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The dynamic behaviors of microRNA and mRNA under external stress are studied with biological experiments and mathematics models. In this study, we developed a mathematic model to describe the biological phenomenon and for the first time reported that, as responses to external stress, the expression levels of microRNA and mRNA sustained oscillation. And the period of the oscillation is much shorter than several reported transcriptional regulation negative feedback loop., Comment: There were some mistakes in the analysis in this paper's first version submitted on 22 Apr 2013. We corrected them in the second version submitted on 23 Sep 2013. So please delete the "v1" version of this paper, Thank you!

Cancer cells maintain a high level of aerobic glycolysis (the Warburg effect), which is associated with their rapid proliferation. Many studies have reported that the suppression of glycolysis and activation of oxidative phosphorylation can repress the growth of cancer cells through regulation of key regulators. Whether Warburg effect of cancer cells could be switched by some other environmental stimulus? Herein, we report an interesting phenomenon in which cells alternated between glycolysis and mitochondrial respiration depending on the type of radiation they were exposed to. We observed enhanced glycolysis and mitochondrial respiration in HeLa cells exposed to 2-Gy X-ray and 2-Gy carbon ion radiation, respectively. This discovery may provide novel insights for tumor therapy.