1. Influence of Postoperative Pneumonia on Esophageal Cancer Survival and Recurrence
- Author
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Sho Sawazaki, Yosuke Atsumi, Kazuki Kano, Munetaka Masuda, Tsutomu Sato, Ayako Tamagawa, Mihwa Ju, Masaaki Murakawa, Toru Aoyama, Keisuke Kazama, Norio Yukawa, Yasushi Rino, Masakatsu Numata, Kentaro Hara, Hiroshi Tamagawa, Keisuke Komori, and Yukio Maezawa
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Multivariate analysis ,Esophageal Neoplasms ,Disease-Free Survival ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Cancer Survivors ,Risk Factors ,medicine ,Overall survival ,Humans ,Risk factor ,Adverse effect ,Aged ,business.industry ,Pneumonia ,General Medicine ,Middle Aged ,Esophageal cancer ,Postoperative pneumonia ,medicine.disease ,respiratory tract diseases ,Surgery ,Oncology ,Respiratory failure ,030220 oncology & carcinogenesis ,Female ,Neoplasm Recurrence, Local ,business - Abstract
Background/aim Postoperative pneumonia after esophageal cancer can lead to additional pain, prolonged hospital stay, and respiratory failure. These adverse events might lead to early recurrence and/or death. We investigated the influence of postoperative pneumonia on the esophageal cancer survival and recurrence after curative surgery. Patients and methods This study included 122 patients who underwent curative surgery for esophageal cancer between 2008 and 2018. The patients were classified into: i) those with postoperative pneumonia (pneumonia group) and ii) those without postoperative pneumonia (non-pneumonia group). The risk factors for the overall survival (OS) and recurrence-free survival (RFS) were identified. The rate of postoperative pneumonia was measured by the revised Uniform Pneumonia Score. Results Postoperative complications were found in 34 of the 122 patients (27.9%). The OS rate at 5 years following surgery was 28.2% in the pneumonia group and 55.1% in the non-pneumonia group (p=0.006). The RFS rate at 5 years after surgery was 18.9% in the pneumonia group and 49.2% in the non-pneumonia group (p=0.061). A multivariate analysis showed that postoperative pneumonia was a significant independent risk factor for OS. Conclusion The development of postoperative pneumonia was a risk factor for a decreased overall survival in patients who underwent curative surgery for esophageal cancer. The surgical procedure, perioperative care and surgical strategy should be carefully planned in order to avoid postoperative pneumonia.
- Published
- 2019