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The article talks about development of an organolithium addition to a chiral ketimine at pilot-plant scale using flow chemistry. It is mentioned that company Merck's chemist optimized the optimized an organometallic flow chemistry reaction. The article adds that these experiments at provided improved operating parameters that enabled the implementation of this chemistry for the commercial manufacture of verubecestat for the treatment of Alzheimer's disease.

This section offers news briefs on research-related issues. A novel dispersion process is considered the crucial element in a range of polyolefins dispersions launched by Dow Chemical. A vibration generator has been developed at the University of Southampton in England that was said to break efficiency record. An alternative process in producing polypeptides that use imines as a starting material has been discovered by researchers at Nankai University in Tianjin, China.

The article informs that researchers Li Deng and others has developed a Chiral phase-transfer catalysts approach for converting imines to amines enantioselectively.

The article informs that scientist Keiji Maruoka and colleagues of Kyoto University have developed a method in which they used enolate-type intermediates from alkylallene dicarboxylates and then treated them with imine electrophiles for manufacturing allenes.

The article offers information on a method to prepare various types of piperidines which is a basic molecule involved in formation of several drugs including morphine, quinine and tadalafil. The synthesis of piperidine begins with a cascade reaction catalyzed by rhodium which couples an imine with an alkyne and the coupled molecule act as starter for the chain reaction.

The article focuses on a research in which researchers have found how togenerate powerful metal-free catalysts for important imine reduction reactions by starting from boron-based Lewis acid-base complexes.

The article reports that immobilized bimetallic nanoclusters catalysts on reaction with cofactor 4-tert-butylcatechol helps in converting dibenzylamines to imines under mild reaction conditions.

The article reports on the use of cyclopropenimines as enantioselective catalysts. Columbia University graduate student Jeffrey S. Bandar and associate professor Tristan H. Lambert tell that a highly basic 2,3 bis cylcopropenimines are far more effective chiral organocatalysts. They used a dicyclohexyl cyclopropenimine in a preparative-scale procedure to catalyze a rapid Michael addition. Henk Hiemstra of the University of Amsterdam is amazed of how the catalyst can be easily made.

The article provides information on the amplification process of molecules that have the ability to catalyze themselves. In a highlighted incident when researchers Douglas Philp and Jan W. Sadownik were testing four reagents' that transform into imines and reactive nitrones, the nitrones were accordingly found to have undergone irreversible dipolar cycloaddion reactions. Meanwhile, an illustration of the chemical reaction is likewise presented in order to fully analyze the chemical reaction.

The article reports that Chinese researcher have developed a much-easier metal-catalyzed method to make polypeptide-like compounds from inexpensive and readily available imines a carbon monoxide. The team used N-methylimines and the resulting polymers bear a methyl group on the nitrogens instead of the hydrogen that occupies corresponding sites in polypeptides.

Corrections to articles in previous issues including the caption for the opening picture and the discoverer of aniline-catalyzed imine formation and transimination are presented.

The article reports on the highlights of the results of a study of aniline, conducted by associate professor of cell biology and chemistry Philip E. Dawson of Scripps Research Institute and colleagues. The study showed that aniline strongly catalyzes aqueous reactions of aldehydes and ketones with amines to form stable imines. In their follow-up study, the team concluded that aniline also catalyzes aqueous transiminations.

Reports that the dynamic resolution of crystalline imines can convert an entire racemic mixture of an unfunctionalized ketone or aldehyde into one pure enantiomer.