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A recent study by Takeda Pharmaceutical Co. Ltd. in Fujisawa, Japan, focused on amyotrophic lateral sclerosis (ALS) and the search for prognostic biomarkers to predict disease progression. The study analyzed cerebrospinal fluid (CSF) samples from ALS patients and disease controls, identifying proteins related to neuroinflammation and glycosylation that were significantly correlated with disease progression rates. The findings suggest that these proteins could serve as useful prognostic biomarkers for ALS, potentially improving clinical trial design and patient care. [Extracted from the article]

A recent study conducted by researchers at the University of Tubingen explored the levels of tissue factor (TF) in the cerebrospinal fluid (CSF) of individuals with Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The study aimed to determine if there were differences in TF levels between controls and patients with PD and DLB, as well as to investigate the association between TF levels and disease progression in PD. The findings showed that higher CSF levels of TF were associated with older age and later onset of postural instability in PD patients. The researchers concluded that TF could be a potential candidate for further exploration in PD and DLB. [Extracted from the article]

A study conducted by researchers at Kagoshima University in Japan examined the impact of lumbar spinal stenosis (LSS) on cerebrospinal fluid (CSF) protein concentration. The study analyzed CSF samples from 61 LSS patients and found that patients with medium block to contrast below the lumbar puncture level had significantly higher CSF protein concentration compared to those without medium block. The researchers suggest that damage to the cauda equina in LSS patients may be responsible for the elevated CSF protein levels. This information may be useful for individuals researching spinal stenosis and its effects on the central nervous system. [Extracted from the article]

A recent study conducted by researchers at Harran University in Sanliurfa, Turkey, examined the association between cerebrospinal fluid (CSF) protein levels, inflammatory markers, and electrophysiological values in pediatric patients with Guillain-Barre syndrome (GBS). The study found that CSF protein levels were positively correlated with certain electrophysiological parameters, such as motor nerve distal latency, and negatively correlated with sensorial nerve conduction velocities. The researchers concluded that standardized ranges of these electrophysiological markers could be sensitive indicators for GBS in pediatric patients, and early rehabilitation programs may help prevent disability in immobile patients. [Extracted from the article]

This article discusses a study that measured the levels of proteins in the cerebrospinal fluid (CSF) of individuals with untreated and treated chronic HIV-1 infection. The study found that there were changes in CSF protein levels across the spectrum of HIV-1 infection, with the highest concentrations of proteins observed in individuals with HIV-associated dementia and neurosymptomatic CSF escape. The study also found that antiretroviral therapy reduced some of these protein perturbations, but not always to control levels. The dataset from this study is available online and further research will provide a more detailed understanding of the impact of HIV-1 infection on the CSF proteome. [Extracted from the article]

A recent study conducted in Andhra Pradesh, India, investigated the potential of peripheral myelin protein 2 (P2) and Alpha B-crystallin (aBC) as predictive biomarkers in Guillain-Barre syndrome (GBS). The study found that there was a significant increase in P2 and aBC levels in GBS patients, which correlated with improved muscle strength. However, the study had limitations, including a small sample size and the absence of a control group. Therefore, caution should be exercised when generalizing the findings. [Extracted from the article]

A study conducted by researchers at Boston University compared the levels of commonly measured plasma and cerebrospinal fluid (CSF) proteins to determine their significance in characterizing cognitive impairment status. The study found that a panel of six plasma proteins outperformed a panel of seven CSF proteins and CSF markers in distinguishing mild cognitive impairment (MCI) from Alzheimer's disease (AD) and cognitively normal (CN) individuals. These findings suggest that the combination of these six plasma proteins could serve as an effective marker for differentiating MCI from AD and CN. The study was published in the Journal of Alzheimer's Disease. [Extracted from the article]

A preprint abstract from medrxiv.org discusses the utility of cerebrospinal fluid (CSF) protein levels as a potential predictive biomarker of disease severity in HIV-associated cryptococcal meningitis. The study analyzed data from 890 adults with HIV-associated cryptococcal meningitis in Uganda and found that individuals with CSF protein levels of 100 mg/dL or higher were more likely to present with seizures, altered mental status, immune activation, and favorable fungal outcomes. Additionally, those with lower CSF protein levels had a higher mortality risk. The study suggests that baseline CSF protein levels may serve as a surrogate marker of immune activation and prognosis in cryptococcal meningitis. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

Pittsburgh, State:Pennsylvania, United States, North and Central America, Cerebrospinal Fluid Proteins, Drugs and Therapies Keywords: Pittsburgh; State:Pennsylvania; United States; North and Central America; Cerebrospinal Fluid Proteins; Drugs and Therapies EN Pittsburgh State:Pennsylvania United States North and Central America Cerebrospinal Fluid Proteins Drugs and Therapies 3159 3159 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on Proteins - Cerebrospinal Fluid Proteins have been published. [Extracted from the article]

Keywords: Biomarkers; Cerebrospinal Fluid Proteins; Delirium; Diagnostics and Screening; Health and Medicine; Mental Health; Nervous System Diseases and Conditions; Neurobehavioral Manifestations; Neurologic Manifestations; Proteomics; Risk and Prevention EN Biomarkers Cerebrospinal Fluid Proteins Delirium Diagnostics and Screening Health and Medicine Mental Health Nervous System Diseases and Conditions Neurobehavioral Manifestations Neurologic Manifestations Proteomics Risk and Prevention 79 79 1 10/03/23 20231006 NES 231006 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Mental Health Weekly Digest -- New research on delirium is the subject of a new report. Our news editors obtained a quote from the research from Beth Israel Deaconess Medical Center: "Circulating proteins in cerebrospinal fluid (CSF) may reflect biological processes causing delirium. [Extracted from the article]

Keywords: Alzheimer Disease; Biomarkers; Brain Diseases and Conditions; Central Nervous System Diseases and Conditions; Cerebrospinal Fluid Proteins; Dementia; Diagnostics and Screening; Health and Medicine; Neurodegenerative Diseases and Conditions; Tauopathies EN Alzheimer Disease Biomarkers Brain Diseases and Conditions Central Nervous System Diseases and Conditions Cerebrospinal Fluid Proteins Dementia Diagnostics and Screening Health and Medicine Neurodegenerative Diseases and Conditions Tauopathies 179 179 1 05/29/23 20230602 NES 230602 2023 MAY 29 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on Alzheimer disease. The news reporters obtained a quote from the research from Emory University School of Medicine: "However, these diagnostic biomarkers do not reflect the complex changes in AD brain beyond amyloid (A) and Tau (T) pathologies. [Extracted from the article]

Keywords: Cerebrospinal Fluid Proteins; Diagnostics and Screening; Drugs and Therapies; Health and Medicine EN Cerebrospinal Fluid Proteins Diagnostics and Screening Drugs and Therapies Health and Medicine 1080 1080 1 05/29/23 20230602 NES 230602 2023 JUN 2 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on cerebrospinal fluid proteins. His cerebrospinal fluid (CSF) was yellow and cloudy, the Pandy test was strongly positive (++++), the protein was 46 g/L (normal range 0.15-0.45 g/L), which attracted our attention. [Extracted from the article]

Brain Diseases and Conditions, Central Nervous System Diseases and Conditions, Cerebrospinal Fluid Proteins, Health and Medicine, Hydrocephalus, Intracranial Hypertension Keywords: Brain Diseases and Conditions; Central Nervous System Diseases and Conditions; Cerebrospinal Fluid Proteins; Health and Medicine; Hydrocephalus; Intracranial Hypertension EN Brain Diseases and Conditions Central Nervous System Diseases and Conditions Cerebrospinal Fluid Proteins Health and Medicine Hydrocephalus Intracranial Hypertension 903 903 1 04/17/23 20230421 NES 230421 2023 APR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- A new study on hydrocephalus is now available. [Extracted from the article]

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2006.06.018 Byline: Enyi Shi (a)(c), Xiaojing Jiang (b), Teruhisa Kazui (a), Naoki Washiyama (a), Katsushi Yamashita (a), Hitoshi Terada (a), Abul Hasan Muhammad Bashar (a) Abbreviations: CNS, central nervous system; CSF, cerebrospinal fluid; HGF, hepatocyte growth factor; HVJ, hemagglutinating virus of Japan; VEGF, vascular endothelial growth factor; VSMC, vascular smooth muscle cell Abstract: Paraplegia caused by spinal cord ischemia remains a serious complication after surgical repair of thoracoabdminal aortic aneurysms. Hepatocyte growth factor is a potent angiogenic and neurotrophic factor. We sought to investigate the neuroprotective effect of gene transfer of hepatocyte growth factor on spinal cord ischemia in rabbits. Author Affiliation: (a) First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan (b) Department of Anesthesiology, Hamamatsu University School of Medicine, Hamamatsu, Japan (c) Department of Cardiac Surgery, the First Affiliated Hospital, China Medical University, Shenyang, China. Article History: Received 24 April 2006; Revised 11 June 2006; Accepted 16 June 2006

Research findings, 'Quantitative proteomics and metabolomics analysis of normal human cerebrospinal fluid samples,' are discussed in a new report. 'The analysis of cerebrospinal fluid (CSF) is used in biomarker discovery [...]

Increase in cryptococcal infection has been noticed after acquired immunodeficiency syndrome pandemic. Cryptococcus neoformans can be isolated from blood in the process of dissemination to brain. We report a case [...]

Purpose : To evaluate the role of the radiometric BACTEC 460TB system and the conventional Lowenstein-Jensen (LJ) medium for isolation of M. tuberculosis from cerebrospinal fluid (CSF) samples of tuberculous [...]

Purpose: Ten years retrospective study to evaluate the bacteriological spectrum of community acquired acute bacterial meningitis (CAABM). Methods: Cerebrospinal fluid (CSF) samples from 385 clinically suspected cases of pyogenic meningitis [...]

A 52-year-old woman had systemic symptoms including nausea and vomiting. A Seven months prior to admission she had a subarachnoid hemorrhage and needed multiple ventriculo-pleural shunts. The newest shunt was 2 months old at the time of the patient's admission. She was alert on admission, but had a left pleural effusion. The shunt was externalized and the external ventricular drain provided. Cerebral spinal fluid (CSF) then was sampled and sent daily for chemistries and culture. The initial CSF formula included 10,000 RBCs and 40 WBCs, of which 58% were monos. CSF glucose and protein were normal. The daily CSF sample was a light green color, had Gram-negative rods on microscopic examination, and consistently grew Pseudomonas aeruginosa. The patient was treated with cefipime 2 g Q 8 hours, but the organism was only intermediately susceptible. The spinal fluid persisted to be green. Cefepime was stopped and meropenem 2 g Q 12 hours was begun. The CSF remained green. Intrathecal amikacin 20 mg/day was initiated. After 1 day, the CSF cleared and the patient eventually had a complete recovery. [ABSTRACT FROM AUTHOR]

The article presents clinical updates in neurology that were released through Reuters Health Information. A research by a Spanish researcher reveals the viability of clinical and radiologic data that were gathered during the first six hours after severe head injury in predicting early death of patients. A study on neurochemical markers in cerebrospinal fluid conducted by medical researchers in Sweden shows that amateur boxing lead to acute neuronal and astroglial injury.

Discusses the findings of a study on the use of positron-emission tomography in measuring beta amyloid protein levels in cerebrospinal fluid (CSF) in conjunction with brain amyloid imaging as the best diagnostic test for presymptomatic dementia. Relationship between amyloid containing plaques in the brain and beta amyloid 42 in CSF; Details of the findings; Factor that impedes surgeons's efforts to develop new therapies according to Anne M. Fagan, research associate professor of neurology at Washington University School of Medicine.

The article focuses on the retrospective analysis by researchers Pedro Lourenco and colleagues regarding the association of cerebrospinal fluid (CSF) protein markers/oligoclonal bands (OCB) in the disease course and progression in multiple sclerosis patients (MS).

The article presents a research which reveals that children with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have a good long-term outcome and IV immunoglobulin is an effective treatment in the U.S. Researchers found that 26 children had an elevated level of cerebrospinal fluid (CSF) protein when treated with IV immunoglobulin. It confirms that childhood CIDP have a long-term outcome for most patients and IV immunoglobulin therapy is an effective treatment for most children.

The article reports on the use of magnetic resonance imaging (MRI) and intrathecal gadolinium for cerebrospinal fluid (CSF) leak detection. Neurologist Ludo J. Vanopdenbosch states that CSF leak can be suspected in patients with clear nasal drip, bacterial meningitis, and spontaneous intracranial hypotension syndrome. The intrathecal gadolinium injection is noted by Vanopdenbosch as a technically very easy procedure that allows investigators to have an excellent time window.

The article presents a study which measures the levels of biomakers in the cerebrospinal fluid (CSF) of patients with very mild dementia. Researchers found that the rate of dementia progression was significantly more rapid in individuals with lower baseline CSF levels. Result of the study shows that levels of biomakers are strongly predictive of the actual rate of decline compared to patients who are diagnosed by dementia of the Alzheimer type.

The article discusses the case of a 51-year-old man with Non-Hodgkin's lymphoma who developed Guillain-Barre syndrome during treatment with cyclophosphamide, doxorubicin, vincristine, methylprednisolone (CHOP) and rituximab. The man reported mild fingertip paresthesia after initial course of the said drugs. Based on laboratory investigations, he had decreased white blood cells (WBC) and lymphocytes counts and increased cerebrospinal fluid proteins.

The article focuses on the Bacterial Meningitis Score, a clinical prediction rule developed by physician Lise E. Nigrovic of the Department of Medicine at Cildren's Hospital, Boston which concerns the risk of bacterial meningitis in children with cerebrospinal fluid (CSF) pleocytosis . The validation study for the Bacterial Meningitis Score is discussed. The researchers recommend its use in concert with careful clinical assessment of the patient.