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Background/aims: Hypercalciuria is the most common identifiable risk factor predisposing to CaOx stone formation. Increased oral magnesium intake may lead to decreased CaOx stone formation by binding intestinal Ox leading to decreased absorption and/or binding urinary Ox to decrease urinary supersaturation. This study assessed the effect of oral magnesium on 24-h urine ion excretion, supersaturation, and kidney stone formation in a genetic hypercalciuric stone-forming (GHS) rat model of human idiopathic hypercalciuria., Methods: When fed the oxalate precursor, hydroxyproline, every GHS rat develops CaOx stones. The GHS rats, fed a normal calcium and phosphorus diet supplemented with hydroxyproline to induce CaOx, were divided into three groups of ten rats per group: control diet with 4.0 g/kg MgO, low MgO diet (0.5 g/kg), and high MgO diet (8 g/kg). At 6 weeks, 24-h urines were collected, and urine chemistry and supersaturation were determined. Stone formation was quantified., Results: The GHS rats fed the low and high Mg diets had a significant reduction and increase, respectively, in urinary Mg compared to those fed the control diet. Dietary Mg did not alter urine Ca excretion while the low Mg diet led to a significant fall in urinary Ox. Urine supersaturation with respect to CaOx was significantly increased with low Mg, whereas urine supersaturation was significantly decreased with high Mg. There was no effect of dietary Mg on stone formation within 6 weeks of treatment., Conclusion: Dietary magnesium decreases urine supersaturation but not CaOx stone formation in GHS rats., (© 2024 S. Karger AG, Basel.)

It wasn't always crystal clear: Ada Yonath. [ABSTRACT FROM AUTHOR]

Kidney stone disease is a serious public health concern that is getting worse with changes in diet, obesity, medical conditions, certain supplements etc. A kidney stone also called a renal calculus, is a hard buildup of urine minerals that form in the kidneys. Computed tomography (CT) is one of the imaging models used to identify kidney stones by clinical experts. Due to the low resolution of these images, sometimes detecting kidney stones is tedious with the naked eye, which may lead to false alarms. In this work, a computer-based diagnosis system with a deep learning technique has been developed as a practical solution to aid clinicians in their diagnosis. The traditional convolutional neural network (CNN)-based deep learning technology can detect stones in the kidney. Still, it suffers from the performance and standard implementation of the convolution operations in convolution layers. A Kronecker product-based convolution technique is incorporated in the proposed deep learning architecture to reduce the redundancy in feature maps without convolution overlapping. Our proposed method helps to make the network more effective by extracting abstract and in-depth features from the input images. The publicly available GitHub kidney stone CT scans are utilized to develop the proposed architecture. Our automated model detected kidney stones with an accuracy of 98.56% utilizing CT images. Our system is more effective than the most recent and cutting-edge techniques developed for identifying kidney stones of any size, including the smallest ones. [ABSTRACT FROM AUTHOR]

Acute renal colic is an incapacitating condition. Advances in understanding the pathogenesis of calculi and their detection and treatment require a new approach to aeromedical risk assessment. Can this new information support the stratification of aeromedical risk into "High" and "Low" categories, and fulfill the paramount responsibility of the Civil Aviation Safety Authority, Australia's aviation regulator, which is the maintenance of aviation safety? This article reviews the epidemiology of calculi and finds 2-10% annual risk of a symptomatic event following incidental detection of a calculus. While calculi 4 mm or less in size may not require surgical intervention, this does not equate to a pain-free passage. Similarly, calculus recurrence rates may vary in different anatomical locations, but no location can be considered "safe." The recognition of parenchymal calcification and Randall's plaques as precursors to the development of calculi places such individuals at elevated risk of developing calculi. More recently evidence has supported a link between metabolic syndrome and calculus formation. In an occupational group where there is potential for elevated radiation exposure, appropriate imaging is of particular importance. CT, X-ray, and ultrasound modalities are reviewed with recommendations presented for aeromedical assessment and surveillance based on identification of those at high risk of colic and minimization of investigational radiation exposure. [ABSTRACT FROM AUTHOR]

Background: Nephrolithiasis is a common medical condition among aviation personnel that can negatively impact their health and careers. Due to the potentially severe consequences of in-flight renal colic associated with nephrolithiasis, current Navy regulations stipulate extensive evaluation for any aircrew member who has an instance of kidney stones. Case Report: Two cases of Naval aircrew members with kidney stones are reviewed and current Navy standards regarding nephrolithiasis are discussed. Discussion: Current Navy standards for granting aeromedical waivers for kidney stones do not differentiate between pilots in actual control of the aircraft and other aircrew members among aircraft personnel. Furthermore, a premium is placed on stone-free status, even for asymptomatic, incidentally found nephroliths. This policy has many similarities, but also significant differences from those of other services and those of civilian aviation authorities. This difference in protocols across aviation communities should be re-examined in order to promote more efficient return to flying duties of operational personnel without compromising safety of flight. [ABSTRACT FROM AUTHOR]

The article focuses on the development of renal stones among astronauts. Humans are living longer in the microgravity environment because of the continued construction of the International Space Station. Astronauts must be prescribed individualized recommendations and may include increased fluid intake, dietary changes or medications to minimize the risk of stone formation.

Discusses the inhibitory effect of green tea on urinary stone formation, referencing the study "Effects of Green Tea on Urinary Stone Formation: An in Vivo and In Vitro Study," B. C. Jeong et al.