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A new microstructured surface has been developed by Virginia Tech engineer Jonathan Boreyko and his colleagues to improve heat-transfer efficiency in liquid-cooling systems for data centers and power plants. By creating an array of 80-micron-diameter cavities and 40-micron-wide grooves on the bottom of a boiling chamber, the surface allows for the formation of smaller, more closely packed bubbles that quickly coalesce with nearby bubbles, resulting in more efficient heat transfer. The technology has potential applications in heat exchangers, boilers, and electronics cooling, but further research is needed to determine its effectiveness. [Extracted from the article]

The article "Zapping PFAS Away" from Time International (Atlantic Edition) discusses Gradiant's ForeverGone technology, which aims to remove per- and polyfluoroalkyl substances (PFAS) from water supplies. PFAS have been linked to cancers, prompting governments to set legal limits on their presence in drinking water. Gradiant's innovative approach involves injecting microbubbles into water to separate PFAS, which are then zapped away by electrodes. The company's clients include utilities, Coca-Cola, and BMW, highlighting the importance of addressing this environmental issue. [Extracted from the article]

A case report in the journal "Reactions Weekly" describes a patient with recurrent glioblastoma who showed lack of efficacy while being treated with carboplatin. The patient, enrolled in a clinical study in Japan, received IV carboplatin along with other therapies but experienced worsened symptoms despite 4 cycles of treatment. As a result, carboplatin was discontinued due to progressive disease. [Extracted from the article]

According to a preprint abstract from biorxiv.org, researchers have discovered a new mechanism for drug delivery using ultrasound-activated microbubbles. The study found that oscillating microbubbles can disrupt F-actin, a protein involved in cell structure, leading to the formation of gaps in the endothelial barrier. This allows for drug delivery into the surrounding tissue. The research used high-resolution confocal microscopy and ultra-high-speed camera imaging to observe the process. It is important to note that this study has not yet undergone peer review. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the use of ultrasound-activated microbubbles to increase vascular permeability and facilitate drug transport from blood to extravascular tissue. The study used a microvessel-on-a-chip model to investigate the effects of different ultrasound treatments on permeability. The results showed that shorter ultrasound cycles had a slower onset rate and induced less permeability increase compared to longer cycles. The study also found that vascular permeability increases did not correlate with microbubble behavior, while sonoporation correlated with microbubble clustering. This research contributes to the development of safe and efficient microbubble-mediated drug transport. [Extracted from the article]

A patent has been issued for a multi-sensor infusion system that can detect air or an occlusion in the infusion system. The system includes a pump, multiple types of sensors, a processor, and memory. The sensors are designed to indicate the presence of air in the fluid delivery line, and the processor uses measurements from the sensors to determine if there is air, a partial occlusion, or a total occlusion in the line. The system can also determine the percentage of air present or the probability of air being in the line. The patent aims to address the limitations of existing single-sensor based systems. The patent was filed by inventors from various locations in the United States and is assigned to ICU Medical Inc. [Extracted from the article]

A recent report from researchers at the National Defense Medical Center in Taipei, Taiwan, discusses the use of ultrasound-mediated lysozyme microbubbles to target the NOX4 protein and alleviate ototoxicity caused by cisplatin therapy. The study found that the transfection of siNOX4 using lysozyme-shelled microbubbles significantly inhibited the generation of reactive oxygen species (ROS) induced by cisplatin. The researchers concluded that this therapy modality shows promise for future clinical applications in alleviating cisplatin-induced ototoxicity. The full article can be accessed for free at the International Journal of Molecular Sciences website. [Extracted from the article]

A new study conducted at Erasmus University Medical Center explores the impact of microbubble size on drug delivery outcomes. The researchers generated monodisperse microbubbles (mMBs) with different radii and conducted in vitro experiments to observe their effects on drug uptake and membrane pore formation. The study found that smaller mMBs exhibited higher drug uptake rates, but also had lower excursion amplitudes. Additionally, tunnel formation was more common than resealing pore formation during insonification. This research provides valuable insights into the influence of microbubble size on drug delivery outcomes. [Extracted from the article]

A patent has been issued to Fresenius Medical Care Holdings Inc. for a drip chamber that effectively removes microbubbles during hemodialysis. Microbubbles can enter the bloodstream during hemodialysis and have been linked to lung injuries and brain damage. The drip chamber includes a nucleation column that provides sites for microbubbles to collect and amalgamate into larger bubbles, preventing them from entering the blood return line. The chamber can be treated to include microfeatures or coatings that enhance nucleation efficiency. This invention aims to improve patient safety during hemodialysis procedures. [Extracted from the article]

A patent has been issued for a treatment tool sterilizer for dental hospitals. The sterilizer uses micro bubble type ozone water supply and a sterilizing method to effectively sterilize dental tools. The invention aims to address the high risk of infection associated with the use of non-disposable dental tools. The sterilizer is compact, affordable, and uses high concentration ozone water, reducing the time required for sterilization. It includes features such as a sterilization tub, fresh water supply, ozone water supply, ultrasonic generator, drain, heater, and controller. The patent was filed by Cho, Hee Keun and assigned to Andong National University Industry-Academic Cooperation Foundation. [Extracted from the article]

A recent study conducted by researchers from Drexel University in Philadelphia, Pennsylvania, explores the use of ultrasound-triggered bursting of polymer microbubbles for potential therapeutic delivery to spinal cord injury (SCI) patients. The study investigates the feasibility of clinical ultrasound bursting, optimal bursting parameters, and the loading and release of a model bio-active DNA. The researchers found that poly(lactic acid) (PLA) microbubbles made with ammonium carbonate have the potential to safely improve intrathecal therapeutic delivery to SCI using targeted ultrasound. The study provides valuable insights into the use of ultrasound technology for treating spinal cord injuries. [Extracted from the article]

Researchers at the University of Massachusetts in Amherst have conducted a study on the efficacy of ozone microbubbles and conventional aqueous ozone as inactivation agents against Tulane virus, a human norovirus surrogate. Noroviruses are the primary cause of foodborne illnesses in the US, so finding effective inactivation agents is important. The study found that ozone microbubbles had a longer half-life than aqueous ozone and showed promising results in reducing the viral load of Tulane virus. However, further research is needed to fully understand the potential of ozone microbubbles. This research was supported by the University of Massachusetts, Amherst. [Extracted from the article]

A recent study conducted at Peking University Third Hospital in Beijing, China, has explored the use of nanosheets in ultrasound imaging guided targeted sonodynamic therapy (SDT) for breast cancer treatment. The researchers developed a micro-nanoplatform consisting of black phosphorus nanosheets loaded with Fe3O4 nanoparticles connected to microbubbles. This platform demonstrated efficient SDT effects and targeted ultrasound imaging both in vitro and in vivo. The researchers proposed that the mechanism of SDT involved the generation of reactive oxygen species (ROS) and the induction of apoptosis. This research has been peer-reviewed and provides insights into the potential of nanotechnology in cancer therapy. [Extracted from the article]

A study conducted at Sahand University of Technology in Tabriz, Iran, has developed a novel polymeric microbubble for targeted cancer therapy. The microbubble is composed of poly(lactic-co-glycolic acid), chitosan, polyethylene glycol, and folic acid, and loaded with gold nanoparticles. The researchers synthesized the microbubble using a modified emulsion method and characterized its properties. The study found that the microbubble exhibited enhanced stability, ultrasound and temperature responsiveness, and potential as a theranostic agent for cancer imaging and therapy. The research has been peer-reviewed and published in the Journal of Drug Delivery Science and Technology. [Extracted from the article]

Direxion has launched two new exchange-traded funds (ETFs) for professional investors who have a bullish or bearish outlook on artificial intelligence (AI) stocks. The Direxion Daily AI and Big Data Bull 2X Shares ETF aims to achieve 200% of the daily returns from its benchmark, while the bear equivalent seeks to gain 200% in the opposite direction. These leveraged funds are designed to reflect single-day moves and do not accumulate gains over time. The introduction of these ETFs comes at a time when the AI stock rally has stalled due to concerns over excessive valuations. [Extracted from the article]

Direxion is launching two exchange-traded funds (ETFs) that allow professional investors to leverage their investments in artificial intelligence (AI) stocks. The Direxion Daily AI and Big Data Bull 2X Shares ETF aims to achieve 200% of the daily returns from its benchmark, while the bear equivalent seeks to garner 200% in the opposite direction. These leveraged funds are designed to reflect single-day moves and are not meant for retail investors or those with a limited risk appetite. The introduction of these ETFs comes at a time when AI stocks are facing concerns over excessive valuations. [Extracted from the article]

Investors are withdrawing billions of dollars from exchange-traded funds (ETFs) that focus on thematic investments such as clean energy and cloud computing. This shift is due to the availability of cash-like instruments that offer nearly 5% returns and the popularity of Big Tech funds. As a result, many ETF providers are closing funds or adjusting their offerings. Smaller issuers like Defiance ETFs are particularly affected, with a higher closure rate and shorter average lifespan for their ETFs. However, some industry experts believe that thematic ETFs may regain favor as emerging technologies become more relevant. [Extracted from the article]

We study nonlinear dynamics in a model of three interacting encapsulated gas bubbles in a liquid. The model is a system of three coupled nonlinear oscillators with an external periodic force. Such bubbles have numerous applications, for instance, they are used as contrast agents in ultrasound visualization. Certain types of bubbles oscillations may be beneficial or undesirable depending on a given application and, hence, the dependence of the regimes of bubbles oscillations on the control parameters is worth studying. We demonstrate that there is a wide variety of types of dynamics in the model by constructing a chart of dynamical regimes in the control parameters space. Here we focus on hyperchaotic attractors characterized by three positive Lyapunov exponents and strange attractors with one or two positive Lyapunov exponents possessing an additional zero Lyapunov exponent, which have not been observed previously in the context of bubbles oscillations. We also believe that we provide a first example of a hyperchaotic attractor with additional zero Lyapunov exponent. Furthermore, the mechanisms of the onset of these types of attractors are still not well studied. We identify two-parametric regions in the control parameter space where these hyperchaotic and chaotic attractors appear and study one-parametric routes leading to them. We associate the appearance of hyperchaotic attractors with three positive Lyapunov exponents with the inclusion of a periodic orbit with a three-dimensional unstable manifold, while the onset of chaotic oscillations with an additional zero Lyapunov exponent is connected to the partial synchronization of bubbles oscillations. We propose several underlying bifurcation mechanisms that explain the emergence of these regimes. We believe that these bifurcation scenarios are universal and can be observed in other systems of coupled oscillators. • Mechanisms of the emergence of chaotic and hyperchaotic oscillations of microbubbles. • Partial synchronization and hyperchaotic attractors with an additional zero LE. • Inclusion of unstable periodic orbits into chaotic attractors. [ABSTRACT FROM AUTHOR]

A patent application titled "System And Method For Comminution Of Biomineralizations Using Microbubbles" has been filed by inventors William Behnke-Parks and David Bell. The application describes a method for detecting, characterizing, and treating unwanted biomineralizations, such as kidney and urinary stones, using small gas bubbles and ultrasound. The invention aims to overcome the limitations of current treatment methods by providing a minimally invasive approach that utilizes the acoustic and hydrodynamic forces of ultrasound-induced cavitation of microbubbles to break down the biomineralizations. The patent application includes various embodiments of the method and system for applying ultrasound energy to target regions containing biomineralizations. [Extracted from the article]

A recent report from the University of Illinois Urbana-Champaign discusses the use of ultrasound localization microscopy (ULM) to image deep tissue microvasculature by tracking microbubbles injected into the bloodstream. The researchers introduce a new technique called LOcalization with Awareness (LOCA)-ULM, which utilizes deep learning-based microbubble simulation and localization to improve the accuracy and efficiency of microbubble detection in high concentrations. LOCA-ULM outperformed conventional and deep learning-based methods in terms of accuracy and missing rate reduction. The researchers also demonstrated the superior performance of LOCA-ULM in functional ULM, where it increased the sensitivity of functional imaging in the rat brain. [Extracted from the article]

Working with the Clinton Health Access Initiative and the Global Ultrasound Institute, Butterfly aims to provide 500 portable probes to South Africa. [ABSTRACT FROM AUTHOR]

A report from Universitas Diponegoro discusses the challenges posed by emerging contaminants in hospital wastewater and explores the potential of ozone microbubbles as a treatment approach. The use of ozone microbubbles, a cutting-edge technology in water treatment, shows promise for removing and degrading various emerging contaminants. The report provides an overview of the current state of knowledge, identifies research gaps, and proposes future directions for effectively mitigating emerging contaminants in hospital wastewater using ozone microbubbles. The research aims to address the impact of these pollutants on the environment and public health. [Extracted from the article]

A study conducted by researchers at Justus-Liebig-University Giessen in Germany has proposed a new method for checking the position of central venous catheters (CVCs) in intensive care and emergency medicine. The researchers used a microbubbles test (MBT) to confirm correct CVC positioning and found that a threshold of 1 second for the rapid atrial swirl sign (RASS) in the MBT was reliable and accurate. The study concluded that the MBT with the new threshold of 1 second should be routinely used in patient care due to its speed, safety, and accuracy compared to traditional chest X-rays. [Extracted from the article]

A recent study conducted at Case Western Reserve University in Cleveland, Ohio, has explored the use of ultrasound-mediated drug delivery to treat liver tumors. The researchers compared the effectiveness of doxorubicin-loaded nanobubbles (NBs) and microbubbles (MBs) in delivering the drug to orthotopic rat liver tumors. The results showed that both NBs and MBs were effective in delivering the drug to the tumors, but the use of NBs resulted in significantly increased apoptotic cell death in the tumor and fewer off-target apoptotic cells in the normal liver. This suggests that the use of NBs with ultrasound could be a promising treatment modality for liver tumors. The researchers hope that their findings will contribute to the development of more effective liver cancer treatments with improved patient outcomes and decreased side effects. [Extracted from the article]

A study conducted by researchers at Dalian Medical University in Liaoning, China, explored the therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its mechanism. The study found that the schisandrin A microbubbles, when destroyed at the site of the tumor under ultrasound irradiation, promoted the intake of schisandrin A in tumor cells, resulting in the best anti-tumor effect. The research suggests that schisandrin A may have an anti-tumor effect by inhibiting the PI3K/AKT/mTOR signaling pathway. The study provides valuable insights into potential treatments for liver cancer. [Extracted from the article]

Researchers at Peking University in Guangdong, China have made advancements in the treatment of Parkinson's disease (PD) by using black phosphorus microbubbles (BP@MBs) combined with focused ultrasound (FUS) to open the blood-brain barrier (BBB). The study found that low concentrations of BP were safe and that BP quantum dot microbubbles (BPQDs@MBs) showed better biocompatibility than BP nanosheet microbubbles (BPNSs@MBs). In vitro and in vivo experiments demonstrated that BPQDs@MBs and BPNSs@MBs had antioxidant effects, reduced neuronal apoptosis, and improved motor symptoms of PD. The researchers suggest that BPQDs@MBs combined with FUS could be a promising treatment option for PD. [Extracted from the article]

A recent study conducted by researchers at the University of Southampton in the United Kingdom explored the cytotoxic effects of microbubbles and their constituents on osteosarcoma and bone marrow stromal cells. The study aimed to determine the potential toxicity of phospholipid-shelled microbubbles on human bone-derived cells. The results showed that the microbubbles had little effect on cell viability and growth, with polyoxyethylene(40) stearate (PEG40S) identified as the main inhibitory component. These findings suggest that microbubbles could be used for localized drug delivery in regenerative medicine without significant cytotoxic effects. [Extracted from the article]

A recent research article from Shandong University in China discusses the progress and preclinical application status of ultrasound microbubbles in cancer gene therapy. The article highlights the importance of targeted drug delivery to specific tissues in order to minimize systemic toxicity and optimize treatment outcomes. Ultrasound-controlled targeting using microbubbles has gained attention as a promising strategy for drug and gene delivery. The article explores the advancements in ultrasound microbubble technology, including factors influencing drug delivery and treatment strategies for diseases, with a focus on cancer therapy. The research concludes by emphasizing the potential application of ultrasound microbubbles in disease treatment. [Extracted from the article]

A recent study conducted by researchers at Hiroshima University in Japan has found that machine learning can be used to estimate the number of microbubbles generated during cardiopulmonary bypass (CPB) procedures. Microbubbles are known to occur within CPB systems and can lead to complications after cardiac surgery. The researchers developed a neural network-based model that uses five parameters to estimate the microbubble count rate. The results showed high estimation accuracy, suggesting that this system has the potential to improve patient outcomes and reduce complications associated with microbubbles. [Extracted from the article]

A patent application has been submitted for the invention of long acyl-chain phospholipid oxygen microbubbles (OMB) for treating tumor hypoxia. The OMB are designed to improve the stability, circulation, and oxygen delivery to tissues and cells, particularly hypoxic tumors. The patent application also mentions the diagnostic and therapeutic uses of OMB, including ultrasound-based imaging, drug delivery, and radiation-based cancer treatments. The inventors propose that the OMB could enhance the effectiveness of radiation treatment for hypoxic tumors. The patent application provides detailed information about the composition, methods of production, and potential applications of the OMB. [Extracted from the article]

A patent application from the University of Texas System describes a method for creating microbubbles that can deliver drugs or genetic material to cells. The microbubbles are decorated with spermine molecules and can be mixed with a solution containing payload molecules. The microbubble composition can also include targeting molecules to bind to specific cells. The method involves exposing cells to the microbubbles and using ultrasound to sonoporate the cells, allowing the payload to enter. The patent application provides detailed information about the composition and size of the microbubbles. [Extracted from the article]

A new report from Army Medical University in Chongqing, China, presents fresh data on the use of ultrasound and microbubbles to enhance tumor perfusion. The study aimed to determine the optimal ultrasound exposure time and mechanical index for this effect and explore the underlying mechanisms. The researchers found that tumor perfusion increased after ultrasound-stimulated microbubble treatment, with the best results achieved at a mechanical index of 0.3 and an ultrasound exposure time of 450 seconds. The study suggests that this "sononeoperfusion" effect could be a novel approach to improving tumor hypoperfusion and hypoxia. [Extracted from the article]

Researchers at Guangxi University in Nanning, China have made progress in the field of bioengineering by developing a microfluidic device that can modulate membrane permeability through oscillating three-dimensional arrays of microbubbles. This technique, known as sonoporation, has applications in cell therapy, drug delivery, and biomanufacturing. The researchers used a high-precision 3D printer to fabricate microstructures that generate microbubbles, which oscillate with consistent amplitudes and frequencies to ensure efficient and stable sonoporation. The study found that at a driving voltage of 30 Vpp, the sonoporation efficiency of cells reached 93.9%. [Extracted from the article]

A new microdroplet generation technique based on the bubble oscillation in a funnel-like chamber is developed and investigated numerically using combined BEM-finite difference method. In this technique, the droplet is generated and ejected from the top opening of the chamber due to the oscillation of a transient bubble inside. The water in the chamber is exposed to the atmospheric air from the top side and is connected to a liquid reservoir from the bottom side. The bubble may be generated by an electrical spark, a laser beam or a high-intensity focused ultrasound (HIFU). The effects of the bubble-free surface distance (standoff distance) on the bubble and the ensuing droplet characteristics are evaluated. It was found that the when the bubble is initiated at the narrow part of the chamber it will be affected by the chamber's lateral wall so that parts of its surface that are closer to the wall takes the wall shape. As the bubble gets closer to the free surface, the wall effects are attenuated. In addition, the droplet size and pinch off time depend on the standoff distance so that as the standoff distance increases the droplet size decreases but its pinch off time increases. [ABSTRACT FROM AUTHOR]

A new report discusses the research on ultrasound technology and its potential applications in medicine. The researchers from Ariel University in Israel highlight the non-invasive and cost-effective nature of ultrasound technology, which can be used for clinical imaging and cancer therapy. The study explores the use of ultrasound in colloidal nanocrystal synthesis and biomedical applications, such as neuromodulation and sonodynamic immunotherapy. The researchers emphasize the need for further development of ultrasound technology to improve efficiency, precision, and patient care. The full research article can be accessed for free through the provided link. [Extracted from the article]

A patent application has been submitted by inventors Hirokazu Ando and Takahiro Shibata for a medical introducer sheath with a measure against air intrusion. The sheath is designed for medical treatment methods such as catheter ablation and has a wire-driven steerable tip. The inventors discovered that micro bubbles can occasionally intrude into the sheath, leading to the development of this device. The patent application provides detailed information about the structure and components of the introducer sheath. The assignee of the patent is Togo Medikit Co. Ltd. [Extracted from the article]

Researchers at Peking Union Medical College Hospital in Beijing, China have conducted a study on portal hypertension (PH) discrimination and the estimation of portal vein pressure (PVP). The study focused on the use of ultrasound contrast agent microbubbles to measure PVP in canine models. The results showed promising correlations between the subharmonic amplitude of the microbubbles and PVP, as well as high diagnostic capacity for PH. This noninvasive technique could potentially serve as an alternative to invasive measurements for portal pressure. Further research is planned to assess its feasibility in clinical practice. [Extracted from the article]

A recent study explored the use of gold nanoparticles as contrast agents for CT imaging of the gastrointestinal tract in patients with ulcerative colitis (UC), a chronic inflammatory bowel disease. The study found that the size of the nanoparticles did not significantly affect their ability to produce contrast in CT imaging. In vivo imaging using a mouse model of acute colitis showed strong contrast generation throughout the gastrointestinal tract for all nanoparticle sizes tested. The study suggests that gold nanoparticles have potential as effective contrast agents for CT imaging of the gastrointestinal tract in UC, but further research is needed to develop agents that can specifically image disease processes in this setting. [Extracted from the article]

Researchers from Nanjing University in China have conducted a study on exocytosis, the process by which cells release substances. They have developed a cell-like construct called EMB-Hu that can disrupt biofilms, enhance the penetration of antibacterial species, and activate macrophages for the elimination of biofilms. This research has potential therapeutic effects against implant infections caused by methicillin-resistant Staphylococcus aureus (MRSA) biofilms. The study was funded by various organizations, including the Natural Science Foundation of Jiangsu Province and the National Natural Science Foundation of China. [Extracted from the article]

A recent study conducted by China Agricultural University in Beijing, China, has found that ozone microbubble treatment can effectively remove pesticide residues from fruits. The study focused on three fruits (strawberry, cherry, and apricot) and four pesticide residues (emamectin benzoate, azoxystrobin, boscalid, and difenoconazole). The researchers discovered that the ozone treatment resulted in substantial removal of the pesticide residues, with removal rates ranging from 51% to 84%. Importantly, the treatment did not significantly affect the vitamin C content of the fruits. This research provides a pollution-free method for enhancing food safety by reducing pesticide residues on fruits. [Extracted from the article]

Insightec Ltd. has been granted a patent for a simulation-based drug treatment planning system that aims to temporarily and locally open the blood-brain barrier (BBB) to allow therapeutic agents to reach the brain tissue. The system uses focused ultrasound and microbubble cavitation to disrupt the BBB, and treatment is planned and adjusted through computational simulations. This system has the potential to benefit patients with brain diseases such as infections, neurodegenerative diseases, enzyme defects, and brain cancer. [Extracted from the article]

Researchers at National Tsing Hua University in Taiwan have conducted a study on the relationship between the surface drug distribution of drug-loaded microbubbles (MBs) and drug release/cavitation behaviors with ultrasound. The study found that stable cavitation was sufficient for triggering uniform-loaded MBs to release their payload, while stable cavitation and inertial cavitation were required for cluster-loaded MBs. The study also revealed that cluster-loaded MBs had the potential for multiple drug releases upon ultrasound sonication. This research provides valuable insights into drug-loaded MBs and their potential for enhancing drug delivery. [Extracted from the article]

A recent study conducted by the Institute of Experimental Molecular Imaging in Aachen, Germany, has provided new information about drug delivery systems. The study focused on the use of nonspherical microbubbles (MB) for ultrasound imaging and drug delivery. The researchers found that nonspherical MB, which were surface-modified with blood-brain barrier (BBB)-specific targeting ligands, were more efficient at binding to BBB endothelium and enhancing drug delivery to the brain compared to spherical MB. These findings demonstrate the potential of antibody-modified nonspherical MB for targeted and triggered drug delivery to the brain. [Extracted from the article]

Researchers at Nanjing University of Posts and Telecommunications in Nanjing, People's Republic of China, have developed a coordination-crystallization approach to prepare platinum nanoparticle-anchored metal-organic complexes (Pt-MOCs) for enhanced sonodynamic therapy of tumors. The Pt-MOCs possess uniform and adjustable diameters and show excellent cytotoxicity for tumor cells under ultrasound irradiation. The research highlights the potential of combining noble metal nanoparticles with metal-organic complexes in biomedical applications. This study provides valuable insights into the synthesis and application of Pt-MOCs for sonodynamic therapy. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the potential use of ultrasmall silver sulfide nanoparticles (Ag2S-NP) as contrast agents for dual-energy mammography. The abstract highlights the advantages of Ag2S-NP over currently available agents, including higher contrast and biocompatibility. The researchers report the use of a scalable silicon microfluidic system (SSMS) for large-scale synthesis of Ag2S-NP, which yielded similar quality nanoparticles as measured by core size, concentration, and contrast generation. In vivo imaging and renal clearance of the nanoparticles were also confirmed. The study suggests that this method could pave the way for clinical translation of Ag2S-NP. [Extracted from the article]

A recent report from George Washington University discusses the use of ultrasound contrast agents, which are micron-sized bubbles coated with lipids/proteins, in tissue engineering. The report highlights the harmful and beneficial effects of these agents and focuses on their role in non-invasive pressure estimation and ultrasound-assisted bone and cartilage tissue engineering. The researchers studied the oscillations and microstreaming of the microbubbles using simulation and perturbative analysis. The effects of ultrasound parameters and the mechanical properties of the coating on bubble behavior and fluid pressure were also investigated. The full article can be accessed for free through the provided link. [Extracted from the article]

A study conducted at Tianjin University in China has explored the use of ultrasound and microbubbles in enhancing cancer therapy. The researchers designed a 3D vascularized microfluidic cancer model to study the mechanisms of this therapy. They found that increasing microbubble concentration and flow rate, as well as decreasing the viscosity of the gel, enhanced microbubble penetration in agarose gel. The study also demonstrated improved cancer cell penetration and direct damage in the 3D tissue model. These findings provide new insights into the mechanisms of ultrasound and microbubble enhanced cancer therapy at the tissue level. [Extracted from the article]

A study conducted at Zhengzhou University in China explores the use of green synthesis to improve the contrast-enhancing effect of microbubbles in ultrasound imaging. The researchers synthesized reduced graphene oxide using ellagic acid and mixed it with SonoVue to create SV@rGO-EA microbubbles. The microbubbles were found to have enhanced echo intensity and mechanical index tolerance, surpassing the performance of SV microbubbles both in vitro and in vivo. This research demonstrates the potential application of graphene derivatives in ultrasound precision medicine. [Extracted from the article]