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Researchers from Hospital Universitario in Madrid, Spain, have developed a predictive model using machine learning to assess the risk of occult cancer after a venous thromboembolism event. The study included 815 patients with VTE, with 6.9% being diagnosed with cancer during follow-up. The CatBoost algorithm showed the best performance in predicting hidden malignancy, with an ROC-AUC of 0.86 in the test set. The researchers emphasized the need for external validation of their risk score due to potential limitations in the study. [Extracted from the article]

A recent report from researchers at Bern University Hospital in Switzerland discusses the impact of early cancer diagnosis on the mortality rates of patients who have experienced an acute ischemic stroke (AIS). The study compared mortality rates between AIS patients with occult cancer diagnosed during their hospitalization and those diagnosed after discharge. The findings showed that the timing of cancer diagnosis did not significantly affect long-term survival. However, due to the small sample size, larger studies are needed to confirm these results. [Extracted from the article]

A study conducted at Xiamen University in China focused on the relationship between cancer and stroke, specifically occult cancer in patients with ischemic stroke (IS). The study aimed to develop a predictive tool for early diagnosis of occult cancer and personalized treatment for stroke associated with cancer. The researchers used a training dataset of 136 IS patients with concurrent cancer and a control group, and developed a nomogram based on logistic regression to predict the risk of occult cancer. The nomogram showed strong performance in both the training and external test datasets. This research provides a cost-effective platform for secondary care in the framework of personalized medicine. [Extracted from the article]

A recent study conducted at Hospital Universitario in Seville, Spain, explored the challenge of detecting occult cancer in patients with unprovoked venous thromboembolism (VTE). The researchers investigated the potential predictive role of coagulation-related biomarkers in diagnosing occult malignancies. They found that increased levels of soluble P-selectin (sP-selectin) were statistically significant in patients with occult cancer. Additionally, when sP-selectin exceeded 62 ng/mL and D-dimer surpassed 10,000 g/L, the diagnosis of occult cancer demonstrated a specificity of up to 91%. The combination of sP-selectin and D-dimer could be a valuable biomarker in detecting occult cancer in patients with unprovoked VTE, although further research is needed to confirm its effectiveness. [Extracted from the article]

A recent study conducted in the Republic of Korea investigated the incidence of occult cancer in patients diagnosed with adenocarcinoma in situ through punch biopsy or endocervical curettage. The study found that out of 20 patients diagnosed with adenocarcinoma in situ, six had occult cervical cancer, with four of them having cervical cancer at or greater than stage 1A1 with lymphovascular space invasion. The study suggests that conization should be performed to identify occult cancer and optimize the extent of surgery. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]

Biomedicine, Cancer, Carcinomas, Colorectal Research, Digestive System Surgical Procedures, Gastroenterology, Health and Medicine, Hepatectomy, Liver Transplantation, Liver Transplants, Occult Cancer, Oncology, Organ Transplants, Surgery, Transplant Medicine Keywords: Biomedicine; Cancer; Carcinomas; Colorectal Research; Digestive System Surgical Procedures; Gastroenterology; Health and Medicine; Hepatectomy; Liver Transplantation; Liver Transplants; Occult Cancer; Oncology; Organ Transplants; Surgery; Transplant Medicine EN Biomedicine Cancer Carcinomas Colorectal Research Digestive System Surgical Procedures Gastroenterology Health and Medicine Hepatectomy Liver Transplantation Liver Transplants Occult Cancer Oncology Organ Transplants Surgery Transplant Medicine 319 319 1 10/24/23 20231024 NES 231024 2023 OCT 26 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in occult cancer. [Extracted from the article]