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The article focuses on research published in "Journal of the American Chemical Society" in 2014 in which researcher Frank Glorius and coworkers made 1,2-diazepines or pyrazoles by switching the reactivity of enals with hydrazones in cycloaddition reaction.

The article informs that the scientists at specialty chemical company Solvay have come up with a cost-effective synthesis of a difluoromethylpyrazole intermediate which is thought to be a key structural unit in the fastgrowing family of succinate dehydrogenase inhibitor (SDHI) fungicides.

The article reports that iron-catalyzed reaction to make N-aryl pyrazoles and other aryl-substituted nitrogen compounds has been developed by Arkaitz Correa and Carsten Bolm at RWTH Aachen University in Germany. According to researchers, the synthetic method provides a less expensive and environmentally friendlier alternative to palladium and cooper-catalyzed C-N coupling reactions.