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Driving the nuclear fusion reaction p+11B -> 3 alpha + 8.7 MeV in laboratory conditions, by interaction between high-power laser pulses and matter, has become a popular field of research, due to numerous applications that it can potentially allow: an alternative to deuterium-tritium (DT) for fusion energy production, astrophysics studies and alpha-particle generation for medical treatments. A possible scheme for laser-driven p-11B reactions is to direct a beam of laser-accelerated protons onto a boron sample (the so-called 'pitcher-catcher' scheme). This technique was successfully implemented on large, energetic lasers, yielding hundreds of joules per shot at low repetition. We present here a complementary approach, exploiting the high-repetition rate of the VEGA III petawatt laser at CLPU (Spain), aiming at accumulating results from many interactions at much lower energy, for better controlling the parameters and the statistics of the measurements. Despite a moderate energy per pulse, our experiment allowed exploring the laser-driven fusion process with tens (up to hundreds) of laser shots. The experiment provided a clear signature of the produced reactions and of the fusion products, accumulated over many shots, leading to an improved optimization of the diagnostic for these experimental campaigns In this paper we discuss the effectiveness of the laser-driven p-11B fusion in the pitcher-catcher scheme, at high-repetition rate, addressing the challenges of this experimental scheme and highlighting its critical aspects. Our proposed methodologies allow evaluating the performance of this scheme for laser-driven alpha particle production and can be adapted to high-repetition rate laser facilities with higher energy and intensity.

Laser technologies improved after the understanding of the Chirped Pulse Amplification (CPA) which allows energetic laser beams to be compressed to tens of femtosecond (fs) pulse durations and focused to few $\mu$m. Protons of tens of MeV can be accelerated using for instance the Target Normal Sheath Acceleration (TNSA) method and focused on secondary targets. In such conditions, nuclear reactions can occur and radioisotopes relevant for medical purposes be produced. High repetition lasers can be used to produce enough isotopes for medical applications. This route is competitive to conventional methods mostly based on accelerators. In this paper we study the production of $^{67}$Cu, $^{63}$Zn, $^{18}$F and $^{11}$C currently used in positron emission tomography (PET) and other applications. At the same time, we study the reaction $^{10}$B(p,$\alpha$)$^{7}$Be and $^{70}$Zn(p,4n)$^{67}$Ga to put further constraints to the proton distributions at different angles and to the reaction $^{11}$B(p,$\alpha$)$^{8}$Be relevant for energy production. The experiment was performed at the 1 petawatt (PW) laser facility at Vega III located in Salamanca-Spain. Angular distributions of radioisotopes in the forward (with respect to the laser direction) and backward directions were measured using a High Purity Germanium Detector (HPGE). Our results are reasonably reproduced by the numerical estimates following the approach of Kimura et al. (NIMA637(2011)167)

We demonstrate laser-driven Helium ion acceleration with cut-off energies above 25 MeV and peaked ion number above $10^8$ /MeV for 22(2) MeV projectiles from near-critical density gas jet targets. We employed shock gas jet nozzles at the high-repetition-rate (HRR) VEGA-2 laser system with 3 J in pulses of 30 fs focused down to intensities in the range between $9\times10^{19}$ W/cm$^2$ and $1.2\times10^{20}$ W/cm$^2$. We demonstrate acceleration spectra with minor shot-to-shot changes for small variations in the target gas density profile. Difference in gas profiles arise due to nozzles being exposed to a experimental environment, partially ablating and melting., Comment: 22 pages, 28 figures