Search

Researchers from the University of Texas MD Anderson Cancer Center have released a new report on the immunobiology of myelodysplastic neoplasms (MDS). The report focuses on the interactions between immune cells, cytokines, and dysplastic cells within the tumor microenvironment in the bone marrow. It discusses how immune dysregulation and evasion impact the initiation and progression of MDS, as well as resistance to therapy and progression to acute myeloid leukemia (AML). The report also highlights various therapeutic strategies and proposes future research directions to enhance clinical outcomes and survival for MDS patients. [Extracted from the article]

A new study published in the journal Science Immunology suggests that inherited diseases of metabolism and immunity have more similarities than previously recognized. The study found that a large number of genes associated with inborn errors of metabolism can also potentially affect T cell function when they are mutated. This suggests that patients with an inborn error of metabolism may also have immune defects, and vice versa. The findings could lead to new therapies and improve care for patients with these rare and complex diseases. The study was conducted by researchers at Vanderbilt University Medical Center using a gene-editing CRISPR approach. [Extracted from the article]

A recent study conducted by researchers at the University of California explores the immunobiology of herpes simplex virus 1 (HSV-1) and its impact on the cornea. HSV-1 primarily infects the epithelial cells lining the orofacial mucosa and establishes lifelong latency in neurons within the trigeminal ganglion. Patients with compromised immune systems experience frequent reactivation of HSV-1, which can lead to herpetic stromal keratitis (HSK), a chronic immuno-inflammatory condition that can cause vision loss and blindness. Currently, there is no cure or successful vaccine for HSV-1 infections, and the conventional clinical management of HSK relies on antivirals, anti-inflammatory drugs, and surgical interventions. However, these treatments have limitations, such as drug toxicities and the emergence of drug-resistant strains. The study suggests exploring alternate therapeutic strategies, including immunoregulatory cytokines and immunometabolism modulators, to effectively manage HSK. [Extracted from the article]

A recent report from Massachusetts General Hospital highlights the emerging roles of TANK-binding kinase 1 (TBK1) in cancer immunobiology. TBK1 is a protein kinase that plays a role in innate immunity, metabolism, autophagy, cell death, and inflammation. It has been found to have a role in cancer cell-intrinsic immune evasion and in regulating lymphoid and myeloid cells in the tumor immune microenvironment. The research provides insights into the tumor-intrinsic and -extrinsic roles and regulation of TBK1 in tumor immunity. This information may be valuable for those studying cancer and its immunobiology. [Extracted from the article]

The James P. Allison Institute at The University of Texas MD Anderson Cancer Center has appointed two new associate members, Susan Bullman, Ph.D., and Xi Chen, Ph.D., to contribute to their ongoing immunobiology research. Bullman and Chen are experts in studying the intratumoral microbiome and the immune microenvironment's impact on patient responses to immunotherapy. As members of the Allison Institute, they will lead research programs focused on understanding tumor immunity and developing novel therapies. The Allison Institute aims to integrate immunobiology across disciplines to advance cancer research and treatment. [Extracted from the article]

A study from the Max Planck Institute of Immunobiology and Epigenetics has uncovered a mechanism by which daughter cells protect themselves from UV-induced RNA damage inherited from their mother cells. The researchers discovered that a protein called DHX9 forms droplet structures in the cytoplasm of cells after UV radiation. These droplets, known as DHX9 granules, contain damaged RNA and effectively trap and neutralize the harmful molecules, preventing them from causing further harm. Understanding this defense mechanism could lead to new therapeutic targets for diseases related to RNA mismanagement or dysregulation of the stress response. [Extracted from the article]

A recent study conducted by researchers from Adamas University in West Bengal, India, explores the use of neoantigens in cancer immunotherapy. Neoantigens are tumor-specific antigens expressed on cancer cells, making them ideal targets for the immune system to identify and attack. The study highlights the potential of neoantigen-based vaccines in personalized and effective tumor treatments. The research emphasizes the significance of neoantigens in cancer immunotherapy, their classification and identification, the synthesis of neoantigen vaccines, clinical trials, and the principles underlying their therapeutic efficacy. [Extracted from the article]

A recent study published in the scientific journal Nature has discovered a mechanism that safeguards the expression of certain genes in humans. The researchers found that a protein called MSL2 ensures the expression of both alleles of specific genes, which is crucial for maintaining the right dosage of messenger RNA. This mechanism is particularly important for haploinsufficient genes, which rely on the continuous expression of two intact alleles. The researchers believe that this discovery could have implications for understanding diseases and developing potential treatments. [Extracted from the article]

A recent study conducted at the Mayo Clinic in Scottsdale, Arizona, explores the immunobiology of cancer stem cells (CSCs) and their ability to evade the immune system. CSCs are a small fraction of cells within tumors that possess stem cell-like characteristics and are resistant to therapy. The study highlights the importance of understanding the interactions between CSCs and the tumor microenvironment, particularly immune cells, in order to develop effective therapies and improve patient outcomes. The research aims to provide insights into the immunoevasion mechanisms employed by CSCs. This study has been peer-reviewed and published in Molecular Biology Reports. [Extracted from the article]

A report from Yale University School of Medicine discusses the immunobiology and metabolic pathways of renal cell carcinoma (RCC). The researchers emphasize the importance of understanding the specific immunobiology and metabolic dysregulation of RCC for the development of future therapeutics. They note that while RCC is immunogenic, conventional biomarkers of immune checkpoint inhibitor response are not predictive. The researchers also highlight the impact of metabolic changes on infiltrating immune cells and the tumor microenvironment in RCC. Strategies to pharmacologically target these metabolic changes have so far been unsuccessful. [Extracted from the article]

The implications of this discovery are far-reaching, suggesting that the balance of protein acetylation in mitochondria may be a critical factor in protecting cells from metabolic catastrophe. Keywords: Acetyltransferases; Cellular Structures; Cytoplasm; Cytoplasmic Structures; Enzymes and Coenzymes; Genetics; Health and Medicine; Immunobiology; Intracellular Space; Max Planck Institute of Immunobiology and Epigenetics; Mitochondria; Mitochondrial Proteins; Organelles; Subcellular Fractions EN Acetyltransferases Cellular Structures Cytoplasm Cytoplasmic Structures Enzymes and Coenzymes Genetics Health and Medicine Immunobiology Intracellular Space Max Planck Institute of Immunobiology and Epigenetics Mitochondria Mitochondrial Proteins Organelles Subcellular Fractions 413 413 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- The intricate control of cellular metabolism relies on the coordinated and harmonious interplay between the nucleus and mitochondria. In previous studies, Asifa Akhtar's lab was able to detect MOF and several of its protein partners in mitochondria. [Extracted from the article]

Keywords for this news article include: Cilia, Podocytes, Organelles, Cellular Structures, Health and Medicine, Intracellular Space, Cytoplasmic Structures, Cell Surface Extensions, Max Planck Institute of Immunobiology and Epigenetics. Keywords: Cell Surface Extensions; Cellular Structures; Cilia; Cytoplasmic Structures; Genetics; Health and Medicine; Immunobiology; Intracellular Space; Max Planck Institute of Immunobiology and Epigenetics; Organelles; Podocytes EN Cell Surface Extensions Cellular Structures Cilia Cytoplasmic Structures Genetics Health and Medicine Immunobiology Intracellular Space Max Planck Institute of Immunobiology and Epigenetics Organelles Podocytes 2303 2303 1 09/11/23 20230911 NES 230911 2023 SEP 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Cilia are thin, eyelash-like extensions on the surface of cells. Cell Surface Extensions, Cellular Structures, Cilia, Cytoplasmic Structures, Genetics, Health and Medicine, Immunobiology, Intracellular Space, Max Planck Institute of Immunobiology and Epigenetics, Organelles, Podocytes. [Extracted from the article]

The goal of this discovery and exploratory study is to: Understand changes in the immune system associated with various cancer treatments, in order to better design new therapies or tests to predict how these treatments might work. Keywords: Antigens; Biological Factors; Blood Cells; Bronchoscopy; Cancer; Cancer Therapy; Cell Research; Clinical Research; Clinical Trials and Studies; Diagnostics and Screening; Drugs and Therapies; Epidemiology; Gastroenterology; Genetics; Health and Medicine; Hemic and Immune Systems; Immunobiology; Immunology; Immunotherapy; Lymph Nodes; Lymphoid Tissue; Oncology; Oncology - Cancer; Risk and Prevention; Surgical Procedures EN Antigens Biological Factors Blood Cells Bronchoscopy Cancer Cancer Therapy Cell Research Clinical Research Clinical Trials and Studies Diagnostics and Screening Drugs and Therapies Epidemiology Gastroenterology Genetics Health and Medicine Hemic and Immune Systems Immunobiology Immunology Immunotherapy Lymph Nodes Lymphoid Tissue Oncology Oncology - Cancer Risk and Prevention Surgical Procedures 202 202 1 08/28/23 20230831 NES 230831 2023 AUG 31 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Vaccine Week -- Staff editors report on the newly launched clinical trial, NCT05995821, which has the following summary description: "This research is being done to collect and store biological specimens (biospecimens) from people with cancer, regardless of tumor type, who are receiving treatments known or thought to have an effect on the immune system. The goal of this discovery and exploratory study is to: Understand changes in the immune system associated with various cancer treatments, in order to better design new therapies or tests to predict how these treatments might work. [Extracted from the article]

For more information on this research see: System Biology Investigation Revealed Lipopolysaccharide and Alcohol-Induced Hepatocellular Carcinoma Resembled Hepatitis B Virus Immunobiology and Pathogenesis. Keywords: Bacterial Polysaccharides; Bacterial Toxins; Biological Factors; Cancer; Carcinomas; DNA Viruses; Digestive System Diseases and Conditions; Endotoxins; Gastroenterology; Genetics; Health and Medicine; Hepadnaviridae; Hepatitis; Hepatitis B Virus; Hepatology; Immunobiology; Infectious Diseases and Conditions; Lipopolysaccharides; Liver Cancer; Liver Diseases and Conditions; Oncology; Orthohepadnavirus; Risk and Prevention; Virology EN Bacterial Polysaccharides Bacterial Toxins Biological Factors Cancer Carcinomas DNA Viruses Digestive System Diseases and Conditions Endotoxins Gastroenterology Genetics Health and Medicine Hepadnaviridae Hepatitis Hepatitis B Virus Hepatology Immunobiology Infectious Diseases and Conditions Lipopolysaccharides Liver Cancer Liver Diseases and Conditions Oncology Orthohepadnavirus Risk and Prevention Virology 277 277 1 07/24/23 20230724 NES 230724 2023 JUL 25 (NewsRx) -- By a News Reporter-Staff News Editor at Hepatitis Weekly -- Fresh data on hepatitis B virus are presented in a new report. [Extracted from the article]

Keywords: Cytokines; Drugs and Therapies; Health and Medicine; Immunobiology; Immunotherapy; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Myeloid Cells; Therapy; Tumor Necrosis Factors EN Cytokines Drugs and Therapies Health and Medicine Immunobiology Immunotherapy Intercellular Signaling Peptides and Proteins Membrane Proteins Myeloid Cells Therapy Tumor Necrosis Factors 1490 1490 1 06/26/23 20230627 NES 230627 2023 JUN 30 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- A new study on immunotherapy is now available. The news correspondents obtained a quote from the research from Russian Academy of Sciences: "Due to the particular organization of the TNF gene coding sequence, all cells producing soluble TNF also carry a membrane-bound cytokine on their surface. [Extracted from the article]

Keywords: Breast Cancer; Cancer; Genetics; Health and Medicine; Immunobiology; Immunology; Oncology; Women's Health EN Breast Cancer Cancer Genetics Health and Medicine Immunobiology Immunology Oncology Women's Health 1245 1245 1 06/19/23 20230620 NES 230620 2023 JUN 20 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New study results on breast cancer have been published. Breast Cancer, Cancer, Genetics, Health and Medicine, Immunobiology, Immunology, Oncology, Women's Health. [Extracted from the article]

KP2 was treated with oxaliplatin and olaparib (OXPARPi), and a resistant cell line was subsequently cloned to generate multiple genetically distinct cell lines (KP2-OXPARPi clones). Keywords: St. Louis; State:Missouri; United States; North and Central America; Cancer; Cell Line; Gastroenterology; Genetics; Health and Medicine; Immunobiology; Immunology; Oncology; Pancreas; Pancreatic Cancer; Pancreatic Neoplasms EN St. Louis State:Missouri United States North and Central America Cancer Cell Line Gastroenterology Genetics Health and Medicine Immunobiology Immunology Oncology Pancreas Pancreatic Cancer Pancreatic Neoplasms 33 33 1 06/12/23 20230612 NES 230612 2023 JUN 12 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Vaccine Week -- Fresh data on Oncology - Pancreatic Cancer are presented in a new report. [Extracted from the article]

These active genes are transcribed from the DNA template into distinct messenger RNA (mRNA) molecules and will encode the proteins the cell needs to function. Keywords: Genetics; Health and Medicine; Immunobiology; Max Planck Institute of Immunobiology and Epigenetics; Technology EN Genetics Health and Medicine Immunobiology Max Planck Institute of Immunobiology and Epigenetics Technology 6576 6576 1 05/29/23 20230602 NES 230602 2023 JUN 2 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- All cells in an organism contain identical DNA sequence. Genetics, Health and Medicine, Immunobiology, Max Planck Institute of Immunobiology and Epigenetics, Technology. [Extracted from the article]

Keywords: Genetics; Government Agencies Offices and Entities; Health and Medicine; Immunobiology; Insulin Dependent Diabetes Mellitus; Non-Insulin Dependent Diabetes Mellitus; Nutritional and Metabolic Diseases and Conditions; Peptide Hormones; Peptide Proteins; Proinsulin; Proteins; Transcription Factors; Type 2 Diabetes; Van Andel Research Institute EN Genetics Government Agencies Offices and Entities Health and Medicine Immunobiology Insulin Dependent Diabetes Mellitus Non-Insulin Dependent Diabetes Mellitus Nutritional and Metabolic Diseases and Conditions Peptide Hormones Peptide Proteins Proinsulin Proteins Transcription Factors Type 2 Diabetes Van Andel Research Institute 302 302 1 04/10/23 20230410 NES 230410 2023 APR 10 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- GRAND RAPIDS, Mich. () - A team led by Van Andel Institute and Max Planck Institute of Immunobiology and Epigenetics scientists has identified two distinct subtypes of insulin-producing beta cells, or b cells, each with crucial characteristics that may be leveraged to better understand and treat Type 1 and Type 2 diabetes. b cells are critical guardians of the body's metabolic balance. Type 2 diabetes arises from insulin resistance; the resulting excess blood sugar from a person's diet causes b cells in the pancreas to work overtime. [Extracted from the article]

Keywords for this news article include: University of Coimbra, Coimbra, Portugal, Europe, Immunobiology, Health and Medicine. Keywords: Health and Medicine; Immunobiology EN Health and Medicine Immunobiology 5470 5470 1 03/24/23 20230224 NES 230224 2023 FEB 24 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on agriculture is now available. [Extracted from the article]

Cancer Research, Drugs and Therapies, Health and Medicine, Immunobiology Keywords: Cancer Research; Drugs and Therapies; Health and Medicine; Immunobiology EN Cancer Research Drugs and Therapies Health and Medicine Immunobiology 943 943 1 03/24/23 20230224 NES 230224 2023 FEB 21 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on cancer research. The news correspondents obtained a quote from the research from University of Navarra: "However, ENPP1 is frequently overexpressed in local relapses, and tumor metastases, which associates with poor prognosis and survival in a range of solid tumors. [Extracted from the article]

Keywords: Milan; Italy; Europe; DNA Viruses; Digestive System Diseases and Conditions; Gastroenterology; Health and Medicine; Hepadnaviridae; Hepadnaviridae Infections; Hepatitis; Hepatitis B Virus; Hepatology; Immunobiology; Immunology; Infectious Diseases and Conditions; Liver Diseases and Conditions; Orthohepadnavirus; Risk and Prevention; Viral; Virology EN Milan Italy Europe DNA Viruses Digestive System Diseases and Conditions Gastroenterology Health and Medicine Hepadnaviridae Hepadnaviridae Infections Hepatitis Hepatitis B Virus Hepatology Immunobiology Immunology Infectious Diseases and Conditions Liver Diseases and Conditions Orthohepadnavirus Risk and Prevention Viral Virology 2023 FEB 20 (NewsRx) -- By a News Reporter-Staff News Editor at Hepatitis Weekly -- Data detailed on Liver Diseases and Conditions - Hepatitis B Virus have been presented. For more information on this research see: Immunobiology and Pathogenesis of Hepatitis B Virus Infection. [Extracted from the article]

Aloe is a genus of medicinal plants with a notable history of medical use. Basic research over the past couple of decades has begun to reveal the ex tent of Aloe's pharmaceutical potential, particularly against neoplastic disease. This review look at Aloe, both the genus and the folk medicine often being called informally "aloes", and delineates their chemistry and anticancer pharmacognosy. Structures of key compounds are provided, and their pharmacological activities reviewed. Particular attention is given to their free radical scavenging, antiproliferative, and immunostimulatory properties. This reviewhighlightsmajor research directions on aloes, reflecting the enormous potential of natural sources, and of the genus Aloe in particular, in preventing and treating cancer. [ABSTRACT FROM AUTHOR]