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Your search keyword '"Magnusdottir, Stefania"' showing total 2 results
Start Over Author "Magnusdottir, Stefania" Publication Type Reports
2 results on '"Magnusdottir, Stefania"'

1. DEMETER: Efficient simultaneous curation of genome-scale reconstructions guided by experimental data and refined gene annotations

Author

Heinken, Almut, Magnúsdóttir, Stefanía, Fleming, Ronan M. T., and Thiele, Ines

Subjects
Quantitative Biology - Genomics, Quantitative Biology - Molecular Networks
Abstract

Motivation: Manual curation of genome-scale reconstructions is laborious, yet existing automated curation tools typically do not take species-specific experimental data and manually refined genome annotations into account. Results: We developed DEMETER, a COBRA Toolbox extension that enables the efficient simultaneous refinement of thousands of draft genome-scale reconstructions while ensuring adherence to the quality standards in the field, agreement with available experimental data, and refinement of pathways based on manually refined genome annotations. Availability: DEMETER and tutorials are available at https://github.com/opencobra/cobratoolbox., Comment: 6 pages, 1 Figure

Published
2021

2. Creation and analysis of biochemical constraint-based models: the COBRA Toolbox v3.0

Author

Heirendt, Laurent, Arreckx, Sylvain, Pfau, Thomas, Mendoza, Sebastián N., Richelle, Anne, Heinken, Almut, Haraldsdóttir, Hulda S., Wachowiak, Jacek, Keating, Sarah M., Vlasov, Vanja, Magnusdóttir, Stefania, Ng, Chiam Yu, Preciat, German, Žagare, Alise, Chan, Siu H. J., Aurich, Maike K., Clancy, Catherine M., Modamio, Jennifer, Sauls, John T., Noronha, Alberto, Bordbar, Aarash, Cousins, Benjamin, Assal, Diana C. El, Valcarcel, Luis V., Apaolaza, Iñigo, Ghaderi, Susan, Ahookhosh, Masoud, Guebila, Marouen Ben, Kostromins, Andrejs, Sompairac, Nicolas, Le, Hoai M., Ma, Ding, Sun, Yuekai, Wang, Lin, Yurkovich, James T., Oliveira, Miguel A. P., Vuong, Phan T., Assal, Lemmer P. El, Kuperstein, Inna, Zinovyev, Andrei, Hinton, H. Scott, Bryant, William A., Artacho, Francisco J. Aragón, Planes, Francisco J., Stalidzans, Egils, Maass, Alejandro, Vempala, Santosh, Hucka, Michael, Saunders, Michael A., Maranas, Costas D., Lewis, Nathan E., Sauter, Thomas, Palsson, Bernhard Ø., Thiele, Ines, and Fleming, Ronan M. T.

Subjects
Quantitative Biology - Quantitative Methods
Abstract

COnstraint-Based Reconstruction and Analysis (COBRA) provides a molecular mechanistic framework for integrative analysis of experimental data and quantitative prediction of physicochemically and biochemically feasible phenotypic states. The COBRA Toolbox is a comprehensive software suite of interoperable COBRA methods. It has found widespread applications in biology, biomedicine, and biotechnology because its functions can be flexibly combined to implement tailored COBRA protocols for any biochemical network. Version 3.0 includes new methods for quality controlled reconstruction, modelling, topological analysis, strain and experimental design, network visualisation as well as network integration of chemoinformatic, metabolomic, transcriptomic, proteomic, and thermochemical data. New multi-lingual code integration also enables an expansion in COBRA application scope via high-precision, high-performance, and nonlinear numerical optimisation solvers for multi-scale, multi-cellular and reaction kinetic modelling, respectively. This protocol can be adapted for the generation and analysis of a constraint-based model in a wide variety of molecular systems biology scenarios. This protocol is an update to the COBRA Toolbox 1.0 and 2.0. The COBRA Toolbox 3.0 provides an unparalleled depth of constraint-based reconstruction and analysis methods.

Published
2017

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