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A fundamental inequality governing the spike activity of peripheral neurons is derived and tested against auditory data. This inequality states that the steady-state firing rate must lie between the arithmetic and geometric means of the spontaneous and peak activities during adaptation. Implications towards the development of auditory mechanistic models are explored.

We present a new probabilistic graphical model which generalizes factorial hidden Markov models (FHMM) for the problem of single-channel speech separation (SCSS) in which we wish to separate the two speech signals $X(t)$ and $V(t)$ from a single recording of their mixture $Y(t)=X(t)+V(t)$ using the trained models of the speakers' speech signals. Current techniques assume the data used in the training and test phases of the separation model have the same loudness. In this paper, we introduce GFHMM, gain adapted FHMM, to extend SCSS to the general case in which $Y(t)=g_xX(t)+g_vV(t)$, where $g_x$ and $g_v$ are unknown gain factors. GFHMM consists of two independent-state HMMs and a hidden node which model spectral patterns and gain difference, respectively. A novel inference method is presented using the Viterbi algorithm and quadratic optimization with minimal computational overhead. Experimental results, conducted on 180 mixtures with gain differences from 0 to 15~dB, show that the proposed technique significantly outperforms FHMM and its memoryless counterpart, i.e., vector quantization (VQ)-based SCSS.

The rate coding response of a single peripheral sensory neuron in the asymptotic, near-equilibrium limit can be derived using information theory, asymptotic Bayesian statistics and a theory of complex systems. Almost no biological knowledge is required. The theoretical expression shows good agreement with spike-frequency adaptation data across different sensory modalities and animal species. The approach permits the discovery of a new neurophysiological equation and shares similarities with statistical physics.

As the provision of potable water is critical for successful habitation of the International Space Station (ISS), life support systems were installed in December 2008 to recycle both humidity from the atmosphere and urine to conserve available water in the vehicle. Pre-consumption testing from the dispensing needle at the Potable Water Dispenser (PWD) indicated that bacterial concentrations exceeded the current ISS specifications of 50 colony forming units (CFU) per ml. Subsequent investigations revealed that a corrugated stainless steel flex hose upstream of the dispensing needle in the PWD was filled with non-sterile water and left at room temperature for over one month before launch. To simulate biofilm formation that was suspected in the flight system, sterile flex hoses were seeded with a consortium of bacterial isolates previously recovered from other ISS water systems, which included Ralstonia pickettii, Burkholderia multivorans, Caulobacter vibrioides., and Cupriavidus pauculus. After 5 days of incubation, these hoses were challenged with various chemical disinfectants including hydrogen peroxide, colloidal silver, and buffered pH solutions to determine the ability of the disinfectants to decrease and maintain bacterial concentrations below ISS specifications. Disinfection efficacy over time was measured by collecting daily heterotrophic plate counts following exposure to the disinfectants. A single flush with either 6% hydrogen peroxide solution or a mixture of 3% hydrogen peroxide and 400 ppb colloidal silver effectively reduced the bacterial concentrations to less than 1 CFU/ml for a period of up to 2 months. Testing results indicated that hydrogen peroxide and mixtures of hydrogen peroxide and colloidal silver have tremendous potential as alternative disinfectants for ISS water systems.

This slide presentation reviews the basics of biosafety and the importance of assuring proper biosafety practices. The objectives of the presentation are to review regulations about biosafety, and the different biosafety levels; the biosafety facilities at Johnson Space Center; the usage and maintenance of the biosafety cabinet, the proper methods to handle biologically hazardous materials upon exposure, and the methods of cleanup in the event of a spill, and the training requirements that are mandated for personnel handling biologically hazardous materials.