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The article discusses aspects of ocular surface sensory function particularly on physiology, pathology, and its therapeutic interventions. Indicated is the delicateness of the cornea as it is one of the most densely innervated issues in the human body. Highlighted is the non-specific cation channels called as transient receptor potential (TRP) channels as the key transducers of sensory stimuli. Also emphasized are the ocular surface cells which are responsible for influencing sensory neurons.

The article discusses a study conducted by researcher Alban Latremoliere, published in the periodical "Neuron" in 2015 related to treatment of pain by inhibition of an enzyme in mice. It noted that pain-tolerant people have genetic differences in the gene that codes for the enzyme Guanosine-5'-triphosphate (GTP) cyclohydrolase 1 (GCHi). It mentions production of a defective version of GCHi in sensory neurons of genetically engineered mice.

The article discusses the study by a team led by Harvard Medical School's Stephen D. Liberles that was published in the "Proceedings of the National Academy of Sciences of the U.S.," about the effect of 2-phenyl-ethylamine found in the urine of carnivores, on mouse olfactory receptors and sensory neurons.