In this paper we investigate analytic properties of sextet polynomials of hexagonal systems. For the pyrene chains, we show that zeros of the sextet polynomials $P_n(x)$ are real, located in the open interval $(-3-2\sqrt{2},-3+2\sqrt{2})$ and dense in the corresponding closed interval. We also show that coefficients of $P_n(x)$ are symmetric, unimodal, log-concave, and asymptotically normal. For general hexagonal systems, we show that real zeros of all sextet polynomials are dense in the interval $(-\infty,0]$, and conjecture that every sextet polynomial has log-concave coefficients., Comment: 18 pages, 6 figures