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The current gathering is intended for examining the synthesis of a chemical moiety, oxazole. Oxazole is a vital heterocycle moiety, devouring effective healing action with three loci for substitution. Oxazole nucleus comprises one pyridine type nitrogen and a single oxygen atom in a heterocyclic system that has been inspected in the expansion of novel molecules relying upon various substitutions with encouraging pharmaceutical possessions. This review focuses on 47 synthetic schemes involving radiation, metal-mediated, one-pot, and other approaches for oxazoles and their derivatives, which headed to the improvement of new-fangled man-made methods along with modifications of standard approaches. These therapeutically active oxazole conjugates have fascinated plentiful investigators globally to scout and synthesize this attractive skeleton for clinically innovative latent beneficial intermediates. [ABSTRACT FROM AUTHOR]