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Using particle data from the ELFIN satellites, we present a statistical study of 284 proton isotropy boundary events on the nightside magnetosphere, characterizing their occurrence and distribution in local time, latitude (L-shell), energy, and precipitating energy flux, as a function of geomagnetic activity. For a given charged particle species and energy, its isotropy boundary (IB) is the magnetic latitude poleward of which persistently isotropic pitch-angle distributions ($J_{prec}/J_{perp}\sim 1$) are first observed to occur. This isotropization is interpreted as resulting from magnetic field-line curvature (FLC) scattering in the equatorial magnetosphere. We find that proton IBs are observed under all observed activity levels, spanning 16 to 05 MLT with $\sim$100% occurrence between 19 and 03 MLT, trending toward 60% at dawn/dusk. These results are also compared with electron IB properties observed using ELFIN, where we find similar trends across local time and activity, with the onset in $\geq$50 keV proton IB occurring on average 2 L-shells lower, and providing between 3 and 10 times as much precipitating power. Proton IBs typically span $64^\circ$-$66^\circ$ in magnetic latitude (5-6 in L-shell), corresponding to the outer edge of the ring current, tending toward lower IGRF latitudes as geomagnetic activity increases. The IBs were found to commonly occur 0.3-2.1 Re beyond the plasmapause. Proton IBs typically span $<$50 keV to $\sim$1 MeV in energy, maximizing near 22 MLT, and decreasing to a typical upper limit of 300-400 keV toward dawn and dusk, with peak observed isotropic energy increasing by $\sim$500 keV during active intervals. These results suggest that FLC in the vicinity of IBs can provide a substantial depletion mechanism for energetic protons, with the total nightside precipitating power from FLC-scattering found to be on the order of 100 MW, at times $\geq$10 GW.

Recent advancements in deep-learning-based driving planners have primarily focused on elaborate network engineering, yielding limited improvements. This paper diverges from conventional approaches by exploring three fundamental yet underinvestigated aspects: training policy, data efficiency, and evaluation robustness. We introduce EasyChauffeur, a reproducible and effective planner for both imitation learning (IL) and reinforcement learning (RL) on Waymax, a GPU-accelerated simulator. Notably, our findings indicate that the incorporation of on-policy RL significantly boosts performance and data efficiency. To further enhance this efficiency, we propose SNE-Sampling, a novel method that selectively samples data from the encoder's latent space, substantially improving EasyChauffeur's performance with RL. Additionally, we identify a deficiency in current evaluation methods, which fail to accurately assess the robustness of different planners due to significant performance drops from minor changes in the ego vehicle's initial state. In response, we propose Ego-Shifting, a new evaluation setting for assessing planners' robustness. Our findings advocate for a shift from a primary focus on network architectures to adopting a holistic approach encompassing training strategies, data efficiency, and robust evaluation methods.

While Parameter-Efficient Fine-Tuning (PEFT) methods like LoRA have effectively addressed GPU memory constraints during fine-tuning, their performance often falls short, especially in multidimensional task scenarios. To address this issue, one straightforward solution is to introduce task-specific LoRA modules as domain experts, leveraging the modeling of multiple experts' capabilities and thus enhancing the general capability of multi-task learning. Despite promising, these additional components often add complexity to the training and inference process, contravening the efficient characterization of PEFT designed for. Considering this, we introduce an innovative PEFT method, TeamLoRA, consisting of a collaboration and competition module for experts, and thus achieving the right balance of effectiveness and efficiency: (i) For collaboration, a novel knowledge-sharing and -organizing mechanism is devised to appropriately reduce the scale of matrix operations, thereby boosting the training and inference speed. (ii) For competition, we propose leveraging a game-theoretic interaction mechanism for experts, encouraging experts to transfer their domain-specific knowledge while facing diverse downstream tasks, and thus enhancing the performance. By doing so, TeamLoRA elegantly connects the experts as a "Team" with internal collaboration and competition, enabling a faster and more accurate PEFT paradigm for multi-task learning. To validate the superiority of TeamLoRA, we curate a comprehensive multi-task evaluation(CME) benchmark to thoroughly assess the capability of multi-task learning. Experiments conducted on our CME and other benchmarks indicate the effectiveness and efficiency of TeamLoRA. Our project is available at https://github.com/Lin-Tianwei/TeamLoRA.

Ophthalmic image segmentation serves as a critical foundation for ocular disease diagnosis. Although fully convolutional neural networks (CNNs) are commonly employed for segmentation, they are constrained by inductive biases and face challenges in establishing long-range dependencies. Transformer-based models address these limitations but introduce substantial computational overhead. Recently, a simple yet efficient Multilayer Perceptron (MLP) architecture was proposed for image classification, achieving competitive performance relative to advanced transformers. However, its effectiveness for ophthalmic image segmentation remains unexplored. In this paper, we introduce MM-UNet, an efficient Mixed MLP model tailored for ophthalmic image segmentation. Within MM-UNet, we propose a multi-scale MLP (MMLP) module that facilitates the interaction of features at various depths through a grouping strategy, enabling simultaneous capture of global and local information. We conducted extensive experiments on both a private anterior segment optical coherence tomography (AS-OCT) image dataset and a public fundus image dataset. The results demonstrated the superiority of our MM-UNet model in comparison to state-of-the-art deep segmentation networks., Comment: OMIA2024

Recent advancements in pre-trained large foundation models (LFM) have yielded significant breakthroughs across various domains, including natural language processing and computer vision. These models have been particularly impactful in the domain of medical diagnostic tasks. With abundant unlabeled data, an LFM has been developed for fundus images using the Vision Transformer (VIT) and a self-supervised learning framework. This LFM has shown promising performance in fundus disease diagnosis across multiple datasets. On the other hand, deep learning models have long been challenged by dataset quality issues, such as image quality and dataset bias. To investigate the influence of data quality on LFM, we conducted explorations in two fundus diagnosis tasks using datasets of varying quality. Specifically, we explored the following questions: Is LFM more robust to image quality? Is LFM affected by dataset bias? Can fine-tuning techniques alleviate these effects? Our investigation found that LFM exhibits greater resilience to dataset quality issues, including image quality and dataset bias, compared to typical convolutional networks. Furthermore, we discovered that overall fine-tuning is an effective adapter for LFM to mitigate the impact of dataset quality issues., Comment: 10 pages, 6 figures

Generative Artificial Intelligence (GAI) is taking the world by storm with its unparalleled content creation ability. Large Language Models (LLMs) are at the forefront of this movement. However, the significant resource demands of LLMs often require cloud hosting, which raises issues regarding privacy, latency, and usage limitations. Although edge intelligence has long been utilized to solve these challenges by enabling real-time AI computation on ubiquitous edge resources close to data sources, most research has focused on traditional AI models and has left a gap in addressing the unique characteristics of LLM inference, such as considerable model size, auto-regressive processes, and self-attention mechanisms. In this paper, we present an edge intelligence optimization problem tailored for LLM inference. Specifically, with the deployment of the batching technique and model quantization on resource-limited edge devices, we formulate an inference model for transformer decoder-based LLMs. Furthermore, our approach aims to maximize the inference throughput via batch scheduling and joint allocation of communication and computation resources, while also considering edge resource constraints and varying user requirements of latency and accuracy. To address this NP-hard problem, we develop an optimal Depth-First Tree-Searching algorithm with online tree-Pruning (DFTSP) that operates within a feasible time complexity. Simulation results indicate that DFTSP surpasses other batching benchmarks in throughput across diverse user settings and quantization techniques, and it reduces time complexity by over 45% compared to the brute-force searching method.

Deep learning models often encounter challenges in making accurate inferences when there are domain shifts between the source and target data. This issue is particularly pronounced in clinical settings due to the scarcity of annotated data resulting from the professional and private nature of medical data. Despite the existence of decent solutions, many of them are hindered in clinical settings due to limitations in data collection and computational complexity. To tackle domain shifts in data-scarce medical scenarios, we propose a Random frequency filtering enabled Single-source Domain Generalization algorithm (RaffeSDG), which promises robust out-of-domain inference with segmentation models trained on a single-source domain. A filter-based data augmentation strategy is first proposed to promote domain variability within a single-source domain by introducing variations in frequency space and blending homologous samples. Then Gaussian filter-based structural saliency is also leveraged to learn robust representations across augmented samples, further facilitating the training of generalizable segmentation models. To validate the effectiveness of RaffeSDG, we conducted extensive experiments involving out-of-domain inference on segmentation tasks for three human tissues imaged by four diverse modalities. Through thorough investigations and comparisons, compelling evidence was observed in these experiments, demonstrating the potential and generalizability of RaffeSDG. The code is available at https://github.com/liamheng/Non-IID_Medical_Image_Segmentation.

Revolutionary advancements in text-to-image models have unlocked new dimensions for sophisticated content creation, e.g., text-conditioned image editing, allowing us to edit the diverse images that convey highly complex visual concepts according to the textual guidance. Despite being promising, existing methods focus on texture- or non-rigid-based visual manipulation, which struggles to produce the fine-grained animation of smooth text-conditioned image morphing without fine-tuning, i.e., due to their highly unstructured latent space. In this paper, we introduce a tuning-free LLM-driven attention control framework, encapsulated by the progressive process of LLM planning, prompt-Aware editing, StablE animation geneRation, abbreviated as LASER. LASER employs a large language model (LLM) to refine coarse descriptions into detailed prompts, guiding pre-trained text-to-image models for subsequent image generation. We manipulate the model's spatial features and self-attention mechanisms to maintain animation integrity and enable seamless morphing directly from text prompts, eliminating the need for additional fine-tuning or annotations. Our meticulous control over spatial features and self-attention ensures structural consistency in the images. This paper presents a novel framework integrating LLMs with text-to-image models to create high-quality animations from a single text input. We also propose a Text-conditioned Image-to-Animation Benchmark to validate the effectiveness and efficacy of LASER. Extensive experiments demonstrate that LASER produces impressive, consistent, and efficient results in animation generation, positioning it as a powerful tool for advanced digital content creation., Comment: 10 pages, 7 figures

Instrument-tissue interaction detection task, which helps understand surgical activities, is vital for constructing computer-assisted surgery systems but with many challenges. Firstly, most models represent instrument-tissue interaction in a coarse-grained way which only focuses on classification and lacks the ability to automatically detect instruments and tissues. Secondly, existing works do not fully consider relations between intra- and inter-frame of instruments and tissues. In the paper, we propose to represent instrument-tissue interaction as quintuple and present an Instrument-Tissue Interaction Detection Network (ITIDNet) to detect the quintuple for surgery videos understanding. Specifically, we propose a Snippet Consecutive Feature (SCF) Layer to enhance features by modeling relationships of proposals in the current frame using global context information in the video snippet. We also propose a Spatial Corresponding Attention (SCA) Layer to incorporate features of proposals between adjacent frames through spatial encoding. To reason relationships between instruments and tissues, a Temporal Graph (TG) Layer is proposed with intra-frame connections to exploit relationships between instruments and tissues in the same frame and inter-frame connections to model the temporal information for the same instance. For evaluation, we build a cataract surgery video (PhacoQ) dataset and a cholecystectomy surgery video (CholecQ) dataset. Experimental results demonstrate the promising performance of our model, which outperforms other state-of-the-art models on both datasets.

Medical image registration is vital for disease diagnosis and treatment with its ability to merge diverse information of images, which may be captured under different times, angles, or modalities. Although several surveys have reviewed the development of medical image registration, these surveys have not systematically summarized methodologies of existing medical image registration methods. To this end, we provide a comprehensive review of these methods from traditional and deep learning-based directions, aiming to help audiences understand the development of medical image registration quickly. In particular, we review recent advances in retinal image registration at the end of each section, which has not attracted much attention. Additionally, we also discuss the current challenges of retinal image registration and provide insights and prospects for future research.

Recent advancements indicate that scaling up Multimodal Large Language Models (MLLMs) effectively enhances performance on downstream multimodal tasks. The prevailing MLLM paradigm, \emph{e.g.}, LLaVA, transforms visual features into text-like tokens using a \emph{static} vision-language mapper, thereby enabling \emph{static} LLMs to develop the capability to comprehend visual information through visual instruction tuning. Although promising, the \emph{static} tuning strategy~\footnote{The static tuning refers to the trained model with static parameters.} that shares the same parameters may constrain performance across different downstream multimodal tasks. In light of this, we introduce HyperLLaVA, which involves adaptive tuning of the projector and LLM parameters, in conjunction with a dynamic visual expert and language expert, respectively. These experts are derived from HyperNetworks, which generates adaptive parameter shifts through visual and language guidance, enabling dynamic projector and LLM modeling in two-stage training. Our experiments demonstrate that our solution significantly surpasses LLaVA on existing MLLM benchmarks, including MME, MMBench, SEED-Bench, and LLaVA-Bench. ~\footnote{Our project is available on the link https://github.com/DCDmllm/HyperLLaVA}.

Current state-of-the-art (SOTA) 3D object detection methods often require a large amount of 3D bounding box annotations for training. However, collecting such large-scale densely-supervised datasets is notoriously costly. To reduce the cumbersome data annotation process, we propose a novel sparsely-annotated framework, in which we just annotate one 3D object per scene. Such a sparse annotation strategy could significantly reduce the heavy annotation burden, while inexact and incomplete sparse supervision may severely deteriorate the detection performance. To address this issue, we develop the SS3D++ method that alternatively improves 3D detector training and confident fully-annotated scene generation in a unified learning scheme. Using sparse annotations as seeds, we progressively generate confident fully-annotated scenes based on designing a missing-annotated instance mining module and reliable background mining module. Our proposed method produces competitive results when compared with SOTA weakly-supervised methods using the same or even more annotation costs. Besides, compared with SOTA fully-supervised methods, we achieve on-par or even better performance on the KITTI dataset with about 5x less annotation cost, and 90% of their performance on the Waymo dataset with about 15x less annotation cost. The additional unlabeled training scenes could further boost the performance. The code will be available at https://github.com/gaocq/SS3D2.

Convolutional neural networks (CNNs) have long been the paradigm of choice for robust medical image processing (MIP). Therefore, it is crucial to effectively and efficiently deploy CNNs on devices with different computing capabilities to support computer-aided diagnosis. Many methods employ factorized convolutional layers to alleviate the burden of limited computational resources at the expense of expressiveness. To this end, given weak medical image-driven CNN model optimization, a Singular value equalization generalizer-induced Factorized Convolution (SFConv) is proposed to improve the expressive power of factorized convolutions in MIP models. We first decompose the weight matrix of convolutional filters into two low-rank matrices to achieve model reduction. Then minimize the KL divergence between the two low-rank weight matrices and the uniform distribution, thereby reducing the number of singular value directions with significant variance. Extensive experiments on fundus and OCTA datasets demonstrate that our SFConv yields competitive expressiveness over vanilla convolutions while reducing complexity.

Previous research on radiology report generation has made significant progress in terms of increasing the clinical accuracy of generated reports. In this paper, we emphasize another crucial quality that it should possess, i.e., inter-report consistency, which refers to the capability of generating consistent reports for semantically equivalent radiographs. This quality is even of greater significance than the overall report accuracy in terms of ensuring the system's credibility, as a system prone to providing conflicting results would severely erode users' trust. Regrettably, existing approaches struggle to maintain inter-report consistency, exhibiting biases towards common patterns and susceptibility to lesion variants. To address this issue, we propose ICON, which improves the inter-report consistency of radiology report generation. Aiming at enhancing the system's ability to capture the similarities in semantically equivalent lesions, our approach involves first extracting lesions from input images and examining their characteristics. Then, we introduce a lesion-aware mix-up augmentation technique to ensure that the representations of the semantically equivalent lesions align with the same attributes, by linearly interpolating them during the training phase. Extensive experiments on three publicly available chest X-ray datasets verify the effectiveness of our approach, both in terms of improving the consistency and accuracy of the generated reports.

Object detection in aerial imagery presents a significant challenge due to large scale variations among objects. This paper proposes an evolutionary reinforcement learning agent, integrated within a coarse-to-fine object detection framework, to optimize the scale for more effective detection of objects in such images. Specifically, a set of patches potentially containing objects are first generated. A set of rewards measuring the localization accuracy, the accuracy of predicted labels, and the scale consistency among nearby patches are designed in the agent to guide the scale optimization. The proposed scale-consistency reward ensures similar scales for neighboring objects of the same category. Furthermore, a spatial-semantic attention mechanism is designed to exploit the spatial semantic relations between patches. The agent employs the proximal policy optimization strategy in conjunction with the evolutionary strategy, effectively utilizing both the current patch status and historical experience embedded in the agent. The proposed model is compared with state-of-the-art methods on two benchmark datasets for object detection on drone imagery. It significantly outperforms all the compared methods., Comment: Accepted by AAAI 2024

The morphologies of vessel-like structures, such as blood vessels and nerve fibres, play significant roles in disease diagnosis, e.g., Parkinson's disease. Deep network-based refinement segmentation methods have recently achieved promising vessel-like structure segmentation results. There are still two challenges: (1) existing methods have limitations in rehabilitating subsection ruptures in segmented vessel-like structures; (2) they are often overconfident in predicted segmentation results. To tackle these two challenges, this paper attempts to leverage the potential of spatial interconnection relationships among subsection ruptures from the structure rehabilitation perspective. Based on this, we propose a novel Vessel-like Structure Rehabilitation Network (VSR-Net) to rehabilitate subsection ruptures and improve the model calibration based on coarse vessel-like structure segmentation results. VSR-Net first constructs subsection rupture clusters with Curvilinear Clustering Module (CCM). Then, the well-designed Curvilinear Merging Module (CMM) is applied to rehabilitate the subsection ruptures to obtain the refined vessel-like structures. Extensive experiments on five 2D/3D medical image datasets show that VSR-Net significantly outperforms state-of-the-art (SOTA) refinement segmentation methods with lower calibration error. Additionally, we provide quantitative analysis to explain the morphological difference between the rehabilitation results of VSR-Net and ground truth (GT), which is smaller than SOTA methods and GT, demonstrating that our method better rehabilitates vessel-like structures by restoring subsection ruptures.

Medical imaging provides many valuable clues involving anatomical structure and pathological characteristics. However, image degradation is a common issue in clinical practice, which can adversely impact the observation and diagnosis by physicians and algorithms. Although extensive enhancement models have been developed, these models require a well pre-training before deployment, while failing to take advantage of the potential value of inference data after deployment. In this paper, we raise an algorithm for source-free unsupervised domain adaptive medical image enhancement (SAME), which adapts and optimizes enhancement models using test data in the inference phase. A structure-preserving enhancement network is first constructed to learn a robust source model from synthesized training data. Then a teacher-student model is initialized with the source model and conducts source-free unsupervised domain adaptation (SFUDA) by knowledge distillation with the test data. Additionally, a pseudo-label picker is developed to boost the knowledge distillation of enhancement tasks. Experiments were implemented on ten datasets from three medical image modalities to validate the advantage of the proposed algorithm, and setting analysis and ablation studies were also carried out to interpret the effectiveness of SAME. The remarkable enhancement performance and benefits for downstream tasks demonstrate the potential and generalizability of SAME. The code is available at https://github.com/liamheng/Annotation-free-Medical-Image-Enhancement., Comment: 14 pages, 9 figures, in IEEE Transactions on Medical Imaging

Gait recognition holds the promise to robustly identify subjects based on walking patterns instead of appearance information. In recent years, this field has been dominated by learning methods based on two principal input representations: dense silhouette masks or sparse pose keypoints. In this work, we propose a novel, point-based Contour-Pose representation, which compactly expresses both body shape and body parts information. We further propose a local-to-global architecture, called GaitContour, to leverage this novel representation and efficiently compute subject embedding in two stages. The first stage consists of a local transformer that extracts features from five different body regions. The second stage then aggregates the regional features to estimate a global human gait representation. Such a design significantly reduces the complexity of the attention operation and improves efficiency and performance simultaneously. Through large scale experiments, GaitContour is shown to perform significantly better than previous point-based methods, while also being significantly more efficient than silhouette-based methods. On challenging datasets with significant distractors, GaitContour can even outperform silhouette-based methods.

Diffusion models have advanced generative AI significantly in terms of editing and creating naturalistic images. However, efficiently improving generated image quality is still of paramount interest. In this context, we propose a generic "naturalness" preserving loss function, viz., kurtosis concentration (KC) loss, which can be readily applied to any standard diffusion model pipeline to elevate the image quality. Our motivation stems from the projected kurtosis concentration property of natural images, which states that natural images have nearly constant kurtosis values across different band-pass versions of the image. To retain the "naturalness" of the generated images, we enforce reducing the gap between the highest and lowest kurtosis values across the band-pass versions (e.g., Discrete Wavelet Transform (DWT)) of images. Note that our approach does not require any additional guidance like classifier or classifier-free guidance to improve the image quality. We validate the proposed approach for three diverse tasks, viz., (1) personalized few-shot finetuning using text guidance, (2) unconditional image generation, and (3) image super-resolution. Integrating the proposed KC loss has improved the perceptual quality across all these tasks in terms of both FID, MUSIQ score, and user evaluation.

Early-stage diabetic retinopathy (DR) presents challenges in clinical diagnosis due to inconspicuous and minute microangioma lesions, resulting in limited research in this area. Additionally, the potential of emerging foundation models, such as the segment anything model (SAM), in medical scenarios remains rarely explored. In this work, we propose a human-in-the-loop, label-free early DR diagnosis framework called GlanceSeg, based on SAM. GlanceSeg enables real-time segmentation of microangioma lesions as ophthalmologists review fundus images. Our human-in-the-loop framework integrates the ophthalmologist's gaze map, allowing for rough localization of minute lesions in fundus images. Subsequently, a saliency map is generated based on the located region of interest, which provides prompt points to assist the foundation model in efficiently segmenting microangioma lesions. Finally, a domain knowledge filter refines the segmentation of minute lesions. We conducted experiments on two newly-built public datasets, i.e., IDRiD and Retinal-Lesions, and validated the feasibility and superiority of GlanceSeg through visualized illustrations and quantitative measures. Additionally, we demonstrated that GlanceSeg improves annotation efficiency for clinicians and enhances segmentation performance through fine-tuning using annotations. This study highlights the potential of GlanceSeg-based annotations for self-model optimization, leading to enduring performance advancements through continual learning., Comment: 12 pages, 10 figures

Web-scale ranking systems at Meta serving billions of users is complex. Improving ranking models is essential but engineering heavy. Automated Machine Learning (AutoML) can release engineers from labor intensive work of tuning ranking models; however, it is unknown if AutoML is efficient enough to meet tight production timeline in real-world and, at the same time, bring additional improvements to the strong baselines. Moreover, to achieve higher ranking performance, there is an ever-increasing demand to scale up ranking models to even larger capacity, which imposes more challenges on the efficiency. The large scale of models and tight production schedule requires AutoML to outperform human baselines by only using a small number of model evaluation trials (around 100). We presents a sampling-based AutoML method, focusing on neural architecture search and hyperparameter optimization, addressing these challenges in Meta-scale production when building large capacity models. Our approach efficiently handles large-scale data demands. It leverages a lightweight predictor-based searcher and reinforcement learning to explore vast search spaces, significantly reducing the number of model evaluations. Through experiments in large capacity modeling for CTR and CVR applications, we show that our method achieves outstanding Return on Investment (ROI) versus human tuned baselines, with up to 0.09% Normalized Entropy (NE) loss reduction or $25\%$ Query per Second (QPS) increase by only sampling one hundred models on average from a curated search space. The proposed AutoML method has already made real-world impact where a discovered Instagram CTR model with up to -0.36% NE gain (over existing production baseline) was selected for large-scale online A/B test and show statistically significant gain. These production results proved AutoML efficacy and accelerated its adoption in ranking systems at Meta., Comment: Hang Yin and Kuang-Hung Liu contribute equally

Neural Architecture Search (NAS) has demonstrated its efficacy in computer vision and potential for ranking systems. However, prior work focused on academic problems, which are evaluated at small scale under well-controlled fixed baselines. In industry system, such as ranking system in Meta, it is unclear whether NAS algorithms from the literature can outperform production baselines because of: (1) scale - Meta ranking systems serve billions of users, (2) strong baselines - the baselines are production models optimized by hundreds to thousands of world-class engineers for years since the rise of deep learning, (3) dynamic baselines - engineers may have established new and stronger baselines during NAS search, and (4) efficiency - the search pipeline must yield results quickly in alignment with the productionization life cycle. In this paper, we present Rankitect, a NAS software framework for ranking systems at Meta. Rankitect seeks to build brand new architectures by composing low level building blocks from scratch. Rankitect implements and improves state-of-the-art (SOTA) NAS methods for comprehensive and fair comparison under the same search space, including sampling-based NAS, one-shot NAS, and Differentiable NAS (DNAS). We evaluate Rankitect by comparing to multiple production ranking models at Meta. We find that Rankitect can discover new models from scratch achieving competitive tradeoff between Normalized Entropy loss and FLOPs. When utilizing search space designed by engineers, Rankitect can generate better models than engineers, achieving positive offline evaluation and online A/B test at Meta scale., Comment: Wei Wen and Kuang-Hung Liu contribute equally

Optical Coherence Tomography Angiography (OCTA) is a promising tool for detecting Alzheimer's disease (AD) by imaging the retinal microvasculature. Ophthalmologists commonly use region-based analysis, such as the ETDRS grid, to study OCTA image biomarkers and understand the correlation with AD. However, existing studies have used general deep computer vision methods, which present challenges in providing interpretable results and leveraging clinical prior knowledge. To address these challenges, we propose a novel deep-learning framework called Polar-Net. Our approach involves mapping OCTA images from Cartesian coordinates to polar coordinates, which allows for the use of approximate sector convolution and enables the implementation of the ETDRS grid-based regional analysis method commonly used in clinical practice. Furthermore, Polar-Net incorporates clinical prior information of each sector region into the training process, which further enhances its performance. Additionally, our framework adapts to acquire the importance of the corresponding retinal region, which helps researchers and clinicians understand the model's decision-making process in detecting AD and assess its conformity to clinical observations. Through evaluations on private and public datasets, we have demonstrated that Polar-Net outperforms existing state-of-the-art methods and provides more valuable pathological evidence for the association between retinal vascular changes and AD. In addition, we also show that the two innovative modules introduced in our framework have a significant impact on improving overall performance., Comment: Accepted by MICCAI2023

Automating radiology report generation can significantly alleviate radiologists' workloads. Previous research has primarily focused on realizing highly concise observations while neglecting the precise attributes that determine the severity of diseases (e.g., small pleural effusion). Since incorrect attributes will lead to imprecise radiology reports, strengthening the generation process with precise attribute modeling becomes necessary. Additionally, the temporal information contained in the historical records, which is crucial in evaluating a patient's current condition (e.g., heart size is unchanged), has also been largely disregarded. To address these issues, we propose RECAP, which generates precise and accurate radiology reports via dynamic disease progression reasoning. Specifically, RECAP first predicts the observations and progressions (i.e., spatiotemporal information) given two consecutive radiographs. It then combines the historical records, spatiotemporal information, and radiographs for report generation, where a disease progression graph and dynamic progression reasoning mechanism are devised to accurately select the attributes of each observation and progression. Extensive experiments on two publicly available datasets demonstrate the effectiveness of our model., Comment: Accepted by Findings of EMNLP 2023

Recognition and localization of surgical detailed actions is an essential component of developing a context-aware decision support system. However, most existing detection algorithms fail to provide high-accuracy action classes even having their locations, as they do not consider the surgery procedure's regularity in the whole video. This limitation hinders their application. Moreover, implementing the predictions in clinical applications seriously needs to convey model confidence to earn entrustment, which is unexplored in surgical action prediction. In this paper, to accurately detect fine-grained actions that happen at every moment, we propose an anchor-context action detection network (ACTNet), including an anchor-context detection (ACD) module and a class conditional diffusion (CCD) module, to answer the following questions: 1) where the actions happen; 2) what actions are; 3) how confidence predictions are. Specifically, the proposed ACD module spatially and temporally highlights the regions interacting with the extracted anchor in surgery video, which outputs action location and its class distribution based on anchor-context interactions. Considering the full distribution of action classes in videos, the CCD module adopts a denoising diffusion-based generative model conditioned on our ACD estimator to further reconstruct accurately the action predictions. Moreover, we utilize the stochastic nature of the diffusion model outputs to access model confidence for each prediction. Our method reports the state-of-the-art performance, with improvements of 4.0% mAP against baseline on the surgical video dataset., Comment: Accepted early by MICCAI2023 (Oral)

Pathological myopia (PM) is the leading ocular disease for impaired vision worldwide. Clinically, the characteristic of pathology distribution in PM is global-local on the fundus image, which plays a significant role in assisting clinicians in diagnosing PM. However, most existing deep neural networks focused on designing complex architectures but rarely explored the pathology distribution prior of PM. To tackle this issue, we propose an efficient pyramid channel attention (EPCA) module, which fully leverages the potential of the clinical pathology prior of PM with pyramid pooling and multi-scale context fusion. Then, we construct EPCA-Net for automatic PM recognition based on fundus images by stacking a sequence of EPCA modules. Moreover, motivated by the recent pretraining-and-finetuning paradigm, we attempt to adapt pre-trained natural image models for PM recognition by freezing them and treating the EPCA and other attention modules as adapters. In addition, we construct a PM recognition benchmark termed PM-fundus by collecting fundus images of PM from publicly available datasets. The comprehensive experiments demonstrate the superiority of our EPCA-Net over state-of-the-art methods in the PM recognition task. The results also show that our method based on the pretraining-and-finetuning paradigm achieves competitive performance through comparisons to part of previous methods based on traditional fine-tuning paradigm with fewer tunable parameters, which has the potential to leverage more natural image foundation models to address the PM recognition task in limited medical data regime., Comment: 37 pages

Controller synthesis, including reset controller, feedback controller, and switching logic controller, provides an essential mechanism to guarantee the correctness and reliability of hybrid systems in a correct-by-construction manner. Unfortunately, reset controller synthesis is still in an infant stage in the literature, although it makes theoretical and practical significance. In this paper, we propose a convex programming based method to synthesize reset controllers for polynomial hybrid systems subject to safety, possibly together with liveness. Such a problem essentially corresponds to computing an initial set of continuous states in each mode and a reset map associated with each discrete jump such that any trajectory starting from any computed initial state keeps safe if only safety constraints are given or reaches the target set eventually and keeps safe before that if both safety and liveness are given, through the computed reset maps. Both cases can be reduced to reach-avoid and/or differential invariant generation problems, further encoded as convex optimization problems. Finally, several examples are provided to demonstrate the efficiency and effectiveness of our method., Comment: 26 pages, 8 figures

A reset controller plays a crucial role in designing hybrid systems. It restricts the initial set and redefines the reset map associated with discrete transitions, in order to guarantee the system to achieve its objective. Reset controller synthesis, together with feedback controller synthesis and switching logic controller synthesis, provides a correct-by-construction approach to designing hybrid systems. However, time-delay is an inevitable factor in hybrid systems, which can degrade control performance and render verification certificates obtained by abstracting away time-delay invalid in practice. In this paper, we investigate this issue in a practical manner by taking time-delay into account. We propose an approach that reduces the synthesis of reset controllers to the generation of reach-avoid sets for the hybrid system under consideration, which can be efficiently solved using off-the-shell convex optimization solvers., Comment: 15 pages, 10 figures

Recently, utilizing deep neural networks to build the opendomain dialogue models has become a hot topic. However, the responses generated by these models suffer from many problems such as responses not being contextualized and tend to generate generic responses that lack information content, damaging the user's experience seriously. Therefore, many studies try introducing more information into the dialogue models to make the generated responses more vivid and informative. Unlike them, this paper improves the quality of generated responses by learning the implicit pattern information between contexts and responses in the training samples. In this paper, we first build an open-domain dialogue model based on the pre-trained language model (i.e., GPT-2). And then, an improved scheduled sampling method is proposed for pre-trained models, by which the responses can be used to guide the response generation in the training phase while avoiding the exposure bias problem. More importantly, we design a response-aware mechanism for mining the implicit pattern information between contexts and responses so that the generated replies are more diverse and approximate to human replies. Finally, we evaluate the proposed model (RAD) on the Persona-Chat and DailyDialog datasets; and the experimental results show that our model outperforms the baselines on most automatic and manual metrics.

Fundus photography is prone to suffer from image quality degradation that impacts clinical examination performed by ophthalmologists or intelligent systems. Though enhancement algorithms have been developed to promote fundus observation on degraded images, high data demands and limited applicability hinder their clinical deployment. To circumvent this bottleneck, a generic fundus image enhancement network (GFE-Net) is developed in this study to robustly correct unknown fundus images without supervised or extra data. Levering image frequency information, self-supervised representation learning is conducted to learn robust structure-aware representations from degraded images. Then with a seamless architecture that couples representation learning and image enhancement, GFE-Net can accurately correct fundus images and meanwhile preserve retinal structures. Comprehensive experiments are implemented to demonstrate the effectiveness and advantages of GFE-Net. Compared with state-of-the-art algorithms, GFE-Net achieves superior performance in data dependency, enhancement performance, deployment efficiency, and scale generalizability. Follow-up fundus image analysis is also facilitated by GFE-Net, whose modules are respectively verified to be effective for image enhancement., Comment: Accepted by Medical Image Analysis in Auguest, 2023

Given the prevalence of rolling bearing fault diagnosis as a practical issue across various working conditions, the limited availability of samples compounds the challenge. Additionally, the complexity of the external environment and the structure of rolling bearings often manifests faults characterized by randomness and fuzziness, hindering the effective extraction of fault characteristics and restricting the accuracy of fault diagnosis. To overcome these problems, this paper presents a novel approach termed constructive Incremental learning-based ensemble domain adaptation (CIL-EDA) approach. Specifically, it is implemented on stochastic configuration networks (SCN) to constructively improve its adaptive performance in multi-domains. Concretely, a cloud feature extraction method is employed in conjunction with wavelet packet decomposition (WPD) to capture the uncertainty of fault information from multiple resolution aspects. Subsequently, constructive Incremental learning-based domain adaptation (CIL-DA) is firstly developed to enhance the cross-domain learning capability of each hidden node through domain matching and construct a robust fault classifier by leveraging limited labeled data from both target and source domains. Finally, fault diagnosis results are obtained by a majority voting of CIL-EDA which integrates CIL-DA and parallel ensemble learning. Experimental results demonstrate that our CIL-DA outperforms several domain adaptation methods and CIL-EDA consistently outperforms state-of-art fault diagnosis methods in few-shot scenarios.

In this paper, we study the problem of end-to-end multi-person pose estimation. State-of-the-art solutions adopt the DETR-like framework, and mainly develop the complex decoder, e.g., regarding pose estimation as keypoint box detection and combining with human detection in ED-Pose, hierarchically predicting with pose decoder and joint (keypoint) decoder in PETR. We present a simple yet effective transformer approach, named Group Pose. We simply regard $K$-keypoint pose estimation as predicting a set of $N\times K$ keypoint positions, each from a keypoint query, as well as representing each pose with an instance query for scoring $N$ pose predictions. Motivated by the intuition that the interaction, among across-instance queries of different types, is not directly helpful, we make a simple modification to decoder self-attention. We replace single self-attention over all the $N\times(K+1)$ queries with two subsequent group self-attentions: (i) $N$ within-instance self-attention, with each over $K$ keypoint queries and one instance query, and (ii) $(K+1)$ same-type across-instance self-attention, each over $N$ queries of the same type. The resulting decoder removes the interaction among across-instance type-different queries, easing the optimization and thus improving the performance. Experimental results on MS COCO and CrowdPose show that our approach without human box supervision is superior to previous methods with complex decoders, and even is slightly better than ED-Pose that uses human box supervision. $\href{https://github.com/Michel-liu/GroupPose-Paddle}{\rm Paddle}$ and $\href{https://github.com/Michel-liu/GroupPose}{\rm PyTorch}$ code are available., Comment: Accepted by ICCV 2023

The annotation scarcity of medical image segmentation poses challenges in collecting sufficient training data for deep learning models. Specifically, models trained on limited data may not generalize well to other unseen data domains, resulting in a domain shift issue. Consequently, domain generalization (DG) is developed to boost the performance of segmentation models on unseen domains. However, the DG setup requires multiple source domains, which impedes the efficient deployment of segmentation algorithms in clinical scenarios. To address this challenge and improve the segmentation model's generalizability, we propose a novel approach called the Frequency-mixed Single-source Domain Generalization method (FreeSDG). By analyzing the frequency's effect on domain discrepancy, FreeSDG leverages a mixed frequency spectrum to augment the single-source domain. Additionally, self-supervision is constructed in the domain augmentation to learn robust context-aware representations for the segmentation task. Experimental results on five datasets of three modalities demonstrate the effectiveness of the proposed algorithm. FreeSDG outperforms state-of-the-art methods and significantly improves the segmentation model's generalizability. Therefore, FreeSDG provides a promising solution for enhancing the generalization of medical image segmentation models, especially when annotated data is scarce. The code is available at https://github.com/liamheng/Non-IID_Medical_Image_Segmentation.

Fault diagnosis of rolling bearings is of great significance for post-maintenance in rotating machinery, but it is a challenging work to diagnose faults efficiently with a few samples. Additionally, faults commonly occur with randomness and fuzziness due to the complexity of the external environment and the structure of rolling bearings, hindering effective mining of fault characteristics and eventually restricting accuracy of fault diagnosis. To overcome these problems, stochastic configuration network (SCN) based cloud ensemble learning, called SCN-CEL, is developed in this work. Concretely, a cloud feature extraction method is first developed by using a backward cloud generator of normal cloud model to mine the uncertainty of fault information. Then, a cloud sampling method, which generates enough cloud droplets using bidirectional cloud generator, is proposed to extend the cloud feature samples. Finally, an ensemble model with SCNs is developed to comprehensively characterize the uncertainty of fault information and advance the generalization performance of fault diagnosis machine. Experimental results demonstrate that the proposed method indeed performs favorably for distinguishing fault categories of rolling bearings in the few shot scenarios.

Deep neural networks (DNNs) have been widely applied in medical image classification and achieve remarkable classification performance. These achievements heavily depend on large-scale accurately annotated training data. However, label noise is inevitably introduced in the medical image annotation, as the labeling process heavily relies on the expertise and experience of annotators. Meanwhile, DNNs suffer from overfitting noisy labels, degrading the performance of models. Therefore, in this work, we innovatively devise noise-robust training approach to mitigate the adverse effects of noisy labels in medical image classification. Specifically, we incorporate contrastive learning and intra-group attention mixup strategies into the vanilla supervised learning. The contrastive learning for feature extractor helps to enhance visual representation of DNNs. The intra-group attention mixup module constructs groups and assigns self-attention weights for group-wise samples, and subsequently interpolates massive noisy-suppressed samples through weighted mixup operation. We conduct comparative experiments on both synthetic and real-world noisy medical datasets under various noise levels. Rigorous experiments validate that our noise-robust method with contrastive learning and attention mixup can effectively handle with label noise, and is superior to state-of-the-art methods. An ablation study also shows that both components contribute to boost model performance. The proposed method demonstrates its capability of curb label noise and has certain potential toward real-world clinic applications., Comment: 11pages, 8 figures

This paper explores the task of radiology report generation, which aims at generating free-text descriptions for a set of radiographs. One significant challenge of this task is how to correctly maintain the consistency between the images and the lengthy report. Previous research explored solving this issue through planning-based methods, which generate reports only based on high-level plans. However, these plans usually only contain the major observations from the radiographs (e.g., lung opacity), lacking much necessary information, such as the observation characteristics and preliminary clinical diagnoses. To address this problem, the system should also take the image information into account together with the textual plan and perform stronger reasoning during the generation process. In this paper, we propose an observation-guided radiology report generation framework (ORGAN). It first produces an observation plan and then feeds both the plan and radiographs for report generation, where an observation graph and a tree reasoning mechanism are adopted to precisely enrich the plan information by capturing the multi-formats of each observation. Experimental results demonstrate that our framework outperforms previous state-of-the-art methods regarding text quality and clinical efficacy, Comment: Accepted by ACL 2023

Few-shot named entity recognition (NER) exploits limited annotated instances to identify named mentions. Effectively transferring the internal or external resources thus becomes the key to few-shot NER. While the existing prompt tuning methods have shown remarkable few-shot performances, they still fail to make full use of knowledge. In this work, we investigate the integration of rich knowledge to prompt tuning for stronger few-shot NER. We propose incorporating the deep prompt tuning framework with threefold knowledge (namely TKDP), including the internal 1) context knowledge and the external 2) label knowledge & 3) sememe knowledge. TKDP encodes the three feature sources and incorporates them into the soft prompt embeddings, which are further injected into an existing pre-trained language model to facilitate predictions. On five benchmark datasets, our knowledge-enriched model boosts by at most 11.53% F1 over the raw deep prompt method, and significantly outperforms 8 strong-performing baseline systems in 5-/10-/20-shot settings, showing great potential in few-shot NER. Our TKDP can be broadly adapted to other few-shot tasks without effort., Comment: under review

Robust and accurate segmentation for elongated physiological structures is challenging, especially in the ambiguous region, such as the corneal endothelium microscope image with uneven illumination or the fundus image with disease interference. In this paper, we present a spatial and scale uncertainty-aware network (SSU-Net) that fully uses both spatial and scale uncertainty to highlight ambiguous regions and integrate hierarchical structure contexts. First, we estimate epistemic and aleatoric spatial uncertainty maps using Monte Carlo dropout to approximate Bayesian networks. Based on these spatial uncertainty maps, we propose the gated soft uncertainty-aware (GSUA) module to guide the model to focus on ambiguous regions. Second, we extract the uncertainty under different scales and propose the multi-scale uncertainty-aware (MSUA) fusion module to integrate structure contexts from hierarchical predictions, strengthening the final prediction. Finally, we visualize the uncertainty map of final prediction, providing interpretability for segmentation results. Experiment results show that the SSU-Net performs best on cornea endothelial cell and retinal vessel segmentation tasks. Moreover, compared with counterpart uncertainty-based methods, SSU-Net is more accurate and robust.

Detecting 3D mask attacks to a face recognition system is challenging. Although genuine faces and 3D face masks show significantly different remote photoplethysmography (rPPG) signals, rPPG-based face anti-spoofing methods often suffer from performance degradation due to unstable face alignment in the video sequence and weak rPPG signals. To enhance the rPPG signal in a motion-robust way, a landmark-anchored face stitching method is proposed to align the faces robustly and precisely at the pixel-wise level by using both SIFT keypoints and facial landmarks. To better encode the rPPG signal, a weighted spatial-temporal representation is proposed, which emphasizes the face regions with rich blood vessels. In addition, characteristics of rPPG signals in different color spaces are jointly utilized. To improve the generalization capability, a lightweight EfficientNet with a Gated Recurrent Unit (GRU) is designed to extract both spatial and temporal features from the rPPG spatial-temporal representation for classification. The proposed method is compared with the state-of-the-art methods on five benchmark datasets under both intra-dataset and cross-dataset evaluations. The proposed method shows a significant and consistent improvement in performance over other state-of-the-art rPPG-based methods for face spoofing detection.

Utilizing observations from the ELFIN satellites, we present a statistical study of $\sim$2000 events in 2019-2020 characterizing the occurrence in magnetic local time (MLT) and latitude of $\geq$50 keV electron isotropy boundaries (IBs) at Earth, and the dependence of associated precipitation on geomagnetic activity. The isotropy boundary for an electron of a given energy is the magnetic latitude poleward of which persistent isotropized pitch-angle distributions ($J_{prec}/J_{perp}\sim 1$) are first observed to occur, interpreted as resulting from magnetic field-line curvature scattering (FLCS) in the equatorial magnetosphere. We find that energetic electron IBs can be well-recognized on the nightside from dusk until dawn, under all geomagnetic activity conditions, with a peak occurrence rate of almost 90% near $\sim$22 hours in MLT, remaining above 80% from 21 to 01 MLT. The IBs span a wide range of IGRF magnetic latitudes from $60^\circ$-$74^\circ$, with a maximum occurrence between $66^\circ$-$71^\circ$ (L of 6-8), shifting to lower latitudes and pre-midnight local times with activity. The precipitating energy flux of $\geq$50 keV electrons averaged over the IB-associated latitudes varies over four orders of magnitude, up to $\sim$1 erg/cm$^2$-s, and often includes electron energies exceeding 1 MeV. The local time distribution of IB-associated energies and precipitating fluxes also exhibit peak values near midnight for low activity, shifting toward pre-midnight for elevated activity. The percentage of the total energy deposited over the high-latitude regions ($55^\circ$ to $80^\circ$; or IGRF $L\gtrsim 3$) attributed to IBs is 10-20%, on average, or about 10 MW of total atmospheric power input, but at times can be up to $\sim$100% of the total $\geq$50 keV electron energy deposition over the entire sub-auroral and auroral zone region, exceeding 1 GW in atmospheric power input.

The increasingly pervasive facial recognition (FR) systems raise serious concerns about personal privacy, especially for billions of users who have publicly shared their photos on social media. Several attempts have been made to protect individuals from being identified by unauthorized FR systems utilizing adversarial attacks to generate encrypted face images. However, existing methods suffer from poor visual quality or low attack success rates, which limit their utility. Recently, diffusion models have achieved tremendous success in image generation. In this work, we ask: can diffusion models be used to generate adversarial examples to improve both visual quality and attack performance? We propose DiffProtect, which utilizes a diffusion autoencoder to generate semantically meaningful perturbations on FR systems. Extensive experiments demonstrate that DiffProtect produces more natural-looking encrypted images than state-of-the-art methods while achieving significantly higher attack success rates, e.g., 24.5% and 25.1% absolute improvements on the CelebA-HQ and FFHQ datasets., Comment: Code will be available at https://github.com/joellliu/DiffProtect/

The increasingly pervasive facial recognition (FR) systems raise serious concerns about personal privacy, especially for billions of users who have publicly shared their photos on social media. Several attempts have been made to protect individuals from unauthorized FR systems utilizing adversarial attacks to generate encrypted face images to protect users from being identified by FR systems. However, existing methods suffer from poor visual quality or low attack success rates, which limit their usability in practice. In this paper, we propose Attribute Guided Encryption with Facial Texture Masking (AGE-FTM) that performs a dual manifold adversarial attack on FR systems to achieve both good visual quality and high black box attack success rates. In particular, AGE-FTM utilizes a high fidelity generative adversarial network (GAN) to generate natural on-manifold adversarial samples by modifying facial attributes, and performs the facial texture masking attack to generate imperceptible off-manifold adversarial samples. Extensive experiments on the CelebA-HQ dataset demonstrate that our proposed method produces more natural-looking encrypted images than state-of-the-art methods while achieving competitive attack performance. We further evaluate the effectiveness of AGE-FTM in the real world using a commercial FR API and validate its usefulness in practice through an user study.

Modern autonomous driving systems are typically divided into three main tasks: perception, prediction, and planning. The planning task involves predicting the trajectory of the ego vehicle based on inputs from both internal intention and the external environment, and manipulating the vehicle accordingly. Most existing works evaluate their performance on the nuScenes dataset using the L2 error and collision rate between the predicted trajectories and the ground truth. In this paper, we reevaluate these existing evaluation metrics and explore whether they accurately measure the superiority of different methods. Specifically, we design an MLP-based method that takes raw sensor data (e.g., past trajectory, velocity, etc.) as input and directly outputs the future trajectory of the ego vehicle, without using any perception or prediction information such as camera images or LiDAR. Our simple method achieves similar end-to-end planning performance on the nuScenes dataset with other perception-based methods, reducing the average L2 error by about 20%. Meanwhile, the perception-based methods have an advantage in terms of collision rate. We further conduct in-depth analysis and provide new insights into the factors that are critical for the success of the planning task on nuScenes dataset. Our observation also indicates that we need to rethink the current open-loop evaluation scheme of end-to-end autonomous driving in nuScenes. Codes are available at https://github.com/E2E-AD/AD-MLP., Comment: Technical report. Code is available

Segmentation is vital for ophthalmology image analysis. But its various modal images hinder most of the existing segmentation algorithms applications, as they rely on training based on a large number of labels or hold weak generalization ability. Based on Segment Anything (SAM), we propose a simple but effective learnable prompt layer suitable for multiple target segmentation in ophthalmology multi-modal images, named Learnable Ophthalmology Segment Anything (SAM). The learnable prompt layer learns medical prior knowledge from each transformer layer. During training, we only train the prompt layer and task head based on a one-shot mechanism. We demonstrate the effectiveness of our thought based on four medical segmentation tasks based on nine publicly available datasets. Moreover, we only provide a new improvement thought for applying the existing fundamental CV models in the medical field. Our codes are available at \href{https://github.com/Qsingle/LearnablePromptSAM}{website}.

Deep neural networks (DNNs) have promoted the development of computer aided diagnosis (CAD) systems for fundus diseases, helping ophthalmologists reduce missed diagnosis and misdiagnosis rate. However, the majority of CAD systems are data-driven but lack of medical prior knowledge which can be performance-friendly. In this regard, we innovatively proposed a human-in-the-loop (HITL) CAD system by leveraging ophthalmologists' eye-tracking information, which is more efficient and accurate. Concretely, the HITL CAD system was implemented on the multiple instance learning (MIL), where eye-tracking gaze maps were beneficial to cherry-pick diagnosis-related instances. Furthermore, the dual-cross-attention MIL (DCAMIL) network was utilized to curb the adverse effects of noisy instances. Meanwhile, both sequence augmentation module and domain adversarial module were introduced to enrich and standardize instances in the training bag, respectively, thereby enhancing the robustness of our method. We conduct comparative experiments on our newly constructed datasets (namely, AMD-Gaze and DR-Gaze), respectively for the AMD and early DR detection. Rigorous experiments demonstrate the feasibility of our HITL CAD system and the superiority of the proposed DCAMIL, fully exploring the ophthalmologists' eye-tracking information. These investigations indicate that physicians' gaze maps, as medical prior knowledge, is potential to contribute to the CAD systems of clinical diseases., Comment: 10 pages, 9 figures

Spatial attention mechanism has been widely incorporated into deep neural networks (DNNs), significantly lifting the performance in computer vision tasks via long-range dependency modeling. However, it may perform poorly in medical image analysis. Unfortunately, existing efforts are often unaware that long-range dependency modeling has limitations in highlighting subtle lesion regions. To overcome this limitation, we propose a practical yet lightweight architectural unit, Pyramid Pixel Context Adaption (PPCA) module, which exploits multi-scale pixel context information to recalibrate pixel position in a pixel-independent manner dynamically. PPCA first applies a well-designed cross-channel pyramid pooling to aggregate multi-scale pixel context information, then eliminates the inconsistency among them by the well-designed pixel normalization, and finally estimates per pixel attention weight via a pixel context integration. By embedding PPCA into a DNN with negligible overhead, the PPCANet is developed for medical image classification. In addition, we introduce supervised contrastive learning to enhance feature representation by exploiting the potential of label information via supervised contrastive loss. The extensive experiments on six medical image datasets show that PPCANet outperforms state-of-the-art attention-based networks and recent deep neural networks. We also provide visual analysis and ablation study to explain the behavior of PPCANet in the decision-making process., Comment: 15 pages

The micro-electromechanical-system (MEMS) force and acceleration sensor utilizing the graphene-induced non-radiative transition was investigated. The graphene-induced non-radiative transition is very sensitive to the distance, and the deflection of the graphene ribbon is highly susceptive to applied force or acceleration. Thus, a high-sensitivity MEMS sensor can be achieved with detecting the graphene ribbon's deflection of 1 nm, the force of 0.1 pN, and the acceleration of 0.1 mg. The MEMS sensor, with a size of only tens of microns, can be charged by light irradiation without connecting power sources. In addition, it allows long-distance detection, i.e., wireless transmitter circuit can be omitted. Therefore, it will have significant application prospects in the fields of micro-smart devices, wearable devices, biomedical systems, and so on., Comment: 21 pages, 4 figures

In this work, instead of directly predicting the pixel-level segmentation masks, the problem of referring image segmentation is formulated as sequential polygon generation, and the predicted polygons can be later converted into segmentation masks. This is enabled by a new sequence-to-sequence framework, Polygon Transformer (PolyFormer), which takes a sequence of image patches and text query tokens as input, and outputs a sequence of polygon vertices autoregressively. For more accurate geometric localization, we propose a regression-based decoder, which predicts the precise floating-point coordinates directly, without any coordinate quantization error. In the experiments, PolyFormer outperforms the prior art by a clear margin, e.g., 5.40% and 4.52% absolute improvements on the challenging RefCOCO+ and RefCOCOg datasets. It also shows strong generalization ability when evaluated on the referring video segmentation task without fine-tuning, e.g., achieving competitive 61.5% J&F on the Ref-DAVIS17 dataset., Comment: CVPR 2023. Project Page: https://polyformer.github.io/

Learning fine-grained interplay between vision and language allows to a more accurate understanding for VisionLanguage tasks. However, it remains challenging to extract key image regions according to the texts for semantic alignments. Most existing works are either limited by textagnostic and redundant regions obtained with the frozen detectors, or failing to scale further due to its heavy reliance on scarce grounding (gold) data to pre-train detectors. To solve these problems, we propose Self-Locator Aided Network (SLAN) for cross-modal understanding tasks without any extra gold data. SLAN consists of a region filter and a region adaptor to localize regions of interest conditioned on different texts. By aggregating cross-modal information, the region filter selects key regions and the region adaptor updates their coordinates with text guidance. With detailed region-word alignments, SLAN can be easily generalized to many downstream tasks. It achieves fairly competitive results on five cross-modal understanding tasks (e.g., 85.7% and 69.2% on COCO image-to-text and text-to-image retrieval, surpassing previous SOTA methods). SLAN also demonstrates strong zero-shot and fine-tuned transferability to two localization tasks., Comment: 12 pages

Hard exudates (HE) is the most specific biomarker for retina edema. Precise HE segmentation is vital for disease diagnosis and treatment, but automatic segmentation is challenged by its large variation of characteristics including size, shape and position, which makes it difficult to detect tiny lesions and lesion boundaries. Considering the complementary features between segmentation and super-resolution tasks, this paper proposes a novel hard exudates segmentation method named SS-MAF with an auxiliary super-resolution task, which brings in helpful detailed features for tiny lesion and boundaries detection. Specifically, we propose a fusion module named Multi-scale Attention Fusion (MAF) module for our dual-stream framework to effectively integrate features of the two tasks. MAF first adopts split spatial convolutional (SSC) layer for multi-scale features extraction and then utilize attention mechanism for features fusion of the two tasks. Considering pixel dependency, we introduce region mutual information (RMI) loss to optimize MAF module for tiny lesions and boundary detection. We evaluate our method on two public lesion datasets, IDRiD and E-Ophtha. Our method shows competitive performance with low-resolution inputs, both quantitatively and qualitatively. On E-Ophtha dataset, the method can achieve $\geq3\%$ higher dice and recall compared with the state-of-the-art methods., Comment: Accepted by IEEE BIBM 2022