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Diffuse Correlation Spectroscopy (DCS) allows the label-free investigation of microvascular dynamics deep within living tissue. However, common implementations of DCS are currently limited to measurement depths of $\sim 1-1.5cm$, which can limit the accuracy of cerebral hemodynamics measurement. Here we present massively parallelized DCS (pDCS) using novel single photon avalanche detector (SPAD) arrays with up to 500x500 individual channels. The new SPAD array technology can boost the signal-to-noise ratio by a factor of up to 500 compared to single-pixel DCS, or by more than 15-fold compared to the most recent state-of-the-art pDCS demonstrations. Our results demonstrate the first in vivo use of this massively parallelized DCS system to measure cerebral blood flow changes at $\sim 2cm$ depth in human adults. We compared different modes of operation and applied a dual detection strategy, where a secondary SPAD array is used to simultaneously assess the superficial blood flow as a built-in reference measurement. While the blood flow in the superficial scalp tissue showed no significant change during cognitive activation, the deep pDCS measurement showed a statistically significant increase in the derived blood flow index of 8-12% when compared to the control rest state.

In frequency division duplex (FDD) massive multiple-input multiple-output (mMIMO) systems, the reciprocity mismatch caused by receiver distortion seriously degrades the amplitude prediction performance of channel state information (CSI). To tackle this issue, from the perspective of distortion suppression and reciprocity calibration, a lightweight neural network-based amplitude prediction method is proposed in this paper. Specifically, with the receiver distortion at the base station (BS), conventional methods are employed to extract the amplitude feature of uplink CSI. Then, learning along the direction of the uplink wireless propagation channel, a dedicated and lightweight distortion-learning network (Dist-LeaNet) is designed to restrain the receiver distortion and calibrate the amplitude reciprocity between the uplink and downlink CSI. Subsequently, by cascading, a single hidden layer-based amplitude-prediction network (Amp-PreNet) is developed to accomplish amplitude prediction of downlink CSI based on the strong amplitude reciprocity. Simulation results show that, considering the receiver distortion in FDD systems, the proposed scheme effectively improves the amplitude prediction accuracy of downlink CSI while reducing the transmission and processing delay., Comment: 10 pages, 5 figures

In this paper, we study the stability of nuclear magnetic resonance gyroscope (NMRG), which employs Xe nuclear spins to measure inertial rotation rate. The Xe spin polarization is sensed by an in-situ Rb-magnetometer. The Rb-magnetometer works in a parametric oscillation mode (henceforth referred to as the Rb parametric magnetometer, or Rb-PM), in which the Larmor frequency of the Rb spins is modulated and the transverse components of Xe nuclear spin polarization are measured. As the measurement output of the Rb-PM, the phase of the Xe nuclear spin precession is eventually converted to the Xe nuclear magnetic resonance (NMR) frequencies and the inertial rotation rate. Here we provide a comprehensive study of the NMR phase measured by the Rb-PM, and analyze the influence of various control parameters, including the DC magnetic field, the frequency and phase of the modulation field, and the Rb resonance linewidth, on the stability of the NMR phase. Based on these analysis, we propose and implement a self-calibrating method to compensate the NMR phase drift during the Rb-PM measurement. With the self-calibrating Rb-PM, we demonstrate a significant improvement of the bias stability of NMRG., Comment: 16 pages, 11 figures

Superconducting transition temperature (Tc) and critical current density (Jc) are two key factors that are not only crucial for probing high-temperature superconducting mechanisms, but also for practical applications. The simple crystal structure of FeSe is very favorable for the fabrication of thin films and wires, but its application is limited by the relatively low Tc and small Jc. A previous study has found that the Tc of FeSe can be significantly enhanced over 40 K by using the protonation method. Here, we present a systematic study of Jc and vortex properties of H+-intercalated FeSe (Hx-FeSe) single crystals. The value of Jc for Hx-FeSe single crystal is significantly enhanced, exceeding 1.3*10^6 A/cm2 at 4 K, which is more than two orders of magnitude larger than 1.1*10^4 A/cm2 of pristine FeSe. The vortex pinning mechanism of Hx-FeSe is found to be surface pinning, which is different from the dominant strong point-like pinning in pristine FeSe. Moreover, the systematic study of the vortex phase transition and the underlying mechanism provides a wealth of information for the vortex phase diagram of Hx-FeSe single crystal. Our results confirm that the introduction of H+ intercalations into FeSe not only enhances the Tc, but also significantly increases the value of Jc, which is favorable for practical applications., Comment: 13 pages, 5 figures

In unmanned aerial vehicle (UAV)-assisted millimeter wave (mmWave) systems, channel state information (CSI) feedback is critical for the selection of modulation schemes, resource management, beamforming, etc. However, traditional CSI feedback methods lead to significant feedback overhead and energy consumption of the UAV transmitter, therefore shortening the system operation time. To tackle these issues, inspired by superimposed feedback and integrated sensing and communications (ISAC), a line of sight (LoS) sensing-based superimposed CSI feedback scheme is proposed. Specifically, on the UAV transmitter side, the ground-to-UAV (G2U) CSI is superimposed on the UAVto-ground (U2G) data to feed back to the ground base station (gBS). At the gBS, the dedicated LoS sensing network (LoSSenNet) is designed to sense the U2G CSI in LoS and NLoS scenarios. With the sensed result of LoS-SenNet, the determined G2U CSI from the initial feature extraction will work as the priori information to guide the subsequent operation. Specifically, for the G2U CSI in NLoS, a CSI recovery network (CSI-RecNet) and superimposed interference cancellation are developed to recover the G2U CSI and U2G data. As for the LoS scenario, a dedicated LoS aid network (LoS-AidNet) is embedded before the CSI-RecNet and the block of superimposed interference cancellation to highlight the feature of the G2U CSI. Compared with other methods of superimposed CSI feedback, simulation results demonstrate that the proposed feedback scheme effectively improves the recovery accuracy of the G2U CSI and U2G data. Besides, against parameter variations, the proposed feedback scheme presents its robustness., Comment: 12 pages, 7 figures

Fast noninvasive probing of spatially varying decorrelating events, such as cerebral blood flow beneath the human skull, is an essential task in various scientific and clinical settings. One of the primary optical techniques used is diffuse correlation spectroscopy (DCS), whose classical implementation uses a single or few single-photon detectors, resulting in poor spatial localization accuracy and relatively low temporal resolution. Here, we propose a technique termed Classifying Rapid decorrelation Events via Parallelized single photon dEtection (CREPE)}, a new form of DCS that can probe and classify different decorrelating movements hidden underneath turbid volume with high sensitivity using parallelized speckle detection from a $32\times32$ pixel SPAD array. We evaluate our setup by classifying different spatiotemporal-decorrelating patterns hidden beneath a 5mm tissue-like phantom made with rapidly decorrelating dynamic scattering media. Twelve multi-mode fibers are used to collect scattered light from different positions on the surface of the tissue phantom. To validate our setup, we generate perturbed decorrelation patterns by both a digital micromirror device (DMD) modulated at multi-kilo-hertz rates, as well as a vessel phantom containing flowing fluid. Along with a deep contrastive learning algorithm that outperforms classic unsupervised learning methods, we demonstrate our approach can accurately detect and classify different transient decorrelation events (happening in 0.1-0.4s) underneath turbid scattering media, without any data labeling. This has the potential to be applied to noninvasively monitor deep tissue motion patterns, for example identifying normal or abnormal cerebral blood flow events, at multi-Hertz rates within a compact and static detection probe., Comment: Journal submission

In frequency-division duplexing (FDD) massive multiple-input multiple-output (MIMO) systems, 1-bit compressed sensing (CS)-based superimposed channel state information (CSI) feedback has shown many advantages, while still faces many challenges, such as low accuracy of the downlink CSI recovery and large processing delays. To overcome these drawbacks, this paper proposes a deep learning (DL) scheme to improve the 1-bit compressed sensing-based superimposed CSI feedback. On the user side, the downlink CSI is compressed with the 1-bit CS technique, superimposed on the uplink user data sequences (UL-US), and then sent back to the base station (BS). At the BS, based on the model-driven approach and assisted by the superimposition-interference cancellation technology, a multi-task detection network is first constructed for detecting both the UL-US and downlink CSI. In particular, this detection network is jointly trained to detect the UL-US and downlink CSI simultaneously, capturing a globally optimized network parameter. Then, with the recovered bits for the downlink CSI, a lightweight reconstruction scheme, which consists of an initial feature extraction of the downlink CSI with the simplified traditional method and a single hidden layer network, is utilized to reconstruct the downlink CSI with low processing delay. Compared with the 1-bit CS-based superimposed CSI feedback scheme, the proposed scheme improves the recovery accuracy of the UL-US and downlink CSI with lower processing delay and possesses robustness against parameter variations., Comment: 12 pages, 11 figures

Due to the discarding of downlink channel state information (CSI) amplitude and the employing of iteration reconstruction algorithms, 1-bit compressed sensing (CS)-based superimposed CSI feedback is challenged by low recovery accuracy and large processing delay. To overcome these drawbacks, this letter proposes a fusion learning scheme by exploiting the bi-directional channel reciprocity. Specifically, a simplified version of the conventional downlink CSI reconstruction is utilized to extract the initial feature of downlink CSI, and a single hidden layer-based amplitude-learning network (AMPL-NET) is designed to learn the auxiliary feature of the downlink CSI amplitude. Then, based on the extracted and learned amplitude features, a simple but effective amplitude-fusion network (AMPF-NET) is developed to perform the amplitude fusion of downlink CSI and thus improves the reconstruction accuracy for 1-bit CS-based superimposed CSI feedback while reducing the processing delay. Simulation results show the effectiveness of the proposed feedback scheme and the robustness against parameter variations., Comment: 5 pages, 4 figures

Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well-established that the temporal correlation of scattered coherent light diffuses through tissue much like optical intensity. Few works to date, however, have aimed to experimentally measure and process such temporal correlation data to demonstrate deep-tissue video reconstruction of decorrelation dynamics. In this work, we utilize a single-photon avalanche diode (SPAD) array camera to simultaneously monitor the temporal dynamics of speckle fluctuations at the single-photon level from 12 different phantom tissue surface locations delivered via a customized fiber bundle array. We then apply a deep neural network to convert the acquired single-photon measurements into video of scattering dynamics beneath rapidly decorrelating tissue phantoms. We demonstrate the ability to reconstruct images of transient (0.1-0.4s) dynamic events occurring up to 8 mm beneath a decorrelating tissue phantom with millimeter-scale resolution, and highlight how our model can flexibly extend to monitor flow speed within buried phantom vessels.

Structured illumination microscopy (SIM) achieves doubled spatial resolution by exciting the specimen with a high-contrast, high-frequency sinusoidal pattern. Such an excitation pattern can be generated by interference between multiple laser beams, which are diffracted from a grating. In SIM, 2D imaging requires 9 patterns and 3D imaging requires 15 patterns. Compared to mechanical movement of gratings, opti-electro devices provide rapid switch of the excitation patterns, in which Digital Micro-mirror Device (DMD) is most common in industry. Here we model DMD as the blazed grating and report a fast and cost-efficient SIM. Our home-built DMD-based laser interference structured illumination microscopy (DMD-ISIM) system reveals the nuclear pore complex and microtubule in mammalian cells with doubled spatial resolution. We further proposed multi-color DMD-ISIM system with simulation, which could potentially exploit the full power of DMD-ISIM.

Fluorescence polarization microscopy images both the intensity and orientation of fluorescent dipoles, which plays a vital role in studying the molecular structure and dynamics of bio-complex. However, it is difficult to resolve the dipole assemblies on the subcellular structure and their dynamics in living cells with super-resolution. Here we report polarized structured illumination microscopy (pSIM), which decouples the entangled spatial and angular structured illumination through interpreting the dipoles in spatio-angular hyperspace. We demonstrate its application on a series of biological filamentous systems such as cytoskeleton networks and lambda-DNA, and report the dynamics of short actin sliding through myosin-coated surface. Further, pSIM reveals "side-by-side" organization of the actin ring structure in the membrane-associated periodic skeleton in hippocampal neurons. It also images the dipole dynamics of green fluorescent proteins labeled to the microtubules in live U2OS cells. pSIM can be applied directly to a large variety of commercial or home-built SIM systems., Comment: 18 pages,5 figures, typos fixed

Sign truncated matching pursuit (STrMP) algorithm is presented in this paper. STrMP is a new greedy algorithm for the recovery of sparse signals from the sign measurement, which combines the principle of consistent reconstruction with orthogonal matching pursuit (OMP). The main part of STrMP is as concise as OMP and hence STrMP is simple to implement. In contrast to previous greedy algorithms for one-bit compressed sensing, STrMP only need to solve a convex and unconstraint subproblem at each iteration. Numerical experiments show that STrMP is fast and accurate for one-bit compressed sensing compared with other algorithms., Comment: 16 pages, 7 figures