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The first-passage-time problem for a Brownian motion with alternating infinitesimal moments through a constant boundary is considered under the assumption that the time intervals between consecutive changes of these moments are described by an alternating renewal process. Bounds to the first-passage-time density and distribution function are obtained, and a simulation procedure to estimate first-passage-time densities is constructed. Examples of applications to problems in environmental sciences and mathematical finance are also provided.

We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological washboard potential model proposed by some of us in a previous paper. In this new model a Brownian motion harnessing thermal energy is assumed to co-exist with the deterministic swing of the lever-arm, to yield an excellent fit of the set of data obtained by some of us on the sliding of Myosin II heads on immobilized actin filaments under various load conditions. Our theoretical arguments are complemented by accurate numerical simulations, and the robustness of the model is tested via different choices of parameters and potential profiles., Comment: 6 figures, 8 tables, to appear on Biosystems

We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological washboard potential model proposed by some of us in a previous paper. In this new model a Brownian motion harnessing thermal energy is assumed to co-exist with the deterministic swing of the lever-arm, to yield an excellent fit of the set of data obtained by some of us on the sliding of Myosin II heads on immobilized actin filaments under various load conditions. Our theoretical arguments are complemented by accurate numerical simulations, and the robustness of the model is tested via different choices of parameters and potential profiles., Comment: 6 figures, 8 tables

We address the controversial hot question concerning the validity of the loose-coupling versus the lever-arm models in the actomyosin dynamics by re-interpreting and extending the washboard potential model proposed by some of us in a previous paper. In the new theory, a loose-coupling mechanism co-exists with the deterministic lever-arm model. The synergetic action of a random component, originating from the harnessed thermal energy, and of the power-stroke generated by the lever-arm classical mechanism is seen to yield an excellent fit of the set of data obtained in T. Yanagida's laboratory on the sliding of Myosin II heads on actin filaments under various load conditions. Our theoretical arguments are complemented by accurate numerical simulations, and the robustness of theory is tested via different combination of parameters and potential profiles., Comment: 16 pages, 8 tables, 6 figures

For a birth-death process subject to catastrophes, defined on the state-space $S=\{r,r+1,r+2,...\}$, with $r$ a positive integer or zero, the first-visit time to a state $k\in S$ is considered and the Laplace transform of its probability density function is determined, use of which is then made to obtain mean and variance. The Laplace transform of the probability density function of the first effective catastrophe occurrence time and its expected value are also obtained. Some extensions to time-non-homogeneous processes are then provided. Finally, certain additional results concerning the determination of the steady-state distribution and the representation of the transition probabilities are worked out, while some applications to particular birth-death processes are shown in the Appendix., Comment: 23 pages, no figures

This paper focuses on the outline of some computational methods for the approximate solution of the integral equations for the neuronal firing probability density and an algorithm for the generation of sample-paths in order to construct histograms estimating the firing densities. Our results originate from the study of non-Markov stationary Gaussian neuronal models with the aim to determine the neuron's firing probability density function. A parallel algorithm has been implemented in order to simulate large numbers of sample paths of Gaussian processes characterized by damped oscillatory covariances in the presence of time dependent boundaries. The analysis based on the simulation procedure provides an alternative research tool when closed-form results or analytic evaluation of the neuronal firing densities are not available., Comment: 10 pages, 3 figures, to be published in Scientiae Mathematicae Japonicae

Making use of a Rice-like series expansion, for a class of stationary Gaussian processes the asymptotic behavior of the first passage time probability density function through certain time-varying boundaries, including periodic boundaries, is determined. Sufficient conditions are then given such that the density asymptotically exhibits an exponential behavior when the boundary is either asymptotically constant or asymptotically periodic., Comment: 21 pages, 7 figures, to be published in Methodology and Computing in Applied Probability

A jump-diffusion process is proposed to describe the displacements performed by single myosin heads along actin filaments during the rising phases. The process consists of the superposition of a Wiener and a jump process, with jumps originated by sequences of Poisson-distributed energy-supplying pulses. In a previous paper, the amplitude of the jumps was described by a mixture of two Gaussian distributions. To embody the effects of ATP hydrolysis, we now refine such a model by assuming that the jumps' amplitude is described by a mixture of three Gaussian distributions. This model has been inspired by the experimental data of T. Yanagida and his co-workers concerning observations at single molecule processes level., Comment: 9 pages, 4 figures

With reference to the experimental observations by T. Yanagida and his co-workers on actomyosin interaction, a Brownian motor of fluctuating ratchet kind is designed with the aim to describe the interaction between a Myosin II head and a neighboring actin filament. Our motor combines the dynamics of the myosin head with a chemical external system related to the ATP cycle, whose role is to provide the energy supply necessary to bias the motion. Analytical expressions for the duration of the ATP cycle, for the Gibbs free energy and for the net displacement of the myosin head are obtained. Finally, by exploiting a method due to Sekimoto (1997, J. Phys. Soc. Jpn., 66, 1234), a formula is worked out for the amount of energy consumed during the ATP cycle., Comment: 15 pages. 1 figure