10 results on '"Hu, Zhibin"'
Search Results
2. Validation of the physical activity neighborhood environment scale using geographic information systems among urban men and women in regional China
- Author
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Ye, Qing, Qin, Zhenzhen, Xu, Zhen, Yang, Yihan, Zhang, Bing, Xu, Fei, and Hu, Zhibin
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- 2024
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3. Understanding the failing of social gamification: A perspective of user fatigue
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Yang, Hualong, Wang, Le, Hu, Zhibin, and Li, Dan
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- 2024
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4. Inter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism
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Wei, Xiaoyu, primary, Zhang, Zhonghao, additional, Gu, Yayun, additional, Zhang, Rong, additional, Huang, Jie, additional, Li, Feng, additional, He, Yuanlin, additional, Lu, Shuai, additional, Wu, Yifei, additional, Zeng, Wentao, additional, Liu, Xiaorui, additional, Liu, Chenzi, additional, Liu, Jinyi, additional, Ao, Lin, additional, Shi, Fuquan, additional, Chen, Qing, additional, Lin, Yuan, additional, Du, Jiangbo, additional, Jin, Guangfu, additional, Xia, Yankai, additional, Ma, Hongxia, additional, Zheng, Yuxin, additional, Huo, Ran, additional, Cao, Jia, additional, Shen, Hongbing, additional, and Hu, Zhibin, additional
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- 2024
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5. Application of Cut-and-Sew Technique in Thoracoscopic Minimally Invasive Mitral Valve Surgery and Concomitant Maze Procedure
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Han, Erlei, primary, Liu, Zhifang, additional, Zhou, Bing, additional, Wang, Shuwei, additional, Hu, Zhibin, additional, and Cui, Yong, additional
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- 2024
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6. Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China
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Hu, Zhiliang, Song, Ci, Xu, Chuanjun, Jin, Guangfu, Chen, Yaling, Xu, Xin, Ma, Hongxia, Chen, Wei, Lin, Yuan, Zheng, Yishan, Wang, Jianming, Hu, Zhibin, Yi, Yongxiang, and Shen, Hongbing
- Abstract
Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease (COVID-19) and the evidence of person-to-person transmission. Limited data are available for asymptomatic infections. This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers. Epidemiological investigations were conducted among all close contacts of COVID-19 patients (or suspected patients) in Nanjing, Jiangsu Province, China, from Jan 28 to Feb 9, 2020, both in clinic and in community. Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples. Their clinical records, laboratory assessments, and chest CT scans were reviewed. As a result, none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening. Five cases (20.8%) developed symptoms (fever, cough, fatigue, etc.) during hospitalization. Twelve (50.0%) cases showed typical CT images of ground-glass chest and 5 (20.8%) presented stripe shadowing in the lungs. The remaining 7 (29.2%) cases showed normal CT image and had no symptoms during hospitalization. These 7 cases were younger (median age: 14.0 years; P=0.012) than the rest. None of the 24 cases developed severe COVID-19 pneumonia or died. The median communicable period, defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests, was 9.5 days (up to 21 days among the 24 asymptomatic cases). Through epidemiological investigation, we observed a typical asymptomatic transmission to the cohabiting family members, which even caused severe COVID-19 pneumonia. Overall, the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization. However, the communicable period could be up to three weeks and the communicated patients could develop severe illness. These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests. Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged.
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- 2024
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7. Maternal Hypertensive Disorder in Pregnancy and Childhood Strabismus in Offspring.
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Zhu H, You X, Jing Y, Chen Y, Jiang Y, Lin Y, Jiang T, Qin R, Lv H, Lu Q, Liu C, Xu X, Liu Y, Sun T, Jiang M, Xu B, Han X, Chen J, Jiang Y, Liu X, Zhou K, Jin G, Ma H, Hu Z, Liu H, and Du J
- Subjects
- Humans, Pregnancy, Female, China epidemiology, Adult, Child, Preschool, Male, Incidence, Birth Cohort, Cohort Studies, Risk Factors, Pre-Eclampsia epidemiology, Strabismus epidemiology, Strabismus etiology, Prenatal Exposure Delayed Effects epidemiology, Hypertension, Pregnancy-Induced epidemiology
- Abstract
Importance: Maternal hypertensive disorder in pregnancy (HDP) might affect ocular health in offspring; however, its association with strabismus remains unclear., Objective: To examine the association of maternal HDP with overall and type-specific strabismus in offspring., Design, Setting, and Participants: In the Jiangsu Birth Cohort study, a population-based study in China, pregnant women were recruited from April 24, 2014, to November 30, 2018. A total of 6195 offspring had maternal HDP diagnosis information, of whom 3078 were excluded due to having no information on ocular alignment or due to having ocular diseases other than strabismus or refractive error. Offspring underwent ocular examinations at 3 years of age, completed May 21, 2022. Data were analyzed from May 28, 2022, through December 15, 2023., Exposure: Maternal HDP, categorized into hypertension and preeclampsia or with blood pressure (BP) well controlled (systolic BP, <130; diastolic BP, <80 mm Hg) and poorly controlled (systolic BP, ≥130; diastolic BP, ≥80 mm Hg)., Main Outcomes and Measures: The primary outcome was the incidence of strabismus in offspring. Poisson generalized linear mixed models were used to estimate the association between maternal HDP and strabismus., Results: Among the included 3117 children (mean [SD] age, 36.30 [0.74] months; 1629 boys [52.3%]), 143 (4.6%) were exposed to maternal HDP and 368 (11.8%) had strabismus. Offspring exposed to maternal HDP had an 82% increased risk of overall strabismus (relative risk [RR], 1.82 [95% CI, 1.21-2.74]), an 82% increased risk of exophoria (RR, 1.82 [95% CI, 1.11-3.00]), and a 136% increased risk of intermittent exotropia (RR, 2.36 [95% CI, 1.13-4.93]) compared with unexposed offspring. When considering the type of maternal HDP, the risk for all strabismus was high for offspring exposed to preeclampsia (RR, 2.38 [95% CI, 1.39-4.09]) compared with unexposed offspring. When considering the BP control level of maternal HDP, the risk for all strabismus was high for offspring born to mothers with HDP and poorly controlled BP (RR, 2.07 [95% CI, 1.32-3.24]) compared with unexposed offspring., Conclusions and Relevance: These findings suggest that maternal HDP is associated with an increased risk of offspring strabismus. Early screening of strabismus might be recommended for offspring with maternal HDP. Further exploration of the underlying mechanism of the association between HDP and strabismus is warranted.
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- 2024
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8. Associations of combined phenotypic aging and genetic risk with incident cancer: A prospective cohort study.
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Bian L, Ma Z, Fu X, Ji C, Wang T, Yan C, Dai J, Ma H, Hu Z, Shen H, Wang L, Zhu M, and Jin G
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- Humans, Male, Female, Prospective Studies, Middle Aged, Aged, Incidence, Risk Factors, Genetic Predisposition to Disease, United Kingdom epidemiology, Adult, Proportional Hazards Models, Neoplasms genetics, Neoplasms epidemiology, Aging genetics, Phenotype
- Abstract
Background: Age is the most important risk factor for cancer, but aging rates are heterogeneous across individuals. We explored a new measure of aging-Phenotypic Age (PhenoAge)-in the risk prediction of site-specific and overall cancer., Methods: Using Cox regression models, we examined the association of Phenotypic Age Acceleration (PhenoAgeAccel) with cancer incidence by genetic risk group among 374,463 participants from the UK Biobank. We generated PhenoAge using chronological age and nine biomarkers, PhenoAgeAccel after subtracting the effect of chronological age by regression residual, and an incidence-weighted overall cancer polygenic risk score (CPRS) based on 20 cancer site-specific polygenic risk scores (PRSs)., Results: Compared with biologically younger participants, those older had a significantly higher risk of overall cancer, with hazard ratios (HRs) of 1.22 (95% confidence interval, 1.18-1.27) in men, and 1.26 (1.22-1.31) in women, respectively. A joint effect of genetic risk and PhenoAgeAccel was observed on overall cancer risk, with HRs of 2.29 (2.10-2.51) for men and 1.94 (1.78-2.11) for women with high genetic risk and older PhenoAge compared with those with low genetic risk and younger PhenoAge. PhenoAgeAccel was negatively associated with the number of healthy lifestyle factors (Beta = -1.01 in men, p<0.001; Beta = -0.98 in women, p<0.001)., Conclusions: Within and across genetic risk groups, older PhenoAge was consistently related to an increased risk of incident cancer with adjustment for chronological age and the aging process could be retarded by adherence to a healthy lifestyle., Funding: This work was supported by the National Natural Science Foundation of China (82230110, 82125033, 82388102 to GJ; 82273714 to MZ); and the Excellent Youth Foundation of Jiangsu Province (BK20220100 to MZ)., Competing Interests: LB, ZM, XF, CJ, TW, CY, JD, HM, ZH, HS, LW, MZ, GJ No competing interests declared, (© 2024, Bian, Ma et al.)
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- 2024
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9. Inter- and trans-generational impacts of real-world PM 2.5 exposure on male-specific primary hypogonadism.
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Wei X, Zhang Z, Gu Y, Zhang R, Huang J, Li F, He Y, Lu S, Wu Y, Zeng W, Liu X, Liu C, Liu J, Ao L, Shi F, Chen Q, Lin Y, Du J, Jin G, Xia Y, Ma H, Zheng Y, Huo R, Cao J, Shen H, and Hu Z
- Abstract
Exposure to PM
2.5 , a harmful type of air pollution, has been associated with compromised male reproductive health; however, it remains unclear whether such exposure can elicit transgenerational effects on male fertility. Here, we aim to examine the effect of paternal exposure to real-world PM2.5 on the reproductive health of male offspring. We have observed that paternal exposure to real-world PM2.5 can lead to transgenerational primary hypogonadism in a sex-selective manner, and we have also confirmed this phenotype by using an external model. Mechanically, we have identified small RNAs (sRNAs) that play a critical role in mediating these transgenerational effects. Specifically, miR6240 and piR016061, which are present in F0 PM sperm, regulate intergenerational transmission by targeting Lhcgr and Nsd1, respectively. We have also uncovered that piR033435 and piR006695 indirectly regulate F1 PM sperm methylation by binding to the 3'-untranslated region of Tet1 mRNA. The reduced expression of Tet1 resulted in hypermethylation of several testosterone synthesis genes, including Lhcgr and Gnas, impaired Leydig cell function and ultimately led to transgenerational primary hypogonadism. Our findings provide insights into the mechanisms underlying the transgenerational effects of paternal PM2.5 exposure on reproductive health, highlighting the crucial role played by sRNAs in mediating these effects. The findings underscore the significance of paternal pre-conception interventions in alleviating the adverse effects of environmental pollutants on reproductive health., (© 2024. The Author(s).)- Published
- 2024
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10. Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment.
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Xin J, Gu D, Li S, Qian S, Cheng Y, Shao W, Ben S, Chen S, Zhu L, Jin M, Chen K, Hu Z, Zhang Z, Du M, Shen H, and Wang M
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- Humans, Proportional Hazards Models, Survival Rate, Risk Factors, Life Style, Colorectal Neoplasms pathology
- Abstract
The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) for stratifying colorectal cancer overall survival. Leveraging two cohorts of 3703 patients, we first perform a genome-wide survival association analysis to develop eight candidate PPSs. Further using an independent cohort with 470 patients, we identify the 287 variants-derived PPS (i.e., PPS
287 ) achieving an optimal prediction performance [hazard ratio (HR) per SD = 1.99, P = 1.76 × 10-8 ], accompanied by additional tests in two external cohorts, with HRs per SD of 1.90 (P = 3.21 × 10-14 ; 543 patients) and 1.80 (P = 1.11 × 10-9 ; 713 patients). Notably, the detrimental impact of pathologic characteristics and genetic risk could be attenuated by a healthy lifestyle, yielding a 7.62% improvement in the 5-year overall survival rate. Therefore, our findings demonstrate the integrated contribution of pathologic characteristics, germline variants, and lifestyle exposure to the prognosis of colorectal cancer patients., (© 2024. The Author(s).)- Published
- 2024
- Full Text
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