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A recent study conducted by the Department of Biological and Health Sciences explored the urinary metabolome profile of individuals with obesity and overweight and its relation to different obesity profiles. The study included 75 patients with a mean age of 38.3 years, and the results showed that higher concentrations of trigonelline, sarcosine, and phenylalanine in urine were associated with patients who had visceral fat over 16 kg. These metabolites are related to insulin resistance, muscle mass and strength, and glucose metabolism and abdominal fat, respectively. The findings suggest that these biomarkers could be used for non-invasive estimation of visceral fat and provide insights into the metabolic pathways involved in obesity. [Extracted from the article]

A recent study conducted by researchers at Seoul National University College of Medicine & Hospital in South Korea explored the metabolic profiles of patients with psoriasis vulgaris (PV) and palmoplantar pustulosis (PPP) compared to healthy volunteers (HVs). The study found distinct metabolic differences between PV and PPP patients, with increased levels of sarcosine in both groups. The researchers suggest that sarcosine may serve as a potential biomarker for psoriasis. This study provides new insights into the pathogenesis of psoriasis and may contribute to the development of targeted treatments. [Extracted from the article]

A recent study conducted at the Department of Pharmaceutical Chemistry in Maharashtra, India, has explored the use of luminescent carbon nanoparticles, specifically carbon quantum dots (CQDs) and graphene quantum dots (GQDs), for the detection of sarcosine. Sarcosine is a biomarker that holds significance for therapeutic purposes and disease identification, particularly in prostate cancer. The study highlights the advantages of carbon-based sensors, such as their eco-friendliness, recyclability, and affordability, in sarcosine detection. The research discusses the synthesis and fluorescent properties of CQDs and GQDs, as well as their potential applications in diverse sensing technologies. [Extracted from the article]

A recent study conducted at Hebei Medical University in Shijiazhuang, China, has explored the use of pharmaceutical cocrystals to enhance the efficacy of antineoplastic drugs. The researchers successfully assembled a cocrystal composed of 5-fluorouracil (5-FU) and sarcosine (SAR) using a wet powder grinding method. The cocrystal was found to have improved bioavailability compared to 5-FU alone and demonstrated superior cellular inhibition activity on cancer cells. The study suggests that cocrystals using bioactive amino acids as precursors could be a novel strategy for developing more effective drugs. [Extracted from the article]

A recent study conducted by researchers at Jilin University in Changchun, China, has developed a highly sensitive detection platform for sarcosine, a compound that has potential for predicting prostate cancer. The platform utilizes zirconium-based metal organic frameworks (Zr-MOFs) with multi-enzyme immobilization to detect sarcosine through fluorescence and colorimetry. The researchers successfully tested the method on urine samples from healthy individuals and prostate cancer patients, obtaining satisfactory results. This research has been peer-reviewed and provides valuable insights into cancer research. [Extracted from the article]

A recent report from Sao Paulo State University (UNESP) discusses a novel approach to detecting prostate cancer using an electrochemical sensor integrated with molecular imprinting technology and ionic liquid. The researchers enhanced the carbon paste electrode with ionic liquid and molecularly printed polymers to detect the sarcosine biomarker. The proposed method showed a concentration linear range of 2.0 x 10-7 to 1.04 x 10-4 mol L-1 and a low detection limit of 5.1 x 10-8 mol L-1. Tests with biological samples demonstrated the efficiency of the proposed sensor. This research provides new insights into the detection of prostate cancer. [Extracted from the article]

This article discusses the role of GlyT1, a glycine transporter, in regulating the activation of NMDA receptors in the spinal cord, brainstem, and forebrain. The study explores how glycine accumulation triggers the release of GlyT1, which facilitates the activation of NMDA receptors by glutamate. The results suggest that GlyT1-mediated efflux positively regulates the occupancy of the co-agonist site on NMDA receptors. The study also highlights the potential therapeutic implications of GlyT1 inhibitors and sarcosine in reversing NMDA receptor hypofunction in schizophrenia. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A study conducted at China Pharmaceutical University in Jiangsu, People's Republic of China, has developed a new ratiometric fluorescence sensor for the detection of sarcosine, a potential biomarker for prostate cancer. The sensor demonstrates high sensitivity, selectivity, and reliability, with a wide linear range and a low detection limit. Additionally, the researchers have created a smartphone-based microfluidic sensing platform for precise determination of sarcosine in urine samples, which could be a valuable tool for early diagnosis of prostate cancer. The study has been peer-reviewed and published in Sensors and Actuators B: Chemical. [Extracted from the article]

A study conducted by Guangxi Medical University in Nanning, China, investigated the prognostic value and clinical significance of sarcosine dehydrogenase (SARDH) in hepatocellular carcinoma (HCC). The study analyzed the expression of SARDH mRNA and protein in HCC and normal liver tissue, and examined their relationship with clinicopathological features. The results showed that SARDH expression was significantly lower in HCC compared to normal liver tissue, and lower expression was associated with worse prognosis. Bioinformatic analysis also revealed a correlation between SARDH expression and immune infiltration. The study concluded that SARDH expression is related to key genes in the Ferroptosis pathway. [Extracted from the article]

A study conducted at Guangxi University in Nanning, People's Republic of China, explores the use of a novel electrochemical sensor called NH2-MIL88B(Fe)-porphyrin/riboflavin (NM88B-POR/Rf) for the detection of sarcosine, a biomarker for prostate cancer. The sensor utilizes a hyperoxia microenvironment and a cascade reaction to enhance the detection sensitivity of sarcosine. The research found that the sensor had a low limit of detection and good selectivity and stability, making it suitable for detecting sarcosine in real urine samples. This study contributes to the development of ultrasensitive biosensors for cancer biomarkers. [Extracted from the article]

Researchers at the Medical University of Lodz in Poland have conducted a study on the effects of sarcosine, a glutamatergic modulator, on patients with chronic schizophrenia. The study found that sarcosine did not directly affect epidermal growth factor (EGF) levels in the patients' serum, but it did lead to significant improvements in negative symptoms and overall psychopathology. The researchers concluded that sarcosine may induce the production of EGF or inhibit the decline in EGF concentrations, suggesting a neuroprotective effect of the treatment. This study provides valuable insights into potential therapeutic options for individuals with schizophrenia. [Extracted from the article]

A recent study conducted by researchers at Shenzhen University in China explores the use of a nanosystem for the specific screening of prostate cancer. The researchers developed a photonic crystal-enhanced plasmonic nanosystem using a live diatom and bimetallic nanoparticles to detect sarcosine, an early stage prostate cancer biomarker. The nanosystem demonstrated improved detection capabilities compared to other methods and could potentially be used for noninvasive biomarker screening. The study was published in ACS Applied Nano Materials and was supported by various funding sources. [Extracted from the article]

Drugs and Therapies, FK506 Therapy, Health and Medicine, Immunosuppressive Agents, Macrolides, N-substituted Glycines, Pharmaceuticals, Sarcosine, Tacrolimus, Tacrolimus Therapy Keywords: Drugs and Therapies; FK506 Therapy; Health and Medicine; Immunosuppressive Agents; Macrolides; N-substituted Glycines; Pharmaceuticals; Sarcosine; Tacrolimus; Tacrolimus Therapy EN Drugs and Therapies FK506 Therapy Health and Medicine Immunosuppressive Agents Macrolides N-substituted Glycines Pharmaceuticals Sarcosine Tacrolimus Tacrolimus Therapy 2163 2163 1 07/31/23 20230804 NES 230804 2023 AUG 4 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Fresh data on FK506 therapy are presented in a new report. [Extracted from the article]

According to the news editors, the research concluded: "The synthesized grafted plate was able to absorb sarcosine selectively in the presence of other amino acids, showing that the proposed method enabled the rapid determination of sarcosine." Biomarkers, Cancer, Diagnostics and Screening, Health and Medicine, N-substituted Glycines, Oncology, Sarcosine Keywords: Biomarkers; Cancer; Diagnostics and Screening; Health and Medicine; N-substituted Glycines; Oncology; Sarcosine EN Biomarkers Cancer Diagnostics and Screening Health and Medicine N-substituted Glycines Oncology Sarcosine 777 777 1 07/10/23 20230710 NES 230710 2023 JUL 11 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- Researchers detail new data in cancer. [Extracted from the article]

Keywords: Antigen-Presenting Cells; Bone Marrow Cells; Brain Cancer; Cancer; Dendritic Cells; Drugs and Therapies; Health and Medicine; Hematology; Hematopoietic; Hematopoietic Stem Cells; Hemic and Immune Systems; Immunization; Immunology; Immunotherapy; Lymph Nodes; Lymphoid Tissue; Mononuclear Phagocyte System; N-substituted Glycines; Oncology; Public Health; Sarcosine; Stem Cell Research; Tetanus Toxoid; Therapy; Tumors; University of Florida Research Foundation Inc.; Vaccination; Vaccines EN Antigen-Presenting Cells Bone Marrow Cells Brain Cancer Cancer Dendritic Cells Drugs and Therapies Health and Medicine Hematology Hematopoietic Hematopoietic Stem Cells Hemic and Immune Systems Immunization Immunology Immunotherapy Lymph Nodes Lymphoid Tissue Mononuclear Phagocyte System N-substituted Glycines Oncology Public Health Sarcosine Stem Cell Research Tetanus Toxoid Therapy Tumors University of Florida Research Foundation Inc. Vaccination Vaccines 100 100 1 07/03/23 20230703 NES 230703 2023 JUL 3 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Vaccine Week -- A patent by the inventors Azari, Hassan (Gainesville, FL, US), Lovaton, Rolando (Lima, PE), Mitchell, Duane (Gainesville, FL, US), Rahman, Maryam (Gainesville, FL, US), filed on March 22, 2017, was published online on June 13, 2023, according to news reporting originating from Alexandria, Virginia, by NewsRx correspondents. A cell culture composition comprising: liquid medium containing sarcosine at a concentration of 6 mM to 1 M, and an antigen presenting cell (APC), wherein the APC is a dendritic cell (DC). In some aspects of the invention the subject may be treated using a strategy for enhancing migration of dendritic cells (DCs) to the local lymph node using other cellular therapies, for example, Provenge (Dendreon), DCVax (Northwest Biotherapeutics), AGS vaccines (Argos Therapeutics), or CAR T cells (Juno Therapeutics, Novartis, Kite Pharma, and Cellestis).". [Extracted from the article]

"In another embodiment of the COVID-19 diagnostic apparatus, the one or more metabolites are kynurenine and arginine, and wherein the diagnosis of COVID-19 positive is indicated when a ratio of arginine/kynurenine levels is statistically decreased from known normal ratio levels of arginine/kynurenine. "In another embodiment of the method of diagnosing COVID-19 in the subject, only when the subject is COVID-19 positive, the method further comprising treating the subject for COVID-19. "In another embodiment of the method of diagnosing COVID-19, the one or more metabolites is one more of kynurenine, arginine, sarcosine, lysoPC18:1, lysoPC20:4, lysoPC14:0, lysoPC17:0, and lysoPC18:2. "In another embodiment of the method of diagnosing COVID-19, the one or more metabolites are kynurenine and arginine, and wherein the diagnosis of COVID-19 positive is indicated when a ratio of arginine/kynurenine levels is statistically decreased from known normal ratio levels of arginine/kynurenine. [Extracted from the article]

Prague, Czech Republic, Europe, Cancer Research, Cerium, Lanthanoid Series Elements, Sarcosine, N-substituted Glycines Keywords: Prague; Czech Republic; Europe; Cancer Research; Cerium; Lanthanoid Series Elements; N-substituted Glycines; Sarcosine EN Prague Czech Republic Europe Cancer Research Cerium Lanthanoid Series Elements N-substituted Glycines Sarcosine 253 253 1 05/15/23 20230516 NES 230516 2023 MAY 16 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- Current study results on Cancer Research have been published. [Extracted from the article]

"In some embodiments, the method can further include converting via an enzyme the analyte, wherein the converted analyte is configured to allow binding of the regulator and the promoter thus activating transcription of the reporter gene. "In some embodiments, the reporter can include a first plasmid containing a transcriptional regulator and a second plasmid containing a reporter gene operatively linked to a promoter, wherein expression from the promoter is controlled by the amount of the regulator. "In some embodiments, the method can further include converting 310 via an enzyme the analyte, wherein the converted analyte is configured to allow binding of the regulator and the promoter thus activating transcription of the reporter gene. [Extracted from the article]

For more information on this research see: Enzyme-encapsulated Protein Trap Engineered Metal-organic Framework-derived Biomineral Probes for Non-invasive Prostate Cancer Surveillance. Keywords: Fuzhou; People's Republic of China; Asia; Cancer; Engineering; Enzymes and Coenzymes; Health and Medicine; N-substituted Glycines; Oncology; Prostate Cancer; Prostatic Neoplasms; Sarcosine EN Fuzhou People's Republic of China Asia Cancer Engineering Enzymes and Coenzymes Health and Medicine N-substituted Glycines Oncology Prostate Cancer Prostatic Neoplasms Sarcosine 375 375 1 04/10/23 20230411 NES 230411 2023 APR 11 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Oncology - Prostate Cancer. [Extracted from the article]

A miniaturised, portable, and cost-effective nanobiosensor was constructed using chitosan as a biocompatible glue for the ultrasensitive detection of prostate cancer biomarker sarcosine. Keywords: Bioengineering; Biomarkers; Bionanotechnology; Biosensing; Biosensors; Biotechnology; Cancer; Cancer Biomarkers; Carcinoma Biomarkers; Chemicals; Diagnostics and Screening; Electrochemicals; Emerging Technologies; Health and Medicine; N-substituted Glycines; Nanobiosensors; Nanobiotechnology; Nanotechnology; Oncology; Prostate Cancer; Prostatic Neoplasms; Sarcosine EN Bioengineering Biomarkers Bionanotechnology Biosensing Biosensors Biotechnology Cancer Cancer Biomarkers Carcinoma Biomarkers Chemicals Diagnostics and Screening Electrochemicals Emerging Technologies Health and Medicine N-substituted Glycines Nanobiosensors Nanobiotechnology Nanotechnology Oncology Prostate Cancer Prostatic Neoplasms Sarcosine 1167 1167 1 04/03/23 20230407 NES 230407 2023 APR 4 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Investigators publish new report on biosensors. [Extracted from the article]

Keywords: Kerala; India; Asia; Acute-Phase Proteins; Albumins; Biomarkers; Blood Proteins; Bovine Serum Albumin; Cancer; Cancer Biomarkers; Carcinoma Biomarkers; Diagnostics and Screening; Emerging Technologies; Gold Nanoclusters; Health and Medicine; N-substituted Glycines; Nanoclusters; Nanotechnology; Oncology; Prostate Cancer; Prostatic Neoplasms; Proteins; Sarcosine; Serum Albumin EN Kerala India Asia Acute-Phase Proteins Albumins Biomarkers Blood Proteins Bovine Serum Albumin Cancer Cancer Biomarkers Carcinoma Biomarkers Diagnostics and Screening Emerging Technologies Gold Nanoclusters Health and Medicine N-substituted Glycines Nanoclusters Nanotechnology Oncology Prostate Cancer Prostatic Neoplasms Proteins Sarcosine Serum Albumin 1096 1096 1 03/23/23 20230321 NES 230321 2023 MAR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Diagnostics and Screening - Cancer Biomarkers is the subject of a report. For more information on this research see: Europium (Iii) Incorporated Bovine Serum Albumin Stabilized Gold Nanoclusters As Fluorescent Probes for the Detection of Sarcosine, a Prostate Cancer Biomarker. [Extracted from the article]

Keywords: Porto; Portugal; Europe; Alcohols; Biosensors; Biotechnology; Chemicals; Electrochemical Biosensors; Electrochemicals; Methanol; N-substituted Glycines; Nanotechnology; Sarcosine EN Porto Portugal Europe Alcohols Biosensors Biotechnology Chemicals Electrochemical Biosensors Electrochemicals Methanol N-substituted Glycines Nanotechnology Sarcosine 2023 MAR 7 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Biosensors. The final DMFC/biosensor-EC platform showed a colour change perceptible to the naked eye in the presence of increasing sarcosine concentrations. [Extracted from the article]

Keywords: Fort Lauderdale; State:Florida; United States; North and Central America; Alanine; Amino Acids; Angiotensins; Autacoids; Biological Factors; Branched-Chain Amino Acids; Clinical Research; Clinical Trials and Studies; Essential Amino Acids; Health and Medicine; Isoleucine; N-substituted Glycines; Neuropeptides; Oligopeptides; Peptide Hormones; Peptide Proteins; Peptides; Proteins; Sarcosine EN Fort Lauderdale State:Florida United States North and Central America Alanine Amino Acids Angiotensins Autacoids Biological Factors Branched-Chain Amino Acids Clinical Research Clinical Trials and Studies Essential Amino Acids Health and Medicine Isoleucine N-substituted Glycines Neuropeptides Oligopeptides Peptide Hormones Peptide Proteins Peptides Proteins Sarcosine 2023 FEB 20 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators discuss new findings in Peptide Proteins - Peptide Hormones. For more information on this research see: Comparative Evaluation of Biased Agonists Sarcosine(1), D-alanine(8)-angiotensin (Ang) Ii (Sd Ang Ii) and Sarcosine(1), Isoleucine(8)-ang Ii (Si Ang Ii) and Their Radioiodinated Congeners Binding To Rat Liver Membrane At(1) Receptors. [Extracted from the article]