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Pretoria, Dec 03, 2008 (BuaNews/All Africa Global Media via COMTEX) -- South Africa's Council for Scientific and Industrial Research (CSIR) has stepped up its battle against HIV and AIDS by […]

To the Editor: We fear the pessimism of 'The Unyielding AIDS Epidemic' (editorial, June 17) creates the misimpression that we have little to offer those who suffer from this terrible […]

In a test of a new Federal policy to speed approval of desperately needed drugs, an advisory committee to the Food and Drug Administration recommended today that a new AIDS […]

A new drug being tested to treat people with AIDS is less effective than the standard one for many patients, the drug's manufacturer announced Thursday. The company, Hoffmann-La Roche of […]

Two new analyses indicate that the AIDS drug AZT is just as effective in black and Hispanic men and in women of all races as it is in white men. […]

Advocates for people with AIDS said yesterday that the Federal Health and Human Services Department would announce approval this week of dideoxyinosine, the first new treatment for the immune deficiency […]

The Federal Government wants to break the Burroughs Wellcome Company's monopoly on the AIDS-fighting drug AZT and encourage competition in an effort to lower the price. The National Cancer Institute […]

To the acclaim of AIDS researchers and advocates for people with AIDS, the Food and Drug Administration yesterday approved a new drug to treat anemia in people with AIDS. The […]

LEAD: Waiving its usual rules for drug testing for the first time, the Food and Drug Administration yesterday approved AZT as a treatment for AIDS virus infections in children. Waiving […]

LEAD: Many doctors say they are advising their patients with AIDS to keep taking an experimental drug whose safety has been questioned by some AIDS researchers. Many doctors say they […]

LEAD: A Federal advisory committee recommended today that the AIDS drug AZT be approved for the treatment of people who are infected with the AIDS virus and have faltering immune […]

Fresh data on life sciences are presented in the report 'Pro-oxidant properties of AZT and other thymidine analogues in macrophages: implication of the azido moiety in oxidative stress.' 'Zidovudine (azidothymidine, [...]

According to recent research from the United States, "The discovery of azidothymidine's (AZT) activity against human immunodeficiency virus (HIV) provided strong rationale for the design of additional thymidine analogues." "One [...]

According to recent research from the United States, "Zidovudine (3'-azido-3'-deoxythymidine; AZT), which is currently used in the treatment of acquired immunodeficiency syndrome, has been shown to have anticancer properties. In [...]

'The centrosome directs chromosomal migration by a complex process of tubulin-chromatin binding. In this contribution centrosomal abnormalities, including centrosomal amplification, were explored in Chinese hamster ovary (CHO) and normal human [...]

"The main disadvantages of 3'-azido-3'-deoxythymidine (zidovudine, AZT), the most common anti-HIV drug, are toxicity and a short half-life in the organism. The introduction of an H-phosphonate group into the AZT [...]

Researchers detail in 'Interference of cell cycle progression by zidovudine and lamivudine in NIH 3T3 cells,' new data in life sciences. According to recent research from the United States, "Zidovudine [...]

According to recent research published in the journal Clinical Cancer Research, "Auger electron emitting radiopharmaceuticals are attractive for targeted nanoirradiation therapy, provided that DNA of malignant cells is selectively addressed. [...]

"Herpes virus type 1 thymidine kinase (HSV1-tk) and the mutant HSV1-sr39tk are the 2 most widely used ''reporter genes'' for radiotracer-based imaging. Two pyrimidine nucleoside analogs, [F-18]FEAU (1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyl-uridine) and [F-18]FFEAU [...]

Data detailed in 'The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants' have been presented (see also [...]

Fresh data on drug resistance are presented in the report 'Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria.' According to recent research from Copenhagen, Denmark, 'Common bacterial pathogens are [...]

DiaSorin is proud to introduce the new LIAISON(R) Thymidine Kinase (TK) assay, the first chemiluminescence assay for the quantitative determination of the Thymidine Kinase enzymatic activity in serum or plasma. [...]

Apoptosis data are the focus of recent research from the United States, Germany and Japan. Study 1: Azidothymidine (AZT) treatment of T-cell leukemia virus I-infected cells in adult T-cell leukemia/lymphoma [...]

Azidothymidine (AZT) treatment of T-cell leukemia virus I-infected cells in adult T-cell leukemia/lymphoma (ATL) patients results in tumor cell death. According to recent research published in the journal Blood, 'The [...]

Angiogenesis is disrupted by 5'-O-tritylated nucleoside derivatives. "Thymidine phosphorylase (TPase) is one of the key enzymes involved in the pyrimidine nucleoside salvage pathway. However, TPase also stimulates angiogenesis, and its [...]

Investigators in the United States have published new HIV/AIDS data. Study 1: HIV-1 reverse transcriptase K65R and thymidine analog mutations exhibit bidirectional phenotypic antagonism. According to a study from the [...]

Breast cancer response to chemotherapy could be predicted by 3'-[F-18]Fluoro-3'-deoxythymidine (FLT) with positron emission tomography (PET). "The usefulness of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-PET in monitoring breast cancer response to chemotherapy has previously [...]

The herpes simplex virus-1 thymidine kinase delivered by human immunodeficiency virus-1-based virus-like particles induced cell death. According to recent research published in the journal Molecular Therapy, "HIV-1 Nef incorporates into [...]

A study from the United States has reported on the imaging of herpes viral thymidine kinase-1 reporter gene expression. 'The preparation and radiolabeling of 2'-fluoro-2'-deoxy-l-beta-D-arabinofuranosyl-5-(2-fluoroethyl)-uracil (FFEAU) with F-18 and its [...]

Recent research from Canada has reported on a human osteosarcoma cell line expressing herpes simplex type-l thymidine kinase. '(E)-5-(2-lodovinyl)-2'-fluoro-2'-deoxyuridine (IVFRU) is a pyrimidine nucleoside analogue that accumulates selectively in murine [...]

Data on drug resistance are outlined in reports from the United States. Study 1: The HIV-1 L74V mutation enhances AZT susceptibility by removing ATP-dependent phosphorolysis. "Thymidine analog mutations (TAMs) in [...]

The HIV-1 L74V mutation enhances AZT susceptibility by removing ATP-dependent phosphorolysis. "Thymidine analog mutations (TAMs) in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) confer resistance to zidovudine (AZT) [...]

Thymidine analogue derivatives suppress multidrug-resistant HIV-1 reverse transcriptase. "A dipeptide insertion between codons 69 and 70 together with the amino acid substitution T215Y in the reverse transcriptase (RT)-coding region of [...]

Cyclooxygenase-2 and thymidine phosphorylase profile cervical cancer patients. Researchers in South Korea conducted a study 'to evaluate the prognostic significance of thymidine phosphorylase (TP) and coexpression of cyclooxygenase-2 (COX-2)/TP, and [...]

GADD45A and thymidine phosphorylase expression levels predicted survival in gastric cancer patients. According to recent research from Germany, 'We evaluated the expression of seven therapy-related genes to predict the clinical [...]

2001 APR 3 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - An Epstein-Barr virus (EBV) thymidine kinase antigen may offer a more reliable way to test [...]

2001 APR 3 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - An Epstein-Barr virus (EBV) thymidine kinase antigen may offer a more reliable way to test [...]

2001 MAR 6 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer -- New research suggests thymidine phosphorylase is a marker for progression and metastasis in gastric carcinoma, [...]

LEAD: Amid impassioned debate over what access a patient with a fatal disease should have to experimental drugs, the Food and Drug Administration is nearing a decision on whether to […]

LEAD: The British Government has approved the experimental drug azidothymidine for the treatment of AIDS in Britain, saying it appears to prolong the lives of people suffering from the disease, […]

LEAD: Deciding that the promise of prolonging the lives of some AIDS patients outweighs serious side effects, the Food and Drug Administration last week approved the use of the drug […]

LEAD: Although he has been told he is dying of AIDS, Nick Pippin - a 32-year-old actor - considers himself on a lucky roll. Although he has been told he […]

LEAD: The first drug proved to prolong the lives of AIDS patients was given Federal approval today. Both Government and drug company officials emphasized, however, that the drug was not […]

LEAD: AZT was all but forgotten, an ineffective cancer drug, when the Burroughs Wellcome Company moved its North American headquarters and research laboratories in 1970 from New York's Westchester County […]

LEAD: New tests on the AIDS drug AZT are scheduled to begin Monday at the University of Rochester Medical Center, but officials say they need at least 100 more volunteers […]

An experimental anti-AIDS drug has bolstered the immune systems in 15 of the first 19 patients to receive it and has produced short-term improvement in some of their symptoms, but […]

LEAD: It will be at least a year before any new drugs are available for treating AIDS patients, leading AIDS researchers say. It will be at least a year before […]

LEAD: Defying official recommendations, a growing number of doctors who treat carriers of the AIDS virus are prescribing a powerful, potentially toxic drug even before the patients develop serious signs […]

The advent of a drug that shows promise against AIDS has paradoxically raised a host of thorny new ethical and practical problems for researchers developing treatments for the deadly disorder. […]

Federal health officials announced today that an experimental drug had markedly improved the health of a group of AIDS patients, adding months to the lives of some. They said thousands […]