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The article discusses the role of the new generation of superficially porous silica particles in enhancing the selectivity of ionizable analytes. Topics include recent advancement in liquid chromatography (LC) column technology with silica particles, presence of ionizable moieties such as carboxylic or amino groups in pharmaceutical compounds, and HPLC column stability being a critical factor impacting method performance.

The article discusses study on creation of an organic polymer with molecular branches by Ian Rose and Neil B. McKeown of the University of Edinburgh and coworkers published in the Nature Material journal. It mentions permeable material may lead to membranes for separation of air gases, biogas purification and carbon capture. It adds combination of rigid bicyclic triptycene (Trip) units with bulky tetramethyltetrahydronaphthalene (TMN) moieties.

Examples of pharmaceutical products employing ZORBAX SB-Phenyl Rapid Resolution High Throughput (RRHT) columns are shown. SB-Phenyl possesses useful selectivity for compounds containing phenyl-type moieties. Using RRHT columns, several combinations of stationary and mobile phase were quickly investigated to determine the best selectivity and resolution for analgesics and steroids. In both cases, ZORBAX SB-Phenyl yielded excellent peak shape in acetonitrile, but in methanol even more selectivity was obtained. [ABSTRACT FROM AUTHOR]

The article focuses on various issues related to selection of correct columns during gas chromatography (GC). It states that several stationary-phase interactions need to be considered before selecting a column including dispersive interaction between nonpolar molecules, interaction between two dipolar molecules and Hydrogen bonding interactions. It states that the internal diameter of columns should be taken care of, as it affects the retention and efficiency of columns in chromatography.

The article reports on the success of a team of chemists based in Germany and China in creating a metal-free material which selectively mediates oxidation of aliphatic C-H moieties under mild conditions.

The article discusses research on the role of (2-nitrophenyl)acetyl (NPAc) in masking hydroxyl moieties, by Katalin Daragics and Péter Fügedi, published in "Original Letters."

The article reports on the effort of Canadian research team led by Kristin L. Horton to develop a peptide-based biochemical tools that traverse the mitochondrial membrane. The researchers have developed molecular shuttles that can enter and accumulate in mitochondria and found that the right blend of hydrophobic and cationic moieties allows peptides to enter the important organelle. It also reveals that other mitochondria-targeting tags can deliver only small, nonpolar cargo.

The article reports on the move of researchers at Massachusetts General Hospital to develop a controllable synthesis of multifunctional imaging probes and nanomaterials. They attached multiple functional moieties to a peptide scaffold that has a single reactive site, then they use the site to attach the entire construct on a substrate in one step. Professor Mansoor M. Amiji reveals that the ability to control the stoichiometry of different groups using the peptide scaffold is very elegant.