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In this paper, we combine nonlinear diffusion with the regularized optimal mass transport (rOMT) model. As we will demonstrate, this new approach provides further insights into certain applications of fluid flow analysis in the brain. From the point of view of image processing, the anisotropic diffusion method, based on Perona-Malik, explicitly considers edge information. Applied to rOMT analysis of glymphatic transport based on DCE-MRI data, this new framework appears to capture a larger advection-dominant volume.

Vector-valued Gaussian mixtures form an important special subset of vector-valued distributions. In general, vector-valued distributions constitute natural representations for physical entities, which can mutate or transit among alternative manifestations distributed in a given space. A key example is color imagery. In this note, we vectorize the Gaussian mixture model and study several different optimal mass transport related problems associated to such models. The benefits of using vector Gaussian mixture for optimal mass transport include computational efficiency and the ability to preserve structure.