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A study conducted by researchers at Sichuan Normal University in China investigated the toxic effects of beta-cypermethrin (3-CYP) and its chiral isomers on HTR-8/SVneo cells. The results showed that these compounds inhibited cell proliferation, induced apoptosis and cell cycle arrest, and reduced cell migration. The study also found that the compounds had a higher affinity for phosphodiesterase 3A (PDE3A) than for estrogen receptors, leading to decreased cell viability. The researchers suggest that the PI3K-AKT signaling pathway may be involved in the toxicity of these compounds. This research provides a comprehensive evaluation of the cytotoxicity of chiral pesticides and their mechanisms. [Extracted from the article]

A report from Wageningen University and Research discusses the use of insects as food and feed. The study focuses on the toxicity, transfer, and metabolization of the pyrethroid insecticides cypermethrin and deltamethrin by black soldier fly larvae. The research found that deltamethrin is highly toxic to the larvae, while cypermethrin is comparatively less toxic but can still have adverse effects. The presence of the synergist piperonyl butoxide (PBO) increases both transfer and toxicity. The study concludes that more research is needed to understand resistance mechanisms and the potential issue of transfer from substrate to larvae. [Extracted from the article]

A recent study conducted at the Agricultural Research Centre in Giza, Egypt, examined the effects of insecticides on the enzymes and histology of the pink bollworm Pectinophora gossypiella. The researchers treated larvae with sublethal concentrations of various insecticides and orange oil, and measured the activity of specific enzymes involved in detoxification. They found that cypermethrin had the highest activity in acetylcholinesterase (AChE), while orange oil had the highest activity in glutathione S-transferase (GST). The study also observed histological differences in the mid-gut of the larvae exposed to different insecticides. This research provides valuable insights into the effects of insecticides on the pink bollworm and can contribute to the development of effective pest management strategies in agriculture. [Extracted from the article]

Researchers from American College have conducted a study on the mycotransformation potential of Aspergillus terreus PDB-B, a fungal isolate that was found in the lake sediments of Kulamangalam tropical lake in Madurai, India. The strain was able to tolerate high levels of cypermethrin, a pesticide. The researchers compared the biotransformation potential of this strain with five other strains and conducted batch culture and soil microcosm studies to explore the biotransformation process. The study also predicted a mycotransformation pathway based on the analysis of transformation products. The presence of certain compounds was found to be relevant to the high rate of lethality. The full research article can be accessed for free through the provided link. [Extracted from the article]

A recent study conducted by researchers at the University of Medical Sciences in Nigeria examined the effects of cypermethrin, a commonly used pesticide, on rats. The study found that cypermethrin exposure led to oxidative stress and pathological changes in the rats' organs. However, the researchers discovered that the co-administration of ascorbate and alpha-tocopherol, both antioxidants, effectively mitigated the oxidative damage caused by cypermethrin. This research suggests that the combination of these substances may have synergistic antioxidant properties. [Extracted from the article]

A recent report from the College of Pharmacy in Seoul, South Korea, highlights the potential estrogenic effects of pyrethroids, which are widely used insecticides derived from chrysanthemum flowers. The study aims to address data gaps and inconsistencies in previous research by defining the molecular initiating events and key events associated with pyrethroid-induced estrogenic effects. The researchers propose using Integrated Approaches to Testing and Assessment (IATA) to comprehensively investigate these effects. The study emphasizes the need for comprehensive research and standardized testing methods to accurately assess the impact of pyrethroid exposure on human and environmental health. [Extracted from the article]

Environmental toxicants are pervasive in nature, but sub-lethal effects on non-target organisms and their parasites are often overlooked. Particularly, studies on terrestrial hosts and their parasites exposed to agricultural toxicants are lacking. Here, we studied the effect of sequence and timing of sub-lethal exposures of the pyrethroid insecticide alpha-cypermethrin on parasite establishment using the tapeworm Hymenolepis diminuta and its intermediate insect host Tenebrio molitor as a model system. We exposed T. molitor to alpha-cypermethrin (LD20) before and after experimental H. diminuta infection and measured the establishment success of larval tapeworms. Also, we conducted in vitro studies quantifying the direct effect of the insecticide on parasite viability. Our results showed that there was no direct lethal effect of alpha-cypermethrin on H. diminuta cysticercoids at relevant concentrations (LD10 to LD90 of the intermediate host). However, we observed a significantly increased establishment of H. diminuta in beetles exposed to alpha-cypermethrin (LD20) after parasite infection. In contrast, parasite establishment was significantly lower in beetles exposed to the insecticide before parasite infection. Thus, our results indicate that environmental toxicants potentially impact host-parasite interactions in terrestrial systems, but that the outcome is context-dependent by enhancing or reducing parasite establishment depending on timing and sequence of exposure. [ABSTRACT FROM AUTHOR]

A study conducted at Ataturk University in Erzurum, Turkey, examined the protective effects of green tea extract against cypermethrin-induced neurotoxicity in rainbow trout brain tissues. The study found that exposure to cypermethrin resulted in a reduction in acetylcholinesterase activity, oxidative stress, immune response, histopathology, apoptosis, and DNA damage in the brain tissues of the trout. However, the administration of green tea extract demonstrated remarkable neuroprotective effects, reducing oxidative stress, apoptosis, and DNA damage, while enhancing the immune response. The study concluded that a higher dosage of green tea extract (200 mg) yielded more pronounced neuroprotective effects than a lower dosage (100 mg). [Extracted from the article]

Florida International University Board of Trustees has been issued a patent for arsinothricin as a multi-stage antimalarial. Malaria is a severe vector-borne disease that causes millions of cases and deaths worldwide. The patent describes the use of arsinothricin as an antimalarial agent that inhibits the essential enzyme glutamine synthetase of malaria pathogens with less toxicity to humans. The invention provides methods for treating and preventing malaria infection and transmission, and the patent claims cover the use of arsinothricin or its salt for these purposes. [Extracted from the article]

A recent study conducted by researchers at the Animal Health Research Institute in Egypt explored the toxic impact of cypermethrin, a commonly used pesticide, on the fertility of male rats. The study found that cypermethrin exposure led to a significant decrease in testosterone, LH and FSH hormones, testes weights, sperm count and motility, and live sperm percentage. However, when the rats were treated with the androgenic drug Panax ginseng, these negative effects were reduced. The study concluded that cypermethrin exposure can cause defects in male reproductive function, but these can be mitigated by administering Panax ginseng. [Extracted from the article]

A study conducted at the University of Alexandria in Egypt has investigated the protective effects of l-carnitine (LC) against the neurotoxicity induced by the neonicotinoid insecticide thiamethoxam (TMX) in male rats. The study found that TMX caused various negative effects in the brain, including oxidative stress, inflammation, disruptions in neurotransmitter levels, and increased expression of apoptotic and astrogliosis markers. However, pretreatment with LC attenuated these effects and demonstrated antioxidant, anti-inflammatory, anti-astrogliosis, and anti-apoptotic potential against TMX neurotoxicity. This research provides valuable insights into the potential protective role of LC in mitigating the harmful effects of certain insecticides. [Extracted from the article]

Researchers from Jazan University in Saudi Arabia conducted a study to evaluate the hepatoprotective and antioxidant activities of nanopiperine (NP) against the toxicity of cypermethrin (Cyp), a pyrethroid associated with organ toxicity. The study involved administering Cyp to animals and then treating them with different doses of NP. The results showed that NP reversed the Cyp-induced alterations, reducing serum marker levels, oxidative stress, cytokine production, and caspase expression. Additionally, NP minimized histopathological alterations and exhibited potent antioxidant and anti-inflammatory activities. This research suggests that NP has hepatoprotective effects and can protect against Cyp-induced liver damage. [Extracted from the article]

Keywords for this news article include: Nnamdi Azikiwe University, Neurology, Dichlorvos, Insecticides, Neurodegeneration, Organophosphorus Compounds. Dichlorvos, Insecticides, Neurodegeneration, Neurology, Organophosphorus Compounds Keywords: Dichlorvos; Insecticides; Neurodegeneration; Neurology; Organophosphorus Compounds EN Dichlorvos Insecticides Neurodegeneration Neurology Organophosphorus Compounds 285 285 1 10/03/23 20231005 NES 231005 2023 OCT 5 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Research findings on neurodegeneration are discussed in a new report. [Extracted from the article]

Kyrenia, Cyprus, Europe, Antioxidants, Biochemicals, Biochemistry, Carbocyclic Acids, Chemicals, Cinnamates, Caffeic Acids, Drugs and Therapies, Protective Agents Keywords: Kyrenia; Cyprus; Europe; Antioxidants; Biochemicals; Biochemistry; Caffeic Acids; Carbocyclic Acids; Chemicals; Cinnamates; Drugs and Therapies; Protective Agents EN Kyrenia Cyprus Europe Antioxidants Biochemicals Biochemistry Caffeic Acids Carbocyclic Acids Chemicals Cinnamates Drugs and Therapies Protective Agents 2338 2338 1 09/19/23 20230922 NES 230922 2023 SEP 22 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Drugs and Therapies - Antioxidants. [Extracted from the article]

For more information on this research see: A systematic review of human biomonitoring studies of 3-phenoxybenzoic acid, a urinary biomarker pyrethroid insecticide exposure, 1997 to 2019. Keywords: Biomarkers; Diagnostics and Screening; Health and Medicine; Insecticides EN Biomarkers Diagnostics and Screening Health and Medicine Insecticides 34 34 1 08/21/23 20230825 NES 230825 2023 AUG 22 (NewsRx) -- By a News Reporter-Staff News Editor at Zika & Mosquito Week -- New research on biomarkers is the subject of a new report. [Extracted from the article]

Keywords: Carbofuran; Carboxylic Acids; Chlorpyrifos; Health and Medicine; Insecticides; Organic Chemicals; Organothiophosphorus Compounds; Phenylcarbamates EN Carbofuran Carboxylic Acids Chlorpyrifos Health and Medicine Insecticides Organic Chemicals Organothiophosphorus Compounds Phenylcarbamates 7918 7918 1 08/14/23 20230818 NES 230818 2023 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on agriculture is now available. Carbofuran, Carboxylic Acids, Chlorpyrifos, Health and Medicine, Insecticides, Organic Chemicals, Organothiophosphorus Compounds, Phenylcarbamates Keywords for this news article include: University of Jember, Carbofuran, Chlorpyrifos, Insecticides, Carboxylic Acids, Phenylcarbamates, Organic Chemicals, Health and Medicine, Organothiophosphorus Compounds. [Extracted from the article]

The news correspondents obtained a quote from the research from Nanjing Normal University, "Here, the NHase activities of Escherichia coli pET28a-PsNHase, harboring Pseudomonas stutzeri CGMCC 22915 (Ps) NHase gene, and E. coli pET28a-PsNHase-PsCbiM, harboring genes of PsNHase and a cobalt transporter PsCbiM, were compared. Keywords: Nanjing; People's Republic of China; Asia; Cobalt; Enterobacteriaceae; Enzymes and Coenzymes; Escherichia coli; Genetics; Gram-Negative Bacteria; Health and Medicine; Hydratase; Insecticides; Proteobacteria; Transition Elements EN Nanjing People's Republic of China Asia Cobalt Enterobacteriaceae Enzymes and Coenzymes Escherichia coli Genetics Gram-Negative Bacteria Health and Medicine Hydratase Insecticides Proteobacteria Transition Elements 1084 1084 1 07/03/23 20230707 NES 230707 2023 JUL 7 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Current study results on Gram-Negative Bacteria - Escherichia coli have been published. [Extracted from the article]

Keywords: Agrochemicals; Chlorpyrifos; Food Research; Insects as Food and Feed; Organothiophosphorus Compounds; Pesticides EN Agrochemicals Chlorpyrifos Food Research Insects as Food and Feed Organothiophosphorus Compounds Pesticides 202 202 1 07/03/23 20230706 NES 230706 2023 JUL 6 (NewsRx) -- By a News Reporter-Staff News Editor at Food Weekly News -- Research findings on insects as food and feed are discussed in a new report. Agrochemicals, Food Research, Insects as Food and Feed, Chlorpyrifos, Organothiophosphorus Compounds, Pesticides. [Extracted from the article]

Keywords: Biomedicine; Glutathione; Health and Medicine; Oligopeptides; Peptides EN Biomedicine Glutathione Health and Medicine Oligopeptides Peptides 5223 5223 1 06/26/23 20230630 NES 230630 2023 JUN 30 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on biomedicine are discussed in a new report. Biomedicine, Glutathione, Health and Medicine, Oligopeptides, Peptides. [Extracted from the article]

Haikou, People's Republic of China, Asia, OBGYN and Reproduction, Agrochemicals, Connective Tissue Cells, Gynecology, Health and Medicine, Pesticides, Stromal Cells, Women's Health Keywords: Haikou; People's Republic of China; Asia; OBGYN and Reproduction; Agrochemicals; Connective Tissue Cells; Gynecology; Health and Medicine; Pesticides; Stromal Cells; Women's Health EN Haikou People's Republic of China Asia OBGYN and Reproduction Agrochemicals Connective Tissue Cells Gynecology Health and Medicine Pesticides Stromal Cells Women's Health 131 131 1 05/29/23 20230529 NES 230529 2023 JUN 1 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Research findings on OBGYN and Reproduction are discussed in a new report. [Extracted from the article]

Keywords: Carbofuran; Carboxylic Acids; Health and Medicine; Organic Chemicals; Phenylcarbamates; Spermatogenesis; Women's Health EN Carbofuran Carboxylic Acids Health and Medicine Organic Chemicals Phenylcarbamates Spermatogenesis Women's Health 450 450 1 05/22/23 20230526 NES 230526 2023 MAY 25 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Current study results on spermatogenesis have been published. Carbofuran, Carboxylic Acids, Health and Medicine, Organic Chemicals, Phenylcarbamates, Spermatogenesis, Women's Health. [Extracted from the article]

Keywords: Agrochemicals; Carbamates; Health and Medicine; Life Sciences; Methomyl; Pesticides; Poisoning; Risk and Prevention; Thiocarbamates; Toxicology EN Agrochemicals Carbamates Health and Medicine Life Sciences Methomyl Pesticides Poisoning Risk and Prevention Thiocarbamates Toxicology 868 868 1 05/02/23 20230505 NES 230505 2023 MAY 1 (NewsRx) -- By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- Data detailed on toxicology have been presented. In a multivariate logistic regression model, it was revealed that methomyl pesticide (p = 0.045) or methomyl and cypermethrin pesticide mixture (p = 0.013) were significant risk factors for acute respiratory failure.". [Extracted from the article]

Pirfenidone could replace dexamethasone treatment in the current rat model of CYP-induced severe steroid-resistant asthma via inhibiting the M1 macrophage differentiation through modulation of the STAT6/p38 MAPK pathway." Keywords: Albumins; Allergies; Allergy Research; Antiinflammatory Agents; Asthma; Bronchial Diseases and Conditions; Dietary Egg Proteins; Drugs and Therapies; Egg Proteins; Genetics; Health and Medicine; Immune System Diseases and Conditions; Immunology; Inflammation; Lung Diseases and Conditions; Macrophages; Mononuclear Phagocyte System; Obstructive Lung Diseases and Conditions; Ovalbumin; Phagocytes; Pharmaceuticals; Pirfenidone Therapy; Proteins; Respiratory Hypersensitivity; Respiratory Tract Diseases and Conditions; Serpins EN Albumins Allergies Allergy Research Antiinflammatory Agents Asthma Bronchial Diseases and Conditions Dietary Egg Proteins Drugs and Therapies Egg Proteins Genetics Health and Medicine Immune System Diseases and Conditions Immunology Inflammation Lung Diseases and Conditions Macrophages Mononuclear Phagocyte System Obstructive Lung Diseases and Conditions Ovalbumin Phagocytes Pharmaceuticals Pirfenidone Therapy Proteins Respiratory Hypersensitivity Respiratory Tract Diseases and Conditions Serpins 224 224 1 04/24/23 20230427 NES 230427 2023 APR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- Investigators publish new report on asthma. [Extracted from the article]

Our news editors report that more information may be obtained by contacting Marwa H. El-Sayed, Plant Protection Division, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt. Keywords: Drugs and Therapies; Health and Medicine; Pediculicides EN Drugs and Therapies Health and Medicine Pediculicides 3190 3190 1 04/10/23 20230414 NES 230414 2023 APR 14 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New research on pediculicides is the subject of a new report. [Extracted from the article]

According to the news editors, the research concluded: "However, NC treatment against CPM offers protection by improving antioxidant status and lowering LPO, inflammation, and apoptosis. Afterwards, brain antioxidant status was measured by assessing lipid peroxidation (LPO), 4-HNE, glutathione reduced (GSH), antioxidant enzyme catalase, and superoxide dismutase (SOD) along with neurotoxicity markers Na-K ATPase, AchE, and MAO. Keywords: ATPase; Alkanes; Aromatic Hydrocarbons; Catechols; Curcumin; Diarylheptanoids; Drugs and Therapies; Enzymes and Coenzymes; Genetics; Health and Medicine; Hydrocarbons; Inflammation; Nanotechnology; Organic Chemicals; Risk and Prevention EN ATPase Alkanes Aromatic Hydrocarbons Catechols Curcumin Diarylheptanoids Drugs and Therapies Enzymes and Coenzymes Genetics Health and Medicine Hydrocarbons Inflammation Nanotechnology Organic Chemicals Risk and Prevention 2347 2347 1 03/23/23 20230324 NES 230324 2023 MAR 24 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on nanotechnology. [Extracted from the article]

For more information on this research see: Whole genome sequencing andtranscriptomics-based characterization of a novel b-cypermethrin-degradingGordonia alkanivorans GH-1 isolated from fermented foods. Whole genome sequencingand transcriptomics analyses have demonstrated that the bacteriaaffected the transcription of genes related to cell response andmaterial transport under the stress induced by b-CY, and therebypromoted degradation and transformation of b-CY. [Extracted from the article]

Keywords: Agrochemicals; Carbofuran; Carboxylic Acids; Chlorpyrifos; Health and Medicine; Organic Chemicals; Organothiophosphorus Compounds; Pesticides; Phenylcarbamates EN Agrochemicals Carbofuran Carboxylic Acids Chlorpyrifos Health and Medicine Organic Chemicals Organothiophosphorus Compounds Pesticides Phenylcarbamates 2023 FEB 13 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- A new study on agriculture is now available. Agrochemicals, Carbofuran, Carboxylic Acids, Chlorpyrifos, Health and Medicine, Organic Chemicals, Organothiophosphorus Compounds, Pesticides, Phenylcarbamates. [Extracted from the article]

Alkanes, Aminotransferase, Aromatic Hydrocarbons, Catechols, Curcumin, Diarylheptanoids, Enzymes and Coenzymes, Hydrocarbons, Organic Chemicals, Risk and Prevention Keywords: Alkanes; Aminotransferase; Aromatic Hydrocarbons; Catechols; Curcumin; Diarylheptanoids; Enzymes and Coenzymes; Hydrocarbons; Organic Chemicals; Risk and Prevention EN Alkanes Aminotransferase Aromatic Hydrocarbons Catechols Curcumin Diarylheptanoids Enzymes and Coenzymes Hydrocarbons Organic Chemicals Risk and Prevention 2023 FEB 10 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Fresh data on alkanes are presented in a new report. [Extracted from the article]

The ubiquitous use of pesticides has increased concerns over their direct and indirect effects on disease dynamics. While studies examining the effects of pesticides on host–parasite interactions have largely focused on how pesticides influence the host, few studies have considered the effects of pesticides on parasites. We investigated the toxicity of six common insecticides at six environmentally-relevant concentrations to cercariae of the trematode Echinoparyphium from two populations. All six insecticides reduced the survival of cercariae (overall difference between mortality in control vs pesticide exposure = 86·2 ± 8·7%) but not in a predictable dose-dependent manner. These results suggest that Echinoparyphium are sensitive to a broad range of insecticides commonly used in the USA. The lack of a clear dose-dependent response in Echinoparyphium highlights the potential limitations of toxicity assays in predicting pesticide toxicity to parasites. Finally, population-level variation in cercarial susceptibility to pesticides underscores the importance of accounting for population variation as overlooking this variation can limit our ability to predict toxicity in nature. Collectively, this work demonstrates that consideration of pesticide toxicity to parasites is important to understanding how pesticides ultimately shape disease dynamics in nature. [ABSTRACT FROM AUTHOR]

The article focuses on the study exposure to pesticides suggesting that long term exposure to pesticides can leads to blood toxicity, low number of bone marrow cells and aplastic anemia. It informs that study was done at Biochemistry and Medical Biotechnology department of Calcutta School of Tropical Medicine, India. It found that exposure to some pesticides including organchlorine, organophosphate and cypermethrin may lead to life threatening conditions.

The article focuses on the Action plan of the International Rice Research Institute (IRRI) which calls for a ban on certain insecticides in rice production. It mentions that the Action plan recommends to enhance biodiversity and regulate the marketing and use of insecticides. Moreover, Thailand prohibited the use of abamectin and cypermethrin in rice because they are known to be major causes of planthoper outbreaks.