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A recent study conducted by researchers from the University of Pittsburgh focuses on the importance of allele-specific expression in understanding biological mechanisms. The researchers developed a computational tool called Ornaments, which accurately estimates allele-specific transcript expression while correcting for read mapping biases. The tool improves the efficiency and accuracy of existing methods and has been shown to detect imprinted transcripts with higher sensitivity. This research has been peer-reviewed and published in The American Journal of Human Genetics. For more information, readers can contact Seyoung Kim at the University of Pittsburgh. [Extracted from the article]

A recent study conducted by researchers at the University of Gothenburg has identified alterations in the methylation patterns of imprinted genes in neuroblastoma tumors. The researchers found that several imprinted regions displayed aberrant methylation patterns, which were associated with reduced overall survival in patients. These findings suggest that methylation status of imprinted genes could serve as important clinical epigenetic markers for identifying individuals with adverse prognosis in neuroblastoma. Further research is needed to incorporate these markers into existing risk predictors to refine the prognostication of neuroblastoma patients. [Extracted from the article]

A recent study conducted by Northwestern University and the University of Texas-Southwestern has found that bacterial cells can transmit memories of temporary changes to their bodies and surroundings to their offspring for multiple generations. This challenges the assumption that heritable physical characteristics in bacteria are primarily determined by DNA. The study suggests that these memories, which are not encoded in the cell's genetics, are stored in the regulatory network of genes. This discovery could have implications for medical applications, such as circumventing antibiotic resistance. [Extracted from the article]

A patent has been issued to the Whitehead Institute for Biomedical Research for methods of editing DNA methylation. DNA methylation plays a crucial role in various biological processes, and abnormal methylation has been observed in cancer and neurological disorders. The patent describes methods of modifying genomic sequences in cells by introducing a catalytically inactive nuclease fused to an effector domain with methylation or demethylation activity. These tools have the potential to provide insights into the functional significance of DNA methylation in gene expression, cell fate determination, and chromatin organization. The patent also mentions the possibility of using these methods for screening and generating transgenic mice to study specific DNA methylation events. [Extracted from the article]

A recent study conducted by researchers at Ghent University in Belgium has found that loss-of-imprinting (LOI) of HM13, a gene involved in epitope generation, is associated with poor prognosis in clear cell renal cell carcinoma (ccRCC). The researchers performed a genome-wide analysis on 240 stage 1 ccRCC samples and found LOI of HM13, which led to overexpression of the gene and was associated with decreased survival rates. The study suggests that HM13 LOI is an early event in ccRCC and may serve as a potential prognostic marker for the disease. [Extracted from the article]

A recent study conducted by the University of Duisburg-Essen in Germany explores the role of epigenetics in rare diseases and conditions. Epigenetic control systems, which involve chromatin modifications, play a crucial role in gene expression and cell fate decisions. Aberrant chromatin states, known as epimutations, can contribute to disease development. The research suggests that DNA methylation testing is an important diagnostic tool for several diseases. This study provides valuable insights into the impact of epigenetics on rare diseases and offers potential avenues for further research and diagnosis. [Extracted from the article]

A patent has been issued to Boehringer Ingelheim International GmbH for integration sites in Chinese hamster ovary (CHO) cells. The patent describes a method for stable integration of heterologous polynucleotides into the S100A gene cluster of the CHO cell genome, resulting in increased production of a heterologous gene product. This targeted integration approach eliminates the need for extensive screening procedures and allows for predictable and high-level production of biopharmaceutical proteins. The patent also includes claims for CHO cell lines and methods for their production. [Extracted from the article]

A patent has been issued to the University of Connecticut for compositions and methods for treating disorders of genomic imprinting. The patent focuses on Prader-Willi syndrome (PWS), a genetic disorder that affects 1 in 10,000 to 30,000 people. PWS is characterized by neonatal hypotonia, hyperphagia, obesity, and other behavioral and psychiatric abnormalities. The patent describes a DNA targeting system that aims to activate silenced maternal RNA transcripts at the PWS locus, potentially providing an effective treatment for PWS and its manifestations. The patent also mentions the use of growth hormone therapy and other drugs to manage PWS symptoms. [Extracted from the article]

A recent study from Zhejiang University in China explores the role of epigenetic regulation in cardiovascular diseases. Epigenetics refers to changes in gene expression and function that do not alter DNA sequences. The study highlights the importance of epigenetic modifications in regulating gene expression, cell differentiation, and genome structure. The researchers discuss the links between epigenetic modifications and metabolic cardiovascular diseases such as heart disease, hypertension, and atherosclerosis. They also suggest that nucleic acid epigenetic modifications hold promise for clinical medicine and biomedical applications. [Extracted from the article]

This patent application presents a new method for detecting methylation in DNA or RNA molecules using machine learning. The current methods for measuring methylation have limitations, and the inventors propose using kinetic signals produced during sequencing to determine methylation patterns. By training machine learning models to detect methylation using these signals, more accurate diagnoses and potential clinical applications can be achieved. The method involves sequencing the molecules, measuring pulses in the signal, creating an input data structure, and inputting it into a machine learning model. This method has potential applications in DNA sequencing and epigenetic research. [Extracted from the article]

According to a preprint abstract, researchers have found that the gene Mest is highly expressed in the mesenchymal cells of the blastema, which is involved in the regeneration of the mouse digit tip following amputation. The study shows that Mest expression is specific to regeneration and not upregulated in other parts of the digit. Mice with a homozygous knockout of Mest exhibit delayed bone regeneration, suggesting that Mest is required for proper digit tip regeneration. The study also suggests that Mest expression is involved in modulating the neutrophil response. However, it should be noted that this preprint has not been peer-reviewed. [Extracted from the article]

Researchers from Tongji University in Shanghai, China have conducted a study on transcription factors (TFs) and their role in early embryonic development. The study used uliCUT&RUN-seq to identify a TFAP2C-centered regulatory network that involves promoter-enhancer interactions and regulates cell polarization. The researchers also found that maternal retinoic acid metabolism and genetic information can influence TF positioning and parental gene expressions. The study proposes a ternary model of TF regulation in murine embryonic development, with TFAP2C as the core element. This research has been peer-reviewed and provides valuable insights into the complex mechanisms of embryonic development. [Extracted from the article]

A study conducted by researchers at Indiana University in Indianapolis explores the evolution of testicular germ cell tumors in the molecular era. The study reveals that the current classification of these tumors is based on their pathogenesis driven by different genomic events. Germ cell neoplasia in situ is identified as the precursor lesion for all malignant germ cell tumors. The research also highlights the role of specific molecular markers in diagnosing and managing these tumors, suggesting that they may become gold standards in the future. [Extracted from the article]

A study conducted by researchers at Helmholtz Munich has found that a father's diet before conception can influence the health of their children. The study focused on small RNA molecules in sperm called mitochondrial tRNA fragments (mt-tsRNAs), which play a role in regulating gene expression and the inheritance of health traits. The researchers used data from over 3,000 families and found that the father's body weight independently influences the weight of the children and their susceptibility to metabolic diseases. Experiments with mice also showed that a high-fat diet in fathers led to offspring with an increased tendency for metabolic diseases. The findings suggest that preventive health care for men wishing to become fathers should focus on diet to reduce the risk of diseases like obesity and diabetes in children. [Extracted from the article]

Researchers from the University of A Coruna in Spain have developed a new tool called PARamrfinder that can detect Allele-Specific Methylation (ASM) in large-scale datasets. ASM is important in biology as it regulates genomic imprinting and has been linked to genetic diseases. The tool is based on the amrfinder and is able to identify ASM at a regional level from high-throughput short-read bisulfite sequencing data. PARamrfinder is significantly faster than previous tools, with experiments showing it to be up to 567 times faster on a cluster with 8 nodes. The source code and reference manual for PARamrfinder are available online. [Extracted from the article]

Researchers from Zhejiang University in China have developed a new method called Wemics for quantifying DNA methylation, an epigenetic mechanism that affects gene expression. Wemics quantification of DNA methylation is more accurate and can better predict its regulatory impact on gene transcription. The method also identifies differentially methylated regions (DMRs) that are relevant to cancer and can serve as diagnostic markers. Wemics has been used to discover novel genes with oncogenic potential in lung cancer. This research enhances our understanding of how DNA methylation regulates gene expression. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the use of a Dirichlet-multinomial mixed model to determine the differential abundance of mutational signatures in cancer. Mutational signatures are imprints left in the genome during tumor evolution, and understanding their dynamics is important for characterizing tumor evolution and identifying weaknesses that can be targeted in treatment. The model allows for the analysis of multivariate overdispersed vectors of counts and positive correlations between signatures. The researchers applied the model to analyze differences in mutational processes between clonal and subclonal mutations across 23 cancer types and found differential abundance of signatures and higher variability in the subclonal group. This research has not yet been peer-reviewed. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the effects of noncanonical genomic imprinting on social behaviors. Noncanonical genomic imprinting is a form of epigenetic regulation where one allele of a gene exhibits a bias towards higher expression of one parental allele compared to the other. The study focused on two genes, Dopa decarboxylase (Ddc) and tyrosine hydroxylase (Th), which are involved in the synthesis of neurotransmitters critical for social behavior. The researchers found that the maternal and paternal alleles of these genes had different effects on aggression, social recognition, sociability preferences, and preferences for social novelty in mice. These findings suggest that noncanonical imprinting of these genes plays a role in regulating social behaviors through central and peripheral monoaminergic systems. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A recent study conducted at Stanford University explored the effects of mutations in the DNA methyltransferase type 1 (DNMT1) enzyme on neurodevelopment. The researchers used fibroblasts, induced pluripotent stem cells (iPSCs), and induced neurons (iNs) from patients with autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCA-DN) to investigate the epigenomic and transcriptomic changes associated with these mutations. The study found cell type-specific changes in gene expression and DNA methylation patterns, as well as identified genes associated with clinical phenotypes of ADCA-DN. The results provide insights into the functions of DNMT1 and the molecular changes associated with ADCA-DN, potentially impacting genes related to related phenotypes. [Extracted from the article]

A recent study conducted at Rutgers University in Newark discusses the role of the UBE3A gene in Autism Spectrum Disorders (ASDs) and its potential as a biomarker for diagnostic and therapeutic purposes. The study highlights the prevalence of ASDs and the chromosomal anomalies in the Chr15q11-q13 region that are often associated with ASDs. The researchers focus on the structure and function of the UBE3A protein, its link to ASDs, and the challenges in developing therapies and diagnostic tools. The study provides a comprehensive platform for understanding UBE3A-mediated ASDs and offers insights into future steps for diagnosis, prevention, and therapy. [Extracted from the article]

A recent preprint abstract discusses the creation and validation of the first Infinium DNA Methylation Array for the Human Imprintome. The array contains 22,819 probes, including 9,757 probes that map to 1,088 out of the 1,488 candidate Imprint Control Regions (ICRs). The performance of the array was assessed by comparing methylation levels from shared CpG sites with whole genome bisulfite sequencing (WGBS) and the Infinium Methylation EPIC v2 array. The results showed a mean R2 value of 0.569 with WGBS and 0.796 with the Infinium Methylation EPIC v2 array. The custom array is expected to facilitate accurate assessment and targeted investigation of ICRs, leading to advancements in understanding genomic imprinting and its role in disease formation. [Extracted from the article]

Researchers at the Children's Hospital of Philadelphia have reported new data on Kagami-Ogata syndrome, a rare imprinting disorder that presents challenges for diagnosis due to its phenotypic overlap with other conditions. The study describes a patient with the syndrome who underwent multiple genetic tests before epigenetic testing revealed a small deletion involving the MEG3 transcript and MEG3:TSS-DMR. Long-read sequencing was used to detect the deletion and provide important insights into the mechanism of imprinting effects at this locus. The research highlights the challenges of sequential genetic testing and the utility of long-read sequencing as a comprehensive diagnostic tool. [Extracted from the article]

A patent application titled "Determination and Display of Likelihoods over Time of Developing Age-Associated Disease" has been published online. The inventors propose a method, software, database, and system that utilize genetic and non-genetic data to predict an individual's likelihood of developing age-associated diseases over time. The invention incorporates epigenetic modifications, which can alter gene expression, as well as physical, behavioral, and situational attributes. The patent application also includes claims for a computer-implemented method and a computing system to perform these operations. [Extracted from the article]

A patent has been issued to F. Hoffmann-La Roche Inc. for oligonucleotides that can induce the expression of the UBE3A gene, specifically the paternal copy, in neuronal cells. This is significant because Angelman syndrome, a neuro-genetic disorder, is caused by the deletion or inactivation of the UBE3A gene on the maternally inherited chromosome 15q11.2. The patent describes the design and use of antisense oligonucleotides to target a specific region of the SNHG14 long non-coding RNA, which suppresses UBE3A expression. The invention also includes methods for treating or preventing diseases associated with decreased UBE3A activity, such as Angelman syndrome. [Extracted from the article]

The article discusses a study by Yanchang Wei and his colleagues at Shanghai Jiao Tong University in China which created unfertilised mouse eggs with double the normal number of chromosomes by adding back in DNA ejected in early stages of egg development. Topics include how to make an unfertilised egg develop into an embryo, indication that there are still imprinting regions involved in embryo development, and comments from Tony Perry at the University of Bath, United Kingdom.

The article discusses the changes regarding the discourse about heredity and evolution as well as epigenetic inheritance. It talks on several factors influencing an individual's genetic make-up such as diet and stress and the implications of these for public health education. According to Russell Bonduriansky of the University of New South Wales, the issue would reintroduce development in a direct and strong sense into heredity and evolution.

This article examines genomic findings in the DNA of the world's wild cats and says the information has clarified the cat family tree and uncovered remarkable migrations in their past. DNA evidence shows that all living cats trace back to a pantherlike predator that lived in Southeast Asia nearly 11 million years ago. The big roaring cats were the first to branch off and seven other lineages followed. As the sea levels rose and fell, the cats migrated and developed into new species. INSETS: KEY CONCEPTS;SOLVING THE CAT PUZZLE.

Keywords: Angelman Syndrome; Antisense Technology; Bioengineering; Biotechnology; Central Nervous System; Central Nervous System Diseases and Conditions; Chromosome Disorders; Congenital Abnormalities; Enzymes and Coenzymes; Genetics; Health and Medicine; Movement Disorders; Musculoskeletal Diseases and Conditions; Nuclease; Patent Application EN Angelman Syndrome Antisense Technology Bioengineering Biotechnology Central Nervous System Central Nervous System Diseases and Conditions Chromosome Disorders Congenital Abnormalities Enzymes and Coenzymes Genetics Health and Medicine Movement Disorders Musculoskeletal Diseases and Conditions Nuclease Patent Application 170 170 1 11/06/23 20231110 NES 231110 2023 NOV 9 (NewsRx) -- By a News Reporter-Staff News Editor at Gene Therapy Weekly -- A patent application by the inventor Dindot, Scott Victor (College Station, TX, US), filed on June 30, 2023, was made available online on October 19, 2023, according to news reporting originating from Washington, D.C., by NewsRx correspondents. The modified oligonucleotide of claim 14, wherein the modified oligonucleotide is a nuclease guide RNA oligonucleotide (gRNA)." A modified oligonucleotide comprising a contiguous nucleotide sequence of 10 to 30 nucleotides in length with nucleic acid complementarity to a contiguous portion of the nucleotide sequence set forth in SEQ ID NO: 2. The modified oligonucleotide of claim 14, wherein the modified oligonucleotide is a short hairpin RNA oligonucleotide (shRNA). [Extracted from the article]

Genetic markers such as single nucleotide polymorphisms (SNPs) do not provide a complete picture of a gene's nucleotide sequence or the total genetic variability of the individual. Other markers such as STS, gene locus markers and chromosome loci markers also provide very low resolution and incomplete coverage of the genome. [Extracted from the article]

Genetic markers such as single nucleotide polymorphisms (SNPs) do not provide a complete picture of a gene's nucleotide sequence or the total genetic variability of the individual. Other markers such as STS, gene locus markers and chromosome loci markers also provide very low resolution and incomplete coverage of the genome. Furthermore, SNPs are spaced hundreds of nucleotides apart and do not account for genetic variation that occurs in the genetic sequence lying between, which is vastly more sequence than the single nucleotide position represented by an SNP. [Extracted from the article]

DMRs were enriched in the imprinting control regions (ICRs) of Gnas and Grb10, with 15 and 17 ICR-located DMRs across cortex, blood, and liver in each gene, respectively. An analysis of GO terms associated with DMR-containing genes identified imprinted genes to be impacted by both Pb and DEHP exposure. [Extracted from the article]

Keywords: Assisted Reproduction; Genetics; Health and Medicine; Life Sciences; Molecular Genetics; Reproductive Medicine EN Assisted Reproduction Genetics Health and Medicine Life Sciences Molecular Genetics Reproductive Medicine 1221 1221 1 10/09/23 20231014 NES 231014 2023 OCT 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in molecular genetics. Genetics, Health and Medicine, Life Sciences, Molecular Genetics, Reproductive Medicine, Assisted Reproduction. [Extracted from the article]

An antisense oligonucleotide which comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length with at least 98% complementarity to position 25278410 to 25419462 on human chromosome 15, wherein the antisense oligonucleotide is capable of inducing human paternal UBE3A expression. The oligonucleotide of claim 15, wherein the oligonucleotide is a gapmer of formula 5'-F-G-F'-3', where region F and F' independently comprise 1 to 7 modified nucleosides and G is a region between 6 and 16 nucleosides which are capable of recruiting RNaseH. The oligonucleotide of claim 1 wherein the oligonucleotide is a gapmer of the formula F-G-F' wherein each of regions F and F' independently consists of 2, 3, 4, or 5 modified nucleoside units and region G consists of 9, 10, 11, 12, 13, 14, or 15 nucleoside units. The oligonucleotide of claim 13, wherein at least 60% of the internucleoside linkages in the oligonucleotide are phosphorothioate internucleoside linkages. [Extracted from the article]

According to the news reporters, the research concluded: "We discuss the significant challenges of translating these promising therapies from the preclinical stage to the clinic, especially for genome editing based approaches." Keywords: New Haven; State:Connecticut; United States; North and Central America; Biotechnology; Drugs and Therapies; Gene Editing; Genetics; Genome Editing; Health and Medicine; Molecular Pharmacology; Molecular Therapy EN New Haven State:Connecticut United States North and Central America Biotechnology Drugs and Therapies Gene Editing Genetics Genome Editing Health and Medicine Molecular Pharmacology Molecular Therapy 1737 1737 1 10/09/23 20231009 NES 231009 2023 OCT 9 (NewsRx) -- By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Data detailed on Biotechnology - Gene Editing have been presented. [Extracted from the article]

Focuses on the role of imprinted genes in animal survival. Different traits coded for by the male and female genes; Imprinted genes as a means of adaptation to ensure survival; Analysis of mating behavior and imprinted genes in fruit flies; Extension of behaviors observed in animals to man. INSETS: Stay-at-home dads;Brain genes;Self-conscious scrub jays.

Discusses the effects of parental imprinting of genes. Influence of sex-specific gene imprints to normal development; Graphic demonstrations of imprinting; Technique for studying genome imprinting; Possible outcome of imprinting tumor suppressor genes.

Genetics, Germ Cells, Intrinsic Factor, Oocytes, Ovum, Proteins, Mucoproteins Keywords: Genetics; Germ Cells; Intrinsic Factor; Mucoproteins; Oocytes; Ovum; Proteins EN Genetics Germ Cells Intrinsic Factor Mucoproteins Oocytes Ovum Proteins 1135 1135 1 09/25/23 20230926 NES 230926 2023 SEP 29 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on mucoproteins are presented in a new report. [Extracted from the article]

Keywords: Cell Nucleus; Cellular Structures; Chromosomes; Genetics; Government Agencies Offices and Entities; Health and Medicine; Intracellular Space; Intranuclear Space; Metabolic Diseases and Conditions; Nutritional and Metabolic Diseases and Conditions; Risk and Prevention; Van Andel Research Institute EN Cell Nucleus Cellular Structures Chromosomes Genetics Government Agencies Offices and Entities Health and Medicine Intracellular Space Intranuclear Space Metabolic Diseases and Conditions Nutritional and Metabolic Diseases and Conditions Risk and Prevention Van Andel Research Institute 1805 1805 1 09/19/23 20230922 NES 230922 2023 SEP 22 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- GRAND RAPIDS, Mich. () - Van Andel Institute scientists and collaborators have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring. To better understand the processes that govern imprinting, Szabo and colleagues focused on an imprinting control region in the DNA that regulates the Igf2 gene. [Extracted from the article]

Keywords: Cancer; Genetics; Health and Medicine; Oncology; Prenetics; Risk and Prevention; Television EN Cancer Genetics Health and Medicine Oncology Prenetics Risk and Prevention Television 119 119 1 09/11/23 20230912 NES 230912 2023 SEP 12 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- In a move that had never been seen before, marrying beauty with science, the Miss Hong Kong Pageant 2023, which just aired on TVB, had set out to revolutionize the industry by partnering with CircleDNA to unveil contestants' DNA results live on television. The CircleDNA test results peeled back layers of history, unveiling unexpected and captivating ancestral stories from the contestants of Miss Hong Kong 2023. [Extracted from the article]

The method according to claim 4, wherein the 5 grades are classified respectively according to the total expression of an imprinted gene, the expression of an imprinted gene with loss of imprinting and the expression of an imprinted gene with copy number variation of the 16 imprinted genes Z1 to Z16. The copy number variation is caused by abnormal gene duplication in cancer cells, resulting in the expression of this gene as a triploid or even higher polyploid. Keywords: Biomarkers; Business; Cancer; Diagnostics and Screening; Genetics; Health and Medicine; Lisen Imprinting Diagnostics Wuxi Co. Ltd.; Oncology EN Biomarkers Business Cancer Diagnostics and Screening Genetics Health and Medicine Lisen Imprinting Diagnostics Wuxi Co. Ltd. Oncology 2145 2145 1 09/11/23 20230912 NES 230912 2023 SEP 12 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Lisen Imprinting Diagnostics Wuxi Co. Ltd. (Wuxi, People's Republic of China) has been issued patent number 11734818, according to news reporting originating out of Alexandria, Virginia, by NewsRx editors. [Extracted from the article]

Keywords: Pullman; State:Washington; United States; North and Central America; Biodiversity; Ecology; Genetics EN Pullman State:Washington United States North and Central America Biodiversity Ecology Genetics 579 579 1 09/04/23 20230908 NES 230908 2023 SEP 8 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on Ecology - Biodiversity is now available. Keywords for this news article include: Pullman, Washington, United States, North and Central America, Biodiversity, Ecology, Genetics, Washington State University. [Extracted from the article]

"We identify a consistent enrichment of imprinted genes in stromal cell and mesenchymal stem cell populations across these tissues, suggesting a role in tissue maintenance. "Here we interrogated five single-cell RNA sequencing datasets to identify imprinted gene over-representation in the embryonic and adult mouse focusing on tissues including the bladder, pancreas, mammary gland and muscle. [Extracted from the article]

Keywords for this news article include: University of Messina, Messina, Italy, Europe, Cancer, Oncology, Gender Health, Women's Health, Gender and Health, Health and Medicine. Cancer, Gender Health, Gender and Health, Health and Medicine, Oncology, Women's Health Keywords: Cancer; Gender Health; Gender and Health; Health and Medicine; Oncology; Women's Health EN Cancer Gender Health Gender and Health Health and Medicine Oncology Women's Health 856 856 1 07/31/23 20230801 NES 230801 2023 AUG 1 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on cancer is the subject of a new report. [Extracted from the article]