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Purpose: The purpose of the article is to understand how the literature has been addressing the United Nations' Sixth Sustainable Development Goal (SDG) to obtain an overview of the current scenario and future perspectives. Design/methodology/approach: For that, a bibliometric analysis will be conducted with documents published between 2015 and 2021 and present in the Web of Science database. Initially, 328 documents were identified, and after careful reading of titles and abstracts, 239 documents were analysed. The documents were analysed using tools available on the Web of Science database and the software Bibliometrix. Findings: Amongst the results generated, it should be highlighted the identification of the motor themes "sustainable development" + "developing countries" and "water security", presenting a significant relevance to the field and a high development level. In addition, "human rights" was verified as an emerging theme in the context of SDG 6 debates. Originality/value: The information provided here offers good documentation of the extent to which SDG 6 is documented in the literature and can be helpful for researchers interested in the topic. [ABSTRACT FROM AUTHOR]

Epilepsy, a chronic disease of the central nervous system, is highly prevalent in malaria-endemic regions. Therefore, several studies have evaluated the associations between malaria infection and epilepsy development. A meta-analysis of observational studies published from inception to 10 May 2022 has been conducted to synthesize and pool the existing data on this topic. The relevant publications were systematically searched in PubMed/Medline, Scopus, Embase and Web of Science database collections. A random-effects meta-analysis model (REM) was utilized to generate the pooled odds ratio (OR) at 95% confidence intervals (CIs). The between-studies heterogeneity was assessed with I 2, as well as several subgroups, meta-regression and sensitivity analysis were performed to identify the source of heterogeneity. Overall, 17 eligible studies containing 6285 cases and 13 909 healthy controls were included. The REM showed a significant positive association between malaria infection and epilepsy development (OR 2.36; 95% CI 1.44–3.88). In subgroup analyses, significant positive associations were observed in studies that: epilepsy was the outcome in the follow-up of patients with cerebral malaria (OR 7.10; 95% CI 3.50–14.38); used blood smear to diagnose malaria (OR 4.80; 95% CI 2.36–9.77); included only children (OR 3.92; 95% CI 1.81–8.50); published before 2010 (OR 6.39; 95% CI 4.25–9.62). Our findings indicated that patients with malaria, especially those with cerebral malaria, are at a high risk of epilepsy development; however, further well-designed and controlled studies are needed to verify the strength of the association. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this paper is to conduct a systematic literature review for industry 4.0 maturity modeling research studies to obtain a clear view of the current state-of-the-art. Identifying characteristics of the studies; gaps, limitations and highlighted features has been aimed to guide future research studies. Design/methodology/approach: The study includes a systematic literature review conducted on Scopus, IEEE Xplore and Web of Science databases and 90 publications have been reviewed. A novel qualitative taxonomy has been constructed which aims to reduce the cognitive load of the readers. Findings: While industry 4.0 maturity modeling is an emerging concept and taking researchers' attraction, review studies are still in infancy. Current review papers are inadequate in getting a clear idea about the concept, especially from the perspective of guiding future researchers. By the conducted approach of classification conducted in this paper, it has been seen that there are some challenges for improving the industry 4.0 maturity modeling. Research limitations/implications: Findings represented in this study can serve academicians and practitioners to develop and/or improve industry 4.0 maturity models. Originality/value: The study includes a novel classification for the reviewed papers. Constructed taxonomy is among the first and tabular representations instead of prose analogy that aims to simplify the review of papers. [ABSTRACT FROM AUTHOR]

"Ocular AEs reported during the treatment of AD with dupilumab have been increasing sharply, and were proposed to be under the definition "dupilumab induced ocular surface disease" (DIOSD) by Zirwas et al", commented the authors. Ocular adverse events (AEs) have been increasingly reported after wider use of the monoclonal antibody dupiliumab for the treatment of atopic dermatitis (AD), say authors of a bibliometric analysis published in I Frontiers in Medicine i . A search of the Web of Science database identified 138 articles (or letters) published between 2016 and August 2020 which reported ocular AEs during the treatment of AD with dupilumab. [Extracted from the article]

The risk of gastrointestinal bleeding (GIB) is not increased in patients receiving statins [HMG-CoA reductase inhibitors] alone or with concomitant warfarin, according to findings of a systematic review and meta-analysis published in the I Annals of Pharmacotherapy i . Overall, 48 677 episodes of GIB were reported, including 43 734 in patients who received statins alone and 4943 in patients who received statins with warfarin. [Extracted from the article]

Concomitant use of colchicine and clarithromycin is associated with a potentially life-threatening drug interaction, according to findings of a study published in I Drug Safety i . The potential drug interaction between colchicine and clarithromycin was investigated by searching the US FDA's Adverse Event Reporting System (FAERS) database for case reports in patients eceiving co-administered colchicine and clarithromycin, and searching EMBASE, PubMed and Web of Science databases for articles published between 2015 and 2019 which reported concomitant use of colchicine and clarithromycin. Evidence of Clinically Meaningful Drug-Drug Interaction With Concomitant Use of Colchicine and Clarithromycin. [Extracted from the article]

Implementation of monetary incentives in healthcare is "not always successful" in the setting of physician groups, report researchers in Germany. Fee-for-service (FFS) did not appear to have either an obvious positive or negative impact on outcome of care or structure, whilst FF may have had a negative impact on process quality compared with other reimbursement types. [Extracted from the article]

When safety, efficacy and total costs of treatment and management of adverse events (AEs) are considered, carfilzomib plus dexamethasone appears to be the superior regimen for relapsed or refractory multiple myeloma (RRMM), according to findings of a Bayesian network meta-analysis (NMA) published in I Cancer i . Progression-free survival (PFS), grade 3-4 AEs and the total cost per course (drug costs plus costs for management of AEs) were assessed for each regimen. Association of adverse events and associated cost with efficacy for approved relapsed and/or refractory multiple myeloma regimens: A Bayesian network meta-analysis of phase 3 randomized controlled trials. [Extracted from the article]

When safety, efficacy and total costs of treatment and management of adverse events (AEs) are considered, carfilzomib plus dexamethasone appears to be the superior regimen for relapsed or refractory multiple myeloma (RRMM), according to findings of a Bayesian network meta-analysis (NMA) published in I Cancer i . Progression-free survival (PFS), grade 3-4 AEs and the total cost per course (drug costs plus costs for management of AEs) were assessed for each regimen. Association of adverse events and associated cost with efficacy for approved relapsed and/or refractory multiple myeloma regimens: A Bayesian network meta-analysis of phase 3 randomized controlled trials. [Extracted from the article]