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9,862 results on '"Goldstein, David"'

3. Investigation of the genetic aetiology of Lewy body diseases with and without dementia

Author

Wu, Lesley Yue, Real, Raquel, Martinez-Carrasco, Alejandro, Chia, Ruth, Lawton, Michael A, Shoai, Maryam, Bresner, Catherine, Blauwendraat, Cornelis, Singleton, Andrew B, Ryten, Mina, Abramzon, Yevgeniya, Ahmed, Sarah, Alba, Camille, Albert, Marilyn S, Bacikova, Dagmar, Barrett, Matthew J, Beach, Thomas G, Bennett, David A, Besser, Lilah M, Bigio, Eileen H, Boeve, Bradley F, Bohannan, Ryan C, Caraway, Chad A, Palma, Jose-Alberto, Dalgard, Clifton L, Dickson, Dennis, Ding, Jinhui, Faber, Kelley, Ferman, Tanis, Ferrucci, Luigi, Flanagan, Margaret E, Foroud, Tatiana M, Ghetti, Bernardino, Gibbs, J Raphael, Goate, Alison, Goldstein, David, Graff-Radford, Neill R, Hu, Heng-Chen, Hupalo, Daniel, Kaiser, Scott M, Kaufmann, Horacio, Kim, Ronald C, Klein, Gregory, Kukull, Walter, Kuzma, Amanda, Leverenz, James, Lopez, Grisel, Mao, Qinwen, Martinez-McGrath, Elisa, Masliah, Eliezer, Monuki, Ed, Newell, Kathy L, Norcliffe-Kaufmann, Lucy, Perkins, Matthew, Pletnikova, Olga, Renton, Alan E, Resnick, Susan M, Ross, Owen A, Sabir, Marya S, Scherzer, Clemens R, Scholz, Sonja W, Serrano, Geidy, Shakkotai, Vikram, Sidransky, Ellen, Tanaka, Toshiko, Tayebi, Nahid, Traynor, Bryan J, Troncoso, Juan C, Viollet, Coralie, Walton, Ronald L, Woltjer, Randy, Wszolek, Zbigniew K, Black, Sandra E, Gan-Or, Ziv, Keith, Julia, Masellis, Mario, Rogaeva, Ekaterina, Aarsland, Dag, Al-Sarraj, Safa, Attems, Johannes, Ferrari, Raffaele, Gentleman, Steve, Hardy, John A, Hodges, Angela K, Love, Seth, McKeith, Ian, Morris, Christopher M, Morris, Huw R, Palmer, Laura, Pickering-Brown, Stuart, Reynolds, Regina H, Thomas, Alan J, Tilley, Bension S, Troakes, Claire, Brett, Francesca, Brice, Alexis, and Duyckaerts, Charles

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Neurodegenerative, Genetics, Prevention, Aging, Lewy Body Dementia, Brain Disorders, Dementia, Alzheimer's Disease Related Dementias (ADRD), Parkinson's Disease, Human Genome, Acquired Cognitive Impairment, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), 2.1 Biological and endogenous factors, Neurological, International Lewy Body Dementia Genomics Consortium, APOE, Lewy body diseases, dementia, genome-wide association studies, Clinical sciences, Biological psychology
Abstract

Up to 80% of Parkinson's disease patients develop dementia, but time to dementia varies widely from motor symptom onset. Dementia with Lewy bodies presents with clinical features similar to Parkinson's disease dementia, but cognitive impairment precedes or coincides with motor onset. It remains controversial whether dementia with Lewy bodies and Parkinson's disease dementia are distinct conditions or represent part of a disease spectrum. The biological mechanisms underlying disease heterogeneity, in particular the development of dementia, remain poorly understood, but will likely be the key to understanding disease pathways and, ultimately, therapy development. Previous genome-wide association studies in Parkinson's disease and dementia with Lewy bodies/Parkinson's disease dementia have identified risk loci differentiating patients from controls. We collated data for 7804 patients of European ancestry from Tracking Parkinson's, The Oxford Discovery Cohort, and Accelerating Medicine Partnership-Parkinson's Disease Initiative. We conducted a discrete phenotype genome-wide association study comparing Lewy body diseases with and without dementia to decode disease heterogeneity by investigating the genetic drivers of dementia in Lewy body diseases. We found that risk allele rs429358 tagging APOEe4 increases the odds of developing dementia, and that rs7668531 near the MMRN1 and SNCA-AS1 genes and an intronic variant rs17442721 tagging LRRK2 G2019S on chromosome 12 are protective against dementia. These results should be validated in autopsy-confirmed cases in future studies.

Published
2024

4. Cover

Author

Goldstein, David B. and Tigner, Amy L.

Published
2016

5. Index

Author

Goldstein, David B. and Tigner, Amy L.

Published
2016

6. Back Cover

Author

Goldstein, David B. and Tigner, Amy L.

Published
2016

13. Notes

Author

Goldstein, David B. and Tigner, Amy L.

Published
2016

25. Clinically defining the opioid-exposed birthing person and infant as a dyad to support bedside care, surveillance, and research.

Author

Jilani, Shahla, Davis, Jonathan, Goldstein, David, Grossman, Matthew, Jansson, Lauren, Jones, Hendrée, and Terplan, Mishka

Subjects
dyad, neonatal abstinence syndrome, opioids, outcomes, withdrawal
Abstract

INTRODUCTION: An increased incidence of maternal opioid use disorder (OUD) and neonatal abstinence syndrome (NAS) has prompted recommendations supporting a dyadic approach to care for birthing persons and their infants. However, there are no consensus guidelines outlining how the dyad is clinically defined. METHODS: To examine how the opioid-exposed birthing person-infant dyad has been defined for purposes of data collection and research, a literature review applying the RAND/UCLA Appropriateness Method was conducted. RESULTS: The search yielded 320 abstracts, with 110 articles identified as having a dyadic focus. While no articles included a specific definition for the dyad, 33 (30%) contained a descriptive reference to the birthing person-infant dyad. Thematic analysis revealed eight recurring elements characteristic of the dyad: (1) engagement, (2) communication, (3) bonding, (4) attachment, (5) mutual responsiveness, (6) reciprocity, (7) synchrony, and (8) attunement. Integrating these elements revealed the interactional relationship between the opioid-exposed birthing person and infant as the foundational principle that defines the dyad. DISCUSSION: This definition shifts the focus of the opioid-exposed dyad from two individual patient populations to an interactional relationship that has broad applicability for clinical use, public health data collection, and research considerations.

Published
2024

30. Cover

Author

Goldstein, David S.

Published
2006

32. Preface

Author

Goldstein, David S.

Published
2006

35. 6 Distress

Author

Goldstein, David S.

Published
2006

41. References

Author

Goldstein, David S.

Published
2006

44. Glossary

Author

Goldstein, David S.

Published
2006

45. Index

Author

Goldstein, David S.

Published
2006

46. Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study

Author

Thakral, Abhinav, Lee, John JW., Hou, Tianzhichao, Hueniken, Katrina, Dudding, Tom, Gormley, Mark, Virani, Shama, Olshan, Andrew, Diergaarde, Brenda, Ness, Andrew R., Waterboer, Tim, Smith-Byrne, Karl, Brennan, Paul, Hayes, D. Neil, Sanderson, Eleanor, Brown, M. Catherine, Huang, Sophie, Bratman, Scott V., Spreafico, Anna, De Almeida, John, Davies, Joel C., Bierut, Laura, Macfarlane, Gary J., Lagiou, Pagona, Lagiou, Areti, Polesel, Jerry, Agudo, Antonio, Alemany, Laia, Ahrens, Wolfgang, Healy, Claire M., Conway, David I., Nygard, Mari, Canova, Cristina, Holcatova, Ivana, Richiardi, Lorenzo, Znaor, Ariana, Goldstein, David P., Hung, Rayjean J., Xu, Wei, Liu, Geoffrey, and Espin-Garcia, Osvaldo

Published
2024
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48. Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome

Author

Walitt, Brian, Singh, Komudi, LaMunion, Samuel R., Hallett, Mark, Jacobson, Steve, Chen, Kong, Enose-Akahata, Yoshimi, Apps, Richard, Barb, Jennifer J., Bedard, Patrick, Brychta, Robert J., Buckley, Ashura Williams, Burbelo, Peter D., Calco, Brice, Cathay, Brianna, Chen, Li, Chigurupati, Snigdha, Chen, Jinguo, Cheung, Foo, Chin, Lisa M. K., Coleman, Benjamin W., Courville, Amber B., Deming, Madeleine S., Drinkard, Bart, Feng, Li Rebekah, Ferrucci, Luigi, Gabel, Scott A., Gavin, Angelique, Goldstein, David S., Hassanzadeh, Shahin, Horan, Sean C., Horovitz, Silvina G., Johnson, Kory R., Govan, Anita Jones, Knutson, Kristine M., Kreskow, Joy D., Levin, Mark, Lyons, Jonathan J., Madian, Nicholas, Malik, Nasir, Mammen, Andrew L., McCulloch, John A., McGurrin, Patrick M., Milner, Joshua D., Moaddel, Ruin, Mueller, Geoffrey A., Mukherjee, Amrita, Muñoz-Braceras, Sandra, Norato, Gina, Pak, Katherine, Pinal-Fernandez, Iago, Popa, Traian, Reoma, Lauren B., Sack, Michael N., Safavi, Farinaz, Saligan, Leorey N., Sellers, Brian A., Sinclair, Stephen, Smith, Bryan, Snow, Joseph, Solin, Stacey, Stussman, Barbara J., Trinchieri, Giorgio, Turner, Sara A., Vetter, C. Stephenie, Vial, Felipe, Vizioli, Carlotta, Williams, Ashley, Yang, Shanna B., and Nath, Avindra

Published
2024
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49. Multimodal detection of molecular residual disease in high-risk locally advanced squamous cell carcinoma of the head and neck

Author

Sanz-Garcia, Enrique, Zou, Jinfeng, Avery, Lisa, Spreafico, Anna, Waldron, John, Goldstein, David, Hansen, Aaron, Cho, B. C. John, de Almeida, John, Hope, Andrew, Hosni, Ali, Hahn, Ezra, Perez-Ordonez, Bayardo, Zhao, Zhen, Smith, Christopher, Zheng, Yangqiao, Singaravelan, Nitthusha, Bratman, Scott V., and Siu, Lillian L.

Published
2024
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