular, Medicina Nuclear, Tomografia e Ressonância Magnética Nuclear dedicadas às cardiopatias e vasculopatias associadas ao coração. • Aborda temas complexos de forma amigável e clara, contribuindo para a formação e atualização de profissionais, graduandos, residentes e pós- -graduandos. • Traz a experiência clínica prática acumulada de grande número de médicos brasileiros, enriquecida com abrangente revisão da literatura internacional das mais recentes tecnologias, padronizações e aplicações da imagem cardiovascular – todas exemplificadas por imagens e vídeos de alta qualidade. É, portanto, uma referência brasileira para o melhor estudo e compreensão das doenças do coração e dos vasos. Destina-se a cardiologistas (em suas diversas subespecialidades), cirurgiões cardiovasculares, clínicos gerais, anestesiologistas dedicados às cardiopatias, intensivistas e aos emergencistas.

Zur Überbrückung eines akuten Kreislaufversagens wurden in den letzten Jahren unterschiedliche Unterstützungssysteme mit spezifischen Vorzügen und Nachteilen entwickelt. Das Prinzip, die Indikationen zur Anwendung und mögliche Risiken und Komplikationen aller angewandten Systeme (IABP, Impella, TandemHeart, Zentrifugalpumpen, va-ECMO) sind anschaulich und mit zahlreichen Abbildungen von Experten beschrieben. Grundlagenthemen wie die Pathophysiologie des Schocks und das Gerinnungsmanagement werden ebenso berücksichtigt wie spezielle Anwendungen bei Kindern oder für den Patiententransport.

Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women is a comprehensive investigation into all aspects of sex differences in cardiac electrophysiology. As there are substantial differences between female and male patients in physiology, pathology triggering factors, disease progression, clinical approaches and treatment outcome, this book provides a comprehensive examination. In cardiology, the differences between women and men are more recognized, hence this title summarizes these important differences, providing the essential information needed for clinical specialists and researchers involved in the design and implementation of clinical studies. - Explores topics ranging from the physiologic differences between women and men to the differences in clinical handling of arrhythmic disorders between female and male patients - Provides sex differences in cardiac electrophysiology in separate chapters - Covers the sex differences of cardiac electrical disorders, providing insights beyond cardiac metabolic syndrome, hypertension, atherogenesis and heart failure

The purpose of this book is to discuss available treatments for “scars” and analyze their mechanisms from an international perspective. “Scars” are now receiving considerably more attention internationally, because the topic of patients'quality of life (QOL) of patients has gained in importance. Total Scar Management highlights many “new” and “practical” topics related to scars such as various treatments for post-burn scars, traumatic scars, keloids and hypertrophic scars, aesthetic management of scars, reconstructive surgery of scar contractures, basic researches, etc. Written by an international team of prominent experts in their respective fields, the book presents the latest and most helpful advances regarding “scars,” offering a unique resource for all plastic surgeons, dermatologists, aesthetic surgeons, wound surgeons, wound healing specialists, and general surgeons who are interested in the aesthetic outcomes of their work.

The third edition of The Laboratory Rat features updated information on a variety of topics, including rats as research models for basic and translational research in areas such as genomics, alcoholism, diabetes, metabolic syndrome, obesity, neuroscience, spinal cord injury, traumatic brain injury, regenerative medicine, and infectious disease. New information related to the husbandry and veterinary care of rats is provided including topics related to nutrition, reproduction, anesthesia and surgery, infectious and noninfectious disease, and the care of surgical and other fragile models. It is a premier source of information on the laboratory rat, this book will be of interest to veterinary and medical students, senior graduate students, postdocs and researchers who utilize animals in biomedical research. - New chapters on the care of surgical and fragile models and on the use of rats in research areas such as alcoholism, regenerative medicine, spinal cord injury, traumatic brain injury, and others are included. - All chapters were written by scientific and veterinary experts. - This book condenses information from many sources on topics related to the care and use of rats in research. - It is the premier source of information on the laboratory rat.

Advances and innovations in heart failure is the first publication in the form of a Textbook of Cardiology. Over 250 contributors from India and abroad have contributed chapters in this book. Focuses on every aspect of cardiovascular imaging and intervention, thereby enhancing knowledge and has tremendous innovative and research potential of understanding advances and innovations in heart failure for the undergraduates, postgraduates, practicing cardiologists, endocrinologists, nephrologists, neurologists, critical care, pulmonologists, pediatricians, pediatric surgeons, physicians, cardiovascular surgeons, imaging experts and nutritionists, etc. Various sections of this book include Chapter on Clinical, Echo, Imaging, Coronary artery disease, Stroke, Arrhythmia, Hypertension, Valvular, Congenital heart disease, Metabolic, Nutritional, Cardio-oncology, Inflammatory disorders and heart failure including Rehabilitation, Legal and ethical issues and Future directions, etc.

Cardiology is becoming an increasingly complex field understood by only a select group of medical specialists. This publication demystifies many difficult topics in interventional cardiology and cardiac catheterisation, commencing with the basics of laboratory instrumentation and technology and progressing to a comprehensive review of both new and established cardiac interventions.Unlike other publications that are directed mainly towards clinicians, this text is specifically written to assist newcomers such as such as medical trainees, nurses, technicians, scientific staff and other allied health professionals understand the wonders of interventional cardiology, and includes extensive explanations of the techniques of angiography, and new percutaneous. The comprehensive information presented herein, written by recognised specialists in their respective fields, will no doubt prove of great benefit to clinician and non-medical specialist alike.

As the Baby Boomers age, concerns over healthcare systems'abilities to accommodate geriatric patients grow increasingly challenging. This is especially true with the population deemed to be “the oldest of the old,” specifically those over the age of 85. Unlike any other time in history, this demographic is the fastest growing segment of most developed countries. In the United States the oldest old is projected to double from 4.3 million to 9.6 million by 2030. The increased life expectancy of the population since the early 1900s has been built on the improvement of living conditions, diet, public health and advancement in medical care. With this we have seen a steady decline in the age-specific prevalence of vascular and heart diseases, stroke and even dementia. Older persons are healthier today than their counterparts decades ago. More importantly than in any other age group, the care of the oldest old must be individualized; management decisions should be made taking into consideration the older persons'expressed wishes, quality of life, function and mental capacity. The inevitable consequence is that there will be an increase in the prevalence of older persons with chronic diseases, multiple co-existing pathologies and neuro-degenerative diseases. The oldest of the aging population are often excluded from drug trials and their treatments are largely based on findings extrapolated from that of the younger old. Furthermore, among the oldest old, physiologically they are more diverse than other segments of the population. Their demographic characteristics are unparalleled and different compared to that of the younger old. Several studies have drawn attention to the differing attitudes among health professionals towards elderly people and many show prejudice because they are old. As a result, the use of age as a criteria in determining the appropriateness of treatment is of very limited validity, yet there are limited resources that guide physicians through these challenges. This book creates a greater awareness of these challenges and offers practical guidelines for working within the infrastructures vital to this demographic. This book is designed for geriatricians, primary care physicians, junior medical officers, specialty geriatrics nurses, and gerontologists. It is divided into 3 sections: General Considerations, Chronic diseases and Geriatric Syndromes. Each chapter provides a summary of important and essential information under the heading of Key Points. Case studies are included in some of the chapters to highlight the principles of management.