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This paper proposes the design of decision models based on Computational Intelligence techniques applied to image sequences of dynamic laser speckle. These models aim to identify image regions of biological specimens illuminated by a coherent beam coming from a laser. The field image is pseudo colored using a Self Organizing Map projection. This process is carried out using a set of descriptors applied to the intensity variations along time in every pixel of an image sequence. The models use descriptors selected to improve effectiveness, depending on the specific application. We present two examples of the application of the proposed techniques to assess biological tissues. The results obtained are encouraging and significantly improve those obtained using a single descriptor.