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1,903 results on '"Chong, W."'

3. Telehealth

Author

Lee, Alan Chong W., primary, Lawson, Daryl, additional, Randall, Ken, additional, Russell, Trevor, additional, and Wolf, Steven L., additional

Published
2024
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4. When East Meets West: Considerations in Physical Therapist Care for the Asian American Population

Author

Cauilan-Aguila, Maria 'Consie', Jain, Tarang Kumar, Lee, Alan Chong W., and Peralta, Shirlie Mae

Subjects
Therapeutics, Physiological -- Complications and side effects -- Demographic aspects, Physical therapy -- Complications and side effects -- Demographic aspects, Asians -- Health aspects -- Physiological aspects, Evidence-based medicine -- Evaluation
Abstract

Keywords: Asian American, The label of model minority for the Asian American population first entered the American landscape through a 1966 U.S. News & World Report article. (1) It portrayed these individuals as [...]

Published
2024
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8. Whole genome sequencing data of multiple individuals of Pakistani descent

Author

Khan, Shahid Y, Ali, Muhammad, Lee, Mei-Chong W, Ma, Zhiwei, Biswas, Pooja, Khan, Asma A, Naeem, Muhammad Asif, Riazuddin, Saima, Riazuddin, Sheikh, Ayyagari, Radha, Hejtmancik, J Fielding, and Riazuddin, S Amer

Subjects
Human Genome, Genetics, Genome, Human, Humans, Pakistan, Polymorphism, Single Nucleotide, Whole Genome Sequencing
Abstract

Here we report whole genome sequencing of four individuals (H3, H4, H5, and H6) from a family of Pakistani descent. Whole genome sequencing yielded 1084.92, 894.73, 1068.62, and 1005.77 million mapped reads corresponding to 162.73, 134.21, 160.29, and 150.86 Gb sequence data and 52.49x, 43.29x, 51.70x, and 48.66x average coverage for H3, H4, H5, and H6, respectively. We identified 3,529,659, 3,478,495, 3,407,895, and 3,426,862 variants in the genomes of H3, H4, H5, and H6, respectively, including 1,668,024 variants common in the four genomes. Further, we identified 42,422, 39,824, 28,599, and 35,206 novel variants in the genomes of H3, H4, H5, and H6, respectively. A major fraction of the variants identified in the four genomes reside within the intergenic regions of the genome. Single nucleotide polymorphism (SNP) genotype based comparative analysis with ethnic populations of 1000 Genomes database linked the ancestry of all four genomes with the South Asian populations, which was further supported by mitochondria based haplogroup analysis. In conclusion, we report whole genome sequencing of four individuals of Pakistani descent.

Published
2020

9. Prioritising Product Features to Refine New Product Development Process: A Case Study of Smart Glass

Author

Tsang, Y. P., Lee, C. K. M., Chong, W. W., Au, Y. S., Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Wang, Taosheng, editor, Patnaik, Srikanta, editor, Ip, Andrew W.H., editor, and Tavana, Madjid, editor

Published
2022
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11. Anatomo‐functional changes in neural substrates of cognitive memory in developmental amnesia: Insights from automated and manual Magnetic Resonance Imaging examinations.

Author

Chareyron, Loïc J., Chong, W. K. Kling, Banks, Tina, Burgess, Neil, Saunders, Richard C., and Vargha‐Khadem, Faraneh

Subjects
*RECOLLECTION (Psychology), *BRAIN damage, *MAGNETIC resonance imaging, *EPISODIC memory, *SHORT-term memory
Abstract

Despite bilateral hippocampal damage dating to the perinatal or early childhood period and severely impaired episodic memory, patients with developmental amnesia continue to exhibit well‐developed semantic memory across the developmental trajectory. Detailed information on the extent and focality of brain damage in these patients is needed to hypothesize about the neural substrate that supports their remarkable capacity for encoding and retrieval of semantic memory. In particular, we need to assess whether the residual hippocampal tissue is involved in this preservation, or whether the surrounding cortical areas reorganize to rescue aspects of these critical cognitive memory processes after early injury. We used voxel‐based morphometry (VBM) analysis, automatic (FreeSurfer) and manual segmentation to characterize structural changes in the brain of an exceptionally large cohort of 23 patients with developmental amnesia in comparison with 32 control subjects. Both the VBM and the FreeSurfer analyses revealed severe structural alterations in the hippocampus and thalamus of patients with developmental amnesia. Milder damage was found in the amygdala, caudate, and parahippocampal gyrus. Manual segmentation demonstrated differences in the degree of atrophy of the hippocampal subregions in patients. The level of atrophy in CA‐DG subregions and subicular complex was more than 40%, while the atrophy of the uncus was moderate (−24%). Anatomo‐functional correlations were observed between the volumes of residual hippocampal subregions in patients and selective aspects of their cognitive performance, viz, intelligence, working memory, and verbal and visuospatial recall. Our findings suggest that in patients with developmental amnesia, cognitive processing is compromised as a function of the extent of atrophy in hippocampal subregions. More severe hippocampal damage may be more likely to promote structural and/or functional reorganization in areas connected to the hippocampus. In this hypothesis, different levels of hippocampal function may be rescued following this variable reorganization. Our findings document not only the extent, but also the limits of circuit reorganization occurring in the young brain after early bilateral hippocampal damage. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Identification of novel transcripts and peptides in developing murine lens.

Author

Khan, Shahid Y, Ali, Muhammad, Kabir, Firoz, Chen, Ruiqiang, Na, Chan Hyun, Lee, Mei-Chong W, Pourmand, Nader, Hackett, Sean F, and Riazuddin, S Amer

Subjects
Lens, Crystalline, Animals, Mice, Peptides, Proteome, RNA Splice Sites, Chromatography, Liquid, Sequence Analysis, RNA, Alternative Splicing, Organogenesis, Pregnancy, Introns, Exons, Algorithms, Databases, Genetic, Female, Tandem Mass Spectrometry, High-Throughput Nucleotide Sequencing, Transcriptome, Chromatography, Liquid, Databases, Genetic, Lens, Crystalline, Sequence Analysis, RNA
Abstract

We previously investigated the transcriptome and proteome profiles of the murine ocular lens at six developmental time points including two embryonic (E15 and E18) and four postnatal time points (P0, P3, P6, and P9). Here, we extend our analyses to identify novel transcripts and peptides in developing  mouse lens. We identified a total of 9,707 novel transcripts and 325 novel fusion genes in developing mouse lens. Additionally, we identified 13,281 novel alternative splicing (AS) events in mouse lens including 6,990 exon skipping (ES), 2,447 alternative 3' splice site (A3SS), 1,900 alternative 5' splice site (A5SS), 1,771 mutually exclusive exons (MXE), and 173 intron retention (IR). Finally, we integrated our OMIC (Transcriptome and Proteome) datasets identifying 20 novel peptides in mouse lens. All 20 peptides were validated through matching MS/MS spectra of synthetic peptides. To the best of our knowledge, this is the first report integrating OMIC datasets to identify novel peptides in developing murine lens.

Published
2018

14. Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh

Author

Thayyil, Sudhin, Pant, Stuti, Montaldo, Paolo, Shukla, Deepika, Oliveira, Vania, Ivain, Phoebe, Bassett, Paul, Swamy, Ravi, Mendoza, Josephine, Moreno-Morales, Maria, Lally, Peter J., Benakappa, Naveen, Bandiya, Prathik, Shivarudhrappa, Indramma, Somanna, Jagadish, Kantharajanna, Usha B., Rajvanshi, Ankur, Krishnappa, Sowmya, Joby, Poovathumkal K., Jayaraman, Kumutha, Chandramohan, Rema, Kamalarathnam, Chinnathambi N., Sebastian, Monica, Tamilselvam, Indumathi, Rajendran, Ushadevi, Soundrarajan, Radhakrishnan, Kumar, Vignesh, Sudarsanan, Harish, Vadakepat, Padmesh, Gopalan, Kavitha, Sundaram, Mangalabharathi, Seeralar, Arasar, Vinayagam, Prakash, Sajjid, Mohamed, Baburaj, Mythili, Murugan, Kanchana D., Sathyanathan, Babu P., Kumaran, Elumalai S., Mondkar, Jayashree, Manerkar, Swati, Joshi, Anagha R., Dewang, Kapil, Bhisikar, Swapnil M., Kalamdani, Pavan, Bichkar, Vrushali, Patra, Saikat, Jiwnani, Kapil, Shahidullah, Mohammod, Moni, Sadeka C., Jahan, Ismat, Mannan, Mohammad A., Dey, Sanjoy K., Nahar, Mst. N., Islam, Mohammad N, Shabuj, Kamrul H, Rodrigo, Ranmali, Sumanasena, Samanmali, Abayabandara-Herath, Thilini, Chathurangika, Gayani K, Wanigasinghe, Jithangi, Sujatha, Radhika, Saraswathy, Sobhakumar, Rahul, Aswathy, Radha, Saritha J, Sarojam, Manoj K., Krishnan, Vaisakh, Nair, Mohandas K., Devadas, Sahana, Chandriah, Savitha, Venkateswaran, Harini, Burgod, Constance, Chandrasekaran, Manigandan, Atreja, Gaurav, Muraleedharan, Pallavi, Herberg, Jethro A., Chong, WK 'Kling', Sebire, Neil J., Pressler, Ronit, Ramji, Siddarth, Shankaran, Seetha, Lally, Peter J, Kantharajanna, Usha B, Joby, Poovathumkal K, Kamalarathnam, Chinnathambi N, Tamilselvam, Indumathi A, Rajendran, Usha D, Murugan, Kanchana D, Sathyanathan, Babu P, Kumaran, Elumalai S, Joshi, Anagha R, Bhisikar, Swapnil M, Moni, Sadeka C, Mannan, Mohammad A, Dey, Sanjoy K, Nahar, Mst N, Sarojam, Manoj K, Nair, Mohandas K, Herberg, Jethro A, Kling Chong, W K, and Sebire, Neil J

Published
2021
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20. FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1.

Author

Khan, Shahid Y, Vasanth, Shivakumar, Kabir, Firoz, Gottsch, John D, Khan, Arif O, Chaerkady, Raghothama, Lee, Mei-Chong W, Leitch, Carmen C, Ma, Zhiwei, Laux, Julie, Villasmil, Rafael, Khan, Shaheen N, Riazuddin, Sheikh, Akram, Javed, Cole, Robert N, Talbot, C Conover, Pourmand, Nader, Zaghloul, Norann A, Hejtmancik, J Fielding, and Riazuddin, S Amer

Subjects
Lens, Crystalline, Epithelial Cells, Animals, Zebrafish, Humans, Corneal Opacity, Eye Abnormalities, Gene Expression Profiling, Pedigree, Gene Expression Regulation, Family Health, Autophagy, Female, Male, HSP40 Heat-Shock Proteins, Forkhead Transcription Factors, Gene Knockdown Techniques, HEK293 Cells, Whole Exome Sequencing, Eye Disease and Disorders of Vision, Genetics, 2.1 Biological and endogenous factors, Lens, Crystalline, MD Multidisciplinary
Abstract

FOXE3 is a lens-specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncated FOXE3 responsible for Peters anomaly identified through linkage-coupled next-generation whole-exome sequencing. We found that DNAJB1, an autophagy-associated protein, was the only candidate exhibiting differential expression in both screens. We confirmed the candidacy of DNAJB1 through chromatin immunoprecipitation and luciferase assays while knockdown of DNAJB1 in human lens epithelial cells resulted in a mitotic arrest. Subsequently, we targeted dnajb1a in zebrafish through injection of a splice-blocking morpholino. The dnajb1a morphants exhibited underdeveloped cataractous lenses with persistent apoptotic nuclei. In conclusion, here we report DNAJB1 is a transcriptional target of FOXE3 in a novel pathway that is crucial for the development of the anterior segment of the eye.

Published
2016

23. Transcriptome Profiling of Developing Murine Lens Through RNA SequencingDeveloping Mouse Lens Transcriptome

Author

Khan, Shahid Y, Hackett, Sean F, Lee, Mei-Chong W, Pourmand, Nader, Talbot, C Conover, and Riazuddin, S Amer

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Eye Disease and Disorders of Vision, Genetics, Pediatric, Human Genome, Biotechnology, Underpinning research, 1.1 Normal biological development and functioning, Animals, Animals, Newborn, Cataract, Computational Biology, Disease Models, Animal, Female, Gene Expression Profiling, Gene Library, High-Throughput Nucleotide Sequencing, Lens, Crystalline, Mice, Organogenesis, Pregnancy, Pregnancy, Animal, RNA, Messenger, next-generation sequencing, transcriptome, lens development, mRNA, miRNA, Biological Sciences, Medical and Health Sciences, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PurposeTranscriptome is the entire repertoire of transcripts present in a cell at any particular time. We undertook a next-generation whole transcriptome sequencing approach to gain insight into the transcriptional landscape of the developing mouse lens.MethodsWe ascertained mouse lenses at six developmental time points including two embryonic (E15 and E18) and four postnatal stages (P0, P3, P6, and P9). The ocular tissue at each time point was maintained as two distinct pools serving as biological replicates for each developmental stage. The mRNA and small RNA libraries were paired-end sequenced on Illumina HiSeq 2000 and subsequently analyzed using bioinformatics tools.ResultsMapping of mRNA and small RNA libraries generated 187.56 and 154.22 million paired-end reads, respectively. We detected a total of 14,465 genes in the mouse ocular lens at the above-mentioned six developmental stages. Of these, 46 genes exhibited a 40-fold differential (higher or lower) expression at one the five developmental stages (E18, P0, P3, P6, and P9) compared with their expression level at E15. Likewise, small RNA profiling identified 379 microRNAs (miRNAs) expressed in mouse lens at six developmental time points. Of these, 49 miRNAs manifested an 8-fold differential (higher or lower) expression at one the five developmental stages, as mentioned above compared with their expression level at E15.ConclusionsWe report a comprehensive profile of developing murine lens transcriptome including both mRNA and miRNA through next-generation RNA sequencing. A complete repository of the lens transcriptome of six developmental time points will be monumental in elucidating processes essential for the development of the ocular lens and maintenance of its transparency.

Published
2015

26. Contributors

Author

Alghwiri, Alia A., primary, Anderson, Brady, additional, Avers, Dale, additional, Beissner, Katherine, additional, Bergman, Elizabeth J., additional, Bland, Marghuretta D., additional, Briggs, Richard, additional, Cahalin, Lawrence P., additional, Chen, Tzurei, additional, Christiansen, Cory, additional, Chui, Kevin K., additional, Ciccone, Charles D., additional, Ciolek, Cathy Haines, additional, Denson, Moira Gannon, additional, Elrod, Cathy S., additional, Fordyce, Christine E., additional, Forrester, Jenny, additional, Garcia, Christian, additional, Gelaz, Rosanna, additional, Gollie, Jared M., additional, Hartley, Greg W., additional, Lang, Catherine E., additional, LaStayo, Paul, additional, Lee, Alan Chong W., additional, Lee, Sin Yi, additional, Liebzeit, Daniel, additional, Marcus, Robin L., additional, Miller, Caitlin, additional, Morris, David M., additional, Mueller, Karen, additional, Neville, Cynthia E., additional, Pulling, Brian W., additional, Reidy, Paul, additional, Ries, Julie D., additional, Ruckert, Elizabeth, additional, Sames, Carol, additional, Strunk, Ellen, additional, Thackeray, Anne, additional, Townsend, Martha, additional, Wells, Chris L., additional, Wenker, Susan L., additional, Whitney, Susan L., additional, Wilson, Christopher, additional, Wong, Rita A., additional, and Yen, Sheng-Che, additional

Published
2020
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27. A Multi-Level Dynamic Instructional Planner for an Intelligent Physiology Tutoring System.

Author

Illinois Inst. of Tech., Chicago. and Woo, Chong W.

Abstract

This paper describes the design and development of an instructional planner for an intelligent tutoring system for cardiovascular physiology that assists medical students to learn the causal relationships between the parameters of the circulatory system, to understand how a negative feedback system works, and to solve problems involving disturbances to the system. The instructional planner is responsible for deciding what to do at each point during a tutoring session. It integrates opportunistic control with sophisticated instructional planning, combining lesson planning with discourse planning. The lesson planning is organized in three levels: goal generation, determination of planning strategies, and choice of tactics to refine the goal into subgoals. The mixed-initiative discourse planning is implemented using a two-level approach: pedagogical decision making at the upper level and tactical discourse state-based planning at the lower level in its discourse management network. It generates plans dynamically based on the student model, monitors their execution, repairs plans when necessary, and replans when the student asks a question or makes a comment. (Contains 49 references.) (Author)

Published
1992

28. American Telemedicine Association’s Principles for Delivering Telerehabilitation Services

Author

Tammy Richmond, Christopher Peterson, Jana Cason, Mike Billings, Evelyn Abrahante Terrell, Alan Chong W. Lee, Michael Towey, Bambang Parmanto, Andi Saptano, Ellen R. Cohn, and David Brennan

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Telehealth is a broad term used to describe the use of electronic or digital information and communications technologies to support clinical healthcare, patient and professional health related education, and public health and health administration. Telerehabilitation refers to the delivery of rehabilitation and habilitation services via information and communication technologies (ICT), also commonly referred to as” telehealth” technologies. Telerehabilitation services can include evaluation, assessment, monitoring, prevention, intervention, supervision, education, consultation, and coaching. Telerehabilitation services can be deployed across all patient populations and multiple healthcare settings including clinics, homes, schools, or community-based worksites. This document was adapted from the American Telemedicine Association’s (ATA) “A Blueprint for Telerehabilitation Guidelines” (2010) and reflects the current utilization of telerehabilitation services. It was developed collaboratively by members of the ATA Telerehabilitation Special Interest Group, with input and guidance from other practitioners in the field, strategic stakeholders, and ATA staff. Its purpose is to inform and assist practitioners in providing effective and secure services that are based on client needs, current empirical evidence, and available technologies. Rehabilitation professionals, in conjunction with professional associations and other organizations are encouraged to use this document as a resource for developing discipline-specific standards, guidelines, and practice requirements. Keywords: American Telemedicine Association, Habilitation, Rehabilitation, Telehealth, Telepractice

Published
2017
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34. An investigation of the PM2.5 concentrations and cumulative inhaled dose during subway commutes in Changchun, China.

Author

Chang, L., Chong, W. T., Yau, Y. H., Cui, T., Wang, X. R., Pei, F., Liu, Y. Q., and Pan, S.

Subjects
SUBWAYS, SUBWAY stations, AIR purification, PUBLIC spaces, AIR quality, AIR filters, PARTICULATE matter
Abstract

Air quality in subway systems is crucial as it affects the health of passengers and staff. Although most tests of PM2.5 concentrations in subway stations have taken place in public areas, PM2.5 is less understood in workplaces. Few studies have estimated the cumulative inhaled dose of passengers based on real-time changes in PM2.5 concentrations as they commute. To clarify the above issues, this study first measured PM2.5 concentrations in four subway stations in Changchun, China, where measuring points included five workrooms. Then, passengers' exposure to PM2.5 during the whole subway commute (20–30 min) was measured and segmented inhalation was calculated. The results showed that PM2.5 concentration in public places ranged from 50 to 180 μg/m3, and was strongly correlated with outdoors. While the PM2.5 average concentration in workplaces was 60 µg/m3, and it was less affected by outdoor PM2.5 concentration. Passenger's cumulative inhalations in single commuting were about 42 μg and 100 μg when the outdoor PM2.5 concentrations were 20–30 μg/m3 and 120–180 μg/m3, respectively. The PM2.5 inhalation in carriages accounted for the largest proportion of the entire commuting, about 25–40%, because of the longer exposure time and higher PM2.5 concentrations. It is recommended to improve the tightness of the carriage and filter the fresh air to improve the air quality inside. The average daily PM2.5 inhaled by staff was 513.53 μg, which was 5–12 times higher than that of passengers. Installing air purification devices in workplaces and reminding staff to take personal protection can positively protect their health. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Spatial distribution of ammonia oxidizers in marine sediments of the Bohai, Yellow and East China Seas

Author

Liu, S, Cheng, J, You, H, Chong, W, Zheng, M, Wei, Q, Liu, W, Chen, H, Li, X, Liu, H, Liu, S, Cheng, J, You, H, Chong, W, Zheng, M, Wei, Q, Liu, W, Chen, H, Li, X, and Liu, H

Abstract

Ammonia oxidation, an essential process within the global nitrogen cycle, is mainly performed by ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB). To date, the current knowledge on the biogeography of AOA and AOB in the ocean across a large geographic distance remains poorly known. In this study, the abundance, microbial composition, and diversity of AOA and AOB in marine sediments collected from the Bohai Sea, Yellow Sea, and East China Sea were characterized by employing quantitative PCR and Illumina Miseq sequencing of both archaeal and bacterial amoA genes. qPCR analysis demonstrated significantly higher abundances of archaeal amoA genes than those of bacterial amoA genes with AOA/AOB ratios varying from 1.59 to 292.88, suggesting a greater contribution of AOA to nitrification in the seas. Nitrosopumilus and Nitrosospira were the predominant clusters of AOA and AOB respectively in all sediment samples. The distribution pattern of both AOA and AOB communities revealed by PCoA (principal coordinate analysis) showed distinct geographic separation of sediment samples from the three seas. Correlation analysis indicated that ammonia (NH4+-N) and nitrate (NO3−-N) content were the main selective forces leading to the distinct biogeography of the two ammonia oxidizers in the ocean. The results are of great significance in improving our understanding of the contribution of AOA and AOB in the nitrogen transformation in the marine ecosystem and providing insights into the environmental factors that shape the assembly of aerobic ammonium oxidizers.

Published
2023

41. FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1

Author

Shahid Y. Khan, Shivakumar Vasanth, Firoz Kabir, John D. Gottsch, Arif O. Khan, Raghothama Chaerkady, Mei-Chong W. Lee, Carmen C. Leitch, Zhiwei Ma, Julie Laux, Rafael Villasmil, Shaheen N. Khan, Sheikh Riazuddin, Javed Akram, Robert N. Cole, C. Conover Talbot, Nader Pourmand, Norann A. Zaghloul, J. Fielding Hejtmancik, and S. Amer Riazuddin

Subjects
Science
Abstract

Peter's Anomaly is a developmental disorder of the eye and has been linked to mutations in a range of genes, including the transcription factor FOXE3. Here the authors use next-generation RNA sequencing and mass spectrometry to identify an autophagy-associated protein, DNAJB1 as the transcriptional target of FOXE3.

Published
2016
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42. Expanding the phenotype in argininosuccinic aciduria: need for new therapies

Author

Baruteau, Julien, Jameson, Elisabeth, Morris, Andrew A., Chakrapani, Anupam, Santra, Saikat, Vijay, Suresh, Kocadag, Huriye, Beesley, Clare E., Grunewald, Stephanie, Murphy, Elaine, Cleary, Maureen, Mundy, Helen, Abulhoul, Lara, Broomfield, Alexander, Lachmann, Robin, Rahman, Yusof, Robinson, Peter H., MacPherson, Lesley, Foster, Katharine, Chong, W. Kling, Ridout, Deborah A., Bounford, Kirsten McKay, Waddington, Simon N., Mills, Philippa B., Gissen, Paul, and Davison, James E.

Published
2017
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47. Impact of COVID-19 on the imaging diagnosis of cardiac disease in Europe

Author

Williams, M, Shaw, L, Hirschfeld, C, Maurovich-Horvat, P, Norgaard, B, Pontone, G, Jimenez-Heffernan, A, Sinitsyn, V, Sergienko, V, Ansheles, A, Bax, J, Buechel, R, Milan, E, Slart, R, Nicol, E, Bucciarelli-Ducci, C, Pynda, Y, Better, N, Cerci, R, Dorbala, S, Raggi, P, Villines, T, Vitola, J, Malkovskiy, E, Goebel, B, Cohen, Y, Randazzo, M, Pascual, T, Dondi, M, Paez, D, Einstein, A, Nasery, M, Goda, A, Shirka, E, Benlabgaa, R, Bouyoucef, S, Medjahedi, A, Nailli, Q, Agolti, M, Aguero, R, Del Carmen Alak, M, Alberguina, L, Arronada, G, Astesiano, A, Norton, C, Benteo, P, Blanco, J, Bonelli, J, Bustos, J, Cabrejas, R, Cachero, J, Campisi, R, Canderoli, A, Carames, S, Carrascosa, P, Castro, R, Cendoya, O, Cognigni, L, Collaud, C, Cortes, C, Courtis, J, Cragnolino, D, Daicz, M, De La Vega, A, De Maria, S, Del Riego, H, Dettori, F, Deviggiano, A, Dragonetti, L, Embon, M, Enriquez, R, Ensinas, J, Faccio, F, Facello, A, Garofalo, D, Geronazzo, R, Gonza, N, Gutierrez, L, Guzzo, M, Hasbani, V, Huerin, M, Jager, V, Lewkowicz, J, De Munain, M, Lotti, J, Marquez, A, Masoli, O, Mastrovito, E, Mayoraz, M, Melado, G, Mele, A, Merani, M, Meretta, A, Molteni, S, Montecinos, M, Noguera, E, Novoa, C, Sueldo, C, Ascani, S, Pollono, P, Pujol, M, Radzinschi, A, Raimondi, G, Redruello, M, Rodriguez, M, Romero, R, Acuna, A, Rovaletti, F, Miguel, L, Solari, L, Strada, B, Traverso, S, Traverzo, S, Del Huerto Velazquez Espeche, M, Weihmuller, J, Wolcan, J, Zeffiro, S, Sakanyan, M, Beuzeville, S, Boktor, R, Butler, P, Calcott, J, Carr, L, Chan, V, Chao, C, Chong, W, Dobson, M, Downie, D, Dwivedi, G, Elison, B, Engela, J, Francis, R, Gaikwad, A, Basavaraj, A, Goodwin, B, Greenough, R, Hamilton-Craig, C, Hsieh, V, Joshi, S, Lederer, K, Lee, K, Lee, J, Magnussen, J, Mai, N, Mander, G, Murton, F, Nandurkar, D, Neill, J, O'Rourke, E, O'Sullivan, P, Pandos, G, Pathmaraj, K, Pitman, A, Poulter, R, Premaratne, M, Prior, D, Ridley, L, Rutherford, N, Salehi, H, Saunders, C, Scarlett, L, Seneviratne, S, Shetty, D, Shrestha, G, Shulman, J, Solanki, V, Stanton, T, Stuart, M, Stubbs, M, Swainson, I, Taubman, K, Taylor, A, Thomas, P, Unger, S, Upton, A, Vamadevan, S, Van Gaal, W, Verjans, J, Voutnis, D, Wayne, V, Wilson, P, Wong, D, Wong, K, Younger, J, Feuchtner, G, Mirzaei, S, Weiss, K, Maroz-Vadalazhskaya, N, Gheysens, O, Homans, F, Moreno-Reyes, R, Pasquet, A, Roelants, V, Van De Heyning, C, Rios, R, Soldat-Stankovic, V, Stankovic, S, Siqueira, M, Almeida, A, Togni, P, Andrade, J, Andrade, L, Anselmi, C, Araujo, R, Azevedo, G, Bezerra, S, Biancardi, R, Grossman, G, Brandao, S, Pianta, D, Carreira, L, Castro, B, Chang, T, Cunali, F, Cury, R, Dantas, R, De Amorim Fernandes, F, De Lorenzo, A, De MacEdo Filho, R, Erthal, F, Fernandes, F, Fernandes, J, De Souza, T, Alves, W, Ghini, B, Goncalves, L, Gottlieb, I, Hadlich, M, Kameoka, V, Lima, R, Lima, A, Lopes, R, E Silva, R, Magalhaes, T, Silva, F, Mastrocola, L, Medeiros, F, Meneghetti, J, Naue, V, Naves, D, Nolasco, R, Nomura, C, 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Abstract

Objectives We aimed to explore the impact of the COVID-19 pandemic on cardiac diagnostic testing and practice and to assess its impact in different regions in Europe. Methods The online survey organised by the International Atomic Energy Agency Division of Human Health collected information on changes in cardiac imaging procedural volumes between March 2019 and March/April 2020. Data were collected from 909 centres in 108 countries. Results Centres in Northern and Southern Europe were more likely to cancel all outpatient activities compared with Western and Eastern Europe. There was a greater reduction in total procedure volumes in Europe compared with the rest of the world in March 2020 (45% vs 41%, p=0.003), with a more marked reduction in Southern Europe (58%), but by April 2020 this was similar in Europe and the rest of the world (69% vs 63%, p=0.261). Regional variations were apparent between imaging modalities, but the largest reductions were in Southern Europe for nearly all modalities. In March 2020, location in Southern Europe was the only independent predictor of the reduction in procedure volume. However, in April 2020, lower gross domestic product and higher COVID-19 deaths were the only independent predictors. Conclusion The first wave of the COVID-19 pandemic had a significant impact on care of patients with cardiac disease, with substantial regional variations in Europe. This has potential long-term implications for patients and plans are required to enable the diagnosis of non-COVID- 19 conditions during the ongoing pandemic.

Published
2021

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