1. Comparison of Diagnostic Test Accuracy of Cone-Beam Breast Computed Tomography and Digital Breast Tomosynthesis for Breast Cancer: A Systematic Review and Meta-Analysis Approach.
- Author
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Komolafe, Temitope Emmanuel, Zhang, Cheng, Olagbaju, Oluwatosin Atinuke, Yuan, Gang, Du, Qiang, Li, Ming, Zheng, Jian, and Yang, Xiaodong
- Subjects
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RECEIVER operating characteristic curves , *BREAST , *TOMOSYNTHESIS , *DIAGNOSIS methods , *BREAST cancer , *X-ray imaging , *MEDICAL screening - Abstract
Background: Cone-beam breast computed tomography (CBBCT) and digital breast tomosynthesis (DBT) remain the main 3D modalities for X-ray breast imaging. This study aimed to systematically evaluate and meta-analyze the comparison of diagnostic accuracy of CBBCT and DBT to characterize breast cancers. Methods: Two independent reviewers identified screening on diagnostic studies from 1 January 2015 to 30 December 2021, with at least reported sensitivity and specificity for both CBBCT and DBT. A univariate pooled meta-analysis was performed using the random-effects model to estimate the sensitivity and specificity while other diagnostic parameters like the area under the ROC curve (AUC), positive likelihood ratio ( L R + ), and negative likelihood ratio ( L R − ) were estimated using the bivariate model. Results: The pooled sensitivity specificity, L R + and L R − and AUC at 95% confidence interval are 86.7% (80.3–91.2), 87.0% (79.9–91.8), 6.28 (4.40–8.96), 0.17 (0.12–0.25) and 0.925 for the 17 included studies in DBT arm, respectively, while, 83.7% (54.6–95.7), 71.3% (47.5–87.2), 2.71 (1.39–5.29), 0.20 (0.04–1.05), and 0.831 are the pooled sensitivity specificity, L R + and L R − and AUC for the five studies in the CBBCT arm, respectively. Conclusions: Our study demonstrates that DBT shows improved diagnostic performance over CBBCT regarding all estimated diagnostic parameters; with the statistical improvement in the AUC of DBT over CBBCT. The CBBCT might be a useful modality for breast cancer detection, thus we recommend more prospective studies on CBBCT application. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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