Search

Neuroendocrine prostate cancer, generally arising late in the disease trajectory, is a heterogeneous subtype that infers a worse prognosis and limited treatment options for patients. Characterization of the complex landscape of this disease subtype and scrutiny of the relationship between tumor cells and cells of the surrounding tumor microenvironment have aided in elucidating some of the mechanisms of neuroendocrine disease biology and have uncovered a multitude of signaling pathways involved in disease transdifferentiation under therapeutic selection. In this review, we discuss current efforts to better understand the heterogeneous landscape of neuroendocrine prostate cancer and summarize research efforts to define the inte rplay between tumor cells and the microenvironment, with an emphasis on the immune component. Research efforts have uncovered several potential therapeutic ap proaches that may improve disease outcomes for patients diagnosed with neuroendocrine prostate cancer, including the potential for combination immunotherapies. However, additional research is required to fully address and exploit the contribution of tumor cell and microenvironment heterogeneity in developing effective treatment strategies. [ABSTRACT FROM AUTHOR]

The article reviews several books including "Practising Social Work Ethics Around the World: Cases and Commentaries," edited by S. Banks and K. Nohr, "Thought Paralysis: The Virtues of Discrimination," by F. Dalal and "Recording in Social Work," by Liz O'Rourke.

The article reviews the book "Amenities and Rural Development: Theory, Methods, and Public Policy," edited by Gary Green, Steven Deller, and David Marcouiller.

Reviews books about society and natural resources. "Community on Land: Community, Ecology and the Public Interest," by Janel M. Curry and Steven Mcguire and "Finding Common Ground: Governance and Natural Resources in the American West," by Ronald Brunner, Christine Colburn and others.

Reviews several books. 'Faith in the Market: Religion and the Rise of Urban Commercial Culture,' edited by John M. Giggie and Diane Winston; 'Religion and Media,' edited by Hent de Vries and Samuel Weber; 'Religious Liberty and Human Rights,' edited by Mark Hill.