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A recent study conducted at Mataria Teaching Hospital in Cairo, Egypt, explored the use of topical bromfenac in combination with intravitreal ranibizumab injections for the treatment of diabetic macular edema (DME). The study, which included 40 eyes of patients with DME, found that the combination therapy showed some efficacy over a 6-month follow-up period, although the results were not statistically significant. The research highlighted the importance of evaluating adjunctive treatments for DME to improve patient outcomes. [Extracted from the article]

The article presents a new study from the Military Medical Academy that highlights the benefits of using topical bromfenac as an adjunct to anti-VEGF therapy for macular edema. Topics discussed include the effectiveness of topical non-steroidal anti-inflammatory drugs, the results of a systematic review and meta-analysis of relevant studies, and the potential for reducing treatment burden while maintaining visual acuity and central retinal thickness.

A study conducted at Inje University Haeundae Paik Hospital investigated the effect of topical bromfenac, a nonsteroidal anti-inflammatory drug, on intraretinal cystic lesions (IRC) during simultaneous cataract and idiopathic epiretinal membrane (iERM) surgery. The study included patients with iERM who were followed up for 6 months after vitrectomy, membrane removal, and concurrent cataract surgery. The results showed that topical bromfenac did not have beneficial effects on the prevention and treatment of IRC in both eyes with and without microvascular leakage (ML). This research suggests that bromfenac may not be effective in this context. [Extracted from the article]

Carboxymethyl chitosan (CMCS)-based hydrogels have antibacterial activity, and have shown the abilities of preventing wound infection, promoting cell proliferation, accelerating collagen deposition, and stimulating hyaluronic acid formation during wound healing. As a hormone produced by the pineal gland in humans and animals, melatonin promotes skin wound healing by regulating the release of inflammatory mediators and accelerating the proliferation and migration of cells, angiogenesis, and collagen deposition. However, the combined effects of CMCS and melatonin on wound healing remain unclear. Injectable CMCS-based hydrogels containing melatonin were prepared, and their healing effects were evaluated using a full-thickness cutaneous wound model in rats. Compared with the control and the hydrogel with no melatonin groups, the melatonin-loaded hydrogel significantly increased the percentage of wound closure, promoted the proliferation of granulation tissue and re-epithelialization, and accelerated collagen deposition. Additionally, the melatonin-loaded hydrogel promoted angiogenesis and vascular endothelial growth factor receptor protein expression and increased the expression of cyclooxygenase-2 and inducible nitric oxide synthase. The melatonin-loaded hydrogel also markedly increased the expression of collagen III, α-smooth muscle actin, and transforming growth factor-β1 proteins and reduced collagen I expression. These results suggest that the melatonin-loaded hydrogel promoted granulation tissue formation and accelerated wound healing by reducing inflammation and promoting angiogenesis and collagen deposition. [ABSTRACT FROM AUTHOR]

Oklahoma City, State:Oklahoma, United States, North and Central America, Analgesics, Antiinflammatory, Antiinflammatory Agents, Bromfenac Therapy, Cyclooxygenase Inhibitors, Diclofenac Therapy, Drugs and Therapies, Health and Medicine, Ketorolac Therapy, NSAID, NSAIDS Therapy, Non-Steroidal Antiinflammatory Agents, Ophthalmic Antiinflammatory Agents, Ophthalmic Preparations, Pharmaceuticals, Non-Steroidal Anti-Inflammatory Agents Keywords: Oklahoma City; State:Oklahoma; United States; North and Central America; Analgesics; Antiinflammatory; Antiinflammatory Agents; Bromfenac Therapy; Cyclooxygenase Inhibitors; Diclofenac Therapy; Drugs and Therapies; Health and Medicine; Ketorolac Therapy; NSAID; NSAIDS Therapy; Non-Steroidal Anti-Inflammatory Agents; Non-Steroidal Antiinflammatory Agents; Ophthalmic Antiinflammatory Agents; Ophthalmic Preparations; Pharmaceuticals EN Oklahoma City State:Oklahoma United States North and Central America Analgesics Antiinflammatory Antiinflammatory Agents Bromfenac Therapy Cyclooxygenase Inhibitors Diclofenac Therapy Drugs and Therapies Health and Medicine Ketorolac Therapy NSAID NSAIDS Therapy Non-Steroidal Anti-Inflammatory Agents Non-Steroidal Antiinflammatory Agents Ophthalmic Antiinflammatory Agents Ophthalmic Preparations Pharmaceuticals 766 766 1 11/06/23 20231110 NES 231110 2023 NOV 10 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on Drugs and Therapies - Ophthalmic Antiinflammatory Agents have been published. [Extracted from the article]

Keywords for this news article include: Navi Mumbai, India, Asia, Analgesics, Antiinflammatory, Bromfenac Therapy, Drugs and Therapies, Health and Medicine, Medical Devices, Ophthalmic Antiinflammatory Agents, Ophthalmic Preparations, Ophthalmic Solution, Pharmaceutical Solutions, Pharmaceuticals, Department of Quality Assurance. Keywords: Navi Mumbai; India; Asia; Analgesics; Antiinflammatory; Bromfenac Therapy; Drugs and Therapies; Health and Medicine; Medical Devices; Ophthalmic Antiinflammatory Agents; Ophthalmic Preparations; Ophthalmic Solution; Pharmaceutical Solutions; Pharmaceuticals EN Navi Mumbai India Asia Analgesics Antiinflammatory Bromfenac Therapy Drugs and Therapies Health and Medicine Medical Devices Ophthalmic Antiinflammatory Agents Ophthalmic Preparations Ophthalmic Solution Pharmaceutical Solutions Pharmaceuticals 2023 FEB 3 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Current study results on Drugs and Therapies - Ophthalmic Antiinflammatory Agents have been published. Navi Mumbai, India, Asia, Analgesics, Antiinflammatory, Bromfenac Therapy, Drugs and Therapies, Health and Medicine, Medical Devices, Ophthalmic Antiinflammatory Agents, Ophthalmic Preparations, Pharmaceutical Solutions, Ophthalmic Solution, Pharmaceuticals. [Extracted from the article]

Ingested macroalgae and its extracts can provide antiaging benefits such as inhibition of matrix enzymes, glycation, inflammatory activity and elastin calcification. Here, the authors investigated macroalgal extracts on insulin levels of test subjects to determine whether they could control glucose levels. [ABSTRACT FROM AUTHOR]

Discusses research being done on cyclooxygenase (COX)-2 inhibitors which can reduce postoperative complications of laparoscopic surgery. Reference to a study by Doctor Tong Joo Gan published in the June 2004 issue of the journal "Anesthesia & Analgesia"; Overview of the study; Results of the multicenter Phase III clinical trial on the use of COX-2.