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This article reports that combined estrogen/progesterone hormone replacement therapy increases postmenopausal women's sensitivity to the neurosteroid pregnanolone, a recent study demonstrated. A.C. Wihlback and colleagues, Umea University Hospital, Sweden, compared the pharmacodynamic response to a neuroactive steroid, pregnanolone, before and during different hormonal settings of postmenopausal hormone replacement therapy, using natural progesterone. Their study appeared in the journal "Psychoneuroendocrinology."