1. Relative stereociliary motion in a hair bundle opposes amplification at distortion frequencies
- Author
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Kozlov, Andrei S., Risler, Thomas, Hinterwirth, Armin J., and Hudspeth, A. J.
- Subjects
Quantitative Biology - Subcellular Processes ,Physics - Biological Physics ,Physics - Data Analysis, Statistics and Probability ,Quantitative Biology - Quantitative Methods - Abstract
Direct gating of mechanoelectrical-transduction channels by mechanical force is a basic feature of hair cells that assures fast transduction and underpins the mechanical amplification of acoustic inputs. But the associated nonlinearity - the gating compliance - inevitably distorts signals. Because reducing distortion would make the ear a better detector, we sought mechanisms with that effect. Mimicking in vivo stimulation, we used stiff probes to displace individual hair bundles at physiological amplitudes and measured the coherence and phase of the relative stereociliary motions with a dual-beam differential interferometer. Although stereocilia moved coherently and in phase at the stimulus frequencies, large phase lags at the frequencies of the internally generated distortion products indicated dissipative relative motions. Tip links engaged these relative modes and decreased the coherence in both stimulated and free hair bundles. These results show that a hair bundle breaks into a highly dissipative serial arrangement of stereocilia at distortion frequencies, precluding their amplification., Comment: 33 pages in total, including the main article with one table and three figures, as well as the supplemental information that itself contains two figures
- Published
- 2012
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