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The article reports discusses the genetic risk factors influencing intraocular pressure (IOP). The topics discussed include the early-onset glaucoma inherited as autosomal dominant disease, the complexity of the inherited disease in late-onset glaucoma due to multiple genetic and environmental risk factors, and a study of International Glaucoma Genetics Consortium (IGGC) revealing genes associated with IOP. It mentions myocilin (MYOC) is the gene causing IOP elevation.

The article discusses a study performed by researcher Raquel Lieberman on mutant myocilin targeting glaucoma. Topics discussed include a study by researcher Machelle Pardue on reduction of retinal degeneration by moderate aerobic exercise, mapping of the structure of myocilin, and problems associated with myocilin and its biological role inside the eye. INSET: Exercise May Slow Retinal Degeneration.

The article focuses on the genetic testing for the eye disease glaucoma. It mentions that that the identification of the myocilin gene causing primary open angle glaucoma, and several mouse models, have helped in knowing the cause of the disease. It also mentions some organizations that are working in the field of genetic testing including the Rotterdam Group, the Neighborhood Consortium and the International Glaucoma Genetics Consortium.

The article offers information on a research conducted by scientists at the Georgia Institute of Technology as of February 2014 to identify glaucoma-causing variant of myocilin protein which led to the discovery of potential drug targets for glaucoma.

The article offers the insights of doctor Abbot F. Clark regarding glaucoma meshwork fails. Clark says that glaucoma trabecular meshwork fails are the result of trabecular meshwork physical changes characterized by progressive trabecular meshwork cell loss, oxidative and mitochondrial damage. He also adds that altered signaling pathways including protein and myocilin (MYOC)stress, altered glucocorticoid (GR) isoforms and gremlin are causes of trabecular meshwork fails.

The article reports that a research from the Georgia Institute of Technology (Georgia Tech) has found the trabecular meshwork (TM) blockage in some cases of Glaucoma is caused by myocilin buildup.