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Thomas JB, Petrovsky N, Ambler GR. Addison's disease presenting in four adolescents with type 1 diabetes.Primary adrenocortical insufficiency (Addison's disease) is a potentially fatal condition that often develops insidiously and can be easily overlooked. Although rare in the general population, it is more common in patients with type 1 diabetes mellitus (T1DM). The combination of Addison's disease with T1DM and/or autoimmune thyroid disease is known as autoimmune polyendocrine syndrome type-2 (APS-2). T1DM commonly precedes the development of adrenocortical insufficiency in most patients with APS-2. We, in this study, present four cases of Addison's disease developing in adolescents with pre-existing T1DM. Risk factors for Addison's disease in this population include a history of other organ-specific autoimmunity, particularly thyroid, and a positive family history. In addition to the‘classic’ Addisonian features, the development of unexplained recurrent hypoglycemia, reduction in total insulin requirement, improvement in glycemic control, or abnormal pigmentation should arouse suspicion of adrenocortical insufficiency. Adrenal antibodies have been proposed as a screening tool for Addison's disease in the T1DM population, but doubts remain about their specificity and sensitivity. The addition of specific HLA DRB1 subtyping has been proposed to improve predictive value. [ABSTRACT FROM AUTHOR]

Presents a case of Addison's disease associated with hypothyroidism, which is untreated until twenty-four weeks of pregnancy. Consideration of hypogonadism as a major component of autoimmune syndromes that may result in premature ovarian failure; Potential of hypothyroidism to cause hyperprolactinemic disturbances resulting in anovulation and subsequent subfertility; Likelihood of untreated hypothyroidism in pregnancy to cause adverse effects in the child's subsequent performance on neuropsychological tests.