1. Cell-to-cell mathematical modeling of arrhythmia phenomena in the heart.
- Author
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López Garza, Gabriel, Nicolás Mata, Aurelio, Román Alonso, Graciela, Godínez Fernández, José Rafael, and Castro García, Miguel Alfonso
- Subjects
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RIGHT heart atrium , *ATRIAL flutter , *MATHEMATICAL models , *ARRHYTHMIA , *HEART cells , *HEART , *APERIODICITY - Abstract
In this work, we investigate deterministic mechanisms that generate and perpetuate flutter and fibrillation in the right atrium of the human heart using mathematical models and high-performance computational simulations. Using a GPU, the solutions of systems of as much as 360 000 cells of 29 variables each were distributed among the available processors to simulate a cell-to-cell electric behavior of heart tissue. Moreover, in a smaller array of 462 cells, we showed that fibrillation, fluttering, and fibrillation-to-fluttering can be modeled even by using the simplest excitable cell models including only a few variables as well as with realistic models of heart cells, simply by implementing aperiodicity and fractality to the connections network. Micro-reentries which may be identified with fibrillation of the systems can be simulated in silico experiments where emerge several self-perpetuating, colliding waves associated with non-periodic and mathematically calculated pseudo-EG. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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