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This publication summarizes the activities of the most recent meeting of the nation's most influential drug abuse professionals and measures progress in a variety of areas. Outcomes of symposia, meetings, and presentations are discussed. Symposia include: (1) "Is Dopamine the Answer? Evidence for the Importance of Other Systems in the Reinforcing/Neurochemical Effects of Psychostimulants" (S. Izenwasser and Y. Itzhak); (2) "Substance Abuse, Immunomodulation and Infections"(H. Friedman and T. K. Eisenstein); (3) "hat Are They Thinking? The Mediating Role of Parental Cognitions in the Parenting Processes of Drug-Dependent Mothers and Fathers"(N. E. Suchman and T. J. McMahon); (4) "rug Reward in Humans: What Does Dopamine Do?"(H. deWit); (5) "Medical Consequences of Problems of Drug Dependence" (D. J. Jones and S. Genser); (6) "Understanding the Abuse-Relevant Effects of Drugs: Studies by Young Investigators" (P. W. Czoty and K. M. Wilcox); (8) "Prescription Drug Abuse: What Do We Know?" (S. Schnoll and F. Sapienza); (9) "Cocaine Addiction: To the Amygdala and Beyond" (K. M. Kantak and F. Weiss); (10) "Longitudinal Studies of Pathways to Drug Abuse: Current Status, Emerging Findings, and Implications for Prevention" (J. D. Colliver and M. D. Glantz); (11) "Drugs and Crime" (R. A. Millstein and L. Erinoff); (12) "Violence Exposure and Substance Abuse" (W. Klieweer and D. Svikis); (13) "Neuropeptidergic Responses to Psychostimulant Drugs of Abuse: Strategies for Drug Development" (R. S. Rapaka and G. R. Hanson); (14) "The New Thing: Applying Information Technologies to Drug Abuse Prevention and Treatment" (W. K. Bickel and A. T. McLellan); (15) "French Experience with Buprenorphine" (E. C. Strain and H. W. Clarke); and (16) "Drug Choice: What We Know and What We Need to Know" (S. S. Negus and W. L. Woolverton). (GCP)