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Computer models of cardiac electro-mechanics (EM) show promise as an effective means for quantitative analysis of clinical data and, potentially, for predicting therapeutic responses.realize such advanced applications methodological key challenges must be addressed. Enhanced computational efficiency and robustness is crucial to facilitate, within tractable time frames, model personalization, the simulation of prolonged observation periods under a broad range of conditions, and physiological completeness encompassing therapy-relevant mechanisms is needed to endow models with predictive capabilities beyond the mere replication of observations. Here, we introduce a universal feature-complete cardiac EM modeling framework that builds on a flexible method for coupling a 3D model of bi-ventricular EM to the physiologically comprehensive 0D CircAdapt model representing atrial mechanics and closed-loop circulation. A detailed mathematical description is given and efficiency, robustness, and accuracy of numerical scheme and solver implementation are evaluated. After parameterization and stabilization of the coupled 3D-0D model to a limit cycle under baseline conditions, the model's ability to replicate physiological behaviors is demonstrated, by simulating the transient response to alterations in loading conditions and contractility, as induced by experimental protocols used for assessing systolic and diastolic ventricular properties. Mechanistic completeness and computational efficiency of this novel model render advanced applications geared towards predicting acute outcomes of EM therapies feasible., Comment: This project has received funding from the EU's H2020 programme under the Marie Sklodowska-Curie Action InsiliCardio, GA No. 750835 and under the ERA-NET co-fund action No. 680969 (ERA-CVD SICVALVES) funded by the Austrian Science Fund (FWF), GA I 4652-B to CMA. The research was supported by the Grants F3210-N18 and I2760-B30 from the FWF and a BioTechMed Graz flagship award ILearnHeart to GP

The future 5G wireless infrastructure will support any-to-any connectivity between densely deployed smart objects that form the emerging paradigm known as the Internet of Everything (IoE). Compared to traditional wireless networks that enable communication between devices using a single technology, 5G networks will need to support seamless connectivity between heterogeneous wireless objects and IoE networks. To tackle the complexity and versatility of future IoE networks, 5G will need to guarantee optimal usage of both spectrum and energy resources and further support technology-agnostic connectivity between objects. One way to realize this is to combine intelligent network control with adaptive software defined air interfaces. In this paper, a flexible and compact platform is proposed for on-the-fly composition of low-power adaptive air interfaces, based on hardware/software co-processing. Compared to traditional Software Defined Radio (SDR) systems that perform computationally-intensive signal processing algorithms in software, consume significantly power and have a large form factor, the proposed platform uses modern hybrid FPGA technology combined with novel ideas such as RF Network-on-Chip (RFNoC) and partial reconfiguration. The resulting system enables composition of reconfigurable air interfaces based on hardware/software co-processing on a single chip, allowing high processing throughput, at a smaller form factor and reduced power consumption., Comment: 9 pages, 3 figures